{"id":"https://openalex.org/W7204249963","doi":"https://doi.org/10.29296/25877313-2026-08-06","title":"TWO-PHASE HOMOGENIZATION MODES EFFECT ON THE QUALITY AND SAFETY OF THIRD-GENERATION FAT EMULSIONS","display_name":"TWO-PHASE HOMOGENIZATION MODES EFFECT ON THE QUALITY AND SAFETY OF THIRD-GENERATION FAT EMULSIONS","publication_year":2026,"publication_date":"2026-06-12","ids":{"openalex":"https://openalex.org/W7204249963","doi":"https://doi.org/10.29296/25877313-2026-08-06"},"language":"en","primary_location":{"id":"doi:10.29296/25877313-2026-08-06","doi":"https://doi.org/10.29296/25877313-2026-08-06","is_oa":false,"landing_page_url":"https://doi.org/10.29296/25877313-2026-08-06","pdf_url":null,"source":{"id":"https://openalex.org/S4210216903","display_name":"Problems of Biological Medical and Pharmaceutical Chemistry","issn_l":"1560-9596","issn":["1560-9596","2587-7313"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":"https://openalex.org/P4327874082","host_organization_name":"Russkiy Vrach Publishing House","host_organization_lineage":["https://openalex.org/P4327874082"],"host_organization_lineage_names":["Russkiy Vrach Publishing House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Problems of Biological Medical and Pharmaceutical Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7204249963"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148182078","display_name":"A. Normov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135186","display_name":"MIREA - Russian Technological University","ror":"https://ror.org/04qrtgy16","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210135186"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. Normov","raw_affiliation_strings":["MIREA \u2013 Russian Technological University; 78 Vernadskogo pr., Moscow, 119454, Russian Federation 2- Institute of Pharmaceutical Technologies; of. 1, 21 Skolkovskoe sh., Moscow, 121353, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIREA \u2013 Russian Technological University; 78 Vernadskogo pr., Moscow, 119454, Russian Federation 2- Institute of Pharmaceutical Technologies; of. 1, 21 Skolkovskoe sh., Moscow, 121353, Russian Federation","institution_ids":["https://openalex.org/I4210135186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159812799","display_name":"E. Kholina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135186","display_name":"MIREA - Russian Technological University","ror":"https://ror.org/04qrtgy16","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210135186"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. Kholina","raw_affiliation_strings":["MIREA \u2013 Russian Technological University; 78 Vernadskogo pr., Moscow, 119454, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIREA \u2013 Russian Technological University; 78 Vernadskogo pr., Moscow, 119454, Russian Federation","institution_ids":["https://openalex.org/I4210135186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073928673","display_name":"\u0415\u043b\u0438\u0437\u0430\u0432\u0435\u0442\u0430 \u0410\u043b\u0435\u043a\u0441\u0430\u043d\u0434\u0440\u043e\u0432\u043d\u0430 \u0428\u043d\u044f\u043a","orcid":"https://orcid.org/0000-0001-8560-7060","observed_orcids":["https://orcid.org/0000-0001-8560-7060"]},"institutions":[{"id":"https://openalex.org/I4210135186","display_name":"MIREA - Russian Technological University","ror":"https://ror.org/04qrtgy16","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210135186"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. Shnyak","raw_affiliation_strings":["MIREA \u2013 Russian Technological University; 78 Vernadskogo pr., Moscow, 119454, Russian Federation 2- Institute of Pharmaceutical Technologies; of. 1, 21 Skolkovskoe sh., Moscow, 121353, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIREA \u2013 Russian Technological University; 78 Vernadskogo pr., Moscow, 119454, Russian Federation 2- Institute of Pharmaceutical Technologies; of. 1, 21 Skolkovskoe sh., Moscow, 121353, Russian Federation","institution_ids":["https://openalex.org/I4210135186"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210135186"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"46","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.031199999153614044,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parenteral-nutrition","display_name":"parenteral nutrition","score":0.9570000171661377},{"id":"https://openalex.org/keywords/high-pressure-homogenizer","display_name":"high-pressure