{"id":"https://openalex.org/W7204258538","doi":"https://doi.org/10.5603/ahp.112614","title":"Preliminary report on prophylaxis with emicizumab in Polish infants with hemophilia A","display_name":"Preliminary report on prophylaxis with emicizumab in Polish infants with hemophilia A","publication_year":2026,"publication_date":"2026-08-18","ids":{"openalex":"https://openalex.org/W7204258538","doi":"https://doi.org/10.5603/ahp.112614"},"language":"en","primary_location":{"id":"doi:10.5603/ahp.112614","doi":"https://doi.org/10.5603/ahp.112614","is_oa":true,"landing_page_url":"https://doi.org/10.5603/ahp.112614","pdf_url":"https://journals.viamedica.pl/acta_haematologica_polonica/article/download/112614/90814","source":{"id":"https://openalex.org/S2756040689","display_name":"Acta Haematologica Polonica","issn_l":"0001-5814","issn":["0001-5814","2300-7117"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["ddh","doaj","norway-1","poland-100","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica Polonica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.viamedica.pl/acta_haematologica_polonica/article/download/112614/90814","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005488116","display_name":"Tomasz Urasi\u0144ski","orcid":"https://orcid.org/0000-0003-3107-8575","observed_orcids":["https://orcid.org/0000-0003-3107-8575"]},"institutions":[{"id":"https://openalex.org/I79833322","display_name":"Pomeranian Medical University","ror":"https://ror.org/01v1rak05","country_code":"PL","type":"education","lineage":["https://openalex.org/I79833322"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Tomasz Urasi\u0144ski","raw_affiliation_strings":["Department of Pediatrics and Hemato-Oncology, Pomeranian Medical University in Szczecin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Hemato-Oncology, Pomeranian Medical University in Szczecin, Poland","institution_ids":["https://openalex.org/I79833322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007325086","display_name":"Karolina Ewa Zielezi\u0144ska","orcid":"https://orcid.org/0000-0002-2507-4853","observed_orcids":["https://orcid.org/0000-0002-2507-4853"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Karolina Zielezi\u0144ska","raw_affiliation_strings":["Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128428840","display_name":"Magdalena Bartnik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79833322","display_name":"Pomeranian Medical University","ror":"https://ror.org/01v1rak05","country_code":"PL","type":"education","lineage":["https://openalex.org/I79833322"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Magdalena Bartnik","raw_affiliation_strings":["Department of Pediatrics and Hemato-Oncology, Pomeranian Medical University in Szczecin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Hemato-Oncology, Pomeranian Medical University in Szczecin, Poland","institution_ids":["https://openalex.org/I79833322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051111839","display_name":"Olga Zaj\u0105c\u2010Spycha\u0142a","orcid":"https://orcid.org/0000-0002-8836-8605","observed_orcids":["https://orcid.org/0000-0002-8836-8605"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Olga Zaj\u0105c-Spycha\u0142a","raw_affiliation_strings":["Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091190295","display_name":"Andrzej Ko\u0142tan","orcid":"https://orcid.org/0000-0003-2399-6157","observed_orcids":["https://orcid.org/0000-0003-2399-6157"]},"institutions":[{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]},{"id":"https://openalex.org/I4210148386","display_name":"Collegium Medicum in Bydgoszcz","ror":"https://ror.org/04c5jwj47","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933","https://openalex.org/I4210148386"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Andrzej Ko\u0142tan","raw_affiliation_strings":["Department of Pediatric Hematology, Oncology, Immunology and Transplantology, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology, Oncology, Immunology and Transplantology, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland","institution_ids":["https://openalex.org/I3019271933","https://openalex.org/I4210148386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081355682","display_name":"Julia Rado\u0144\u2010Proskura","orcid":"https://orcid.org/0000-0002-0097-1857","observed_orcids":["https://orcid.org/0000-0002-0097-1857"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Julia Rado\u0144-Proskura","raw_affiliation_strings":["Department of Pediatrics, Hematology and Oncology, Medical University of Gdansk, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Hematology and Oncology, Medical University of Gdansk, Poland","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088769353","display_name":"Danuta Pietrys","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Danuta Pietrys","raw_affiliation_strings":["Department of Pediatric Oncology and