{"id":"https://openalex.org/W7204255083","doi":"https://doi.org/10.1080/00952990.2026.2717745","title":"Extended-release naltrexone versus buprenorphine-naloxone for opioid use disorder: a systematic review and meta-analysis of randomized controlled trials","display_name":"Extended-release naltrexone versus buprenorphine-naloxone for opioid use disorder: a systematic review and meta-analysis of randomized controlled trials","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204255083","doi":"https://doi.org/10.1080/00952990.2026.2717745","pmid":"https://pubmed.ncbi.nlm.nih.gov/42644692"},"language":"en","primary_location":{"id":"doi:10.1080/00952990.2026.2717745","doi":"https://doi.org/10.1080/00952990.2026.2717745","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00952990.2026.2717745","pdf_url":null,"source":{"id":"https://openalex.org/S162477232","display_name":"The American Journal of Drug and Alcohol Abuse","issn_l":"0095-2990","issn":["0095-2990","1097-9891"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Drug and Alcohol Abuse","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102013851","display_name":"Alper Mert","orcid":"https://orcid.org/0000-0001-5944-9089","observed_orcids":["https://orcid.org/0000-0001-5944-9089"]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Alper Mert","raw_affiliation_strings":["Department of Psychiatry","Ume\u00e5 University"],"raw_orcid":"https://orcid.org/0000-0001-5944-9089","affiliations":[{"raw_affiliation_string":"Department of Psychiatry","institution_ids":[]},{"raw_affiliation_string":"Ume\u00e5 University","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015333022","display_name":"Fevzi Duhan Berkan Kilickan","orcid":"https://orcid.org/0000-0002-0893-3476","observed_orcids":["https://orcid.org/0000-0002-0893-3476"]},"institutions":[{"id":"https://openalex.org/I55271957","display_name":"Surrey and Borders Partnership NHS Foundation Trust","ror":"https://ror.org/00f83h470","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I55271957"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Duhan K\u0131l\u0131\u00e7kan","raw_affiliation_strings":["Surrey and Borders Partnership NHS Foundation Trust"],"raw_orcid":"https://orcid.org/0000-0002-0893-3476","affiliations":[{"raw_affiliation_string":"Surrey and Borders Partnership NHS Foundation Trust","institution_ids":["https://openalex.org/I55271957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038797117","display_name":"Maria Luiza Rodrigues Defante","orcid":"https://orcid.org/0000-0003-0524-5616","observed_orcids":["https://orcid.org/0000-0003-0524-5616"]},"institutions":[{"id":"https://openalex.org/I4210111429","display_name":"Hospital S\u00e3o Vicente de Paulo","ror":"https://ror.org/01pmf1z12","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210111429"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Luiza Rodrigues Defante","raw_affiliation_strings":["Centro Universit\u00e1rio Redentor Afya (UniRedentor/Afya)","Hospital S\u00e3o Vicente de Paulo"],"raw_orcid":"https://orcid.org/0000-0003-0524-5616","affiliations":[{"raw_affiliation_string":"Centro Universit\u00e1rio Redentor Afya (UniRedentor/Afya)","institution_ids":[]},{"raw_affiliation_string":"Hospital S\u00e3o Vicente de Paulo","institution_ids":["https://openalex.org/I4210111429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137819018","display_name":"Samuel I dos Santos Pereira","orcid":"https://orcid.org/0009-0009-7304-8287","observed_orcids":["https://orcid.org/0009-0009-7304-8287"]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Samuel Izaias dos Santos Pereira","raw_affiliation_strings":["University of Buenos Aires"],"raw_orcid":"https://orcid.org/0009-0009-7304-8287","affiliations":[{"raw_affiliation_string":"University of Buenos Aires","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137911869","display_name":"Otavio Andre Farias Sousa da Silva","orcid":"https://orcid.org/0009-0001-9788-7677","observed_orcids":["https://orcid.org/0009-0001-9788-7677"]},"institutions":[{"id":"https://openalex.org/I47327664","display_name":"Universidade Federal do Maranh\u00e3o","ror":"https://ror.org/043fhe951","country_code":"BR","type":"education","lineage":["https://openalex.org/I47327664"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Otavio Andr\u00e9 Farias Sousa da Silva","raw_affiliation_strings":["Universidade Federal do Maranh\u00e3o"],"raw_orcid":"https://orcid.org/0009-0001-9788-7677","affiliations":[{"raw_affiliation_string":"Universidade