{"id":"https://openalex.org/W7204238509","doi":"https://doi.org/10.3389/fcimb.2026.1908346","title":"\u03b1-Terpineol reverses mcr-mediated colistin resistance and potentiates colistin\u2019s antibacterial activity in multidrug-resistant Escherichia coli","display_name":"\u03b1-Terpineol reverses mcr-mediated colistin resistance and potentiates colistin\u2019s antibacterial activity in multidrug-resistant Escherichia coli","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204238509","doi":"https://doi.org/10.3389/fcimb.2026.1908346","pmid":"https://pubmed.ncbi.nlm.nih.gov/42718814","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13553474"},"language":"en","primary_location":{"id":"doi:10.3389/fcimb.2026.1908346","doi":"https://doi.org/10.3389/fcimb.2026.1908346","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1908346","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1908346/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1908346/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100748944","display_name":"Yujuan Li","orcid":"https://orcid.org/0000-0002-7953-4130","observed_orcids":["https://orcid.org/0000-0002-7953-4130"]},"institutions":[{"id":"https://openalex.org/I43081956","display_name":"Xiangnan University","ror":"https://ror.org/05by9mg64","country_code":"CN","type":"education","lineage":["https://openalex.org/I43081956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujuan Li","raw_affiliation_strings":["College of Basic Medicine, Xiangnan University","Hunan Provincial Key Laboratory of Gut Microbiota and Chronic Disease Intervention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medicine, Xiangnan University","institution_ids":["https://openalex.org/I43081956"]},{"raw_affiliation_string":"Hunan Provincial Key Laboratory of Gut Microbiota and Chronic Disease Intervention","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148321136","display_name":"Yi Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43081956","display_name":"Xiangnan University","ror":"https://ror.org/05by9mg64","country_code":"CN","type":"education","lineage":["https://openalex.org/I43081956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Yang","raw_affiliation_strings":["College of Basic Medicine, Xiangnan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medicine, Xiangnan University","institution_ids":["https://openalex.org/I43081956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054860406","display_name":"Ting Zhou","orcid":"https://orcid.org/0000-0002-8475-5798","observed_orcids":["https://orcid.org/0000-0002-8475-5798","https://orcid.org/0009-0002-8299-2308"]},"institutions":[{"id":"https://openalex.org/I43081956","display_name":"Xiangnan University","ror":"https://ror.org/05by9mg64","country_code":"CN","type":"education","lineage":["https://openalex.org/I43081956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Zhou","raw_affiliation_strings":["College of Clinical, Xiangnan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Clinical, Xiangnan University","institution_ids":["https://openalex.org/I43081956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148240404","display_name":"Jing Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43081956","display_name":"Xiangnan University","ror":"https://ror.org/05by9mg64","country_code":"CN","type":"education","lineage":["https://openalex.org/I43081956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhou","raw_affiliation_strings":["College of Clinical, Xiangnan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Clinical, Xiangnan University","institution_ids":["https://openalex.org/I43081956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101629648","display_name":"Jie Hu","orcid":"https://orcid.org/0000-0002-6819-1603","observed_orcids":["https://orcid.org/0000-0002-6819-1603"]},"institutions":[{"id":"https://openalex.org/I43081956","display_name":"Xiangnan University","ror":"https://ror.org/05by9mg64","country_code":"CN","type":"education","lineage":["https://openalex.org/I43081956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Hu","raw_affiliation_strings":["College of Basic Medicine, Xiangnan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medicine, Xiangnan University","institution_ids":["https://openalex.org/I43081956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148265291","display_name":"Shuangshuang Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43081956","display_name":"Xiangnan University","ror":"https://ror.org/05by9mg64","country_code":"CN","type":"education","lineage":["https://openalex.org/I43081956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuangshuang Liang","raw_affiliation_strings":["College of Clinical, Xiangnan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Clinical, Xiangnan University","institution_ids":["https://openalex.org/I43081956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159745408","display_name":"Zhenhua Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43081956","display_name":"Xiangnan