Hematology, Collegium Medicum, Jagiellonian University, Cracow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology and Hematology, Collegium Medicum, Jagiellonian University, Cracow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058940624","display_name":"Magdalena Wojdalska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Magdalena Wojdalska","raw_affiliation_strings":["Department of Pediatrics, Oncology and Hematology, Medical University of Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Oncology and Hematology, Medical University of Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054179616","display_name":"Iwona Rura\u0144ska","orcid":"https://orcid.org/0000-0003-0481-5859","observed_orcids":["https://orcid.org/0000-0003-0481-5859"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Iwona Rura\u0144ska","raw_affiliation_strings":["Department of Pediatrics, Hematology and Oncology, Medical University of Silesia, Katowice, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Hematology and Oncology, Medical University of Silesia, Katowice, Poland","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114377010","display_name":"Tomasz Ociepa","orcid":"https://orcid.org/0000-0002-0068-4436","observed_orcids":["https://orcid.org/0000-0002-0068-4436"]},"institutions":[{"id":"https://openalex.org/I79833322","display_name":"Pomeranian Medical University","ror":"https://ror.org/01v1rak05","country_code":"PL","type":"education","lineage":["https://openalex.org/I79833322"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Tomasz Ociepa","raw_affiliation_strings":["Department of Pediatrics and Hemato-Oncology, Pomeranian Medical University in Szczecin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Hemato-Oncology, Pomeranian Medical University in Szczecin, Poland","institution_ids":["https://openalex.org/I79833322"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.5770691,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/emicizumab","display_name":"emicizumab","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hemophilia-a","display_name":"hemophilia A","score":0.9549999833106995},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.593999981880188},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/intracerebral-hemorrhage","display_name":"intracerebral hemorrhage","score":0.7730000019073486},{"id":"https://openalex.org/keywords/central-venous-access","display_name":"central venous access","score":0.6449999809265137},{"id":"https://openalex.org/keywords/real-world-experience","display_name":"real-world experience","score":0.6269999742507935},{"id":"https://openalex.org/keywords/poland","display_name":"Poland","score":0.6959999799728394},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8391000032424927},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.6873999834060669},{"id":"https://openalex.org/C2780446839","wikidata":"https://www.wikidata.org/wiki/Q23808142","display_name":"Venous access","level":3,"score":0.4507000148296356},{"id":"https://openalex.org/C3018901854","wikidata":"https://www.wikidata.org/wiki/Q1329523","display_name":"Preliminary report","level":2,"score":0.3068000078201294},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.30410000681877136},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.26660001277923584},{"id":"https://openalex.org/C3017960651","wikidata":"https://www.wikidata.org/wiki/Q92783654","display_name":"Sick child","level":2,"score":0.23360000550746918},{"id":"https://openalex.org/C2986834420","wikidata":"https://www.wikidata.org/wiki/Q5932254","display_name":"Age groups","level":2,"score":0.226500004529953},{"id":"https://openalex.org/C66882249","wikidata":"https://www.wikidata.org/wiki/Q169336","display_name":"Homogeneous","level":2,"score":0.21979999542236328},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21570000052452087}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5603/ahp.112614","doi":"https://doi.org/10.5603/ahp.112614","is_oa":true,"landing_page_url":"https://doi.org/10.5603/ahp.112614","pdf_url":"https://journals.viamedica.pl/acta_haematologica_polonica/article/download/112614/90814","source":{"id":"https://openalex.org/S2756040689","display_name":"Acta Haematologica Polonica","issn_l":"0001-5814","issn":["0001-5814","2300-7117"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["ddh","doaj","norway-1","poland-100","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica Polonica","raw_type":"journal-article"},{"id":"pmh:oai:czasopisma.viamedica.pl:article/112614","doi":null,"is_oa":true,"landing_page_url":"https://journals.viamedica.pl/acta_haematologica_polonica/article/view/112614","pdf_url":"https://journals.viamedica.pl/acta_haematologica_polonica/article/download/112614/91958","source":{"id":"https://openalex.org/S4377196119","display_name":"Via Medica Journals","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Haematologica Polonica; Vol 