{"id":"https://openalex.org/W7204241091","doi":"https://doi.org/10.64898/2026.08.21.26358780","title":"Cross-trait and multi-polytranscriptomic score analysis of Parkinson\u2019s disease identifies novel associations and improves prediction","display_name":"Cross-trait and multi-polytranscriptomic score analysis of Parkinson\u2019s disease identifies novel associations and improves prediction","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204241091","doi":"https://doi.org/10.64898/2026.08.21.26358780"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.21.26358780","doi":"https://doi.org/10.64898/2026.08.21.26358780","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.21.26358780","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/26/2026.08.21.26358780.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/26/2026.08.21.26358780.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025294277","display_name":"Lachlan Gilchrist","orcid":"https://orcid.org/0009-0005-6484-2105","observed_orcids":["https://orcid.org/0009-0005-6484-2105"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lachlan Gilchrist","raw_affiliation_strings":["Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London"],"raw_orcid":"https://orcid.org/0009-0005-6484-2105","affiliations":[{"raw_affiliation_string":"Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089915080","display_name":"Oliver Pain","orcid":"https://orcid.org/0000-0001-5680-3281","observed_orcids":["https://orcid.org/0000-0001-5680-3281"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Oliver Pain","raw_affiliation_strings":["Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-5680-3281","affiliations":[{"raw_affiliation_string":"Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119516196","display_name":"Sara Calhas","orcid":"https://orcid.org/0009-0007-6364-4144","observed_orcids":["https://orcid.org/0009-0007-6364-4144"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sara Calhas","raw_affiliation_strings":["Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London"],"raw_orcid":"https://orcid.org/0009-0007-6364-4144","affiliations":[{"raw_affiliation_string":"Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066469739","display_name":"Global Parkinson\u2019s Genetics Program","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387154804","display_name":"Aligning Science Across Parkinson's","ror":"https://ror.org/03zj4c476","country_code":"US","type":"other","lineage":["https://openalex.org/I4387154804"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Global Parkinson\u2019s Genetics Program (GP2)","raw_affiliation_strings":["Aligning Science Across Parkinson's"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aligning Science Across Parkinson's","institution_ids":["https://openalex.org/I4387154804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052101031","display_name":"Alastair John Noyce","orcid":"https://orcid.org/0000-0003-3027-5497","observed_orcids":["https://orcid.org/0000-0003-3027-5497"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alastair J. Noyce","raw_affiliation_strings":["Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London"],"raw_orcid":"https://orcid.org/0000-0003-3027-5497","affiliations":[{"raw_affiliation_string":"Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007398166","display_name":"Kajsa Atterling Brolin","orcid":"https://orcid.org/0000-0003-4832-922X","observed_orcids":["https://orcid.org/0000-0003-4832-922X"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"Kajsa Atterling Brolin","raw_affiliation_strings":["Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London","Translational Neurogenetics Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-4832-922X","affiliations":[{"raw_affiliation_string":"Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London","institution_ids":["https://openalex.org/I166337079"]},{"raw_affiliation_string":"Translational Neurogenetics Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003674628","display_name":"Mar\u00eda Teresa Peri\u00f1\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Maria Teresa Peri\u00f1an","raw_affiliation_strings":["Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London","Unidad de Trastornos del Movimiento, Servicio de Neurolog\u00eda y Neurofisiolog\u00eda Cl\u00ednica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Roc\u00edo, Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Universidad de Sevilla, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London","institution_ids":["https://openalex.org/I166337079"]},{"raw_affiliation_string":"Unidad de Trastornos del Movimiento, Servicio de Neurolog\u00eda y Neurofisiolog\u00eda Cl\u00ednica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Roc\u00edo, Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Universidad de Sevilla, Seville, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012553649","display_name":"Petroula Proitsi","orcid":"https://orcid.org/0000-0002-2553-6974","observed_orcids":["https://orcid.org/0000-0002-2553-6974"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Petroula