University","ror":"https://ror.org/05by9mg64","country_code":"CN","type":"education","lineage":["https://openalex.org/I43081956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenhua Xie","raw_affiliation_strings":["College of Basic Medicine, Xiangnan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medicine, Xiangnan University","institution_ids":["https://openalex.org/I43081956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121287065","display_name":"Qing Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43081956","display_name":"Xiangnan University","ror":"https://ror.org/05by9mg64","country_code":"CN","type":"education","lineage":["https://openalex.org/I43081956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Cheng","raw_affiliation_strings":["College of Basic Medicine, Xiangnan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medicine, Xiangnan University","institution_ids":["https://openalex.org/I43081956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075013477","display_name":"Yachao Jiang","orcid":"https://orcid.org/0000-0002-3936-2530","observed_orcids":["https://orcid.org/0000-0002-3936-2530"]},"institutions":[{"id":"https://openalex.org/I43081956","display_name":"Xiangnan University","ror":"https://ror.org/05by9mg64","country_code":"CN","type":"education","lineage":["https://openalex.org/I43081956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yachao Jiang","raw_affiliation_strings":["College of Pharmacy, Xiangnan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Xiangnan University","institution_ids":["https://openalex.org/I43081956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101862404","display_name":"Chao Jiang","orcid":"https://orcid.org/0000-0002-8801-8576","observed_orcids":["https://orcid.org/0000-0002-8801-8576"]},"institutions":[{"id":"https://openalex.org/I43081956","display_name":"Xiangnan University","ror":"https://ror.org/05by9mg64","country_code":"CN","type":"education","lineage":["https://openalex.org/I43081956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Jiang","raw_affiliation_strings":["College of Basic Medicine, Xiangnan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medicine, Xiangnan University","institution_ids":["https://openalex.org/I43081956"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5148233758","display_name":"Qing Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43081956","display_name":"Xiangnan University","ror":"https://ror.org/05by9mg64","country_code":"CN","type":"education","lineage":["https://openalex.org/I43081956"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qing Liu","raw_affiliation_strings":["College of Pharmacy, Xiangnan University","Hunan Provincial Key Laboratory of Gut Microbiota and Chronic Disease Intervention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Xiangnan University","institution_ids":["https://openalex.org/I43081956"]},{"raw_affiliation_string":"Hunan Provincial Key Laboratory of Gut Microbiota and Chronic Disease Intervention","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5148233758"],"corresponding_institution_ids":["https://openalex.org/I43081956"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"1908346","last_page":"1908346"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-terpineol","display_name":"\u03b1-terpineol","score":0.9950000047683716},{"id":"https://openalex.org/keywords/colistin","display_name":"colistin","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mcr-genes","display_name":"mcr genes","score":0.7160000205039978},{"id":"https://openalex.org/keywords/plasmid-mediated-colistin-resistance","display_name":"plasmid-mediated colistin resistance","score":0.9459999799728394},{"id":"https://openalex.org/keywords/multidrug-resistant-escherichia-coli","display_name":"multidrug-resistant Escherichia coli","score":0.9679999947547913},{"id":"https://openalex.org/keywords/synergistic-antibacterial-activity","display_name":"synergistic antibacterial activity","score":0.7710000276565552},{"id":"https://openalex.org/keywords/membrane-fluidity","display_name":"membrane fluidity","score":0.9670000076293945},{"id":"https://openalex.org/keywords/superoxide-dismutase-inhibition","display_name":"superoxide dismutase inhibition","score":0.8579999804496765},{"id":"https://openalex.org/keywords/superoxide-accumulation","display_name":"superoxide accumulation","score":0.890999972820282},{"id":"https://openalex.org/keywords/iron-sulfur-clusters","display_name":"iron-sulfur clusters","score":0.9150000214576721},{"id":"https://openalex.org/keywords/proton-motive-force","display_name":"proton motive force","score":0.7409999966621399},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.7570000290870667},{"id":"https://openalex.org/keywords/galleria-mellonella","display_name":"Galleria mellonella","score":0.7749999761581421},{"id":"https://openalex.org/keywords/gram-negative-infections","display_name":"gram-negative bacterial