{"id":"https://openalex.org/W7204252553","doi":"https://doi.org/10.3389/fmed.2026.1926464","title":"Development of a CHD risk prediction model using novel lipid markers based on lipidomics and VAP technology","display_name":"Development of a CHD risk prediction model using novel lipid markers based on lipidomics and VAP technology","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204252553","doi":"https://doi.org/10.3389/fmed.2026.1926464","pmid":"https://pubmed.ncbi.nlm.nih.gov/42718574","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13553228"},"language":"en","primary_location":{"id":"doi:10.3389/fmed.2026.1926464","doi":"https://doi.org/10.3389/fmed.2026.1926464","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1926464","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1926464/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1926464/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028277128","display_name":"Xiehui Chen","orcid":"https://orcid.org/0000-0002-6907-6885","observed_orcids":["https://orcid.org/0000-0002-6907-6885"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xiehui Chen","raw_affiliation_strings":["Department of Geriatrics, Shenzhen Longhua District Central Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Shenzhen Longhua District Central Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016309244","display_name":"Lvwen Ning","orcid":"https://orcid.org/0000-0001-7978-4028","observed_orcids":["https://orcid.org/0000-0001-7978-4028"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lvwen Ning","raw_affiliation_strings":["Department of Geriatrics, Shenzhen Longhua District Central Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Shenzhen Longhua District Central Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148292225","display_name":"Zixi Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zixi Chen","raw_affiliation_strings":["Department of Geriatrics, Shenzhen Longhua District Central Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Shenzhen Longhua District Central Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063672280","display_name":"Qidi Ying","orcid":"https://orcid.org/0000-0003-2331-3950","observed_orcids":["https://orcid.org/0000-0003-2331-3950"]},"institutions":[{"id":"https://openalex.org/I4210101660","display_name":"Ningbo No. 2 Hospital","ror":"https://ror.org/01apc5d07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210101660","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qidi Ying","raw_affiliation_strings":["Ningbo-Marshall International Joint Medical Laboratory, Centre for Medical Research, Ningbo No. 2 Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningbo-Marshall International Joint Medical Laboratory, Centre for Medical Research, Ningbo No. 2 Hospital","institution_ids":["https://openalex.org/I4210101660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108575320","display_name":"Hu Wei","orcid":"https://orcid.org/0009-0008-3369-229X","observed_orcids":["https://orcid.org/0009-0008-3369-229X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Hu","raw_affiliation_strings":["Ningbo Key Laboratory for Precision Detection of Lipoprotein Subfractions by VAP, Ningbo Meikang Shengde Medical Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningbo Key Laboratory for Precision Detection of Lipoprotein Subfractions by VAP, Ningbo Meikang Shengde Medical Laboratory","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078439039","display_name":"Yanwen Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanwen Qin","raw_affiliation_strings":["Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210119028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137243649","display_name":"Ahlam Mohamed Yusuf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ahlam Mohamed Yusuf","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Ningbo University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Ningbo University","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159828808","display_name":"Yinling Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148790","display_name":"Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine","ror":"https://ror.org/05pwsw714","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148790"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinling Wang","raw_affiliation_strings":["Department of Clinical Laboratory, Hangzhou First People\u2019s Hospital","Department of Clinical Laboratory, Ningbo Yinzhou Hospital of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Hangzhou First People\u2019s