Federal do Maranh\u00e3o","institution_ids":["https://openalex.org/I47327664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103246821","display_name":"Jussi Jokinen","orcid":"https://orcid.org/0000-0001-6766-7983","observed_orcids":["https://orcid.org/0000-0001-6766-7983"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jussi Jokinen","raw_affiliation_strings":["Karolinska University Hospital","Ume\u00e5 University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska University Hospital","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Ume\u00e5 University","institution_ids":["https://openalex.org/I90267481"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5102013851"],"corresponding_institution_ids":["https://openalex.org/I90267481"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.9139999747276306},{"id":"https://openalex.org/keywords/extended-release-naltrexone","display_name":"extended-release naltrexone","score":1.0},{"id":"https://openalex.org/keywords/buprenorphine-naloxone","display_name":"buprenorphine/naloxone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/opioid-antagonists","display_name":"opioid antagonists","score":0.5839999914169312},{"id":"https://openalex.org/keywords/treatment-initiation","display_name":"treatment initiation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/treatment-retention","display_name":"treatment retention","score":0.9850000143051147},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.9539999961853027},{"id":"https://openalex.org/keywords/efficacy-and-safety-comparison","display_name":"comparative efficacy and safety","score":0.7409999966621399},{"id":"https://openalex.org/keywords/harm-reduction","display_name":"harm reduction","score":0.4729999899864197},{"id":"https://openalex.org/keywords/medication-assisted-treatment","display_name":"medication-assisted treatment","score":0.6460000276565552},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7789999842643738},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.31700000166893005},{"id":"https://openalex.org/keywords/treatment-completion","display_name":"treatment completion","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8813999891281128},{"id":"https://openalex.org/C2777972943","wikidata":"https://www.wikidata.org/wiki/Q409587","display_name":"Naltrexone","level":4,"score":0.8549000024795532},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.7217000126838684},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6011999845504761},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5767999887466431},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5755000114440918},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5703999996185303},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5435000061988831},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4781999886035919},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43369999527931213},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.37880000472068787},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.32670000195503235},{"id":"https://openalex.org/C3019590667","wikidata":"https://www.wikidata.org/wiki/Q908096","display_name":"Narcotic antagonist","level":5,"score":0.3188999891281128},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3188000023365021},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.2874999940395355},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.2687000036239624},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.25540000200271606}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/00952990.2026.2717745","doi":"https://doi.org/10.1080/00952990.2026.2717745","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00952990.2026.2717745","pdf_url":null,"source":{"id":"https://openalex.org/S162477232","display_name":"The American Journal of Drug and Alcohol Abuse","issn_l":"0095-2990","issn":["0095-2990","1097-9891"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Drug and Alcohol Abuse","raw_type":"journal-article"},{"id":"pmid:42644692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42644692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of drug and alcohol