{"id":"https://openalex.org/W7204251218","doi":"https://doi.org/10.1039/9781837677436-00001","title":"Enzymes in the Synthesis of Natural Products and Other Small Molecules","display_name":"Enzymes in the Synthesis of Natural Products and Other Small Molecules","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204251218","doi":"https://doi.org/10.1039/9781837677436-00001"},"language":"en","primary_location":{"id":"doi:10.1039/9781837677436-00001","doi":"https://doi.org/10.1039/9781837677436-00001","is_oa":false,"landing_page_url":"https://doi.org/10.1039/9781837677436-00001","pdf_url":null,"source":{"id":"https://openalex.org/S4306463862","display_name":"Royal Society of Chemistry eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemoenzymatic Synthesis of Natural Products and Complex Small Molecules","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W7139096411","display_name":"Chemoenzymatic Synthesis of Natural Products and Complex Small Molecules"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038826554","display_name":"Luca Schlotte","orcid":"https://orcid.org/0000-0002-0299-4921","observed_orcids":["https://orcid.org/0000-0002-0299-4921"]},"institutions":[{"id":"https://openalex.org/I54009628","display_name":"University of Bayreuth","ror":"https://ror.org/0234wmv40","country_code":"DE","type":"education","lineage":["https://openalex.org/I54009628"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L. Schlotte","raw_affiliation_strings":["Faculty for Biology, Chemistry and Earth Sciences, Department of Chemistry, University of Bayreuth, 95447 Bayreuth, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty for Biology, Chemistry and Earth Sciences, Department of Chemistry, University of Bayreuth, 95447 Bayreuth, Germany","institution_ids":["https://openalex.org/I54009628"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5148291075","display_name":"F. Hahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I54009628","display_name":"University of Bayreuth","ror":"https://ror.org/0234wmv40","country_code":"DE","type":"education","lineage":["https://openalex.org/I54009628"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. Hahn","raw_affiliation_strings":["Faculty for Biology, Chemistry and Earth Sciences, Department of Chemistry, University of Bayreuth, 95447 Bayreuth, Germany frank.hahn@uni-bayreuth.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty for Biology, Chemistry and Earth Sciences, Department of Chemistry, University of Bayreuth, 95447 Bayreuth, Germany frank.hahn@uni-bayreuth.de","institution_ids":["https://openalex.org/I54009628"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I54009628"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzymatic-synthesis","display_name":"enzymatic synthesis","score":0.5329999923706055},{"id":"https://openalex.org/keywords/biocatalysis","display_name":"biocatalysis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/chemoenzymatic-synthesis","display_name":"chemoenzymatic synthesis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.8309999704360962},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/polyketide-synthase","display_name":"polyketide synthase","score":0.9340000152587891},{"id":"https://openalex.org/keywords/nonribosomal-peptide-synthetase","display_name":"nonribosomal peptide synthetase","score":1.0},{"id":"https://openalex.org/keywords/methyltransferase","display_name":"methyltransferase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/late-stage-modification","display_name":"late-stage modification","score":0.7310000061988831},{"id":"https://openalex.org/keywords/building-block-synthesis","display_name":"building block synthesis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.6259999871253967},{"id":"https://openalex.org/C191503008","wikidata":"https://www.wikidata.org/wiki/Q16007026","display_name":"Biocatalysis","level":4,"score":0.6111999750137329},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.5892999768257141},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5145999789237976},{"id":"https://openalex.org/C2776608160","wikidata":"https://www.wikidata.org/wiki/Q4785462","display_name":"Natural (archaeology)","level":2,"score":0.49470001459121704},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4406999945640564},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.43320000171661377},{"id":"https://openalex.org/C2778635478","wikidata":"https://www.wikidata.org/wiki/Q516751","display_name":"Polyketide","level":4,"score":0.4327999949455261},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.42579999566078186},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.39739999175071716},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.39309999346733093},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.35440000891685486},{"id":"https://openalex.org/C2780616401","wikidata":"https://www.wikidata.org/wiki/Q1133673","display_name":"Cornerstone","level":2,"score":0.35089999437332153},{"id":"https://openalex.org/C9418097","wikidata":"https://www.wikidata.org/wiki/Q440681","display_name":"Directed evolution","level":4,"score":0.34869998693466187},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34619998931884766},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.3393999934196472},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3260999917984009},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.3246000111103058},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3089999854564667},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.2937999963760376},{"id":"https://openalex.org/C92028520","wikidata":"https://www.wikidata.org/wiki/Q7395025","display_name":"SUPERFAMILY","level":3,"score":0.2897999882698059},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26579999923706055},{"id":"https://openalex.org/C2909999020","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Peptide Biosynthesis","level":5,"score":0.2563999891281128},{"id":"https://openalex.org/C35753019","wikidata":"https://www.wikidata.org/wiki/Q644785","display_name":"Total synthesis","level":2,"score":0.25450000166893005},{"id":"https://openalex.org/C2777210771","wikidata":"https://www.wikidata.org/wiki/Q4927124","display_name":"Block (permutation group theory)","level":2,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1039/9781837677436-00001","doi":"https://doi.org/10.1039/9781837677436-00001","is_oa":false,"landing_page_url":"https://doi.org/10.1039/9781837677436-00001","pdf_url":null,"source":{"id":"https://openalex.org/S4306463862","display_name":"Royal Society of Chemistry eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemoenzymatic Synthesis of Natural Products and Complex Small Molecules","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W1966829074","https://openalex.org/W1967756460","https://openalex.org/W1969951206","https://openalex.org/W1970448671","https://openalex.org/W1980013059","https://openalex.org/W1982017599","https://openalex.org/W1988187251","https://openalex.org/W1990185313","https://openalex.org/W1990361969","https://openalex.org/W2001290593","https://openalex.org/W2019696667","https://openalex.org/W2043899565","https://openalex.org/W2049061140","https://openalex.org/W2063212143","https://openalex.org/W2064073012","https://openalex.org/W2088905973","https://openalex.org/W2098347017","https://openalex.org/W2113296988","https://openalex.org/W2133488878","https://openalex.org/W2150379515","https://openalex.org/W2159489517","https://openalex.org/W2170242620","https://openalex.org/W2323213227","https://openalex.org/W2369191639","https://openalex.org/W2412082922","https://openalex.org/W2461926103","https://openalex.org/W2526001689","https://openalex.org/W2552441723","https://openalex.org/W2590011082","https://openalex.org/W2592790247","https://openalex.org/W2606755062","https://openalex.org/W2611252889","https://openalex.org/W2765997674","https://openalex.org/W2767900770","https://openalex.org/W2791467087","https://openalex.org/W2791931465","https://openalex.org/W2798040726","https://openalex.org/W2810949692","https://openalex.org/W2883269759","https://openalex.org/W2886567044","https://openalex.org/W2890410714","https://openalex.org/W2900757748","https://openalex.org/W2901216069","https://openalex.org/W2951941889","https://openalex.org/W2952291569","https://openalex.org/W2981126616","https://openalex.org/W2999840604","https://openalex.org/W3005536523","https://openalex.org/W3006699155","https://openalex.org/W3011366455","https://openalex.org/W3015016983","https://openalex.org/W3021389251","https://openalex.org/W3025692069","https://openalex.org/W3033007973","