Hospital","institution_ids":["https://openalex.org/I4210148790"]},{"raw_affiliation_string":"Department of Clinical Laboratory, Ningbo Yinzhou Hospital of Traditional Chinese Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148388805","display_name":"Ying Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148790","display_name":"Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine","ror":"https://ror.org/05pwsw714","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148790"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Department of Clinical Laboratory, Hangzhou First People\u2019s Hospital","Department of Clinical Laboratory, Ningbo Yinzhou Hospital of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Hangzhou First People\u2019s Hospital","institution_ids":["https://openalex.org/I4210148790"]},{"raw_affiliation_string":"Department of Clinical Laboratory, Ningbo Yinzhou Hospital of Traditional Chinese Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5137274693","display_name":"Zhanke Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zhanke Wang","raw_affiliation_strings":["Department of Clinical Laboratory, Ningbo Yinzhou Hospital of Traditional Chinese Medicine","Department of Geriatrics, Shenzhen Longhua District Central Hospital","Ningbo Key Laboratory for Precision Detection of Lipoprotein Subfractions by VAP, Ningbo Meikang Shengde Medical Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Ningbo Yinzhou Hospital of Traditional Chinese Medicine","institution_ids":[]},{"raw_affiliation_string":"Department of Geriatrics, Shenzhen Longhua District Central Hospital","institution_ids":[]},{"raw_affiliation_string":"Ningbo Key Laboratory for Precision Detection of Lipoprotein Subfractions by VAP, Ningbo Meikang Shengde Medical Laboratory","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5028277128","https://openalex.org/A5137274693"],"corresponding_institution_ids":[],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"1926464","last_page":"1926464"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.02969999983906746,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/risk-prediction-model","display_name":"risk prediction model","score":0.8059999942779541},{"id":"https://openalex.org/keywords/lipidomics","display_name":"lipidomics","score":0.8669999837875366},{"id":"https://openalex.org/keywords/lipid-subfractions","display_name":"lipid subfractions","score":0.7639999985694885},{"id":"https://openalex.org/keywords/lipoprotein-a","display_name":"lipoprotein(a)","score":0.7239999771118164},{"id":"https://openalex.org/keywords/remnant-like-particle-cholesterol","display_name":"remnant-like particle cholesterol","score":0.8679999709129333},{"id":"https://openalex.org/keywords/small-dense-ldl","display_name":"small dense LDL","score":0.9520000219345093},{"id":"https://openalex.org/keywords/hdl2b","display_name":"HDL2b","score":0.9679999947547913},{"id":"https://openalex.org/keywords/differential-lipids","display_name":"differential lipids","score":0.6830000281333923},{"id":"https://openalex.org/keywords/glycerophospholipid-metabolism","display_name":"glycerophospholipid metabolism","score":0.9480000138282776},{"id":"https://openalex.org/keywords/choline-metabolism","display_name":"choline metabolism","score":0.8119999766349792},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.6430000066757202},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.5410000085830688},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.9390000104904175},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.5210000276565552},{"id":"https://openalex.org/keywords/model-validation","display_name":"model validation","score":0.38199999928474426},{"id":"https://openalex.org/keywords/lipid-biomarkers","display_name":"lipid biomarkers","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C58017582","wikidata":"https://www.wikidata.org/wiki/Q6556376","display_name":"Lipidomics","level":2,"score":0.9018999934196472},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.6144999861717224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5849999785423279},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5611000061035156},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5354999899864197},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4706999957561493},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.44600000977516174},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.4392000138759613},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.3978999853134155},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3747999966144562},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3747999966144562},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3499999940395355},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32989999651908875},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.3224000036716461},{"id":"https://openalex.org/C139572402","wikidata":"https://www.wikidata.org/wiki/Q4927820","display_name":"Blood