{"id":"https://openalex.org/W7204245380","doi":"https://doi.org/10.1002/ohn.70406","title":"Efficacy of Exhalation Delivery System With Fluticasone in Chronic Rhinosinusitis With Versus Without Polyps","display_name":"Efficacy of Exhalation Delivery System With Fluticasone in Chronic Rhinosinusitis With Versus Without Polyps","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204245380","doi":"https://doi.org/10.1002/ohn.70406","pmid":"https://pubmed.ncbi.nlm.nih.gov/42647052"},"language":"en","primary_location":{"id":"doi:10.1002/ohn.70406","doi":"https://doi.org/10.1002/ohn.70406","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ohn.70406","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ohn.70406","source":{"id":"https://openalex.org/S200877091","display_name":"Otolaryngology","issn_l":"0161-6439","issn":["0161-6439","0194-5998","1085-8679","1097-6817"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology\u2013Head and Neck Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ohn.70406","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048490917","display_name":"Rodney J. Schlosser","orcid":"https://orcid.org/0000-0001-6480-0275","observed_orcids":["https://orcid.org/0000-0001-6480-0275"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rodney J. Schlosser","raw_affiliation_strings":["Department of Otolaryngology \u2013 Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"],"raw_orcid":"https://orcid.org/0000-0001-6480-0275","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology \u2013 Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110477224","display_name":"Nithin D. Adappa","orcid":"https://orcid.org/0000-0002-0339-8769","observed_orcids":["https://orcid.org/0000-0002-0339-8769"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nithin D. Adappa","raw_affiliation_strings":["Department of Otorhinolaryngology \u2013 Head and Neck Surgery, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101759434","display_name":"Rakesh K. Chandra","orcid":"https://orcid.org/0000-0002-8330-9809","observed_orcids":["https://orcid.org/0000-0002-8330-9809"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rakesh K. Chandra","raw_affiliation_strings":["Department of Otolaryngology \u2013 Head and Neck Surgery University of Mississippi Medical Center Jackson Mississippi USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Mississippi Medical Center Jackson Mississippi USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007918775","display_name":"Greg E. Davis","orcid":"https://orcid.org/0000-0002-5373-5559","observed_orcids":["https://orcid.org/0000-0002-5373-5559"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Greg E. Davis","raw_affiliation_strings":["Ear Nose Throat and Allergy Associates, Proliance Surgeons Seattle and Puyallup Seattle Washington USA"],"raw_orcid":"https://orcid.org/0000-0002-5373-5559","affiliations":[{"raw_affiliation_string":"Ear Nose Throat and Allergy Associates, Proliance Surgeons Seattle and Puyallup Seattle Washington USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064973236","display_name":"Mahboobeh Mahdavinia","orcid":"https://orcid.org/0000-0003-4004-203X","observed_orcids":["https://orcid.org/0000-0003-4004-203X"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahboobeh Mahdavinia","raw_affiliation_strings":["Division of Allergy & Immunology UT Health Houston Houston Texas USA"],"raw_orcid":"https://orcid.org/0000-0003-4004-203X","affiliations":[{"raw_affiliation_string":"Division of Allergy & Immunology UT Health Houston Houston Texas USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077352083","display_name":"John C. Messina","orcid":"https://orcid.org/0000-0003-0167-2151","observed_orcids":["https://orcid.org/0000-0003-0167-2151"]},"institutions":[{"id":"https://openalex.org/I4210106623","display_name":"OptiNose (United States)","ror":"https://ror.org/01ft7jz29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106623"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Messina","raw_affiliation_strings":["Clinical Research and Medical Affairs Optinose US, Inc Yardley Pennsylvania USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research and Medical Affairs Optinose US, Inc Yardley Pennsylvania USA","institution_ids":["https://openalex.org/I4210106623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088028354","display_name":"Zara