{"id":"https://openalex.org/W7204248652","doi":"https://doi.org/10.1002/jez.70127","title":"Functional Characterization of the PI3K/AKT Pathway in Glucose Metabolism of Macrobrachium rosenbergii","display_name":"Functional Characterization of the PI3K/AKT Pathway in Glucose Metabolism of Macrobrachium rosenbergii","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204248652","doi":"https://doi.org/10.1002/jez.70127","pmid":"https://pubmed.ncbi.nlm.nih.gov/42642952"},"language":"en","primary_location":{"id":"doi:10.1002/jez.70127","doi":"https://doi.org/10.1002/jez.70127","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jez.70127","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jez.70127","source":{"id":"https://openalex.org/S4210175218","display_name":"Journal of Experimental Zoology Part A Ecological and Integrative Physiology","issn_l":"2471-5638","issn":["2471-5638","2471-5646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Zoology Part A: Ecological and Integrative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jez.70127","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148377215","display_name":"Qun Jiang","orcid":"https://orcid.org/0000-0001-9414-4635","observed_orcids":["https://orcid.org/0000-0001-9414-4635"]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qun Jiang","raw_affiliation_strings":["College of Animal Science and Technology Yangzhou University Yangzhou China"],"raw_orcid":"https://orcid.org/0000-0001-9414-4635","affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology Yangzhou University Yangzhou China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuting Teng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuting Teng","raw_affiliation_strings":["College of Animal Science and Technology Yangzhou University Yangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology Yangzhou University Yangzhou China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100538349","display_name":"Xu Wenjing","orcid":"https://orcid.org/0009-0002-0433-4596","observed_orcids":["https://orcid.org/0009-0002-0433-4596"]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjing Xu","raw_affiliation_strings":["College of Animal Science and Technology Yangzhou University Yangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology Yangzhou University Yangzhou China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082102890","display_name":"Makoto Osada","orcid":"https://orcid.org/0000-0001-6247-5106","observed_orcids":["https://orcid.org/0000-0001-6247-5106"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Osada","raw_affiliation_strings":["Environmental Research Promotion Center, Graduate School of Environmental Studies Tohoku University Sendai Japan"],"raw_orcid":"https://orcid.org/0000-0001-6247-5106","affiliations":[{"raw_affiliation_string":"Environmental Research Promotion Center, Graduate School of Environmental Studies Tohoku University Sendai Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148340790","display_name":"Xiaojian Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojian Gao","raw_affiliation_strings":["College of Animal Science and Technology Yangzhou University Yangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology Yangzhou University Yangzhou China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146061006","display_name":"Yao Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Zhang","raw_affiliation_strings":["College of Animal Science and Technology Yangzhou University Yangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology Yangzhou University Yangzhou China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058398123","display_name":"Xiaoyi Pan","orcid":"https://orcid.org/0000-0002-9261-1719","observed_orcids":["https://orcid.org/0000-0002-9261-1719"]},"institutions":[{"id":"https://openalex.org/I4210103131","display_name":"Zhejiang Institute of Freshwater Fisheries","ror":"https://ror.org/01bffta28","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210103131"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoyi Pan","raw_affiliation_strings":["Key Laboratory of Healthy Freshwater Aquaculture, Ministry of Agriculture and Rural Affairs Huzhou Key Laboratory of Fishery Environment and Aquatic Product Quality &amp; Safety; Zhejiang Institute of Freshwater Fisheries Huzhou China"],"raw_orcid":"https://orcid.org/0000-0002-9261-1719","affiliations":[{"raw_affiliation_string":"Key Laboratory of Healthy Freshwater Aquaculture, Ministry of Agriculture and Rural Affairs Huzhou Key Laboratory of Fishery Environment and Aquatic Product Quality &amp; Safety; Zhejiang Institute of Freshwater Fisheries Huzhou China","institution_ids":["https://openalex.org/I4210103131","https://openalex.org/I4210151987"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100362798","display_name":"Xiaojun Zhang","orcid":"https://orcid.org/0000-0003-3480-3322","observed_orcids":["https://orcid.org/0000-0003-3480-3322"]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaojun Zhang","raw_affiliation_strings":["College