Proitsi","raw_affiliation_strings":["Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London","Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-2553-6974","affiliations":[{"raw_affiliation_string":"Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London","institution_ids":["https://openalex.org/I166337079"]},{"raw_affiliation_string":"Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5012553649"],"corresponding_institution_ids":["https://openalex.org/I166337079","https://openalex.org/I183935753"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/transcriptome-wide-association-study","display_name":"transcriptome-wide association study","score":0.7039999961853027},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.6470000147819519},{"id":"https://openalex.org/keywords/whole-blood-gene-expression","display_name":"whole blood gene expression","score":0.7760000228881836},{"id":"https://openalex.org/keywords/disease-prediction","display_name":"disease prediction","score":0.7319999933242798},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7649999856948853},{"id":"https://openalex.org/keywords/sleep-characteristics","display_name":"sleep characteristics","score":0.5989999771118164},{"id":"https://openalex.org/keywords/cardiovascular-traits","display_name":"cardiovascular traits","score":0.9509999752044678},{"id":"https://openalex.org/keywords/respiratory-function","display_name":"respiratory function","score":0.8920000195503235}],"concepts":[{"id":"https://openalex.org/C127808970","wikidata":"https://www.wikidata.org/wiki/Q385989","display_name":"Bonferroni correction","level":2,"score":0.745199978351593},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6830999851226807},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6675000190734863},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47609999775886536},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4702000021934509},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4562999904155731},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.453900009393692},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43560001254081726},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4025000035762787},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.4000999927520752},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.37450000643730164},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37369999289512634},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.36570000648498535},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.34279999136924744},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.33980000019073486},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33379998803138733},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.3328000009059906},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.320499986410141},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31150001287460327},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.3091000020503998},{"id":"https://openalex.org/C3020646490","wikidata":"https://www.wikidata.org/wiki/Q25203551","display_name":"Clinical phenotype","level":4,"score":0.30799999833106995},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.30059999227523804},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.28870001435279846},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2815999984741211},{"id":"https://openalex.org/C45804977","wikidata":"https://www.wikidata.org/wiki/Q7239673","display_name":"Predictive modelling","level":2,"score":0.2720000147819519},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2644999921321869},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.25699999928474426},{"id":"https://openalex.org/C64474127","wikidata":"https://www.wikidata.org/wiki/Q1071953","display_name":"Medical genetics","level":3,"score":0.2565000057220459},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.25380000472068787}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.21.26358780","doi":"https://doi.org/10.64898/2026.08.21.26358780","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.21.26358780","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/26/2026.08.21.26358780.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.21.26358780","doi":"https://doi.org/10.64898/2026.08.21.26358780","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.21.26358780","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/26/2026.08.21.26358780.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204241091.pdf","grobid_xml":"https://content.openalex.org/works/W7204241091.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W1844405070","https://openalex.org/W2012650310","https://openalex.org/W2035618305","https://openalex.org/W2044833878","https://openalex.org/W2073836327","https://openalex.org/W2103783427","https://openalex.org/W2104549677","https://openalex.org/W2107916366","https://openalex.org/W2113699335","https://openalex.org/W2137499573","https://openalex.org/W2171816696","https://openalex.org/W2230505097","https://openalex.org/W2264585211","https://openalex.org/W2324862792","https://openalex.org/W2328393125","https://openalex.org/W2520048741","https://openalex.org/W2592811885","https://openalex.org/W2593272776","https://openalex.org/W2742719784","https://openalex.org/W2746163443","https://openalex.org/W2772779547","https://openalex.org/W2788609121","https://openalex.org/W2898850833","https://openalex.org/W2907288017","https