M. Patel","orcid":"https://orcid.org/0000-0003-2072-982X","observed_orcids":["https://orcid.org/0000-0003-2072-982X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zara M. Patel","raw_affiliation_strings":["Department of Otolaryngology \u2013 Head and Neck Surgery Stanford University School of Medicine Stanford California USA"],"raw_orcid":"https://orcid.org/0000-0003-2072-982X","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology \u2013 Head and Neck Surgery Stanford University School of Medicine Stanford California USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047671590","display_name":"Anju Tripathi Peters","orcid":"https://orcid.org/0000-0003-0745-2379","observed_orcids":["https://orcid.org/0000-0003-0745-2379"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anju T. Peters","raw_affiliation_strings":["Division of Allergy and Immunology Northwestern University Feinberg School of Medicine Chicago Illinois USA"],"raw_orcid":"https://orcid.org/0000-0003-0745-2379","affiliations":[{"raw_affiliation_string":"Division of Allergy and Immunology Northwestern University Feinberg School of Medicine Chicago Illinois USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068090449","display_name":"Raj H. Sindwani","orcid":"https://orcid.org/0000-0002-6584-922X","observed_orcids":["https://orcid.org/0000-0002-6584-922X"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raj Sindwani","raw_affiliation_strings":["Head and Neck Surgery Department, Integrated Surgery Institute Cleveland Clinic Cleveland Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head and Neck Surgery Department, Integrated Surgery Institute Cleveland Clinic Cleveland Ohio USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088433858","display_name":"Zachary M. Soler","orcid":"https://orcid.org/0000-0002-4304-595X","observed_orcids":["https://orcid.org/0000-0002-4304-595X"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary M. Soler","raw_affiliation_strings":["Department of Otolaryngology \u2013 Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology \u2013 Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103119223","display_name":"Andrew A. White","orcid":"https://orcid.org/0000-0002-3273-9008","observed_orcids":["https://orcid.org/0000-0002-3273-9008"]},"institutions":[{"id":"https://openalex.org/I1311914864","display_name":"Scripps Health","ror":"https://ror.org/05bhsww40","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864"]},{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew A. White","raw_affiliation_strings":["Division of Allergy, Asthma and Immunology Scripps Clinic San Diego California USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy, Asthma and Immunology Scripps Clinic San Diego California USA","institution_ids":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110770734","display_name":"Sarah K. Wise","orcid":"https://orcid.org/0000-0002-6398-0056","observed_orcids":["https://orcid.org/0000-0002-6398-0056"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah K. Wise","raw_affiliation_strings":["Department of Otolaryngology\u2010Head and Neck Surgery Emory University School of Medicine Atlanta Georgia USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2010Head and Neck Surgery Emory University School of Medicine Atlanta Georgia USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027109682","display_name":"James N. Palmer","orcid":"https://orcid.org/0000-0002-7535-9339","observed_orcids":["https://orcid.org/0000-0002-7535-9339"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James N. Palmer","raw_affiliation_strings":["Department of Otorhinolaryngology \u2013 Head and Neck Surgery, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5048490917"],"corresponding_institution_ids":["https://openalex.org/I153297377"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":{"value":3600,"currency":"USD","value_usd":3600},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.68290891,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11812","display_name":"Nasal Surgery and Airway Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-rhinosinusitis","display_name":"chronic rhinosinusitis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/nasal-polyps","display_name":"nasal polyps","score":0.902999997138977},{"id":"https://openalex.org/keywords/fluticasone","display_name":"fluticasone","score":0.984000027179718},{"id":"https://openalex.org/keywords/intranasal-corticosteroids","display_name":"intranasal