{"id":"https://openalex.org/W7204243680","doi":"https://doi.org/10.64898/2026.08.27.747565","title":"The insect brain is specified by a conserved transcriptional program distinct from the segmental CNS","display_name":"The insect brain is specified by a conserved transcriptional program distinct from the segmental CNS","publication_year":2026,"publication_date":"2026-08-29","ids":{"openalex":"https://openalex.org/W7204243680","doi":"https://doi.org/10.64898/2026.08.27.747565"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.27.747565","doi":"https://doi.org/10.64898/2026.08.27.747565","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.08.27.747565","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6084/m9.figshare.33338799.v2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001817100","display_name":"Noel Caba\u00f1as","orcid":"https://orcid.org/0000-0003-1867-0013","observed_orcids":["https://orcid.org/0000-0003-1867-0013"]},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Noel Caba\u00f1as","raw_affiliation_strings":["Department of Evolutionary Developmental Genetics, GZMB, University of G\u00f6ttingen, G\u00f6ttingen, 37077, Germany","International Max Planck Research School for Genome Science, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Evolutionary Developmental Genetics, GZMB, University of G\u00f6ttingen, G\u00f6ttingen, 37077, Germany","institution_ids":["https://openalex.org/I74656192"]},{"raw_affiliation_string":"International Max Planck Research School for Genome Science, G\u00f6ttingen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148594965","display_name":"Ana Veloso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ana Veloso","raw_affiliation_strings":["Advanced Light Microscopy & Systems Biology Imaging, Max Delbr\u00fcck Center (MDC) f\u00fcr Molekulare Medizin in der Helmholtzgemeinschaft, Berlin, 10115, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Light Microscopy & Systems Biology Imaging, Max Delbr\u00fcck Center (MDC) f\u00fcr Molekulare Medizin in der Helmholtzgemeinschaft, Berlin, 10115, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091284826","display_name":"Robert P. Zinzen","orcid":"https://orcid.org/0000-0002-8638-5102","observed_orcids":["https://orcid.org/0000-0002-8638-5102"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert Zinzen","raw_affiliation_strings":["Advanced Light Microscopy & Systems Biology Imaging, Max Delbr\u00fcck Center (MDC) f\u00fcr Molekulare Medizin in der Helmholtzgemeinschaft, Berlin, 10115, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Light Microscopy & Systems Biology Imaging, Max Delbr\u00fcck Center (MDC) f\u00fcr Molekulare Medizin in der Helmholtzgemeinschaft, Berlin, 10115, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004218741","display_name":"Gregor Bucher","orcid":"https://orcid.org/0000-0002-4615-6401","observed_orcids":["https://orcid.org/0000-0002-4615-6401"]},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Gregor Bucher","raw_affiliation_strings":["Department of Evolutionary Developmental Genetics, GZMB, University of G\u00f6ttingen, G\u00f6ttingen, 37077, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4615-6401","affiliations":[{"raw_affiliation_string":"Department of Evolutionary Developmental Genetics, GZMB, University of G\u00f6ttingen, G\u00f6ttingen, 37077, Germany","institution_ids":["https://openalex.org/I74656192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004218741"],"corresponding_institution_ids":["https://openalex.org/I74656192"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5640000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5640000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.41920000314712524,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insect-brain","display_name":"insect brain","score":0.7440000176429749},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7680000066757202},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.875},{"id":"https://openalex.org/keywords/tribolium-castaneum","display_name":"Tribolium castaneum","score":1.0},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.7590000033378601},{"id":"https://openalex.org/keywords/hmx","display_name":"HMX","score":0.7229999899864197},{"id":"https://openalex.org/keywords/brain-evolution","display_name":"brain evolution","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.8330000042915344},{"id":"https://openalex.org/C39961270","wikidata":"https://www.wikidata.org/wiki/Q2927095","display_name":"Neuroblast","level":3,"score":0.7889999747276306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7444999814033508},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5929999947547913},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.57669997215271},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5389000177383423},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5113999843597412},{"id":"https://openalex.org/C2776998849","wikidata":"https://www.wikidata.org/wiki/Q3766082","display_name":"Melanogaster","level":4,"score":0.4977000057697296},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46129998564720154},{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.4438999891281128},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.4359000027179718},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.43459999561309814},{"id":"https://openalex.org/C2164484","wikidata":"https://www.wikidata.org/wiki/Q5170150","display_name":"Core (optical fiber)","level":2,"score":0.36880001425743103},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.34540000557899475},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.3337000012397766},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.31049999594688416},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.30399999022483826},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2919999957084656},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2865999937057495},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.27889999747276306},{"id":"https://openalex.org/C2908923196","wikidata":"https://www.wikidata.org/wiki/Q5205742","display_name":"Gene Annotation","level":4,"score":0.2777999937534332},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.26750001311302185},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2549000084400177},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2533999979496002},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.25029999017715454}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.64898/2026.08.27.747565","doi":"https://doi.org/10.64898/2026.08.27.747565","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.08.27.747565","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"doi:10.6084/m9.figshare.33338799.v2","doi":"https://doi.org/10.6084/m9.figshare.33338799.v2","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.33338799.v2","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.6084/m9.figshare.33338799.v2","doi":"https://doi.org/10.6084/m9.figshare.33338799.v2","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.33338799.v2","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":131,"referenced_works":["https://openalex.org/W1575103891","https://openalex.org/W1834007800","https://openalex.org/W1879564354","https://openalex.org/W1880902366","https://openalex.org/W1970330073","https://openalex.org/W1973475928","https://openalex.org/W1978091318","https://openalex.org/W1978648122","https://openalex.org/W1984085917","https://openalex.org/W2005969089","https://openalex.org/W2014042411","https://openalex.org/W2014198636","https://openalex.org/W2014532007","https://openalex.org/W2014926287","https://openalex.org/W2015345738","https://openalex.org/W2016730795","https://openalex.org/W2020011162","https://openalex.org/W2027814822","https://openalex.org/W2034400779","https://openalex.org/W2035922560","https://openalex.org/W2041108526","https://openalex.org/W2041421154","https://openalex.org/W2047272480","https://openalex.org/W2047937714","https://openalex.org/W2050222376","https://openalex.org/W2050691884","https://openalex.org/W2056189300","https://openalex.org/W2056857070","https://openalex.org/W2056896562","https://openalex.org/W2057794075","https://openalex.org/W2058176730","https://openalex.org/W2059701704","https://openalex.org/W2060597975","https://openalex.org/W2061428578","https://openalex.org/W2065293842","https://openalex.org/W2074046107","https://openalex.org/W2079027682","https://openalex.org/W2080792940","https://openalex.org/W2081270405","https://openalex.org/W2082414547","https://openalex.org/W2086492325","https://openalex.org/W2086799457","https://openalex.org/W2088443235","https://openalex.org/W2093001947","https://openalex.org/W2093861386","https://openalex.org/W2099623707","https://openalex.org/W2109837841","https://openalex.org/W2110201610","https://openalex.org/W2110528934","https://openalex.org/W2116363471","https://openalex.org/W2117104012","https://openalex.org/W2120659830","https://openalex.org/W2123627175","https://openalex.org/W2127992319","https://openalex.org/W2142773946","https://openalex.org/W2158092584","https://openalex.org/W2164676263","https://openalex.org/W2165747554","https://openalex.org/W2167069780","https://openalex.org/W2168552260","https://openalex.org/W2280399959","https://openalex.org/W2323595735","https://openalex.org/W2338141765","https://openalex.org/W2345441748","https://openalex.org/W2403922294","https://openalex.org/W2479521384","https://openalex.org/W2767018655","https://openalex.org/W2774072836","https://openalex.org/W2793813700","https://openalex.org/W2800392236","https://openalex.org/W2807798687","https://openalex.org/W2807884764","https://openalex.org/W2881801204","https://openalex.org/W2892311734","https://openalex.org/W2896725978","https://openalex.org/W2897707283","https://openalex.org/W2909137327","https://openalex.org/W2912341255","https://openalex.org/W2912908978","https://openalex.org/W2918346904","https://openalex.org/W2950507998","https://openalex.org/W2975238799","https://openalex.org/W2976457225","https://openalex.org/W2977113542","https://openalex.org/W2981298268","https://openalex.org/W2988396470","https://openalex.org/W2995628808","https://openalex.org/W3015333044","https://openalex.org/W3094574412","https://openalex.org/W3116625060","https://openalex.org/W3121198254","https://openalex.org/W3125247928","https://openalex.org/W3157597006","https://openalex.org/W3176661105","https://openalex.org/W3193387640","https://openalex.org/W3203460316","https://openalex.org/W3215596355","https://openalex.org/W4205576499","https://openalex.org/W4210587306","https://openalex.org/W4210879537","https://openalex.org/W4214577884","https://openalex.org/W4224094774","https://openalex.org/W4224285993