lipids","level":3,"score":0.3188000023365021},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.3172999918460846},{"id":"https://openalex.org/C2776952329","wikidata":"https://www.wikidata.org/wiki/Q420004","display_name":"Glycerophospholipid","level":4,"score":0.3138999938964844},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.31119999289512634},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.31029999256134033},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.30709999799728394},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.3034999966621399},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.2980000078678131},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.29159998893737793},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.28790000081062317},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.27639999985694885},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.2554999887943268},{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.25450000166893005}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fmed.2026.1926464","doi":"https://doi.org/10.3389/fmed.2026.1926464","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1926464","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1926464/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13553228","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13553228/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13553228/pdf/fmed-13-1926464.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Med (Lausanne)","raw_type":"Text"},{"id":"pmid:42718574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42718574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a5a01ffe2b9c4809a02084afc19723d8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a5a01ffe2b9c4809a02084afc19723d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Medicine, Vol 13 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmed.2026.1926464","doi":"https://doi.org/10.3389/fmed.2026.1926464","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1926464","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1926464/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G8469044955","display_name":null,"funder_award_id":"2023ZD0503403","funder_id":"https://openalex.org/F4320329860","funder_display_name":"National Science and Technology Major Project"},{"id":"https://openalex.org/G8828902547","display_name":null,"funder_award_id":"2023ZD0503401","funder_id":"https://openalex.org/F4320329860","funder_display_name":"National Science and Technology Major Project"}],"funders":[{"id":"https://openalex.org/F4320329860","display_name":"National Science and Technology Major Project","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204252553.pdf","grobid_xml":"https://content.openalex.org/works/W7204252553.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1981197903","https://openalex.org/W1994222938","https://openalex.org/W2014959138","https://openalex.org/W2064707131","https://openalex.org/W2088939066","https://openalex.org/W2104355263","https://openalex.org/W2154292243","https://openalex.org/W2265940267","https://openalex.org/W2586057733","https://openalex.org/W2624697526","https://openalex.org/W2791419773","https://openalex.org/W2794383088","https://openalex.org/W2806921831","https://openalex.org/W2895366584","https://openalex.org/W2896008418","https://openalex.org/W2902053525","https://openalex.org/W2949181149","https://openalex.org/W2990218059","https://openalex.org/W3036240546","https://openalex.org/W3113933142","https://openalex.org/W4281484393","https://openalex.org/W4283022970","https://openalex.org/W4312085640","https://openalex.org/W4323318134","https://openalex.org/W4361267603","https://openalex.org/W4362583610","https://openalex.org/W4380087226","https://openalex.org/W4381469946","https://openalex.org/W4385334581","https://openalex.org/W4387472710","https://openalex.org/W4399283179","https://openalex.org/W4399614026","https://openalex.org/W4400641620","https://openalex.org/W4400874372","https://openalex.org/W4400945267","https://openalex.org/W4403841421","https://openalex.org/W4405727660","https://openalex.org/W4406015604","https://openalex.org/W4408187621","https://openalex.org/W4408328815","https://openalex.org/W4408660810","https://openalex.org/W4408735845