corticosteroids","score":0.9150000214576721},{"id":"https://openalex.org/keywords/acute-exacerbation","display_name":"acute exacerbation","score":0.6290000081062317},{"id":"https://openalex.org/keywords/olfactory-function","display_name":"olfactory function","score":0.5260000228881836},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.7319999933242798},{"id":"https://openalex.org/keywords/treatment-by-subgroup-interaction","display_name":"treatment-by-subgroup interaction","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9437999725341797},{"id":"https://openalex.org/C2781212218","wikidata":"https://www.wikidata.org/wiki/Q1002165","display_name":"Fluticasone","level":3,"score":0.7894999980926514},{"id":"https://openalex.org/C2781390199","wikidata":"https://www.wikidata.org/wiki/Q8055111","display_name":"Nasal polyps","level":2,"score":0.7723000049591064},{"id":"https://openalex.org/C2779789940","wikidata":"https://www.wikidata.org/wiki/Q858590","display_name":"Nostril","level":3,"score":0.6496000289916992},{"id":"https://openalex.org/C3019717275","wikidata":"https://www.wikidata.org/wiki/Q183344","display_name":"Chronic rhinosinusitis","level":2,"score":0.6126999855041504},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5562000274658203},{"id":"https://openalex.org/C43396882","wikidata":"https://www.wikidata.org/wiki/Q2197000","display_name":"Exhalation","level":2,"score":0.546999990940094},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.5414999723434448},{"id":"https://openalex.org/C2780973058","wikidata":"https://www.wikidata.org/wiki/Q1755275","display_name":"Nasal spray","level":3,"score":0.5198000073432922},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.46810001134872437},{"id":"https://openalex.org/C2778311950","wikidata":"https://www.wikidata.org/wiki/Q7363","display_name":"Nose","level":2,"score":0.4528000056743622},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.415800005197525},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.41110000014305115},{"id":"https://openalex.org/C2779028295","wikidata":"https://www.wikidata.org/wiki/Q8564098","display_name":"Fluticasone propionate","level":3,"score":0.4090000092983246},{"id":"https://openalex.org/C2779926200","wikidata":"https://www.wikidata.org/wiki/Q468433","display_name":"Anosmia","level":5,"score":0.4058000147342682},{"id":"https://openalex.org/C2909814679","wikidata":"https://www.wikidata.org/wiki/Q1425813","display_name":"Nasal Lavage","level":3,"score":0.39910000562667847},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.3785000145435333},{"id":"https://openalex.org/C2777768476","wikidata":"https://www.wikidata.org/wiki/Q183344","display_name":"Sinusitis","level":2,"score":0.3781999945640564},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.3619000017642975},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36059999465942383},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.31040000915527344},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.3093000054359436},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.30410000681877136},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.298799991607666},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.29269999265670776},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.29010000824928284}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/ohn.70406","doi":"https://doi.org/10.1002/ohn.70406","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ohn.70406","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ohn.70406","source":{"id":"https://openalex.org/S200877091","display_name":"Otolaryngology","issn_l":"0161-6439","issn":["0161-6439","0194-5998","1085-8679","1097-6817"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology\u2013Head and Neck Surgery","raw_type":"journal-article"},{"id":"pmid:42647052","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42647052","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/ohn.70406","doi":"https://doi.org/10.1002/ohn.70406","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ohn.70406","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ohn.70406","source":{"id":"https://openalex.org/S200877091","display_name":"Otolaryngology","issn_l":"0161-6439","issn":["0161-6439","0194-5998","1085-8679","1097-6817"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology\u2013Head and Neck Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320310842","display_name":"Stryker","ror":"https://ror.org/043affe91"},{"id":"https://openalex.org/F4320311600","display_name":"Regeneron Pharmaceuticals","ror":"https://ror.org/02f51rf24"},{"id":"https://openalex.org/F4320312091","display_name":"American Rhinologic Society","ror":"https://ror.org/03myc4w31"},{"id":"https://openalex.org/F4320319810","display_name":"Insmed","ror":null},{"id":"https://openalex.org/F4320327918","display_name":"H. Lundbeck A/S","ror":"https://ror.org/0564cd633"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204245380.pdf","grobid_xml":"https://content.openalex.org/works/W7204245380.