{"id":"https://openalex.org/W7204254881","doi":"https://doi.org/10.3897/pharmacia.73.e206826","title":"Optimization of the procedure for preparation of biopolymeric nanoparticles as carriers of P60 antitumor peptide","display_name":"Optimization of the procedure for preparation of biopolymeric nanoparticles as carriers of P60 antitumor peptide","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204254881","doi":"https://doi.org/10.3897/pharmacia.73.e206826"},"language":"en","primary_location":{"id":"doi:10.3897/pharmacia.73.e206826","doi":"https://doi.org/10.3897/pharmacia.73.e206826","is_oa":true,"landing_page_url":"https://doi.org/10.3897/pharmacia.73.e206826","pdf_url":"https://pharmacia.pensoft.net/article/206826/download/pdf/","source":{"id":"https://openalex.org/S4210231629","display_name":"Pharmacia","issn_l":"0428-0296","issn":["0428-0296","2603-557X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pharmacia.pensoft.net/article/206826/download/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074674645","display_name":"Lyubomira Radeva","orcid":"https://orcid.org/0000-0002-3456-7027","observed_orcids":["https://orcid.org/0000-0002-3456-7027"]},"institutions":[{"id":"https://openalex.org/I30147112","display_name":"Medical University of Sofia","ror":"https://ror.org/01n9zy652","country_code":"BG","type":"education","lineage":["https://openalex.org/I30147112"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Lyubomira Radeva","raw_affiliation_strings":["Department of Pharmaceutical Technology with Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology with Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria","institution_ids":["https://openalex.org/I30147112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073048327","display_name":"Alejandro Serrano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alejandro Serrano","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111393644","display_name":"Mar\u00eda J. Garrido","orcid":"https://orcid.org/0000-0003-3559-4710","observed_orcids":["https://orcid.org/0000-0003-3559-4710"]},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria J. Garrido","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019346291","display_name":"Krassimira Yoncheva","orcid":"https://orcid.org/0000-0003-2704-3054","observed_orcids":["https://orcid.org/0000-0003-2704-3054"]},"institutions":[{"id":"https://openalex.org/I30147112","display_name":"Medical University of Sofia","ror":"https://ror.org/01n9zy652","country_code":"BG","type":"education","lineage":["https://openalex.org/I30147112"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Krassimira Yoncheva","raw_affiliation_strings":["Department of Pharmaceutical Technology with Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology with Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria","institution_ids":["https://openalex.org/I30147112"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":100,"currency":"EUR","value_usd":107},"apc_paid":{"value":100,"currency":"EUR","value_usd":107},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.4805000126361847,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.7829999923706055},{"id":"https://openalex.org/keywords/chitosan-alginate-nanoparticles","display_name":"chitosan-alginate nanoparticles","score":0.8360000252723694},{"id":"https://openalex.org/keywords/peptide-encapsulation","display_name":"peptide encapsulation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/peptide-delivery","display_name":"peptide delivery","score":0.546999990940094},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.6010000109672546},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.6179999709129333},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8629999756813049},{"id":"https://openalex.org/keywords/peptide-loading","display_name":"peptide loading","score":0.4230000078678131},{"id":"https://openalex.org/keywords/biopolymeric-nanoparticles","display_name":"biopolymeric nanoparticles","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.8323000073432922},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.760200023651123},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.7324000000953674},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4943000078201294},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4372999966144562},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41530001163482666},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.41510000824928284},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.39739999175071716},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.38850000500679016},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.37950000166893005},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37599998712539673},{"id":"https://openalex.org/C2779809887","wikidata":"https://www.wikidata.org/wiki/Q14864278","display_name":"Peptide