","https://openalex.org/W4243629783","https://openalex.org/W4280533712","https://openalex.org/W4282931278","https://openalex.org/W4284976642","https://openalex.org/W4285033589","https://openalex.org/W4293105687","https://openalex.org/W4309191898","https://openalex.org/W4309306270","https://openalex.org/W4317936627","https://openalex.org/W4372332501","https://openalex.org/W4376872148","https://openalex.org/W4382989197","https://openalex.org/W4386463918","https://openalex.org/W4387033788","https://openalex.org/W4389606997","https://openalex.org/W4391424688","https://openalex.org/W4392472262","https://openalex.org/W4394689918","https://openalex.org/W4396922393","https://openalex.org/W4399576989","https://openalex.org/W4400261182","https://openalex.org/W4403062911","https://openalex.org/W4404328264","https://openalex.org/W4410127418","https://openalex.org/W4415422068","https://openalex.org/W4416226762","https://openalex.org/W4417264153","https://openalex.org/W7162492626"],"related_works":["https://openalex.org/W7125372542","https://openalex.org/W4401575797","https://openalex.org/W4389581181","https://openalex.org/W4401575556","https://openalex.org/W4408027518","https://openalex.org/W2078874037","https://openalex.org/W2290663496","https://openalex.org/W2041108526","https://openalex.org/W4401638321","https://openalex.org/W3128154972"],"abstract_inverted_index":{"Abstract":[0],"The":[1,215,252],"brain":[2,50,96,158,228,246,253,277,301,313,337,354],"is":[3,29,58,355],"the":[4,16,34,42,61,64,73,92,106,120,125,147,200,226,245,248,261,265,276,296,300,309,336,340,353,360],"central":[5,21],"processing":[6],"center":[7],"that":[8,352],"integrates":[9,254],"information":[10,255],"to":[11,138,199,256],"guide":[12,257],"animal":[13,258],"behavior,":[14],"while":[15,260],"posterior":[17,230,341],"CNS":[18,362],"performs":[19],"less":[20],"functions.":[22],"To":[23,304],"what":[24],"degree":[25],"this":[26],"functional":[27],"distinction":[28],"reflected":[30],"in":[31,72,77,110,236,285,335],"divergence":[32,224,243,350],"of":[33,44,49,66,91,95,150,218,244,264,275,299,312],"genetic":[35,297,310,332],"regulation":[36,298],"remains":[37],"unexplored,":[38],"as":[39,41],"well":[40],"hypothesis":[43],"a":[45,86,115,133,140,222,286,323,326,364],"distinct":[46],"evolutionary":[47],"origin":[48],"and":[51,70,80,88,124,166,194,229,273,325],"trunk":[52,98,361],"CNS.":[53,231],"In":[54,197],"insects,":[55],"neuroblast":[56,68],"biology":[57],"similar":[59,287],"across":[60,319],"CNS,":[62],"but":[63,338],"presence":[65],"brain-specific":[67,173,219],"types":[69],"differences":[71],"gene":[74],"sets":[75],"involved":[76],"their":[78,167,283],"spatial":[79],"temporal":[81],"specification":[82],"indicate":[83],"divergence.":[84,214],"However,":[85],"comprehensive":[87],"unbiased":[89],"comparison":[90],"regulatory":[93],"code":[94],"versus":[97],"neuroblasts":[99,113,185],"has":[100,291],"been":[101],"lacking.":[102],"Here,":[103],"we":[104,131,154,162,206,307],"reveal":[105],"transcription":[107,179],"factors":[108,180],"expressed":[109],"insect":[111,227],"embryonic":[112],"by":[114],"combined":[116,148],"single-cell":[117,317],"analysis":[118],"from":[119,160,247,359,371],"fly":[121,324],"Drosophila":[122],"melanogaster":[123],"beetle":[126],"Tribolium":[127],"castaneum,":[128],"for":[129],"which":[130,161,366],"established":[132],"Gal4":[134],"enhancer":[135],"trap":[136],"system":[137,267],"generate":[139],"line":[141],"marking":[142],"NBs":[143],"with":[144,184,211,233,368],"tGFP.":[145],"From":[146],"dataset":[149],"nearly":[151],"70,000":[152],"neuroblasts,":[153,159],"identified":[155,163,330],"around":[156],"23,000":[157],"cell":[164],"populations":[165],"transcriptional":[168,213],"signatures.":[169],"We":[170,328],"found":[171,207],"188":[172],"TFs,":[174],"including":[175,344],"seven":[176],"spatially":[177],"restricted":[178],"not":[181,339],"previously":[182,346],"associated":[183],"(":[186],"Hmx,":[187],"CG15CSC,":[188],"CG32532,":[189],"dmrtSSB,":[190],"fD5SA,":[191],"TfAP-2":[192],",":[193],"Fer1":[195],").":[196],"addition":[198],"expected":[201],"canonical":[202],"Type":[203],"II":[204],"NBs,":[205],"two":[208,320],"related":[209],"clusters":[210],"intriguing":[212],"large":[216],"number":[217],"TFs":[220],"supports":[221],"profound":[223],"between":[225],"Together":[232],"recent":[234,369],"work":[235],"vertebrates,":[237],"our":[238],"data":[239],"confirm":[240],"an":[241],"ancient":[242],"trunk.":[249],"Significance":[250],"statement":[251],"behaviour":[259],"rear":[262],"parts":[263],"nervous":[266,342],"act":[268],"mainly":[269],"downstream.":[270],"Although":[271],"function":[272],"structures":[274],"are":[278],"quite":[279,356],"distinct,":[280],"they":[281],"start":[282],"development":[284],"way.":[288],"Therefore,":[289],"it":[290],"remained":[292],"unclear":[293],"how":[294],"different":[295,358],"actually":[302],"is.":[303],"answer":[305],"this,":[306],"revealed":[308],"program":[311],"stem":[314],"cells":[315],"at":[316],"resolution":[318],"insects":[321],"\u2014":[322,363],"beetle.":[327],"comprehensively":[329],"key":[331],"regulators":[333],"active":[334],"system,":[343],"several":[345],"unknown":[347],"ones.":[348],"This":[349],"suggests":[351],"fundamentally":[357],"finding":[365],"resonates":[367],"studies":[370],"vertebrates.":[372]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-08-27T00:00:00"}