{"id":"https://openalex.org/W7204258109","doi":"https://doi.org/10.64898/2026.08.25.746685","title":"The Leiden ex vivo human growth plate model in severe tall stature: a proof-of-concept study","display_name":"The Leiden ex vivo human growth plate model in severe tall stature: a proof-of-concept study","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204258109","doi":"https://doi.org/10.64898/2026.08.25.746685"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.25.746685","doi":"https://doi.org/10.64898/2026.08.25.746685","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.25.746685","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/26/2026.08.25.746685.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/26/2026.08.25.746685.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091716086","display_name":"Margo Tuerlings","orcid":"https://orcid.org/0000-0002-1728-7488","observed_orcids":["https://orcid.org/0000-0002-1728-7488"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Margo Tuerlings","raw_affiliation_strings":["Dept. of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-1728-7488","affiliations":[{"raw_affiliation_string":"Dept. of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088267152","display_name":"Y.F. Ramos","orcid":"https://orcid.org/0000-0003-1459-413X","observed_orcids":["https://orcid.org/0000-0003-1459-413X"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Yolande F. M. Ramos","raw_affiliation_strings":["Dept. of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044232630","display_name":"H. Eka D. Suchiman","orcid":"https://orcid.org/0000-0002-7168-5516","observed_orcids":["https://orcid.org/0000-0002-7168-5516"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Helena E. D. Suchiman","raw_affiliation_strings":["Dept. of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073533996","display_name":"Sayedeh Sana Sayedipour","orcid":"https://orcid.org/0000-0002-6686-3074","observed_orcids":["https://orcid.org/0000-0002-6686-3074"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sana S. Sayedipour","raw_affiliation_strings":["Dept. of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-6686-3074","affiliations":[{"raw_affiliation_string":"Dept. of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035387053","display_name":"Sjoerd D. Joustra","orcid":"https://orcid.org/0000-0002-4733-9031","observed_orcids":["https://orcid.org/0000-0002-4733-9031"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I4210131008","display_name":"Willem-Alexander Kinderziekenhuis","ror":"https://ror.org/02xmm1048","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800006345","https://openalex.org/I4210131008"]},{"id":"https://openalex.org/I4210163052","display_name":"Spaarne Gasthuis","ror":"https://ror.org/05d7whc82","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210163052"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sjoerd D. Joustra","raw_affiliation_strings":["Dept. of Paediatric Endocrinology, Willem-Alexander Children\u2019s Hospital, Leiden University Medical Centre, the Netherlands","Dept. of Pediatrics, Spaarne Gasthuis, Haarlem, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Paediatric Endocrinology, Willem-Alexander Children\u2019s Hospital, Leiden University Medical Centre, the Netherlands","institution_ids":["https://openalex.org/I2800006345","https://openalex.org/I4210131008"]},{"raw_affiliation_string":"Dept. of Pediatrics, Spaarne Gasthuis, Haarlem, the Netherlands","institution_ids":["https://openalex.org/I4210163052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148252178","display_name":"Anika Rabelink-Hoogenstraaten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anika Rabelink-Hoogenstraaten","raw_affiliation_strings":["Dept. of Orthopedics, Leiden University Medical Centre, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Orthopedics, Leiden University Medical Centre, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005592998","display_name":"Hermine A. van Duyvenvoorde","orcid":"https://orcid.org/0000-0003-0451-2065","observed_orcids":["https://orcid.org/0000-0003-0451-2065"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hermine A. van Duyvenvoorde","raw_affiliation_strings":["Dept. Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001632912","display_name":"Dagmar R. J. Kempink","orcid":"https://orcid.org/0000-0001-9648-1299","observed_orcids":["https://orcid.org/0000-0001-9648-1299"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Dagmar R. J. Kempink","raw_affiliation_strings":["Dept. of Orthopedics & Sports Medicine, Erasmus Medical Centre / Sophia Children\u2019s Hospital, Rotterdam, The Netherlands","Dept. of Orthopedics, Leiden University Medical Centre, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Orthopedics & Sports Medicine, Erasmus Medical Centre / Sophia Children\u2019s Hospital, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]},{"raw_affiliation_string":"Dept. of Orthopedics, Leiden University Medical Centre, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024600958","display_name":"Pieter Bas de Witte","orcid":"https://orcid.org/0000-0001-9550-1630","observed_orcids":["https://orcid.org/0000-0001-9550-1630"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Pieter Bas de Witte","raw_affiliation_strings":["Dept. of Orthopedics, Leiden University Medical Centre, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Orthopedics, Leiden University Medical Centre, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102851246","display_name":"Ingrid Meulenbelt","orcid":"https://orcid.org/0000-0001-7786-7081","observed_orcids":["https://orcid.org/0000-0001-7786-7081"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Ingrid Meulenbelt","raw_affiliation_strings":["Dept. of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-7786-7081","affiliations":[{"raw_affiliation_string":"Dept. of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032332063","display_name":"Christiaan de Bruin","orcid":"https://orcid.org/0000-0003-1478-2261","observed_orcids":["https://orcid.org/0000-0003-1478-2261"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I4210131008","display_name":"Willem-Alexander Kinderziekenhuis","ror":"https://ror.org/02xmm1048","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800006345","https://openalex.org/I4210131008"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Christiaan de Bruin","raw_affiliation_strings":["Dept. of Paediatric Endocrinology, Willem-Alexander Children\u2019s Hospital, Leiden University Medical Centre, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Paediatric Endocrinology, Willem-Alexander Children\u2019s Hospital, Leiden University Medical Centre, the Netherlands","institution_ids":["https://openalex.org/I2800006345","https://openalex.org/I4210131008"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5102851246"],"corresponding_institution_ids":["https://openalex.org/I2800006345"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.04639999940991402,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-plate-chondrocytes","display_name":"growth plate chondrocytes","score":0.7400000095367432},{"id":"https://openalex.org/keywords/percutaneous-epiphysiodesis","display_name":"percutaneous epiphysiodesis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tall-stature","display_name":"tall stature","score":0.7400000095367432},{"id":"https://openalex.org/keywords/endochondral-bone-growth","display_name":"endochondral bone growth","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cartilage-organoids","display_name":"cartilage organoids","score":0.753000020980835},{"id":"https://openalex.org/keywords/chondrocyte-proliferation","display_name":"chondrocyte proliferation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/nodes-of-ranvier","display_name":"nodes of Ranvier","score":0.8149999976158142},{"id":"https://openalex.org/keywords/pediatric-growth-disorders","display_name":"pediatric growth disorders","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cartilage-matrix-deposition","display_name":"cartilage matrix deposition","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.829200029373169},{"id":"https://openalex.org/C17938293","wikidata":"https://www.wikidata.org/wiki/Q3312710","display_name":"Endochondral ossification","level":3,"score":0.5715000033378601},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5479999780654907},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5422999858856201},{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.43160000443458557},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4262999892234802},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41350001096725464},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.3869999945163727},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.37470000982284546},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.37290000915527344},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.3686999976634979},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.3384000062942505},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3028999865055084},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29440000653266907},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.28610000014305115},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.28209999203681946},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.27880001068115234},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.27570000290870667},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.27250000834465027},{"id":"https://openalex.org/C2777969473","wikidata":"https://www.wikidata.org/wiki/Q373000","display_name":"Epiphysiodesis","level":3,"score":0.27129998803138733},{"id":"https://openalex.org/C90703135","wikidata":"https://www.wikidata.org/wiki/Q3287622","display_name":"Tissue