{"id":"https://openalex.org/W7204247235","doi":"https://doi.org/10.7759/cureus.115220","title":"Solitary Testicular Metastasis as the Only Site of Recurrence in Prostate Adenocarcinoma","display_name":"Solitary Testicular Metastasis as the Only Site of Recurrence in Prostate Adenocarcinoma","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204247235","doi":"https://doi.org/10.7759/cureus.115220","pmid":"https://pubmed.ncbi.nlm.nih.gov/42799107","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13613960"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.115220","doi":"https://doi.org/10.7759/cureus.115220","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.115220","pdf_url":null,"source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.7759/cureus.115220","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117074350","display_name":"MOHAMED AMINE HARCHAOUI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mohamed Amine Harchaoui","raw_affiliation_strings":["Urology, Mohammed V Military Instruction Hospital, Rabat, MAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology, Mohammed V Military Instruction Hospital, Rabat, MAR","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148247061","display_name":"Brahim Masaoudi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brahim Masaoudi","raw_affiliation_strings":["Urology, Mohammed V Military Instruction Hospital, Rabat, MAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology, Mohammed V Military Instruction Hospital, Rabat, MAR","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084830339","display_name":"Mustapha Azzakhmam","orcid":"https://orcid.org/0000-0001-5675-2277","observed_orcids":["https://orcid.org/0000-0001-5675-2277"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mustapha Azzakhmam","raw_affiliation_strings":["Pathology, Mohammed V Military Instruction Hospital, Rabat, MAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Mohammed V Military Instruction Hospital, Rabat, MAR","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022237755","display_name":"Mohammed Alami","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammed Alami","raw_affiliation_strings":["Urology, Mohammed V Military Instruction Hospital, Rabat, MAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology, Mohammed V Military Instruction Hospital, Rabat, MAR","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102160162","display_name":"Ahmed Ameur","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmed Ameur","raw_affiliation_strings":["Urology, Mohammed V Military Instruction Hospital, Rabat, MAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology, Mohammed V Military Instruction Hospital, Rabat, MAR","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5117074350"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"8","first_page":"e115220","last_page":"e115220"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.11749999970197678,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/testicular-metastasis","display_name":"testicular metastasis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/prostate-adenocarcinoma","display_name":"prostate adenocarcinoma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/oligometastatic-disease","display_name":"oligometastatic disease","score":0.8809999823570251},{"id":"https://openalex.org/keywords/distant-recurrence","display_name":"distant recurrence","score":0.6150000095367432},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.7739999890327454},{"id":"https://openalex.org/keywords/abiraterone-acetate","display_name":"abiraterone","score":0.9729999899864197},{"id":"https://openalex.org/keywords/psma-pet-ct","display_name":"PSMA PET/CT","score":0.9169999957084656},{"id":"https://openalex.org/keywords/alpha-methylacyl-coa-racemase","display_name":"AMACR","score":0.8550000190734863},{"id":"https://openalex.org/keywords/radical-orchiectomy","display_name":"radical orchiectomy","score":0.871999979019165},{"id":"https://openalex.org/keywords/lymphatic-spread","display_name":"lymphatic spread","score":0.6340000033378601},{"id":"https://openalex.org/keywords/elevated-prostate-specific-antigen","display_name":"elevated prostate-specific antigen","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9829999804496765},{"id":"https://openalex.org/C2991879385","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate adenocarcinoma","level":4,"score":0.6288999915122986},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5440000295639038},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5116000175476074},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.510200023651123},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4731999933719635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4542999863624573},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4311999976634979},{"id":"https://openalex.org/C2910254342","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostatic adenocarcinoma","level":4,"score":0.4147999882698059},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33799999952316284},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.33719998598098755},{"id":"https://openalex.org/C2994223898","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate disease","level":4,"score":0.30410000681877136},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.29660001397132874},{"id":"https://openalex.org/C3019926457","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Distant metastasis","level":4,"score":0.2809000015258789},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.28029999136924744},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.2669999897480011},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.2639000117778778},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2572999894618988}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.115220","doi":"https://doi.org/10.7759/cureus.115220","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.115220","pdf_url":null,"source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13613960","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13613960/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13613960/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:42799107","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42799107","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.7759/cureus.115220","doi":"https://doi.org/10.7759/cureus.115220","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.115220","pdf_url":null,"source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204247235.pdf","grobid_xml":"https://content.openalex.org/works/W7204247235.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1975577875","https://openalex.org/W2030536448","https://openalex.org/W2156289811","https://openalex.org/W2340422569","https://openalex.org/W2618839199","https://openalex.org/W4407162356","https://openalex.org/W4407700030","https://openalex.org/W4409329909","https://openalex.org/W4410769310","https://openalex.org/W7127079741"],"related_works":["https://openalex.org/W7128683553","https://openalex.org/W7159736924","https://openalex.org/W2470639104","https://openalex.org/W2884994001","https://openalex.org/W7162334625","https://openalex.org/W2967789968","https://openalex.org/W2747517254","https://openalex.org/W7131087567","https://openalex.org/W3099235980","https://openalex.org/W4309321465"],"abstract_inverted_index":{"Prostate":[0],"cancer":[1],"preferentially":[2],"metastasizes":[3],"to":[4],"bone":[5],"and":[6,14,104,122,173,197],"lymph":[7],"nodes.":[8],"Testicular":[9,154],"metastases":[10],"are":[11,15],"exceptionally":[12],"rare":[13],"typically":[16],"observed":[17],"in":[18,65,147,151,176,191],"the":[19,37,102,105,127,131,185],"setting":[20],"of":[21,39,119,130,156,187],"advanced":[22,170],"polymetastatic":[23],"disease.":[24],"Their":[25],"presentation":[26],"as":[27],"an":[28],"isolated":[29],"oligometastatic":[30,192],"relapse":[31],"remains":[32],"highly":[33],"unusual.":[34],"We":[35],"report":[36],"case":[38,183],"a":[40,60,69,148,188],"76-year-old":[41],"patient":[42],"followed":[43],"since":[44],"2019":[45],"for":[46],"de":[47],"novo":[48],"metastatic":[49],"prostate":[50,157],"adenocarcinoma,":[51],"initially":[52],"treated":[53],"with":[54,59,68,143,178],"androgen":[55,140],"deprivation":[56,141],"therapy":[57,142],"(ADT)":[58],"complete":[61],"response,":[62],"who":[63],"presented":[64],"March":[66],"2026":[67],"left":[70],"testicular":[71],"mass.":[72],"Germ":[73],"cell":[74],"tumor":[75],"markers":[76],"were":[77],"negative,":[78],"while":[79],"prostate-specific":[80],"antigen":[81,90],"(PSA)":[82],"was":[83,112,136],"elevated":[84],"at":[85],"30":[86],"ng/mL.":[87],"Prostate-specific":[88],"membrane":[89],"positron":[91],"emission":[92],"tomography-computed":[93],"tomography":[94],"(PSMA":[95],"PET-CT)":[96],"demonstrated":[97],"increased":[98],"uptake":[99],"involving":[100],"both":[101],"testis":[103],"peri-scrotal":[106],"region.":[107],"A":[108],"radical":[109],"inguinal":[110],"orchiectomy":[111],"performed.":[113],"Immunohistochemical":[114],"analysis":[115],"showed":[116],"strong":[117],"expression":[118],"prostein":[120],"(P501S)":[121],"alpha-methylacyl-CoA":[123],"racemase":[124],"(AMACR),":[125],"confirming":[126],"prostatic":[128],"origin":[129],"lesion.":[132],"Postoperatively,":[133],"systemic":[134,199],"treatment":[135],"intensified":[137,198],"using":[138],"combined":[139],"abiraterone":[144],"acetate,":[145],"resulting":[146],"marked":[149],"decline":[150],"PSA":[152,180],"levels.":[153],"dissemination":[155],"adenocarcinoma":[158],"may":[159],"occur":[160],"through":[161],"retrograde":[162],"venous":[163],"or":[164],"lymphatic":[165],"pathways.":[166],"Diagnosis":[167],"relies":[168],"on":[169],"molecular":[171],"imaging":[172],"immunohistochemistry,":[174],"particularly":[175],"cases":[177],"reduced":[179],"expression.":[181],"This":[182],"highlights":[184],"relevance":[186],"multimodal":[189],"strategy":[190],"disease,":[193],"combining":[194],"metastasis-directed":[195],"surgery":[196],"therapy.":[200]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-08-27T00:00:00"}