homogenizer","score":0.9139999747276306},{"id":"https://openalex.org/keywords/scale-up","display_name":"scale-up","score":0.718999981880188},{"id":"https://openalex.org/keywords/emulsion-stability","display_name":"emulsion stability","score":0.6449999809265137},{"id":"https://openalex.org/keywords/zeta-potential","display_name":"zeta potential","score":0.7689999938011169},{"id":"https://openalex.org/keywords/droplet-size","display_name":"droplet size","score":0.718999981880188},{"id":"https://openalex.org/keywords/membrane-filtration","display_name":"membrane filtration","score":0.703000009059906},{"id":"https://openalex.org/keywords/heat-sterilization","display_name":"heat sterilization","score":0.7770000100135803},{"id":"https://openalex.org/keywords/light-protection","display_name":"light protection","score":0.5950000286102295},{"id":"https://openalex.org/keywords/oxidative-degradation","display_name":"oxidative degradation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/peroxide-value","display_name":"peroxide value","score":0.8240000009536743},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.8790000081062317},{"id":"https://openalex.org/keywords/storage-stability","display_name":"storage stability","score":0.8080000281333923},{"id":"https://openalex.org/keywords/product-quality-and-safety","display_name":"product quality and safety","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C192797455","wikidata":"https://www.wikidata.org/wiki/Q4116863","display_name":"Homogenizer","level":2,"score":0.8733000159263611},{"id":"https://openalex.org/C2778722038","wikidata":"https://www.wikidata.org/wiki/Q17030643","display_name":"Homogenization (climate)","level":3,"score":0.8228999972343445},{"id":"https://openalex.org/C96618451","wikidata":"https://www.wikidata.org/wiki/Q3028008","display_name":"Dilution","level":2,"score":0.6746000051498413},{"id":"https://openalex.org/C2778123984","wikidata":"https://www.wikidata.org/wiki/Q187634","display_name":"Emulsion","level":2,"score":0.6535000205039978},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5397999882698059},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.46399998664855957},{"id":"https://openalex.org/C148761745","wikidata":"https://www.wikidata.org/wiki/Q1563203","display_name":"Sterilization (economics)","level":4,"score":0.4392000138759613},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4334999918937683},{"id":"https://openalex.org/C2781294611","wikidata":"https://www.wikidata.org/wiki/Q903545","display_name":"Peroxide value","level":2,"score":0.42660000920295715},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4262999892234802},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.399399995803833},{"id":"https://openalex.org/C48314217","wikidata":"https://www.wikidata.org/wiki/Q1753040","display_name":"Microfiltration","level":3,"score":0.38420000672340393},{"id":"https://openalex.org/C128489963","wikidata":"https://www.wikidata.org/wiki/Q1187724","display_name":"Filtration (mathematics)","level":2,"score":0.33180001378059387},{"id":"https://openalex.org/C2781048764","wikidata":"https://www.wikidata.org/wiki/Q107429","display_name":"Peroxide","level":2,"score":0.32739999890327454},{"id":"https://openalex.org/C528095902","wikidata":"https://www.wikidata.org/wiki/Q2283886","display_name":"Pulp and paper industry","level":1,"score":0.32330000400543213},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.30149999260902405},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.29919999837875366},{"id":"https://openalex.org/C2778927798","wikidata":"https://www.wikidata.org/wiki/Q177540","display_name":"Paraffin wax","level":3,"score":0.29760000109672546}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.29296/25877313-2026-08-06","doi":"https://doi.org/10.29296/25877313-2026-08-06","is_oa":false,"landing_page_url":"https://doi.org/10.29296/25877313-2026-08-06","pdf_url":null,"source":{"id":"https://openalex.org/S4210216903","display_name":"Problems of Biological Medical and Pharmaceutical Chemistry","issn_l":"1560-9596","issn":["1560-9596","2587-7313"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":"https://openalex.org/P4327874082","host_organization_name":"Russkiy Vrach Publishing House","host_organization_lineage":["https://openalex.org/P4327874082"],"host_organization_lineage_names":["Russkiy Vrach Publishing House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Problems of Biological Medical and