{"id":"https://openalex.org/W7204239351","doi":"https://doi.org/10.1186/s13058-026-02368-8","title":"An information-theoretic framework identifies tumor dormancy\u2013associated gene signatures for very late recurrence in ER-positive breast cancer","display_name":"An information-theoretic framework identifies tumor dormancy\u2013associated gene signatures for very late recurrence in ER-positive breast cancer","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204239351","doi":"https://doi.org/10.1186/s13058-026-02368-8"},"language":"en","primary_location":{"id":"doi:10.1186/s13058-026-02368-8","doi":"https://doi.org/10.1186/s13058-026-02368-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13058-026-02368-8","pdf_url":null,"source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13058-026-02368-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031516654","display_name":"Shoma Tamori","orcid":"https://orcid.org/0009-0003-3657-2043","observed_orcids":["https://orcid.org/0009-0003-3657-2043"]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shoma Tamori","raw_affiliation_strings":["Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-Ku, Tokyo, 125-8585, Japan","Research Division of Medical Data Science, Research Institute for Science and Technology, Tokyo University of Science, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-Ku, Tokyo, 125-8585, Japan","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"Research Division of Medical Data Science, Research Institute for Science and Technology, Tokyo University of Science, Chiba, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148220777","display_name":"Keiko Sato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiko Sato","raw_affiliation_strings":["Department of Information Sciences, Faculty of Sciences and Technology, Tokyo University of Science, Chiba, Japan","Research Division of Medical Data Science, Research Institute for Science and Technology, Tokyo University of Science, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Sciences, Faculty of Sciences and Technology, Tokyo University of Science, Chiba, Japan","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"Research Division of Medical Data Science, Research Institute for Science and Technology, Tokyo University of Science, Chiba, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139622596","display_name":"Kazunori Sasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazunori Sasaki","raw_affiliation_strings":["Institute for Diseases of Old Age, Juntendo University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Diseases of Old Age, Juntendo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078195869","display_name":"Shigeo Ohno","orcid":"https://orcid.org/0000-0002-1294-5269","observed_orcids":["https://orcid.org/0000-0002-1294-5269"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeo Ohno","raw_affiliation_strings":["Institute for Diseases of Old Age, Juntendo University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Diseases of Old Age, Juntendo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022645715","display_name":"Kazunori Akimoto","orcid":"https://orcid.org/0000-0003-0618-1765","observed_orcids":["https://orcid.org/0000-0003-0618-1765"]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazunori Akimoto","raw_affiliation_strings":["Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-Ku, Tokyo, 125-8585, Japan","Research Division of Medical Data Science, Research Institute for Science and Technology, Tokyo University of Science, Chiba, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0618-1765","affiliations":[{"raw_affiliation_string":"Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-Ku, Tokyo, 125-8585, Japan","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"Research Division of Medical Data Science, Research Institute for Science and Technology, Tokyo University of Science, Chiba, Japan","institution_ids":["https://openalex.org/I161296585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022645715","https://openalex.org/A5031516654"],"corresponding_institution_ids":["https://openalex.org/I161296585"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65282668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/luminal-a-subtype","display_name":"luminal A","score":0.925000011920929},{"id":"https://openalex.org/keywords/tumor-dormancy","display_name":"tumor dormancy","score":0.781000018119812},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.6330000162124634},{"id":"https://openalex.org/keywords/normalized-mutual-information","display_name":"normalized mutual information","score":0.8140000104904175},{"id":"https://openalex.org/keywords/disseminated-tumor-cells","display_name":"disseminated tumor cells","score":0.8669999837875366},{"id":"https://openalex.org/keywords/endocrine-therapy","display_name":"endocrine therapy","score":0.7419999837875366},{"id":"https://openalex.org/keywords/cytoskeletal-dynamics","display_name":"cytoskeletal dynamics","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.9810000061988831},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prognostic-gene-expression","display_name":"prognostic gene