culture","level":3,"score":0.26660001277923584},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.2587999999523163},{"id":"https://openalex.org/C2777236700","wikidata":"https://www.wikidata.org/wiki/Q178366","display_name":"Tibia","level":2,"score":0.2574999928474426},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.25450000166893005},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.25279998779296875},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25130000710487366},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.25060001015663147}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.25.746685","doi":"https://doi.org/10.64898/2026.08.25.746685","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.25.746685","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/26/2026.08.25.746685.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.25.746685","doi":"https://doi.org/10.64898/2026.08.25.746685","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.25.746685","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/26/2026.08.25.746685.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320929","display_name":"Universiteit Leiden","ror":"https://ror.org/027bh9e22"},{"id":"https://openalex.org/F4320328278","display_name":"Anna Fonds|NOREF","ror":"https://ror.org/00ptjft67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204258109.pdf","grobid_xml":"https://content.openalex.org/works/W7204258109.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2692003462","https://openalex.org/W4396828316","https://openalex.org/W2367675287","https://openalex.org/W2616640493","https://openalex.org/W2111579848","https://openalex.org/W7163744521","https://openalex.org/W2321244381","https://openalex.org/W4408473609","https://openalex.org/W2075475221","https://openalex.org/W2033995676"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"Viable":[2],"human":[3,18,42,88,202,216],"growth":[4,21,24,43,203,217,239,249],"plate":[5,44,71,204,218,240],"(GP)":[6],"tissue":[7,47,72,127,186,205],"is":[8],"rarely":[9],"available":[10],"for":[11,58],"translational":[12],"research,":[13],"limiting":[14],"direct":[15],"investigation":[16],"of":[17,87,111,135,228,235],"longitudinal":[19],"bone":[20,230],"and":[22,73,79,98,145,156,174,198,242],"pediatric":[23,248],"disorders.":[25,250],"In":[26,167],"this":[27],"proof-ofconcept":[28],"study,":[29],"we":[30],"aimed":[31],"to":[32,35,67,142,183,195,224,237],"determine":[33],"feasibility":[34,194],"establish":[36],"a":[37,158,221],"clinically":[38],"integrated":[39],"ex":[40,214],"vivo":[41,215],"model":[45,219],"using":[46,81],"obtained":[48,130],"during":[49,77],"routine":[50,207],"percutaneous":[51],"epiphysiodesis":[52],"(PE)":[53],"procedures":[54],"in":[55,153,187,247],"adolescents":[56],"treated":[57],"extreme":[59],"tall":[60],"stature":[61],"or":[62],"leg":[63],"length":[64],"difference":[65],"due":[66],"trauma.":[68],"Methods":[69],"Growth":[70],"cells":[74,105,144,170],"were":[75,106],"collected":[76],"PE":[78,208],"processed":[80],"protocols":[82],"adapted":[83],"from":[84,103,206],"established":[85],"methods":[86],"osteoarthritic":[89],"cartilage":[90,100],"collection":[91],"within":[92],"the":[93,133,212],"RAAK":[94],"study.":[95],"Collected":[96],"tissues":[97],"three-dimensional":[99],"pellets":[101],"generated":[102],"isolated":[104],"assessed":[107],"by":[108],"histology.":[109],"Proliferation":[110],"GP-derived":[112,169],"chondrocytes":[113,150],"was":[114],"compared":[115,163],"with":[116,137,164],"osteoarthritis-derived":[117],"articular":[118],"chondrocytes.":[119,166],"Results":[120],"Across":[121],"consecutive":[122],"surgical":[123],"procedures,":[124],"viable":[125,201],"GP":[126,149],"could":[128],"be":[129],"reproducibly":[131],"including":[132],"node":[134],"Ranvier,":[136],"only":[138],"few":[139],"samples":[140],"failing":[141],"yield":[143],"no":[146],"contamination.":[147],"Isolated":[148],"expanded":[151],"successfully":[152],"two-dimensional":[154],"culture":[155],"showed":[157],"stronger":[159],"early":[160],"proliferative":[161],"response":[162],"RAAK-derived":[165],"addition,":[168],"formed":[171],"threedimensional":[172],"organoids":[173],"histology":[175],"confirmed":[176],"cartilage-like":[177],"matrix":[178],"deposition":[179],"supporting":[180],"their":[181],"capacity":[182],"generate":[184],"neo-cartilage":[185],"vitro":[188],".":[189],"Conclusion":[190],"This":[191],"study":[192,225],"demonstrates":[193],"obtain,":[196],"culture,":[197],"functionally":[199],"assess":[200],"surgery.":[209],"As":[210],"such,":[211],"Leiden":[213],"provides":[220],"unique":[222],"platform":[223],"local":[226],"mechanisms":[227],"endochondral":[229],"growth,":[231],"link":[232],"genetic":[233],"determinants":[234],"height":[236],"functional":[238],"biology,":[241],"support":[243],"future":[244],"therapeutic":[245],"research":[246]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-27T00:00:00"}