{"id":"https://openalex.org/W7204243134","doi":"https://doi.org/10.1007/s10787-026-02372-6","title":"Cannabinoid receptor agonist WIN 55,212-2 modulates systemic inflammatory and oxidative stress responses in streptozotocin-induced diabetic rats","display_name":"Cannabinoid receptor agonist WIN 55,212-2 modulates systemic inflammatory and oxidative stress responses in streptozotocin-induced diabetic rats","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204243134","doi":"https://doi.org/10.1007/s10787-026-02372-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/42645723"},"language":"en","primary_location":{"id":"doi:10.1007/s10787-026-02372-6","doi":"https://doi.org/10.1007/s10787-026-02372-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10787-026-02372-6","pdf_url":null,"source":{"id":"https://openalex.org/S77466329","display_name":"Inflammopharmacology","issn_l":"0925-4692","issn":["0925-4692","1568-5608"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073924994","display_name":"Fatma K\u00fcbra Tombult\u00fcrk","orcid":"https://orcid.org/0000-0002-4358-2309","observed_orcids":["https://orcid.org/0000-0002-4358-2309"]},"institutions":[{"id":"https://openalex.org/I4210121333","display_name":"Istinye University","ror":"https://ror.org/03081nz23","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210121333"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Fatma Kubra Tombulturk","raw_affiliation_strings":["Medical Laboratory Techniques, Vocational School of Health Services, Istinye University, Istanbul, T\u00fcrkiye. ftombulturk@istinye.edu.tr"],"raw_orcid":"https://orcid.org/0000-0002-4358-2309","affiliations":[{"raw_affiliation_string":"Medical Laboratory Techniques, Vocational School of Health Services, Istinye University, Istanbul, T\u00fcrkiye. ftombulturk@istinye.edu.tr","institution_ids":["https://openalex.org/I4210121333"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078246830","display_name":"Huri Dedeakayo\u011fullar\u0131","orcid":"https://orcid.org/0000-0003-2706-9625","observed_orcids":["https://orcid.org/0000-0003-2706-9625"]},"institutions":[{"id":"https://openalex.org/I4210104933","display_name":"Biruni University","ror":"https://ror.org/01nkhmn89","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210104933"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Huri Dedeakayogullari Demirci","raw_affiliation_strings":["Biruni University Research Center (B@MER), Biruni University, Istanbul, T\u00fcrkiye","Department of Medical Biochemistry, Faculty of Medicine, Biruni University, Istanbul, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0003-2706-9625","affiliations":[{"raw_affiliation_string":"Biruni University Research Center (B@MER), Biruni University, Istanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I4210104933"]},{"raw_affiliation_string":"Department of Medical Biochemistry, Faculty of Medicine, Biruni University, Istanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I4210104933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020731630","display_name":"Zeynep Gizem Todurga Seven","orcid":"https://orcid.org/0000-0002-2529-0118","observed_orcids":["https://orcid.org/0000-0002-2529-0118"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Zeynep Gizem Todurga Seven","raw_affiliation_strings":["Department of Medical Pharmacology, Cerrahpasa Faculty of Medicine, Istanbul University- Cerrahpasa, Istanbul, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-2529-0118","affiliations":[{"raw_affiliation_string":"Department of Medical Pharmacology, Cerrahpasa Faculty of Medicine, Istanbul University- Cerrahpasa, Istanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040228903","display_name":"K\u00fcbra \u00c7i\u011fdem Pekko\u00e7 Uyan\u0131k","orcid":"https://orcid.org/0000-0002-1056-960X","observed_orcids":["https://orcid.org/0000-0002-1056-960X"]},"institutions":[{"id":"https://openalex.org/I25010766","display_name":"Hali\u00e7 University","ror":"https://ror.org/022xhck05","country_code":"TR","type":"education","lineage":["https://openalex.org/I25010766"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Kubra Cigdem Pekkoc-Uyanik","raw_affiliation_strings":["Department of Medical Biology, Medical Faculty, Hali\u00e7 University, Istanbul, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-1056-960X","affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Medical Faculty, Hali\u00e7 University, Istanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I25010766"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5073924994"],"corresponding_institution_ids":["https://openalex.org/I4210121333"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"9","first_page":"6135","last_page":"6150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/win-55-212-2","display_name":"WIN 55,212-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endocannabinoid-system","display_name":"endocannabinoid system","score":0.9760000109672546},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9129999876022339},{"id":"https://openalex.org/keywords/insulin-deficiency","display_name":"insulin