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1994848292","https://openalex.org/W2022980631","https://openalex.org/W2045670750","https://openalex.org/W2046867209","https://openalex.org/W2081374067","https://openalex.org/W2137574477","https://openalex.org/W2171764855","https://openalex.org/W2475105368","https://openalex.org/W2586219733","https://openalex.org/W2808808376","https://openalex.org/W2902583043","https://openalex.org/W2993259418","https://openalex.org/W3110082941","https://openalex.org/W4285993114","https://openalex.org/W4390977346","https://openalex.org/W4401887140"],"related_works":[],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"whether":[3],"treatment":[4,201],"responses":[5],"to":[6,82],"the":[7,36,62,178,183,230,247],"exhalation":[8],"delivery":[9],"system":[10],"with":[11,18,20,68,137,145,205,209],"fluticasone":[12],"(EDS-FLU;":[13],"XHANCE\u00ae)":[14],"differ":[15],"between":[16,41],"patients":[17,25,67,181,204,208],"CRS":[19,219],"nasal":[21,27,190,222],"polyps":[22,28],"(CRSwNP)":[23],"and":[24,44,128,139,163,167,172,207,215,232,254],"without":[26],"(CRSsNP).":[29],"STUDY":[30],"DESIGN:":[31],"Post":[32],"hoc":[33],"analysis":[34],"of":[35,118,121,132,158,161,180,218,221,234,237,249],"ReOpen":[37],"clinical":[38],"trials":[39,64],"conducted":[40],"November":[42,45],"2018":[43],"2021":[46],"for":[47,98,203],"a":[48],"24-week":[49],"duration.":[50],"SETTING:":[51],"Multinational,":[52],"multicenter,":[53],"randomized,":[54],"EDS-placebo-controlled":[55],"studies.":[56],"METHODS:":[57],"Data":[58],"were":[59,78,175],"pooled":[60],"from":[61],"randomized":[63],"in":[65,177,239],"which":[66],"CRSwNP":[69,138,206],"(n":[70,75],"=":[71,76],"206)":[72],"or":[73,88,91,245],"CRSsNP":[74,140],"341)":[77],"randomly":[79],"assigned":[80],"(1:1:1)":[81],"EDS-FLU":[83,146,200,212],"186":[84],"\u03bcg,":[85,87],"372":[86],"EDS-placebo,":[89],"1":[90],"2":[92],"sprays":[93],"twice":[94],"daily":[95],"per":[96],"nostril":[97],"24":[99],"weeks.":[100],"Endpoints":[101],"included":[102],"composite":[103],"symptom":[104,170],"score,":[105],"Smell":[106],"Identification":[107],"Test":[108,126],"(SIT),":[109],"sinus":[110,152],"opacification":[111,153],"on":[112,149,154],"computed":[113],"tomography":[114],"(CT)":[115],"scan,":[116,156],"frequency":[117],"acute":[119,159],"exacerbations":[120,160],"CRS,":[122,162],"22-Item":[123],"Sino-Nasal":[124],"Outcome":[125],"(SNOT-22),":[127],"Patient":[129],"Global":[130],"Impression":[131],"Change":[133],"(PGIC).":[134],"RESULTS:":[135],"Patients":[136],"reported":[141],"substantially":[142],"greater":[143],"benefits":[144],"versus":[147],"EDS-placebo":[148],"symptoms,":[150],"SIT,":[151],"CT":[155],"incidence":[157],"quality-of-life":[164],"outcomes":[165],"(SNOT-22":[166],"PGIC).":[168],"Composite":[169],"score":[171],"SNOT-22":[173],"improvements":[174],"consistent":[176],"subgroup":[179],"entering":[182],"trial":[184],"reporting":[185],"symptoms":[186],"despite":[187],"recent":[188],"standard-delivery":[189],"steroid":[191],"spray":[192],"use.":[193],"Treatment-by-subgroup":[194],"interaction":[195],"effects":[196],"indicated":[197],"similar":[198],"magnitude":[199],"effect":[202],"CRSsNP.":[210],"CONCLUSION:":[211],"improved":[213],"subjective":[214],"objective":[216],"measures":[217],"irrespective":[220],"polyp":[223],"status.":[224],"TRIAL":[225],"REGISTRATION:":[226],"Title:":[227],"Study":[228],"Evaluating":[229],"Efficacy":[231],"Safety":[233],"Intranasal":[235],"Administration":[236],"OPN-375":[238],"Subjects":[240],"With":[241,244],"Chronic":[242],"Rhinosinusitis":[243],"Without":[246],"Presence":[248],"Nasal":[250],"Polyps;":[251],"ID:":[252],"NCT03781804":[253],"NCT03960580,":[255],"Clinicaltrials.gov.":[256]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-08-27T00:00:00"}