abuse","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W2037459329","https://openalex.org/W2091187494","https://openalex.org/W2117613240","https://openalex.org/W2164678034","https://openalex.org/W2294837683","https://openalex.org/W2567362164","https://openalex.org/W2567850197","https://openalex.org/W2608446001","https://openalex.org/W2766969415","https://openalex.org/W2768214444","https://openalex.org/W2792664586","https://openalex.org/W2803830610","https://openalex.org/W2808907017","https://openalex.org/W2897736788","https://openalex.org/W2899112555","https://openalex.org/W2905124455","https://openalex.org/W2941771041","https://openalex.org/W2958293187","https://openalex.org/W2970684805","https://openalex.org/W2995648337","https://openalex.org/W3000475066","https://openalex.org/W3094429089","https://openalex.org/W3118615836","https://openalex.org/W3149786233","https://openalex.org/W3156320829","https://openalex.org/W3163245341","https://openalex.org/W3165633131","https://openalex.org/W3191357965","https://openalex.org/W3205115907","https://openalex.org/W4210917788","https://openalex.org/W4210926571","https://openalex.org/W4214724411","https://openalex.org/W4226231332","https://openalex.org/W4253918629","https://openalex.org/W4385334522","https://openalex.org/W4385564942","https://openalex.org/W4387783690","https://openalex.org/W4393130182","https://openalex.org/W4404251733","https://openalex.org/W4406796456","https://openalex.org/W4410240028","https://openalex.org/W4411484060","https://openalex.org/W4413227170"],"related_works":["https://openalex.org/W4238238277","https://openalex.org/W4413227170","https://openalex.org/W3110775636","https://openalex.org/W2768214444","https://openalex.org/W4401342330","https://openalex.org/W3035885077","https://openalex.org/W3199716029","https://openalex.org/W3176256996","https://openalex.org/W4408632818","https://openalex.org/W2807120996"],"abstract_inverted_index":{"Background:":[0],"Extended-release":[1],"naltrexone":[2],"(XR-NTX)":[3],"and":[4,18,27,36,40,65,76,92,215,229],"buprenorphine-naloxone":[5],"(BUP-NLX)":[6],"are":[7,20],"approved":[8],"for":[9],"opioid":[10,67,190],"use":[11,68,191],"disorder":[12],"(OUD),":[13],"but":[14],"their":[15],"comparative":[16],"efficacy":[17,50],"safety":[19],"unclear.Objectives:":[21],"We":[22],"conducted":[23],"a":[24,154],"systematic":[25],"review":[26],"meta-analysis":[28],"of":[29,60,158],"randomized":[30],"controlled":[31],"trials":[32],"(RCTs)":[33],"comparing":[34],"XR-NTX":[35,120,150,214,228],"BUP-NLX.Methods:":[37],"PubMed,":[38],"Embase,":[39],"Cochrane":[41],"were":[42,52,85,113,133,174],"searched":[43],"from":[44],"inception":[45],"to":[46,57,203,235],"July":[47],"2025.":[48],"Main":[49],"outcomes":[51],"treatment":[53,137,243],"initiation,":[54],"retention,":[55],"time":[56],"relapse,":[58],"number":[59],"relapses,":[61],"opioid-positive":[62,159],"urine":[63,160],"samples,":[64],"self-reported":[66],"days.":[69],"Odds":[70],"ratios":[71,78],"(OR),":[72],"mean":[73],"differences":[74,135,176],"(MD),":[75],"hazard":[77],"(HR)":[79],"with":[80,90,96,119,153,227],"95%":[81,123,141,164,181,199],"confidence":[82],"intervals":[83],"(CI)":[84],"calculated.":[86],"Heterogeneity":[87],"was":[88,117,151,225,232],"assessed":[89],"I2":[91,129,147,170,187,208],"evidence":[93,230],"certainty":[94,231],"rated":[95],"GRADE.Results:":[97],"Five":[98],"RCTs":[99],"comprising":[100],"1,043":[101],"patients":[102],"(68.2%":[103],"male;":[104],"XR-NTX,":[105],"n":[106,110],"=":[107,111,127,130,145,148,171,185,188,206,209],"512;":[108],"BUP-NLX,":[109],"531)":[112],"included.":[114],"Treatment":[115],"initiation":[116,224],"lower":[118,156,226],"(OR":[121,139,162,179],"0.27;":[122],"CI":[124,142,165,182,200],"0.12\u20130.64;":[125],"p":[126,144,167,184,205],".003;":[128],"67.6%).":[131],"There":[132,173],"no":[134,175],"in":[136,177,193],"retention":[138],"0.85;":[140],"0.65\u20131.11;":[143],".25;":[146],"0%).":[149,172],"associated":[152],"significantly":[155],"proportion":[157],"samples":[161],"0.52;":[163],"0.38\u20130.73;":[166],"<":[168],".001;":[169],"relapse":[178],"0.60;":[180],"0.21\u20131.73;":[183],".35;":[186],"89.9%),":[189],"days":[192,195],"30":[194],"(MD":[196],"\u2212":[197,201],"0.99;":[198],"3.62":[202],"1.64;":[204],".46;":[207],"63.8%),":[210],"or":[211],"adverse":[212],"events.Conclusion:":[213],"BUP-NLX":[216],"did":[217],"not":[218],"differ":[219],"across":[220],"most":[221],"outcomes,":[222],"though":[223],"very":[233],"low":[234],"moderate.":[236],"With":[237],"neither":[238],"clearly":[239],"superior,":[240],"initiating":[241],"either":[242],"may":[244],"matter":[245],"most.":[246]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2026-08-27T00:00:00"}
