{"id":"https://openalex.org/W7204258635","doi":"https://doi.org/10.1002/jat.70416","title":"Advances in the Intestinal Toxicity of Microcystin\u2010LR","display_name":"Advances in the Intestinal Toxicity of Microcystin\u2010LR","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204258635","doi":"https://doi.org/10.1002/jat.70416","pmid":"https://pubmed.ncbi.nlm.nih.gov/42648663"},"language":"en","primary_location":{"id":"doi:10.1002/jat.70416","doi":"https://doi.org/10.1002/jat.70416","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jat.70416","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jat.70416","source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7204258635"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jat.70416","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057639176","display_name":"Yichen Li","orcid":"https://orcid.org/0000-0001-5210-2496","observed_orcids":["https://orcid.org/0000-0001-5210-2496"]},"institutions":[{"id":"https://openalex.org/I4400600959","display_name":"Nanfang College Guangzhou","ror":"https://ror.org/04vrxqg89","country_code":"CN","type":"education","lineage":["https://openalex.org/I4400600959"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yichen Li","raw_affiliation_strings":["School of Nursing and Health Nanfang College Guangzhou  Guangzhou Guangdong China"],"raw_orcid":"https://orcid.org/0000-0001-5210-2496","affiliations":[{"raw_affiliation_string":"School of Nursing and Health Nanfang College Guangzhou  Guangzhou Guangdong China","institution_ids":["https://openalex.org/I4400600959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088347398","display_name":"Jiaqian Gong","orcid":"https://orcid.org/0000-0002-2750-8774","observed_orcids":["https://orcid.org/0000-0002-2750-8774"]},"institutions":[{"id":"https://openalex.org/I4400600959","display_name":"Nanfang College Guangzhou","ror":"https://ror.org/04vrxqg89","country_code":"CN","type":"education","lineage":["https://openalex.org/I4400600959"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaqian Gong","raw_affiliation_strings":["School of Nursing and Health Nanfang College Guangzhou  Guangzhou Guangdong China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing and Health Nanfang College Guangzhou  Guangzhou Guangdong China","institution_ids":["https://openalex.org/I4400600959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148376969","display_name":"Rui Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400600959","display_name":"Nanfang College Guangzhou","ror":"https://ror.org/04vrxqg89","country_code":"CN","type":"education","lineage":["https://openalex.org/I4400600959"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Liu","raw_affiliation_strings":["School of Nursing and Health Nanfang College Guangzhou  Guangzhou Guangdong China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing and Health Nanfang College Guangzhou  Guangzhou Guangdong China","institution_ids":["https://openalex.org/I4400600959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5148285252","display_name":"Yuehang Zhang","orcid":"https://orcid.org/0009-0001-3402-3003","observed_orcids":["https://orcid.org/0009-0001-3402-3003"]},"institutions":[{"id":"https://openalex.org/I4400600959","display_name":"Nanfang College Guangzhou","ror":"https://ror.org/04vrxqg89","country_code":"CN","type":"education","lineage":["https://openalex.org/I4400600959"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuehang Zhang","raw_affiliation_strings":["School of Nursing and Health Nanfang College Guangzhou  Guangzhou Guangdong China"],"raw_orcid":"https://orcid.org/0009-0001-3402-3003","affiliations":[{"raw_affiliation_string":"School of Nursing and Health Nanfang College Guangzhou  Guangzhou Guangdong China","institution_ids":["https://openalex.org/I4400600959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057639176","https://openalex.org/A5148285252"],"corresponding_institution_ids":["https://openalex.org/I4400600959"],"apc_list":{"value":3940,"currency":"USD","value_usd":3940},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10236","display_name":"Aquatic Ecosystems and Phytoplankton Dynamics","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10236","display_name":"Aquatic Ecosystems and Phytoplankton Dynamics","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.04569999873638153,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microcystin-lr","display_name":"microcystin-LR","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyanotoxins","display_name":"cyanotoxins","score":0.9409999847412109},{"id":"https://openalex.org/keywords/intestinal-toxicity","display_name":"intestinal toxicity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/intestinal-barrier-dysfunction","display_name":"intestinal barrier dysfunction","score":0.4869999885559082},{"id":"https://openalex.org/keywords/epithelial-cell-apoptosis","display_name":"epithelial apoptosis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/protein-phosphatase-2a-inhibition","display_name":"protein phosphatase 2A inhibition","score":0.824999988079071},{"id":"https://openalex.org/keywords/organic-anion-transporting-polypeptides","display_name":"organic anion transporting polypeptides","score":0.8169999718666077},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7400000095367432},{"id":"https://openalex.org/keywords/tight-junction-disassembly","display_name":"tight