","https://openalex.org/W4413334667","https://openalex.org/W4415439309","https://openalex.org/W4417482474","https://openalex.org/W7128624466","https://openalex.org/W7137952830","https://openalex.org/W7148289114"],"related_works":["https://openalex.org/W4389816760","https://openalex.org/W2278646492","https://openalex.org/W2016918979","https://openalex.org/W7165054290","https://openalex.org/W3167233850","https://openalex.org/W4407932057","https://openalex.org/W3129105541","https://openalex.org/W2904028748","https://openalex.org/W2383516380","https://openalex.org/W2995425502"],"abstract_inverted_index":{"Objective":[0],"This":[1,294],"study":[2,295],"aimed":[3],"to":[4,105,115],"develop":[5],"a":[6,47,59,71,117,254,284,289,298,329],"novel":[7,306],"risk":[8,118,240,302,334],"prediction":[9,119,303],"model":[10,262,282,304,321],"for":[11,132,242,332],"coronary":[12],"heart":[13],"disease":[14],"(CHD)":[15],"based":[16],"on":[17,29,82],"lipid":[18,149,174,307],"subfraction":[19,25],"and":[20,58,172,200,203,231,288,313,326],"lipidomics":[21,79],"data.":[22],"Methods":[23],"Lipid":[24],"analysis":[26,185],"was":[27,80,103,126,138,253],"conducted":[28],"624":[30],"subjects":[31,84],"(312":[32],"CHD,":[33,55,67,86,243],"312":[34],"controls)":[35,57,69,88],"using":[36,96,128,140],"Vertical":[37],"Auto":[38],"Profile":[39],"(VAP).":[40],"The":[41,121,320],"participants":[42],"were":[43,154,179,190],"randomly":[44,89],"divided":[45],"into":[46],"training":[48],"cohort":[49,61],"(":[50,62],"n":[51,63],"=":[52,64,211,215,219,223,229,236,247,279],"422,":[53],"211":[54,56],"validation":[60,259,338],"202,":[65],"101":[66,68],"at":[70],"2:1":[72],"ratio,":[73],"stratified":[74],"by":[75,111],"CHD":[76,165,333],"status.":[77],"Untargeted":[78],"performed":[81],"16":[83],"(8":[85],"8":[87],"selected":[90],"from":[91],"the":[92,129,159,258,261,281],"total":[93,146],"enrolled":[94],"population":[95],"UHPLC-Q-TOF/MS.":[97],"Lasso":[98],"regression":[99,114,207,301],"with":[100],"ten-fold":[101],"cross-validation":[102],"applied":[104],"screen":[106],"key":[107],"predictive":[108,324],"factors,":[109],"followed":[110],"multivariate":[112,299],"logistic":[113,206,300],"construct":[116],"model.":[120],"false":[122],"discovery":[123],"rate":[124],"(FDR)":[125],"controlled":[127],"Benjamini\u2013Hochberg":[130],"procedure":[131],"multiple":[133],"comparisons.":[134],"Model":[135],"discriminative":[136],"performance":[137,325],"evaluated":[139],"ROC":[141],"curve":[142],"analysis.":[143],"Results":[144],"A":[145],"of":[147,170,266,275,286,291],"2,335":[148],"molecules":[150],"across":[151],"eight":[152],"classes":[153],"identified.":[155],"After":[156],"FDR":[157],"correction,":[158],"differential":[160,188],"lipids":[161,178,189],"remained":[162],"statistically":[163],"significant.":[164],"patients":[166],"exhibited":[167],"significant":[168],"upregulation":[169],"RLP-C":[171,213],"sdLDL-C-related":[173],"components,":[175],"while":[176],"HDL2B-related":[177],"markedly":[180],"downregulated.":[181],"KEGG":[182],"pathway":[183],"enrichment":[184],"revealed":[186],"that":[187],"mainly":[191],"enriched":[192],"in":[193,198,339],"glycerophospholipid":[194],"metabolism,":[195],"choline":[196],"metabolism":[197],"cancer,":[199],"fat":[201],"digestion":[202],"absorption.":[204],"Multivariate":[205],"identified":[208],"Lp(a)":[209],"(OR":[210,214,218,222,228,235,246],"1.288),":[212],"3.848),":[216],"sdLDL-C":[217],"5.317),":[220],"age":[221],"1.053),":[224],"systolic":[225],"blood":[226],"pressure":[227],"1.075),":[230],"fasting":[232],"plasma":[233],"glucose":[234],"3.903)":[237],"as":[238],"independent":[239],"factors":[241],"whereas":[244],"HDL2B":[245],"1.416":[248],"\u00d7":[249],"10":[250],"\u22126":[251],")":[252],"protective":[255],"factor.":[256],"In":[257],"cohort,":[260],"achieved":[263],"an":[264,272],"AUC":[265],"0.867":[267],"(95%":[268],"CI:":[269],"0.8087\u20130.9252).":[270],"Using":[271],"optimal":[273],"cutoff":[274],"0.4726":[276],"(Youden":[277],"index":[278],"0.628),":[280],"demonstrated":[283],"sensitivity":[285],"81.4%":[287],"specificity":[290],"81.4%.":[292],"Conclusion":[293],"successfully":[296],"constructed":[297],"integrating":[305],"subfractions":[308],"(sdLDL-C,":[309],"RLP-C,":[310],"HDL2B,":[311],"Lp(a))":[312],"routine":[314],"clinical":[315],"variables":[316],"(age,":[317],"SBP,":[318],"FPG).":[319],"exhibits":[322],"acceptable":[323],"may":[327],"provide":[328],"complementary":[330],"tool":[331],"assessment,":[335],"pending":[336],"external":[337],"larger":[340],"prospective":[341],"cohorts.":[342]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-08-27T00:00:00"}
