{"id":"https://openalex.org/W7204248587","doi":"https://doi.org/10.3390/ijms27177636","title":"Crosstalk Between mTOR and NF-\u03baB Signaling Pathways in Clear Cell Renal Cell Carcinoma","display_name":"Crosstalk Between mTOR and NF-\u03baB Signaling Pathways in Clear Cell Renal Cell Carcinoma","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204248587","doi":"https://doi.org/10.3390/ijms27177636","pmid":"https://pubmed.ncbi.nlm.nih.gov/42737535"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27177636","doi":"https://doi.org/10.3390/ijms27177636","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27177636","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27177636","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048259768","display_name":"Melanie Glueck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Melanie Glueck","raw_affiliation_strings":["Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, Goethe University, 60596 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, Goethe University, 60596 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025379845","display_name":"Alexandra Lucaciu","orcid":"https://orcid.org/0000-0001-5783-088X","observed_orcids":["https://orcid.org/0000-0001-5783-088X"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexandra Lucaciu","raw_affiliation_strings":["Department of Neurology, Goethe University, 60596 Frankfurt am Main, Germany","Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, Goethe University, 60596 Frankfurt am Main, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5783-088X","affiliations":[{"raw_affiliation_string":"Department of Neurology, Goethe University, 60596 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, Goethe University, 60596 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133579594","display_name":"Sumedha Inukollu","orcid":"https://orcid.org/0009-0006-1948-7148","observed_orcids":["https://orcid.org/0009-0006-1948-7148"]},"institutions":[{"id":"https://openalex.org/I175691731","display_name":"Pondicherry University","ror":"https://ror.org/01a3mef16","country_code":"IN","type":"education","lineage":["https://openalex.org/I175691731"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sumedha Inukollu","raw_affiliation_strings":["Department of Bioinformatics, Pondicherry University, Puducherry 605014, India"],"raw_orcid":"https://orcid.org/0009-0006-1948-7148","affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Pondicherry University, Puducherry 605014, India","institution_ids":["https://openalex.org/I175691731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055912473","display_name":"Rushendhiran Kesavan","orcid":"https://orcid.org/0000-0002-8540-8093","observed_orcids":["https://orcid.org/0000-0002-8540-8093"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rushendhiran Kesavan","raw_affiliation_strings":["Children\u2019s Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA"],"raw_orcid":"https://orcid.org/0000-0002-8540-8093","affiliations":[{"raw_affiliation_string":"Children\u2019s Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148244322","display_name":"Amelie Janssen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Amelie Janssen","raw_affiliation_strings":["Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, Goethe University, 60596 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, Goethe University, 60596 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010990190","display_name":"Josef Pfeilschifter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Josef Pfeilschifter","raw_affiliation_strings":["Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, Goethe University, 60596 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, Goethe University, 60596 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052275524","display_name":"Julien Subburayalu","orcid":"https://orcid.org/0000-0001-9243-0558","observed_orcids":["https://orcid.org/0000-0001-9243-0558"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]},{"id":"https://openalex.org/I4405266872","display_name":"Center for Regenerative Therapies Dresden","ror":"https://ror.org/00490nx58","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405266872","https://openalex.org/I4405279746","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I4405269127","display_name":"German Cancer Consortium (DKTK) Dresden","ror":"https://ror.org/036e5z664","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427","https://openalex.org/I4405269127"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julien Subburayalu","raw_affiliation_strings":["Center for Regenerative Therapies Dresden (CRTD), TU Dresden, Fetscherstra\u00dfe 105, 01307 Dresden, Germany","Department of Internal Medicine, University Hospital Carl Gustav Carus TU Dresden, Fetscherstra\u00dfe 74, 01307 Dresden, Germany","German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9243-0558","affiliations":[{"raw_affiliation_string":"Center for Regenerative Therapies Dresden (CRTD), TU Dresden, Fetscherstra\u00dfe 105, 01307 Dresden, Germany","institution_ids":["https://openalex.org/I4405266872","https://openalex.org/I78650965"]},{"raw_affiliation_string":"Department of Internal Medicine, University Hospital Carl Gustav Carus TU Dresden, Fetscherstra\u00dfe 74, 01307 Dresden, Germany","institution_ids":["https://openalex.org/I4210162051","https://openalex.org/I78650965"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4405269127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123955110","display_name":"Ramesh K. Krishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]},{"id":"https://openalex.org/I4210161239","display_name":"Frankfurt Cancer Institute","ror":"https://ror.org/05bx21r34","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210161239"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ramesh K. Krishnan","raw_affiliation_strings":["Department of Medicine, Hematology/Oncology, University Hospital Frankfurt, Goethe University, 60596 Frankfurt am Main, Germany","Frankfurt Cancer Institute, Goethe University, 60596 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Hematology/Oncology, University Hospital Frankfurt, Goethe University, 60596 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]},{"raw_affiliation_string":"Frankfurt Cancer Institute, Goethe University, 60596 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210161239"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040533169","display_name":"Rajkumar Vutukuri","orcid":"https://orcid.org/0000-0002-7890-9471","observed_orcids":["https://orcid.org/0000-0002-7890-9471"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Rajkumar Vutukuri","raw_affiliation_strings":["Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, Goethe University, 60596 Frankfurt am Main, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7890-9471","affiliations":[{"raw_affiliation_string":"Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, Goethe University, 60596 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5040533169","https://openalex.org/A5123955110"],"corresponding_institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578","https://openalex.org/I4210161239"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.61227908,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"17","first_page":"7636","last_page":"7636"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.08569999784231186,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":1.0},{"id":"https://openalex.org/keywords/pathway-crosstalk","display_name":"pathway crosstalk","score":0.8700000047683716},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.8169999718666077},{"id":"https://openalex.org/keywords/ikappabalpha-phosphorylation","display_name":"I\u03baB\u03b1 phosphorylation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.6510000228881836},{"id":"https://openalex.org/keywords/ribosomal-protein-s6","display_name":"ribosomal protein S6","score":0.8479999899864197},{"id":"https://openalex.org/keywords/4e-bp1","display_name":"4E-BP1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/torin1","display_name":"Torin1","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5820000171661377},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.833899974822998},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.8248000144958496},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.708299994468689},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6855000257492065},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5835999846458435},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4747999906539917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44670000672340393},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.4171999990940094},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4169999957084656},{"id":"https://openalex.org/C43060935","wikidata":"https://www.wikidata.org/wiki/Q18043110","display_name":"RPTOR","level":4,"score":0.36500000953674316},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.35269999504089355},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3513999879360199},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34769999980926514},{"id":"https://openalex.org/C107846503","wikidata":"https://www.wikidata.org/wiki/Q14876061","display_name":"mTORC2","level":5,"score":0.3301999866962433},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31610000133514404},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.311599999666214},{"id":"https://openalex.org/C2778560582","wikidata":"https://www.wikidata.org/wiki/Q18347894","display_name":"Clear cell","level":3,"score":0.30799999833106995},{"id":"https://openalex.org/C183713625","wikidata":"https://www.wikidata.org/wiki/Q5282002","display_name":"Discovery and development of mTOR inhibitors","level":4,"score":0.2985999882221222},{"id":"https://openalex.org/C2781322055","wikidata":"https://www.wikidata.org/wiki/Q423725","display_name":"Phosphoinositide 3-kinase","level":4,"score":0.2773999869823456},{"id":"https://openalex.org/C2777949483","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"Mechanistic target of rapamycin","level":4,"score":0.2563999891281128},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.25099998712539673},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.25049999356269836}],"mesh":[{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms27177636","doi":"https://doi.org/10.3390/ijms27177636","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27177636","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:42737535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42737535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13566279","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13566279/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13566279/pdf/ijms-27-07636.