junction disassembly","score":0.7829999923706055},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.5669999718666077},{"id":"https://openalex.org/keywords/intestinal-fibrosis","display_name":"intestinal fibrosis","score":0.8349999785423279},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.6890000104904175},{"id":"https://openalex.org/keywords/colitis","display_name":"colitis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/repeated-low-dose-exposure","display_name":"repeated low-dose exposure","score":0.6869999766349792},{"id":"https://openalex.org/keywords/dose-metrics","display_name":"dose metrics","score":0.4880000054836273},{"id":"https://openalex.org/keywords/benchmark-dose","display_name":"benchmark dose","score":0.5699999928474426},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/organoids","display_name":"organoids","score":0.5609999895095825},{"id":"https://openalex.org/keywords/organ-on-a-chip","display_name":"organ-on-a-chip","score":0.7409999966621399},{"id":"https://openalex.org/keywords/biomonitoring","display_name":"biomonitoring","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5410000085830688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42250001430511475},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.41350001096725464},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.40790000557899475},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.4043000042438507},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.3772999942302704},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.3756999969482422},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3619999885559082},{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.36070001125335693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3495999872684479},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.3443000018596649},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.33970001339912415},{"id":"https://openalex.org/C2781077229","wikidata":"https://www.wikidata.org/wiki/Q509615","display_name":"Intestinal epithelium","level":3,"score":0.3228999972343445},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.3163999915122986},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3095000088214874},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.3066999912261963},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.2992999851703644},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.2897000014781952},{"id":"https://openalex.org/C91478284","wikidata":"https://www.wikidata.org/wiki/Q6623796","display_name":"Human microbiome","level":3,"score":0.28200000524520874},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2782999873161316},{"id":"https://openalex.org/C2778620825","wikidata":"https://www.wikidata.org/wiki/Q1344633","display_name":"Enterohepatic circulation","level":3,"score":0.2623000144958496},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.26010000705718994},{"id":"https://openalex.org/C5426402","wikidata":"https://www.wikidata.org/wiki/Q2462753","display_name":"Brush border","level":4,"score":0.25999999046325684},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.2547000050544739},{"id":"https://openalex.org/C60903277","wikidata":"https://www.wikidata.org/wiki/Q2051926","display_name":"Paracellular transport","level":4,"score":0.25099998712539673},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.25029999017715454}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/jat.70416","doi":"https://doi.org/10.1002/jat.70416","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jat.70416","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jat.70416","source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},{"id":"pmid:42648663","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42648663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied toxicology : JAT","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jat.70416","doi":"https://doi.org/10.1002/jat.70416","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jat.70416","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jat.70416","source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204258635.pdf","grobid_xml":"https://content.openalex.org/works/W7204258635.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W126513398","https://openalex.org/W995307724","https://openalex.org/W1420654867","https://openalex.org/W1510980283","https://openalex.org/W1563660110","https://openalex.org/W1964833864","https://openalex.org/W1965259190","https://openalex.org/W1977532369","https://openalex.org/W1982607634","https://openalex.org/W1989514272","https://openalex.org/W1989957948","https://openalex.org/W1991862615","https://openalex.org/W1992152650","https://openalex.org/W1997511772","https://openalex.org/W2003449465","https://openalex.org/W2003625111","https://openalex.org/W2009164922","https://openalex.org/W2014631152","https://openalex.org/W2027936250","https://openalex.org/W2028502756","https://openalex.org/W2032308096","https://openalex.org/W2037315861","https://openalex.org/W2043099341","https://openalex.org/W2044506041","https://openalex.org/W2046543329","https://openalex.org/W2054334092","https://openalex.org/W2055965181","https://openalex.org/W2061583677","https://openalex.org/W2076359497","https://openalex.org/W2078835487","https://openalex.org/W2082184681","https://openalex.org/W2086667809","https://openalex.org/W2087746854","https