of Animal Science and Technology Yangzhou University Yangzhou China"],"raw_orcid":"https://orcid.org/0000-0003-3480-3322","affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology Yangzhou University Yangzhou China","institution_ids":["https://openalex.org/I78978612"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058398123","https://openalex.org/A5100362798"],"corresponding_institution_ids":["https://openalex.org/I4210103131","https://openalex.org/I4210151987","https://openalex.org/I78978612"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.579278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"345","issue":"9","first_page":"959","last_page":"968"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.6338000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.6338000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11004","display_name":"Crustacean biology and ecology","score":0.15950000286102295,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.0357000008225441,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9279999732971191},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.9359999895095825},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.7670000195503235},{"id":"https://openalex.org/keywords/macrobrachium-rosenbergii","display_name":"Macrobrachium rosenbergii","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":0.9319999814033508},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.9589999914169312},{"id":"https://openalex.org/keywords/hemocytes","display_name":"hemocytes","score":0.8769999742507935},{"id":"https://openalex.org/keywords/trehalose","display_name":"trehalose","score":0.8339999914169312},{"id":"https://openalex.org/keywords/hepatopancreas","display_name":"hepatopancreas","score":0.8610000014305115},{"id":"https://openalex.org/keywords/glycogen-synthesis","display_name":"glycogen synthesis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.6983000040054321},{"id":"https://openalex.org/C2775995008","wikidata":"https://www.wikidata.org/wiki/Q2700085","display_name":"Macrobrachium rosenbergii","level":3,"score":0.652899980545044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6330000162124634},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5285000205039978},{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.4975999891757965},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4957999885082245},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.4796000123023987},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4666000008583069},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4607999920845032},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4519999921321869},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.4088999927043915},{"id":"https://openalex.org/C2910750677","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Glucose Metabolism Disorder","level":4,"score":0.3995000123977661},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.36899998784065247},{"id":"https://openalex.org/C2778977261","wikidata":"https://www.wikidata.org/wiki/Q11358","display_name":"Carbohydrate","level":2,"score":0.3490999937057495},{"id":"https://openalex.org/C192118531","wikidata":"https://www.wikidata.org/wiki/Q86360001","display_name":"Glycogen synthase","level":3,"score":0.33880001306533813},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.32899999618530273},{"id":"https://openalex.org/C2853687","wikidata":"https://www.wikidata.org/wiki/Q18039976","display_name":"Carbohydrate-responsive element-binding protein","level":4,"score":0.3249000012874603},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3160000145435333},{"id":"https://openalex.org/C2778452849","wikidata":"https://www.wikidata.org/wiki/Q421773","display_name":"Trehalose","level":2,"score":0.30570000410079956},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.3012999892234802},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.2928999960422516},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.2924000024795532},{"id":"https://openalex.org/C2777901630","wikidata":"https://www.wikidata.org/wiki/Q24722849","display_name":"GLUT2","level":4,"score":0.28870001435279846},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.28839999437332153},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28209999203681946},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.2572000026702881},{"id":"https://openalex.org/C2776912716","wikidata":"https://www.wikidata.org/wiki/Q4042503","display_name":"LY294002","level":4,"score":0.25609999895095825}],"mesh":[{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D033541","descriptor_name":"Palaemonidae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043143","descriptor_name":"Hepatopancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jez.70127","doi":"https://doi.org/10.1002/jez.70127","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jez.70127","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jez.70127","source":{"id":"https://openalex.org/S4210175218","display_name":"Journal