57, No 5 (2026); 353-359","raw_type":"Peer-reviewed Article"}],"best_oa_location":{"id":"doi:10.5603/ahp.112614","doi":"https://doi.org/10.5603/ahp.112614","is_oa":true,"landing_page_url":"https://doi.org/10.5603/ahp.112614","pdf_url":"https://journals.viamedica.pl/acta_haematologica_polonica/article/download/112614/90814","source":{"id":"https://openalex.org/S2756040689","display_name":"Acta Haematologica Polonica","issn_l":"0001-5814","issn":["0001-5814","2300-7117"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["ddh","doaj","norway-1","poland-100","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica Polonica","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204258538.pdf","grobid_xml":"https://content.openalex.org/works/W7204258538.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392664785","https://openalex.org/W4417006732","https://openalex.org/W4390047763","https://openalex.org/W7168258627","https://openalex.org/W4327932185","https://openalex.org/W4389247870","https://openalex.org/W4391160337","https://openalex.org/W3163975776","https://openalex.org/W4310108086","https://openalex.org/W4416098935"],"abstract_inverted_index":{"Introduction:":[0],"ICH":[1,258,332],"and":[2,26,67,107,111,122,132,149,192,259,287],"early-life":[3],"bleeding":[4,119,326],"remain":[5],"major":[6],"threats":[7],"in":[8,53,180,315],"infants":[9,54,171,177,199,210,229,251,272,316],"with":[10,50,55,273,317,322],"severe":[11,56,318],"HA.":[12],"In":[13,265,306],"infancy,":[14],"intravenous":[15],"FVIII":[16,88,212],"prophylaxis":[17,38,52,101,314],"may":[18],"be":[19],"delayed":[20],"because":[21,183,202],"of":[22,40,94,221,243,271],"difficult":[23],"venous":[24,32,41],"access":[25,33],"the":[27,62,103,156,181,189,269,293,342],"potential":[28],"need":[29],"for":[30,173],"central":[31],"devices.":[34],"Subcutaneous":[35],"emicizumab":[36,51,100,124,174,187,244,313,339],"enables":[37],"independent":[39],"access.":[42],"To":[43],"describe":[44],"early":[45],"Polish":[46,78],"multicentre":[47,72,310],"real-world":[48],"experience":[49],"HA":[57,84,319],"following":[58],"its":[59],"introduction":[60],"into":[61],"national":[63,71,309],"treatment":[64,203],"programme.":[65],"Material":[66],"methods:":[68],"This":[69],"retrospective":[70],"questionnaire-based":[73,311],"survey":[74],"was":[75,85,216,320,344],"conducted":[76],"among":[77],"paediatric":[79],"hemophilia":[80],"care":[81],"centres.":[82],"Severe":[83],"defined":[86],"as":[87,164],"activity":[89],"<1":[90],"IU/dL":[91],"or":[92,333,351],"<1%":[93],"normal":[95],"activity.":[96],"Infants":[97],"who":[98],"started":[99,186],"by":[102,188],"predefined":[104],"data":[105,114,131,190],"cut-off":[106,191],"had":[108,185,193,204,230,252],"available":[109],"pre-":[110],"post-emicizumab":[112],"follow-up":[113,194,245],"were":[115,126,143,153,162,178,200,211,263,303,336],"included.":[116],"Reported":[117],"treated":[118,232,254,275,325],"episodes":[120,327],"before":[121],"after":[123],"initiation":[125],"described":[127],"using":[128,145,155],"individual":[129,288],"patient":[130],"cABR":[133,151,289],"(treated":[134],"bleeds/observation":[135],"months":[136,220,247],"\u00d7":[137],"12).":[138],"Paired":[139],"before-after":[140],"binary":[141],"outcomes":[142,350],"explored":[144],"McNemar's":[146,280],"exact":[147,281],"test,":[148],"paired":[150,267],"values":[152,161],"compared":[154],"Wilcoxon":[157,294],"signed-rank":[158,295],"test.":[159],"p":[160,284,298],"interpreted":[163],"exploratory.":[165],"Results:":[166],"Six":[167],"centres":[168],"reported":[169,231,253,274,324,337],"13":[170],"considered":[172],"prophylaxis;":[175],"11":[176],"included":[179],"analysis":[182],"they":[184],"data.":[195],"The":[196],"remaining":[197],"two":[198],"excluded":[201],"not":[205,345],"yet":[206],"started.":[207],"All":[208],"analysed":[209],"inhibitor":[213],"negative.":[214],"Emicizumab":[215],"initiated":[217],"at":[218],"2\u201310":[219],"age":[222],"(median":[223],"7":[224],"months).":[225],"Before":[226],"emicizumab,":[227],"10/11":[228],"bleeds":[233,276],"over":[234],"66":[235],"infant-months,":[236],"including":[237],"one":[238],"ICH.":[239],"During":[240],"105":[241],"infant-months":[242],"(5\u201312":[246],"per":[248],"patient),":[249],"2/11":[250],"soft-tissue":[255],"bleeds;":[256],"no":[257,260],"adverse":[261,334],"events":[262,335],"reported.":[264,304],"exploratory":[266],"analyses,":[268],"proportion":[270],"decreased":[277,290],"according":[278,291],"to":[279,292,347],"test":[282,296],"(":[283,297],"=":[285,299],"0.0078),":[286],"0.002).":[300],"No":[301,331],"AE/SAE":[302],"Conclusions:":[305],"this":[307],"small":[308],"survey,":[312],"associated":[321],"fewer":[323],"during":[328,338],"short":[329],"follow-up.":[330],"exposure,":[340],"but":[341],"study":[343],"powered":[346],"assess":[348],"rare":[349],"long-term":[352],"safety.":[353]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-08-27T00:00:00"}