https://openalex.org/W3035847987","https://openalex.org/W3037307581","https://openalex.org/W3040009701","https://openalex.org/W3047000077","https://openalex.org/W3050216513","https://openalex.org/W3086393499","https://openalex.org/W3096959837","https://openalex.org/W3119952098","https://openalex.org/W3125924278","https://openalex.org/W3133518875","https://openalex.org/W3167684320","https://openalex.org/W3171420485","https://openalex.org/W3191820221","https://openalex.org/W4205210465","https://openalex.org/W4224243487","https://openalex.org/W4245719503","https://openalex.org/W4288801206","https://openalex.org/W4292684183","https://openalex.org/W4293150377","https://openalex.org/W4295717807","https://openalex.org/W4307353027","https://openalex.org/W4309665937","https://openalex.org/W4377139052","https://openalex.org/W4378373738","https://openalex.org/W4385840424","https://openalex.org/W4386944243","https://openalex.org/W4388557903","https://openalex.org/W4391836356","https://openalex.org/W4392154659","https://openalex.org/W4392740156","https://openalex.org/W4401220553","https://openalex.org/W4401805036","https://openalex.org/W4401891360","https://openalex.org/W4403436339","https://openalex.org/W4403985437","https://openalex.org/W4406288609","https://openalex.org/W4406533301","https://openalex.org/W4407377985","https://openalex.org/W4408721680","https://openalex.org/W4409565523","https://openalex.org/W4410773901","https://openalex.org/W4411882244","https://openalex.org/W4412132536","https://openalex.org/W4413683156"],"related_works":["https://openalex.org/W7139096411","https://openalex.org/W4288074038","https://openalex.org/W2499938832","https://openalex.org/W4233780366","https://openalex.org/W2113296988","https://openalex.org/W7204262584","https://openalex.org/W4385651695","https://openalex.org/W2011073617","https://openalex.org/W3006699155","https://openalex.org/W379292787"],"abstract_inverted_index":{"Due":[0],"to":[1,52,67,156],"their":[2,25,146],"versatile":[3],"biological":[4],"activity,":[5],"natural":[6,42,78],"products":[7],"play":[8],"a":[9,19,50,133,176],"vital":[10],"role":[11],"in":[12,41,124],"many":[13],"current":[14],"societal":[15],"fields":[16],"and":[17,44,60,81,87,111,119,143,149,173],"remain":[18],"cornerstone":[20],"of":[21,37,71,97,127,137,170,182],"drug":[22,45],"discovery.":[23],"However,":[24],"complexity":[26],"poses":[27],"challenges":[28],"for":[29,105],"synthetic":[30,171],"access.":[31],"This":[32],"chapter":[33,131,154],"explores":[34],"the":[35,121,128,168],"use":[36],"enzymes":[38,90,104],"as":[39,49],"biocatalysts":[40],"product":[43],"synthesis":[46,83],"(chemoenzymatic":[47],"synthesis)":[48],"strategy":[51],"overcome":[53],"these":[54],"limitations.":[55],"Enzymes":[56],"exhibit":[57],"formidable":[58],"selectivity":[59],"favourable":[61],"operating":[62],"conditions,":[63],"making":[64],"them":[65],"well-suited":[66],"tackle":[68],"imminent":[69],"problems":[70],"complex":[72],"molecule":[73],"synthesis.":[74],"An":[75],"introduction":[76],"into":[77],"products,":[79],"biocatalysis":[80],"chemo-biotechnological":[82],"approaches":[84],"is":[85,100],"given":[86],"then":[88],"how":[89],"can":[91,165],"be":[92],"useful":[93],"at":[94],"different":[95],"stages":[96],"total":[98],"syntheses":[99],"discussed.":[101],"The":[102],"various":[103],"building":[106],"block":[107],"synthesis,":[108],"scaffold":[109],"formation,":[110],"late-stage":[112],"modification":[113],"are":[114],"also":[115],"highlighted.":[116],"To":[117],"supplement":[118],"complement":[120],"topics":[122],"covered":[123],"other":[125],"parts":[126],"book,":[129],"this":[130,153,180],"provides":[132],"more":[134],"detailed":[135],"discussion":[136],"polyketide":[138],"synthases,":[139],"non-ribosomal":[140],"peptide":[141],"synthetases,":[142],"methyltransferases,":[144],"reflecting":[145],"increasing":[147],"importance":[148],"potential.":[150],"In":[151],"summary,":[152],"aims":[155],"emphasise":[157],"that":[158],"an":[159],"interdisciplinary":[160],"approach":[161],"integrating":[162],"enzyme-based":[163],"methods":[164],"greatly":[166],"improve":[167],"toolkit":[169],"chemists":[172],"thus":[174],"have":[175],"lasting":[177],"impact":[178],"on":[179],"field":[181],"science.":[183]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-27T00:00:00"}