Pharmaceutical Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W324781303","https://openalex.org/W2061340908","https://openalex.org/W2115957445","https://openalex.org/W2395416108","https://openalex.org/W4289203947","https://openalex.org/W4382056980","https://openalex.org/W4401515001","https://openalex.org/W4407634015"],"related_works":["https://openalex.org/W2060364684","https://openalex.org/W2808948987","https://openalex.org/W2605242090","https://openalex.org/W4289203947","https://openalex.org/W1964345909","https://openalex.org/W4255772015","https://openalex.org/W2966832110","https://openalex.org/W2467507266","https://openalex.org/W2087336406","https://openalex.org/W2052670859"],"abstract_inverted_index":{"Aim":[0],"\u2013":[1],"to":[2,18,165,175,204,320],"scale":[3,17],"up":[4],"the":[5,79,115,162,180,271,284,313,317],"technology":[6,285],"for":[7,12,94,199,245,257,286,329],"producing":[8,287],"third\u2011generation":[9,290,336],"fat":[10,291],"emulsions":[11],"parenteral":[13],"nutrition":[14],"from":[15,298],"laboratory":[16],"a":[19,40,49,57,212,288],"semi\u2011industrial":[20],"batch":[21],"while":[22,158],"maintaining":[23],"quality":[24,67],"and":[25,33,56,78,101,108,125,136,178,187,207,225,267,305,332],"safety":[26,81],"parameters":[27,164,240],"compliant":[28],"with":[29,128,250],"Pharmacopoeial":[30],"requirements.":[31],"Material":[32],"methods.":[34],"The":[35,275,323],"homogenization":[36,51,147,160,278],"regime":[37,279],"optimization":[38],"in":[39,220,236],"high\u2011pressure":[41],"homogenizer":[42],"was":[43,68,117,141,173,202],"carried":[44],"out":[45],"using":[46],"two\u2011phase":[47,159,277],"homogenization:":[48],"main":[50],"cycle":[52],"at":[53,61,148,196,258,300],"800\u20131200":[54],"atm":[55,150],"final":[58],"stabilization":[59],"step":[60],"reduced":[62],"pressure":[63],"(100\u2013400":[64],"atm).":[65],"Emulsion":[66],"assessed":[69],"by":[70,232,263],"mean":[71],"droplet":[72],"diameter":[73],"(dmedium),":[74],"zeta":[75,181],"potential,":[76],"pH,":[77],"critical":[80,213],"indicator":[82],"PFAT5":[83,156,266],"(volume":[84],"fraction":[85],"of":[86,114,123,215,283,303,316,335],"droplets":[87],"larger":[88],"than":[89],"5":[90],"\u03bcm).":[91],"Membrane":[92],"materials":[93],"FE":[95,116,253],"filtration":[96],"(nylon":[97],"66,":[98],"PVDF,":[99],"PES)":[100],"thermal":[102],"sterilization":[103],"regimes":[104],"(121":[105],"\u00b0C,":[106],"8":[107,200],"15":[109],"min)":[110],"were":[111],"explored.":[112],"Stability":[113],"also":[118],"evaluated":[119],"over":[120],"30":[121,246,264],"months":[122],"storage":[124,210,304],"after":[126],"dilution":[127,249],"5%":[129],"dextrose":[130],"solution":[131],"under":[132],"both":[133],"light":[134,216,299],"exposure":[135],"protected\u2011from\u2011light":[137],"conditions.":[138],"Results.":[139],"It":[140],"established":[142],"that":[143],"during":[144],"scale\u2011up,":[145],"single\u2011stage":[146],"800":[149],"does":[151],"not":[152,191],"provide":[153],"an":[154],"acceptable":[155,243],"value,":[157],"provides":[161],"required":[163],"be":[166,205,327],"achieved.":[167],"Filtration":[168],"through":[169],"charged":[170],"nylon":[171],"66":[172],"shown":[174],"increase":[176],"dmedium":[177],"make":[179],"potential":[182],"more":[183],"neutral,":[184],"whereas":[185,235],"PES":[186],"PVDF":[188],"membranes":[189],"do":[190],"affect":[192],"emulsion":[193,319],"quality.":[194],"Sterilization":[195],"121":[197],"\u00b0C":[198],"min":[201],"found":[203],"sufficient":[206],"mild.":[208],"Long\u2011term":[209],"revealed":[211],"impact":[214],"on":[217],"oxidative":[218],"processes:":[219],"unprotected":[221],"samples,":[222],"peroxide":[223,268],"value":[224,269],"free":[226],"fatty":[227],"acid":[228],"content":[229],"increased":[230],"significantly":[231],"18\u201324":[233],"months,":[234],"light\u2011protected":[237],"vials":[238],"all":[239,301],"remained":[241],"within":[242],"limits":[244],"months.":[247],"Upon":[248],"infusion":[251,314],"solutions,":[252],"stability":[254],"is":[255,307],"maintained":[256],"least":[259],"24":[260,321],"h;":[261],"however,":[262],"h,":[265],"exceed":[270],"permissible":[272],"limits.":[273],"Conclusion.":[274],"developed":[276],"ensures":[280],"successful":[281],"scale\u2011up":[282],"safe":[289],"emulsion.":[292],"To":[293],"preserve":[294],"product":[295],"quality,":[296],"protection":[297],"stages":[302],"administration":[306],"recommended,":[308],"as":[309,311],"well":[310],"limiting":[312],"time":[315],"diluted":[318],"hours.":[322],"obtained":[324],"results":[325],"can":[326],"used":[328],"industrial":[330],"production":[331],"clinical":[333],"application":[334],"FEs.":[337]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-27T00:00:00"}