deficiency","score":0.5720000267028809},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8669999837875366},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8700000047683716},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8949999809265137},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8479999899864197},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9129999876022339},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8686000108718872},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6836000084877014},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.6535000205039978},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6365000009536743},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6345000267028809},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5597000122070312},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5322999954223633},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.5245000123977661},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5192000269889832},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.476500004529953},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.3894999921321869},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3865000009536743},{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.3824000060558319},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3312000036239624},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.303600013256073},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.3034000098705292},{"id":"https://openalex.org/C2776433454","wikidata":"https://www.wikidata.org/wiki/Q412529","display_name":"Rimonabant","level":5,"score":0.2944999933242798},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.28700000047683716},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.28139999508857727},{"id":"https://openalex.org/C93248783","wikidata":"https://www.wikidata.org/wiki/Q21150595","display_name":"Cannabinoid receptor type 2","level":5,"score":0.28130000829696655},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.26980000734329224},{"id":"https://openalex.org/C2778384471","wikidata":"https://www.wikidata.org/wiki/Q417765","display_name":"Pioglitazone","level":4,"score":0.2644999921321869},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.2619999945163727},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.2500999867916107}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D043885","descriptor_name":"Receptor, Cannabinoid, CB2","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D048588","descriptor_name":"Benzoxazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D048588","descriptor_name":"Benzoxazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063386","descriptor_name":"Cannabinoid Receptor Agonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D063386","descriptor_name":"Cannabinoid Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10787-026-02372-6","doi":"https://doi.org/10.1007/s10787-026-02372-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10787-026-02372-6","pdf_url":null,"source":{"id":"https://openalex.org/S77466329","display_name":"Inflammopharmacology","issn_l":"0925-4692","issn":["0925-4692","1568-5608"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammopharmacology","raw_type":"journal-article"},{"id":"pmid:42645723","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42645723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3589064316","display_name":null,"funder_award_id":"39510","funder_id":"https://openalex.org/F4320319756","funder_display_name":"T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131"}],"funders":[{"id":"https://openalex.org/F4320319756","display_name":"T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131","ror":"https://ror.org/01d6ka036"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1503505289","https://openalex.org/W1910251639","https://openalex.org/W1976464405","https://openalex.org/W1983310681","https://openalex.org/W2015164121","https://openalex.org/W2020267609","https://openalex.org/W2028770468","https://openalex.org/W2030619237","https://openalex.org/W2035181501","https://openalex.org/W2056338968","https://openalex.org/W2064532629","https://openalex.org/W2065488327","https://openalex.org/W2068540155","https://openalex.org/W2096965060","https://openalex.org/W2101369715","https://openalex.org/W2107277218","https://openalex.org/W2110108812","https://openalex.org/W2118629170","https://openalex.org/W2119826244","https://openalex.org/W2124098523","https://openalex.org/W2134041563","https://openalex.org/W2140401104","https://openalex.org/W2147976151","https://openalex.org/W2154278853","https://openalex.org/W2157222302","https://openalex.org/W2157583983","https://openalex.org/W2168111104","https://openalex.org/W2171553260","https://openalex.org/W2172242651","https://openalex.org/W2339767528","https://openalex.org/W2510280377","https://openalex.org/W2749787995","https://openalex.org/W2800528201","https://openalex.org/W2942927828","https://openalex.org/W2947595673","https://openalex.org/W2996080671","https://openalex.org/W2998014803","https://openalex.org/W3005931923","https://openalex.org/W3047750670","https://openalex.org/W3090304132","https://openalex.org/W3132630227","https://openalex.org/W3174874399","https://openalex.org/W3211259680","https://openalex.org/W4200026682","https://openalex.org/W4200581140","https://openalex.org/W4224219981","https://openalex.org/W4303613912","https://openalex.org/W4312172654","https://openalex.org/W4317737937","https://openalex.org/W4327615164","https://openalex.org/W4380087313","https://openalex.org/W4386424380","https://openalex.org/W4388932415","https://openalex.org/W4400769224","https://openalex.org/W4401847398","https://openalex.org/W4403647294","https://openalex.org/W4405381546","https://openalex.org/W4408441623","https://openalex.org/W4410435813","https://openalex.org/W4411231442","https://openalex.org/W4413790625","https://openalex.org/W7125615122"],"related_works":["https://openalex.org/W2065488327","https://openalex.org/W4318829475","https://openalex.org/W4409117256","https://openalex.org/W2969724219","https://openalex.org/W2048916983","https://openalex.org/W7162854910","https://openalex.org/W2207629229","https://openalex.org/W4207033725","https://openalex.org/W2055832982","https://openalex.org/W2065575782"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-27T00:00:00"}