://openalex.org/W2112965326","https://openalex.org/W2117269373","https://openalex.org/W2121276791","https://openalex.org/W2137190583","https://openalex.org/W2141552265","https://openalex.org/W2161923688","https://openalex.org/W2165322824","https://openalex.org/W2296783531","https://openalex.org/W2301567083","https://openalex.org/W2346722402","https://openalex.org/W2360751755","https://openalex.org/W2532183954","https://openalex.org/W2550681015","https://openalex.org/W2561672841","https://openalex.org/W2611882427","https://openalex.org/W2769599326","https://openalex.org/W2845256475","https://openalex.org/W2896724137","https://openalex.org/W2897072199","https://openalex.org/W2901893273","https://openalex.org/W2920009718","https://openalex.org/W2922685652","https://openalex.org/W2924894060","https://openalex.org/W2952564192","https://openalex.org/W2954737258","https://openalex.org/W2969503562","https://openalex.org/W2981463430","https://openalex.org/W2981557809","https://openalex.org/W2990133921","https://openalex.org/W2994894533","https://openalex.org/W3011692720","https://openalex.org/W3025070220","https://openalex.org/W3035580632","https://openalex.org/W3038417277","https://openalex.org/W3047678113","https://openalex.org/W3082231844","https://openalex.org/W3086494806","https://openalex.org/W3111720985","https://openalex.org/W3174457351","https://openalex.org/W3200095756","https://openalex.org/W4211010233","https://openalex.org/W4220746595","https://openalex.org/W4226402490","https://openalex.org/W4284883520","https://openalex.org/W4288040086","https://openalex.org/W4292416083","https://openalex.org/W4293150465","https://openalex.org/W4306969019","https://openalex.org/W4310532679","https://openalex.org/W4316497956","https://openalex.org/W4396509742","https://openalex.org/W4396611878","https://openalex.org/W4396625888","https://openalex.org/W4400934692","https://openalex.org/W4402713482","https://openalex.org/W4406249224","https://openalex.org/W4406348773","https://openalex.org/W4406877192","https://openalex.org/W4407396665","https://openalex.org/W4417104532","https://openalex.org/W7160099323"],"related_works":["https://openalex.org/W4292416083","https://openalex.org/W2532183954","https://openalex.org/W4410856025","https://openalex.org/W3187967372","https://openalex.org/W995307724","https://openalex.org/W4406249224","https://openalex.org/W2901893273","https://openalex.org/W4396611878","https://openalex.org/W2028502756","https://openalex.org/W4400934692"],"abstract_inverted_index":{"Microcystin-LR":[0],"(MC-LR),":[1],"the":[2,23,26],"most":[3],"prevalent":[4],"and":[5,20,40,52,57,72,90,93,98,107,122,132,137,141,154,171,183,189,198],"toxic":[6,55],"microcystin":[7],"congener,":[8],"is":[9,25,33],"a":[10,35,41,148],"persistent":[11],"cyanotoxin":[12],"that":[13,118],"reaches":[14],"humans":[15],"mainly":[16],"through":[17],"contaminated":[18],"water":[19],"food.":[21],"Because":[22],"intestine":[24],"first":[27],"tissue":[28],"exposed":[29],"after":[30],"ingestion,":[31],"it":[32],"both":[34],"portal":[36],"of":[37,109],"systemic":[38,155],"uptake":[39,106],"direct":[42],"toxicological":[43],"target.":[44],"This":[45],"review":[46],"integrates":[47],"evidence":[48],"on":[49],"intestinal":[50,187],"distribution":[51],"absorption,":[53],"exposure-dependent":[54],"phenotypes,":[56],"molecular":[58],"mechanisms.":[59],"Acute":[60],"or":[61,81],"high-dose":[62],"exposure":[63,78,169],"predominantly":[64],"causes":[65],"villus":[66],"erosion,":[67],"epithelial":[68],"apoptosis,":[69,135],"cytoskeletal":[70],"collapse,":[71],"rapid":[73],"barrier":[74],"failure,":[75],"whereas":[76],"repeated":[77],"at":[79],"low":[80],"environmentally":[82,180],"relevant":[83],"doses":[84],"produces":[85],"low-grade":[86],"inflammation,":[87],"fibrosis,":[88],"microbiota":[89,143],"metabolite":[91],"dysregulation,":[92],"increased":[94],"susceptibility":[95],"to":[96],"colitis":[97],"colorectal":[99],"tumor":[100],"progression.":[101],"Mechanistically,":[102],"organic":[103],"anion-transporting":[104],"polypeptide-mediated":[105],"inhibition":[108],"protein":[110,120],"phosphatase":[111],"2A":[112],"(PP2A)":[113],"act":[114],"as":[115],"upstream":[116],"events":[117],"promote":[119],"hyperphosphorylation":[121],"interconnected":[123],"oxidative":[124],"stress,":[125],"DNA":[126],"damage,":[127],"tight-junction":[128],"disassembly,":[129],"inflammatory":[130],"signaling,":[131],"dysregulated":[133],"proliferation,":[134],"migration,":[136],"invasion.":[138],"Recent":[139],"multiomics":[140],"fecal":[142],"transplantation":[144],"studies":[145,177],"further":[146],"support":[147],"bidirectional":[149],"microbiota-barrier-immune":[150],"axis":[151],"in":[152],"local":[153],"effects.":[156],"Quantitative":[157],"interpretation":[158],"nevertheless":[159],"remains":[160],"limited":[161],"by":[162],"heterogeneous":[163],"dose":[164],"metrics,":[165],"short":[166],"experiments,":[167],"nonphysiological":[168],"routes,":[170],"scarce":[172],"human":[173,186],"longitudinal":[174,196],"data.":[175],"Future":[176],"should":[178],"prioritize":[179],"realistic":[181],"chronic":[182],"mixture":[184],"exposures,":[185],"organoids":[188],"organ-on-chip":[190],"systems,":[191],"causal":[192],"PP2A":[193],"pathway":[194],"perturbation,":[195],"biomonitoring,":[197],"harmonized":[199],"benchmark-dose":[200],"analyses.":[201]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-27T00:00:00"}