://openalex.org/W2972025860","https://openalex.org/W2986932567","https://openalex.org/W3010932105","https://openalex.org/W3048245060","https://openalex.org/W3085430416","https://openalex.org/W3097107670","https://openalex.org/W3133859624","https://openalex.org/W3158274091","https://openalex.org/W3174084468","https://openalex.org/W3174664487","https://openalex.org/W3202848931","https://openalex.org/W4211044101","https://openalex.org/W4214833982","https://openalex.org/W4220817346","https://openalex.org/W4231686634","https://openalex.org/W4253754191","https://openalex.org/W4287958750","https://openalex.org/W4304165834","https://openalex.org/W4307966128","https://openalex.org/W4309890377","https://openalex.org/W4309950575","https://openalex.org/W4310945858","https://openalex.org/W4320485628","https://openalex.org/W4322754763","https://openalex.org/W4376959799","https://openalex.org/W4385552718","https://openalex.org/W4385607015","https://openalex.org/W4386524083","https://openalex.org/W4387939452","https://openalex.org/W4390913353","https://openalex.org/W4391836280","https://openalex.org/W4392298472","https://openalex.org/W4392791500","https://openalex.org/W4393319250","https://openalex.org/W4396532040","https://openalex.org/W4399432024","https://openalex.org/W4399993446","https://openalex.org/W4400890948","https://openalex.org/W4401073565","https://openalex.org/W4401158013","https://openalex.org/W4401883079","https://openalex.org/W4404557222","https://openalex.org/W4404591769","https://openalex.org/W4408208852","https://openalex.org/W4408672672","https://openalex.org/W4408742348","https://openalex.org/W4409032454","https://openalex.org/W4411361655","https://openalex.org/W4412008894","https://openalex.org/W4412522102","https://openalex.org/W4413889247","https://openalex.org/W4414670560","https://openalex.org/W4414981552","https://openalex.org/W4416054049","https://openalex.org/W4416797440","https://openalex.org/W7138904573","https://openalex.org/W7223179007"],"related_works":["https://openalex.org/W4408742348","https://openalex.org/W4387969166","https://openalex.org/W4389446487","https://openalex.org/W3093774535","https://openalex.org/W4403027813","https://openalex.org/W4403450645","https://openalex.org/W7123868984","https://openalex.org/W7204742762","https://openalex.org/W4411476952","https://openalex.org/W7169635118"],"abstract_inverted_index":{"Despite":[0],"major":[1],"progress":[2],"in":[3,98,185],"genomic":[4],"risk":[5],"loci":[6],"identification,":[7],"biological":[8],"mechanisms":[9],"underlying":[10],"Parkinson\u2019s":[11,103],"disease":[12,225,231],"(PD)":[13],"remain":[14],"incompletely":[15],"understood":[16],"and":[17,59,77,133,143,183,214],"the":[18,32,48,53,61,73,99,157],"informativity":[19],"of":[20,34,50,56,80,148,160,176,200,217],"polygenic":[21],"score":[22],"(PGS)-based":[23],"prediction":[24,175],"remains":[25],"modest.":[26],"Poly":[27],"transcriptomic":[28,164,210],"scores":[29],"(PTS)":[30],"\u2013":[31,46],"sum":[33],"an":[35,193,198],"individual\u2019s":[36],"observed":[37,152],"gene":[38,57],"expression":[39,58],"weighted":[40],"by":[41,68],"transcriptome-wide":[42],"association":[43],"z":[44],"-scores":[45],"combine":[47],"stability":[49],"genetics":[51,69],"with":[52,123,188,227],"dynamic":[54],"biology":[55,226],"have":[60],"potential":[62,228],"to":[63,229],"identify":[64,116],"associations":[65,122,150],"not":[66],"captured":[67],"alone.":[70],"We":[71,115],"present":[72],"first":[74],"large-scale":[75],"cross-trait":[76,120],"multi-PTS":[78,172],"analysis":[79],"PD,":[81],"calculating":[82],"\u223c550":[83],"PTS":[84,121,168,196],"for":[85],"100":[86],"phenotypes":[87,132],"using":[88,153],"whole-":[89],"blood":[90],"RNA-seq":[91],"data":[92],"from":[93],"three":[94],"independent":[95],"clinical":[96],"cohorts":[97],"Accelerating":[100],"Medicines":[101],"Partnership":[102],"Disease":[104],"programme":[105],"(AMP-PD)":[106],"(":[107,125],"N":[108,111],"=":[109,113],"2,741;":[110],"CASES":[112],"1,644).":[114],"26":[117],"Bonferroni":[118],"significant":[119],"PD":[124,177,213],"p":[126],"<9x10":[127],"-5":[128],")":[129],"involving":[130],"18":[131],"11":[134],"trait":[135],"categories,":[136],"including":[137,192],"neurodegenerative":[138],"diseases,":[139],"respiratory":[140],"function,":[141],"sleep":[142],"cardiovascular":[144],"traits.":[145],"Only":[146],"one":[147],"these":[149],"was":[151],"corresponding":[154],"PGS,":[155],"highlighting":[156],"added":[158],"value":[159],"integrating":[161],"directly":[162],"measured":[163],"data.":[165],"Combining":[166],"multiple":[167],"within":[169],"machine":[170],"learning":[171],"models":[173],"improved":[174],"case/control":[178],"status":[179],"beyond":[180],"age,":[181],"sex":[182],"PD-PGS":[184],"external":[186],"validation,":[187],"a":[189,204,215],"sparse":[190],"model":[191],"additional":[194],"seven":[195],"achieving":[197],"AUC":[199],"0.74":[201],"[0.70-0.78],":[202],"representing":[203],"0.09-point":[205],"improvement.":[206],"These":[207],"findings":[208],"reveal":[209],"overlap":[211],"between":[212],"range":[216],"clinically":[218],"relevant":[219],"traits,":[220],"providing":[221],"novel":[222],"insights":[223],"into":[224],"improve":[230],"prediction.":[232]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-27T00:00:00"}