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms27177636","doi":"https://doi.org/10.3390/ijms27177636","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27177636","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.782160222530365,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2013436488","display_name":null,"funder_award_id":"SFB-1039","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5786758540","display_name":null,"funder_award_id":"SFB1039","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320310693","display_name":"Deutsches Krebsforschungszentrum","ror":"https://ror.org/04cdgtt98"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320890","display_name":"Fondation Leducq","ror":"https://ror.org/01czwga19"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320327569","display_name":"Deutschen Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31"},{"id":"https://openalex.org/F4320329666","display_name":"Berlin Institute of Health","ror":"https://ror.org/0493xsw21"},{"id":"https://openalex.org/F4320332076","display_name":"Vogel Stiftung","ror":"https://ror.org/03qqaft37"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1992961242","https://openalex.org/W1997050190","https://openalex.org/W2059948976","https://openalex.org/W2081161751","https://openalex.org/W2086123367","https://openalex.org/W2087461043","https://openalex.org/W2101546320","https://openalex.org/W2103133890","https://openalex.org/W2109706412","https://openalex.org/W2126783165","https://openalex.org/W2131394075","https://openalex.org/W2153867442","https://openalex.org/W2162303904","https://openalex.org/W2288576450","https://openalex.org/W2331176038","https://openalex.org/W2894115882","https://openalex.org/W3137347296","https://openalex.org/W4385986528","https://openalex.org/W4391840598","https://openalex.org/W4392092898","https://openalex.org/W4392343318","https://openalex.org/W4398213922","https://openalex.org/W4400233229","https://openalex.org/W4400763614","https://openalex.org/W4401171575","https://openalex.org/W4401219830","https://openalex.org/W4408674287","https://openalex.org/W4411619062","https://openalex.org/W4414834035","https://openalex.org/W4416402807"],"related_works":[],"abstract_inverted_index":{"Clear":[0],"cell":[1,3,15,145,237],"renal":[2,14],"carcinoma":[4,16],"(ccRCC)":[5],"is":[6],"the":[7,46,53,60,89,115,164,223,259,273,289],"most":[8],"common":[9],"and":[10,27,59,86,94,100,119,137,148,155,159,175,184,198,210,231,239,269,285,292],"aggressive":[11,31],"type":[12],"of":[13,21,30,40,56,66,135,153,195,215,222,252,258],"(RCC),":[17],"representing":[18],"approximately":[19],"80%":[20],"cases":[22],"globally.":[23],"Despite":[24],"improved":[25],"diagnosis":[26],"therapy,":[28],"treatment":[29],"or":[32,42,217],"metastatic":[33],"ccRCC":[34,98,131,144,192,274,290],"remains":[35,103],"challenging":[36],"due":[37],"to":[38,113],"acquisition":[39],"primary":[41],"secondary":[43],"resistance.":[44],"Among":[45],"dysregulated":[47],"signaling":[48,96,121,271,287],"mechanisms":[49],"identified":[50],"in":[51,75,97,107,122,190,272,288],"ccRCC,":[52],"mechanistic":[54,298],"target":[55],"rapamycin":[57],"(mTOR)":[58],"nuclear":[61],"factor":[62],"kappa":[63],"light-chain":[64],"enhancer":[65],"activated":[67,189],"B":[68],"cells":[69],"(NF-\u03baB)":[70],"pathways":[71,170,186],"play":[72],"central":[73],"roles":[74],"regulating":[76],"various":[77],"biological":[78],"functions":[79],"such":[80],"as":[81],"metabolism,":[82],"inflammation,":[83],"tumor":[84,126],"growth,":[85],"survival.":[87],"However,":[88],"molecular":[90],"crosstalk":[91],"between":[92,117,167,267,283],"mTOR":[93,118,136,154,183,216],"NF-\u03baB":[95,120,138,185],"progression":[99],"therapeutic":[101],"resistance":[102],"poorly":[104],"understood.":[105],"Therefore,":[106],"our":[108],"current":[109],"study,":[110],"we":[111,140,162],"aimed":[112],"investigate":[114],"interplay":[116],"ccRCC.":[123],"We":[124],"analyzed":[125],"tissue":[127],"samples":[128],"from":[129],"human":[130,143,191],"patients.":[132],"For":[133],"validation":[134],"signaling,":[139,157],"used":[141],"two":[142,169],"lines,":[146],"A498":[147,209],"786-O.":[149],"Using":[150],"pharmacological":[151,213],"inhibitors":[152,235],"IKK/NF-\u03baB":[156,218],"Torin-1":[158,248],"MLN120B,":[160],"respectively,":[161],"assessed":[163],"functional":[165,176,265,281],"relationship":[166],"these":[168],"employing":[171],"immunoblotting,":[172],"EdU-based":[173],"immunocytochemistry,":[174],"assays.":[177],"Our":[178,277],"findings":[179,278],"reveal":[180],"that":[181],"both":[182],"are":[187],"aberrantly":[188],"tissues.":[193],"Phosphorylation":[194],"I\u03baB\u03b1,":[196],"S6,":[197,228],"4E-BP1":[199],"was":[200],"increased":[201],"compared":[202],"with":[203,242],"matched":[204],"adjacent":[205],"control":[206],"tissue.":[207],"In":[208],"786-O":[211],"cells,":[212],"inhibition":[214,251],"altered":[219,255],"key":[220,256],"readouts":[221,257],"reciprocal":[224,264],"pathway,":[225,261],"including":[226],"AKT,":[227],"4E-BP1,":[229],"I\u03baB\u03b1":[230],"p65":[232],"phosphorylation.":[233],"Both":[234],"reduced":[236],"number":[238],"EdU":[240],"incorporation,":[241],"stronger":[243],"anti-proliferative":[244],"effects":[245],"observed":[246],"after":[247],"treatment.":[249],"Pharmacological":[250],"either":[253],"pathway":[254,302],"other":[260],"supporting":[262],"a":[263,280,294],"association":[266,282],"mTOR-":[268,284],"NF-\u03baB-associated":[270,286],"models":[275,291],"analyzed.":[276],"support":[279],"provide":[293],"rationale":[295],"for":[296],"further":[297],"studies":[299],"evaluating":[300],"combined":[301],"modulation.":[303]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2026-08-27T00:00:00"}