synthesis","level":3,"score":0.3467000126838684},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.3325999975204468},{"id":"https://openalex.org/C13935069","wikidata":"https://www.wikidata.org/wiki/Q2157266","display_name":"Oligopeptide","level":3,"score":0.3127000033855438},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.27639999985694885},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.265500009059906},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.25519999861717224}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3897/pharmacia.73.e206826","doi":"https://doi.org/10.3897/pharmacia.73.e206826","is_oa":true,"landing_page_url":"https://doi.org/10.3897/pharmacia.73.e206826","pdf_url":"https://pharmacia.pensoft.net/article/206826/download/pdf/","source":{"id":"https://openalex.org/S4210231629","display_name":"Pharmacia","issn_l":"0428-0296","issn":["0428-0296","2603-557X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacia","raw_type":"journal-article"},{"id":"pmh:10.3897/pharmacia.73.e206826","doi":null,"is_oa":true,"landing_page_url":"https://pharmacia.pensoft.net/article/206826/","pdf_url":null,"source":{"id":"https://openalex.org/S199213172","display_name":"ZooKeys","issn_l":"1313-2970","issn":["1313-2970","1313-2989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacia 73: e206826","raw_type":"Research Article"},{"id":"pmh:oai:doaj.org/article:2ecefe60878f4dce838137555de406f9","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2ecefe60878f4dce838137555de406f9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacia, Vol 73, Iss , Pp 1-7 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3897/pharmacia.73.e206826","doi":"https://doi.org/10.3897/pharmacia.73.e206826","is_oa":true,"landing_page_url":"https://doi.org/10.3897/pharmacia.73.e206826","pdf_url":"https://pharmacia.pensoft.net/article/206826/download/pdf/","source":{"id":"https://openalex.org/S4210231629","display_name":"Pharmacia","issn_l":"0428-0296","issn":["0428-0296","2603-557X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204254881.pdf","grobid_xml":"https://content.openalex.org/works/W7204254881.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W42400831","https://openalex.org/W1988415027","https://openalex.org/W2002516695","https://openalex.org/W2015767395","https://openalex.org/W2041998484","https://openalex.org/W2058656892","https://openalex.org/W2061053558","https://openalex.org/W2067428788","https://openalex.org/W2150046629","https://openalex.org/W2170369551","https://openalex.org/W2271430516","https://openalex.org/W2300907733","https://openalex.org/W2613683808","https://openalex.org/W2739817201","https://openalex.org/W2904127379","https://openalex.org/W2946663348","https://openalex.org/W2987962726","https://openalex.org/W3015797184","https://openalex.org/W3029981488","https://openalex.org/W3041252586","https://openalex.org/W3096891923","https://openalex.org/W3176051898","https://openalex.org/W3204904362","https://openalex.org/W3217685798","https://openalex.org/W4212842805","https://openalex.org/W4224007609","https://openalex.org/W4225407737","https://openalex.org/W4250212255","https://openalex.org/W4310673863","https://openalex.org/W4361222640","https://openalex.org/W4376269162","https://openalex.org/W4391403439","https://openalex.org/W4401098471","https://openalex.org/W4403832022","https://openalex.org/W4404967436","https://openalex.org/W4410227983","https://openalex.org/W7126198565"],"related_works":["https://openalex.org/W4412957535","https://openalex.org/W2319427811","https://openalex.org/W2766072469","https://openalex.org/W2354849140","https://openalex.org/W7156855388","https://openalex.org/W2586099574","https://openalex.org/W2602269153","https://openalex.org/W2514470778","https://openalex.org/W2891946594","https://openalex.org/W4224320769"],"abstract_inverted_index":{"P60":[0,86],"is":[1,26],"a":[2,103],"synthetic":[3],"peptide":[4,25,125],"that":[5],"binds":[6],"to":[7,126],"forkhead":[8],"box":[9],"P3":[10],"(FOXP3),":[11],"inhibiting":[12],"its":[13,51],"activity,":[14],"and":[15,35,60],"therefore":[16],"can":[17,138],"be":[18,139],"implemented":[19],"in":[20,30,53,89,94,100],"cancer":[21],"immunotherapies.":[22],"However,":[23,70],"the":[24,40,44,71,80,90,95,119,123,134,146],"characterized":[27,75],"by":[28,50,76],"low":[29],"vivo":[31],"stability,":[32],"poor":[33],"selectivity,":[34],"rapid":[36],"systemic":[37],"clearance.":[38],"Thus,":[39],"present":[41],"study":[42],"evaluates":[43],"possibility":[45],"of":[46,56,79,85,122,133,145],"overcoming":[47],"these":[48],"limitations":[49],"encapsulation":[52],"two":[54],"types":[55,132],"nanoparticles,":[57],"specifically":[58],"chitosan-alginate":[59,96],"chitosan-albumin":[61,72,91],"nanoparticles.":[62,97],"The":[63,82],"developed":[64,135],"nanoparticles":[65,73,92,137],"possessed":[66],"optimal":[67],"physicochemical":[68],"properties.":[69],"were":[74],"higher":[77,88],"loading":[78,83],"peptide.":[81,147],"degree":[84],"was":[87,107,113],"than":[93],"Faster":[98],"release":[99],"media":[101],"with":[102],"slightly":[104],"acidic":[105],"pH":[106],"registered":[108],"for":[109,118],"both":[110,131],"systems,":[111],"which":[112],"considered":[114],"an":[115],"important":[116],"prerequisite":[117],"selective":[120],"delivery":[121],"loaded":[124],"tumor":[127],"tissue.":[128],"In":[129],"conclusion,":[130],"biopolymeric":[136],"further":[140],"evaluated":[141],"as":[142],"possible":[143],"carriers":[144]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-08-27T00:00:00"}