infection","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C2779259085","wikidata":"https://www.wikidata.org/wiki/Q418946","display_name":"Colistin","level":3,"score":0.9592999815940857},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7645999789237976},{"id":"https://openalex.org/C2780950330","wikidata":"https://www.wikidata.org/wiki/Q19903614","display_name":"Broth microdilution","level":4,"score":0.6589000225067139},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6499000191688538},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.6013000011444092},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.484499990940094},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.48080000281333923},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44519999623298645},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44350001215934753},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.38920000195503235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3529999852180481},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.3440999984741211},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.3278999924659729},{"id":"https://openalex.org/C2777620836","wikidata":"https://www.wikidata.org/wiki/Q23578725","display_name":"MCR-1","level":5,"score":0.3222000002861023},{"id":"https://openalex.org/C2776315533","wikidata":"https://www.wikidata.org/wiki/Q3241189","display_name":"Acinetobacter baumannii","level":4,"score":0.3133000135421753},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.31200000643730164},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.3070000112056732},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.30239999294281006},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.3021000027656555},{"id":"https://openalex.org/C2779032433","wikidata":"https://www.wikidata.org/wiki/Q761648","display_name":"Galleria mellonella","level":4,"score":0.3012999892234802},{"id":"https://openalex.org/C2780675486","wikidata":"https://www.wikidata.org/wiki/Q423765","display_name":"Polymyxin","level":3,"score":0.2937000095844269},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.2840000092983246},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.28049999475479126},{"id":"https://openalex.org/C17741926","wikidata":"https://www.wikidata.org/wiki/Q762045","display_name":"Bacterial growth","level":3,"score":0.27730000019073486},{"id":"https://openalex.org/C2776985332","wikidata":"https://www.wikidata.org/wiki/Q311055","display_name":"Escherichia","level":4,"score":0.27410000562667847},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.27320000529289246},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.26190000772476196},{"id":"https://openalex.org/C2909437661","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli infection","level":4,"score":0.25450000166893005},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.2531000077724457},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.2522999942302704}],"mesh":[{"descriptor_ui":"D000081005","descriptor_name":"Cyclohexane Monoterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003091","descriptor_name":"Colistin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008560","descriptor_name":"Membrane Fluidity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D039821","descriptor_name":"Monoterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fcimb.2026.1908346","doi":"https://doi.org/10.3389/fcimb.2026.1908346","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1908346","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1908346/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13553474","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13553474/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13553474/pdf/fcimb-16-1908346.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Infect Microbiol","raw_type":"Text"},{"id":"pmid:42718814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42718814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular and infection microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5ecec28a3bea42a39e2ecf939b2056ab","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5ecec28a3bea42a39e2ecf939b2056ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular and Infection Microbiology, Vol 16 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcimb.2026.1908346","doi":"https://doi.org/10.3389/fcimb.2026.1908346","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1908346","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1908346/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204238509.pdf","grobid_xml":"https://content.openalex.org/works/W7204238509.