expression","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.798799991607666},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7771999835968018},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7124999761581421},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5281000137329102},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5188000202178955},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5063999891281128},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33629998564720154},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.322299987077713},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.30640000104904175},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2865999937057495},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.27639999985694885},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.25220000743865967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s13058-026-02368-8","doi":"https://doi.org/10.1186/s13058-026-02368-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13058-026-02368-8","pdf_url":null,"source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s13058-026-02368-8","doi":"https://doi.org/10.1186/s13058-026-02368-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13058-026-02368-8","pdf_url":null,"source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323395","display_name":"Juntendo University","ror":"https://ror.org/01692sz90"},{"id":"https://openalex.org/F4320327572","display_name":"Promotion and Mutual Aid Corporation for Private Schools of Japan","ror":"https://ror.org/05h2t6865"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Late":[0],"recurrence":[1,48,89,151,223,286],"beyond":[2,152],"10":[3,153],"years":[4],"after":[5,236],"diagnosis":[6,217,300],"remains":[7],"a":[8,128,309],"major":[9],"unresolved":[10],"challenge":[11],"in":[12,73,99,110,136,199,253,274,288],"luminal":[13,69,137,289],"A":[14,70,138,290],"breast":[15,71,129,139,291],"cancer,":[16],"and":[17,104,133,195,227,305],"current":[18],"multigene":[19,168],"assays":[20,135],"have":[21],"limited":[22],"predictive":[23],"power":[24],"for":[25,322],"long-latency":[26],"events.":[27],"We":[28],"developed":[29],"MI-PER":[30,60,145,172,277],"(Mutual":[31],"Information-based":[32],"Person-year-anchored":[33],"Extraction":[34],"of":[35,165,245],"Risk":[36],"markers),":[37],"an":[38,100],"information-theoretic":[39],"framework":[40],"that":[41,171],"integrates":[42],"normalized":[43],"mutual":[44],"information":[45],"with":[46,56,68,86,150,160,220,319],"time-resolved":[47],"rates,":[49],"to":[50,63,112,190,271,283,301,312],"identify":[51,306],"gene":[52,182,280],"expression":[53,244,281],"features":[54,176,298],"associated":[55,149,219],"very":[57,284],"late":[58,174,222,246,285,324],"recurrence.":[59,326],"was":[61,108,120],"applied":[62,109],"461":[64],"endocrine":[65],"therapy-treated":[66],"patients":[67],"cancer":[72,130,140],"the":[74,161,204],"METABRIC":[75,111],"cohort.":[76],"Candidate":[77],"genes":[78,148,156,164,205],"were":[79,97,218],"selected":[80],"by":[81,225],"combining":[82],"MI-based":[83],"feature":[84],"selection":[85],"genome-wide":[87],"person-year":[88,228],"screening.":[90],"Biological":[91],"signatures":[92],"derived":[93],"from":[94,127,179],"enrichment":[95,185],"analysis":[96,186,241],"evaluated":[98],"independent":[101],"cohort":[102],"(GSE17705),":[103],"propensity":[105,237],"score":[106,238],"matching":[107],"assess":[113],"robustness":[114],"against":[115],"clinical":[116],"confounders.":[117],"Mechanistic":[118],"relevance":[119],"explored":[121],"using":[122],"single-cell":[123],"RNA":[124],"sequencing":[125],"(scRNA-seq)":[126],"dormancy":[131],"model":[132],"functional":[134],"cells":[141],"under":[142,265,316],"dormancy-inducing":[143,266,317],"conditions.":[144],"identified":[146],"81":[147],"years.":[154],"These":[155],"showed":[157],"no":[158],"overlap":[159],"prognostic":[162,181],"content":[163],"widely":[166],"adopted":[167],"assays,":[169],"suggesting":[170],"captured":[173],"recurrence-associated":[175,247],"largely":[177],"distinct":[178],"established":[180],"sets.":[183],"Functional":[184],"revealed":[187,242],"pathways":[188],"related":[189],"cytoskeletal":[191],"dynamics,":[192],"cell":[193,201,263,272,314],"adhesion,":[194],"lipid":[196],"metabolism\u2014processes":[197],"implicated":[198],"tumor":[200,256],"dormancy\u2014and":[202],"refined":[203],"into":[206],"four":[207],"biologically":[208],"coherent":[209],"signatures.":[210],"In":[211,230],"GSE17705,":[212],"elevated":[213],"signature":[214],"scores":[215],"at":[216,299],"increased":[221],"risk":[224,287],"Kaplan\u2013Meier":[226],"analyses.":[229],"METABRIC,":[231],"these":[232],"associations":[233],"remained":[234],"consistent":[235],"matching.":[239],"scRNA-seq":[240],"preferential":[243],"genes,":[248],"most":[249],"notably":[250],"SH3KBP1":[251,259,307],",":[252],"dormant":[254],"disseminated":[255],"cell-like":[257],"populations.":[258],"knockdown":[260],"significantly":[261],"impaired":[262],"viability":[264,273,315],"conditions,":[267,318],"supporting":[268],"its":[269],"contribution":[270],"this":[275],"model.":[276],"links":[278],"diagnostic":[279],"profiles":[282],"cancer.":[292],"Our":[293],"findings":[294],"connect":[295],"dormancy-associated":[296],"transcriptomic":[297],"prolonged":[302],"disease":[303],"latency":[304],"as":[308],"candidate":[310],"contributor":[311],"maintaining":[313],"potential":[320],"implications":[321],"understanding":[323],"metastatic":[325]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2026-08-27T00:00:00"}