of Experimental Zoology Part A Ecological and Integrative Physiology","issn_l":"2471-5638","issn":["2471-5638","2471-5646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Zoology Part A: Ecological and Integrative Physiology","raw_type":"journal-article"},{"id":"pmid:42642952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42642952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental zoology. Part A, Ecological and integrative physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jez.70127","doi":"https://doi.org/10.1002/jez.70127","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jez.70127","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jez.70127","source":{"id":"https://openalex.org/S4210175218","display_name":"Journal of Experimental Zoology Part A Ecological and Integrative Physiology","issn_l":"2471-5638","issn":["2471-5638","2471-5646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Zoology Part A: Ecological and Integrative Physiology","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.6224574446678162,"display_name":"Life below water","id":"https://metadata.un.org/sdg/14"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4564848452","display_name":null,"funder_award_id":"32002386","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204248652.pdf","grobid_xml":"https://content.openalex.org/works/W7204248652.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1977219249","https://openalex.org/W1981711832","https://openalex.org/W2004035659","https://openalex.org/W2014887370","https://openalex.org/W2017695960","https://openalex.org/W2023286233","https://openalex.org/W2029576910","https://openalex.org/W2052517312","https://openalex.org/W2058531263","https://openalex.org/W2109326550","https://openalex.org/W2131620631","https://openalex.org/W2136804550","https://openalex.org/W2150898264","https://openalex.org/W2158261823","https://openalex.org/W2162098634","https://openalex.org/W2258537433","https://openalex.org/W2721495521","https://openalex.org/W2789926264","https://openalex.org/W2791278579","https://openalex.org/W2883252549","https://openalex.org/W2886504687","https://openalex.org/W2914185639","https://openalex.org/W2950090780","https://openalex.org/W3014793554","https://openalex.org/W3045198571","https://openalex.org/W3113167936","https://openalex.org/W3135253445","https://openalex.org/W3138920214","https://openalex.org/W4206757179","https://openalex.org/W4220848097","https://openalex.org/W4281287808","https://openalex.org/W4323567455","https://openalex.org/W4324387228","https://openalex.org/W4382918316","https://openalex.org/W4385174139","https://openalex.org/W4385264960","https://openalex.org/W4385336310","https://openalex.org/W4385607070","https://openalex.org/W4392192571","https://openalex.org/W4396566035","https://openalex.org/W4396907521","https://openalex.org/W4404283678","https://openalex.org/W4404475189","https://openalex.org/W4410245685"],"related_works":[],"abstract_inverted_index":{"The":[0],"glucose":[1,28,49,73,96,103,169],"intolerance":[2,170],"of":[3,26,44,89,133,155,171],"the":[4,11,19,42,45,52,62,90,119,130,146,152],"crustacean":[5,35],"limits":[6],"its":[7,32],"carbohydrate":[8,159],"utilization,":[9],"and":[10,104,112,139],"underlying":[12],"metabolic":[13],"mechanisms":[14],"remain":[15],"poorly":[16],"understood.":[17],"While":[18],"PI3K/AKT":[20,46,91,156],"pathway":[21,47,92,157],"is":[22,36],"a":[23,67,72],"central":[24],"regulator":[25],"insulin-mediated":[27],"metabolism":[29,50,160],"in":[30,34,48,51,86,94,118,136,141,158,161],"vertebrates,":[31],"role":[33,154],"largely":[37],"unexplored.":[38],"This":[39,143],"study":[40,144],"investigated":[41],"function":[43],"giant":[53],"freshwater":[54],"prawn,":[55],"Macrobrachium":[56],"rosenbergii.":[57],"Prawns":[58],"were":[59,115],"injected":[60],"with":[61],"PI3K-specific":[63],"inhibitor":[64,120],"LY294002":[65,81],"or":[66],"PBS":[68],"control,":[69],"followed":[70],"by":[71,99],"tolerance":[74],"test.":[75],"Western":[76],"blot":[77],"analysis":[78,124],"confirmed":[79],"that":[80,126],"significantly":[82,100,116],"inhibited":[83,129],"AKT":[84],"phosphorylation":[85],"hemocytes.":[87],"Inhibition":[88],"resulted":[93],"impaired":[95],"clearance,":[97],"evidenced":[98],"higher":[101],"plasma":[102],"trehalose":[105],"levels":[106],"post-glucose":[107],"injection.":[108],"Concurrently,":[109],"hepatopancreatic":[110],"glycogen":[111],"triglyceride":[113],"contents":[114],"reduced":[117],"group.":[121],"Gene":[122],"expression":[123],"revealed":[125],"PI3K":[127],"inhibition":[128],"glucose-induced":[131],"upregulation":[132],"genes":[134],"involved":[135],"glycolysis,":[137],"glycogenesis,":[138],"lipogenesis":[140],"hepatopancreas.":[142],"provides":[145],"first":[147],"direct":[148],"functional":[149],"evidence":[150],"supporting":[151],"conserved":[153],"M.":[162],"rosenbergii,":[163],"providing":[164],"preliminary":[165],"knowledge":[166],"for":[167],"understanding":[168],"crustacean.":[172]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-08-27T00:00:00"}