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1606573610","https://openalex.org/W1843382635","https://openalex.org/W1982240222","https://openalex.org/W2010983045","https://openalex.org/W2026917976","https://openalex.org/W2029130563","https://openalex.org/W2039073430","https://openalex.org/W2056379191","https://openalex.org/W2099752435","https://openalex.org/W2107698718","https://openalex.org/W2108638835","https://openalex.org/W2117087393","https://openalex.org/W2122863984","https://openalex.org/W2146481325","https://openalex.org/W2163015800","https://openalex.org/W2171268876","https://openalex.org/W2345854975","https://openalex.org/W2543967684","https://openalex.org/W2789500779","https://openalex.org/W2802068594","https://openalex.org/W2802324910","https://openalex.org/W2897252040","https://openalex.org/W2897377848","https://openalex.org/W2989205690","https://openalex.org/W2998968401","https://openalex.org/W3042611656","https://openalex.org/W3044721864","https://openalex.org/W3052480489","https://openalex.org/W3083935039","https://openalex.org/W3092359591","https://openalex.org/W3156880528","https://openalex.org/W3200345170","https://openalex.org/W3209308071","https://openalex.org/W3210417673","https://openalex.org/W4205471480","https://openalex.org/W4206034777","https://openalex.org/W4206508627","https://openalex.org/W4213250177","https://openalex.org/W4323810477","https://openalex.org/W4380080057","https://openalex.org/W4385650198","https://openalex.org/W4387874501","https://openalex.org/W4388130135","https://openalex.org/W4392106729","https://openalex.org/W4398774573","https://openalex.org/W4400748607","https://openalex.org/W4406741400","https://openalex.org/W4408265988","https://openalex.org/W4413887637"],"related_works":["https://openalex.org/W4414660172","https://openalex.org/W4220762832","https://openalex.org/W7166836363","https://openalex.org/W4402893120","https://openalex.org/W4303579178","https://openalex.org/W7138307200","https://openalex.org/W4402304324","https://openalex.org/W4416119009","https://openalex.org/W4396871619","https://openalex.org/W4411325491"],"abstract_inverted_index":{"Amid":[0],"the":[1,19,61,82,134,146,173,202],"growing":[2],"antibiotic":[3],"resistance":[4,27,102],"crisis,":[5],"colistin":[6,26,39,69,139,149,163,238],"remains":[7],"a":[8,47,236,253],"last-line":[9],"therapeutic":[10,226],"option":[11],"for":[12,256],"multidrug-resistant":[13],"(MDR)":[14],"Gram-negative":[15,259],"bacterial":[16,260],"infections.":[17,261],"However,":[18],"emergence":[20],"and":[21,79,101,112,124,138,144,154,184,196,248],"rapid":[22],"dissemination":[23],"of":[24,64,85,136,148,175],"plasmid-mediated":[25],"gene":[28],"(":[29,75],"mcr":[30],")":[31,78],"have":[32],"markedly":[33],"reduced":[34],"its":[35,43],"clinical":[36],"effectiveness.":[37],"Utilizing":[38],"adjuvants":[40],"to":[41,50,59,80,179,219],"restore":[42],"antibacterial":[44,242],"potency":[45],"is":[46],"promising":[48,237],"strategy":[49,255],"combat":[51],"this":[52,55,86],"threat.":[53],"In":[54,88,116],"study,":[56],"we":[57],"aimed":[58],"investigate":[60],"synergistic":[62,90,141],"effects":[63,209],"\u03b1-terpineol":[65,137,234],"in":[66,157,228],"combination":[67,135,222],"with":[68,201],"against":[70],"colistin-resistant":[71],"MDR":[72,216,258],"Escherichia":[73],"coli":[74,77,159,218],"E.":[76,158,217],"elucidate":[81],"underlying":[83],"mechanisms":[84],"synergy.":[87],"vitro":[89],"activity":[91,143,243],"was":[92,119],"evaluated":[93],"using":[94,121],"checkerboard":[95],"microdilution":[96],"assays,":[97],"time-kill":[98],"curve":[99],"analyses,":[100],"development":[103,147],"studies.":[104],"Mechanistic":[105],"insights":[106],"were":[107],"obtained":[108],"through":[109],"transcriptomic":[110],"analysis":[111],"fluorescence-probe":[113],"based":[114],"assays.":[115],"vivo":[117],"efficacy":[118,227],"validated":[120],"Galleria":[122],"mellonella":[123],"mouse":[125],"acute":[126],"peritonitis":[127],"infection":[128],"models.":[129,230],"The":[130,221],"results":[131],"showed":[132,224],"that":[133,240],"exhibited":[140],"bactericidal":[142],"suppressed":[145],"resistance.":[150],"\u03b1-Terpineol":[151],"increased":[152],"inner-":[153],"outer-membrane":[155],"fluidity":[156],",":[160],"thereby":[161],"enhancing":[162],"uptake.":[164],"Furthermore,":[165],"it":[166],"inhibited":[167],"superoxide":[168,186],"dismutase":[169],"(SOD)":[170],"activity,":[171],"preventing":[172],"conversion":[174],"O":[176,182,189],"2":[177,181,183,190],"\u00b7\u2013":[178,191],"H":[180],"causing":[185],"accumulation.":[187],"Elevated":[188],"levels":[192],"damaged":[193],"iron\u2013sulfur":[194],"clusters":[195],"impaired":[197,211],"respiratory":[198],"function.":[199],"Together":[200],"proton":[203],"motive":[204],"force":[205],"(PMF)":[206],"dissipation,":[207],"these":[208],"severely":[210],"ATP":[212],"synthesis,":[213],"ultimately":[214],"sensitizing":[215],"colistin.":[220],"also":[223],"significant":[225],"animal":[229],"Our":[231],"findings":[232],"identify":[233],"as":[235],"adjuvant":[239],"restores":[241],"by":[244],"disrupting":[245],"membrane":[246],"integrity":[247],"impairing":[249],"antioxidant":[250],"defenses,":[251],"offering":[252],"viable":[254],"treating":[257]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-08-27T00:00:00"}