{"id":"https://openalex.org/W7204238147","doi":"https://doi.org/10.1016/j.neurot.2026.e01054","title":"Comment on \u201cSafety profile and potential clinical risks of xanomeline and trospium chloride\u201d - Confirmatory findings from an independent FAERS analysis","display_name":"Comment on \u201cSafety profile and potential clinical risks of xanomeline and trospium chloride\u201d - Confirmatory findings from an independent FAERS analysis","publication_year":2026,"publication_date":"2026-07-01","ids":{"openalex":"https://openalex.org/W7204238147","doi":"https://doi.org/10.1016/j.neurot.2026.e01054","pmid":"https://pubmed.ncbi.nlm.nih.gov/42648934"},"language":"en","primary_location":{"id":"doi:10.1016/j.neurot.2026.e01054","doi":"https://doi.org/10.1016/j.neurot.2026.e01054","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neurot.2026.e01054","pdf_url":null,"source":{"id":"https://openalex.org/S75519821","display_name":"Neurotherapeutics","issn_l":"1878-7479","issn":["1878-7479","1933-7213"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.neurot.2026.e01054","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063264326","display_name":"Emily E. Leppien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily E. Leppien","raw_affiliation_strings":["Binghamton University School of Pharmacy & Pharmaceutical Sciences, Johnson City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Binghamton University School of Pharmacy & Pharmaceutical Sciences, Johnson City, NY, USA","institution_ids":["https://openalex.org/I123946342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148282311","display_name":"Alexandra R. Rola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra R. Rola","raw_affiliation_strings":["Binghamton University School of Pharmacy & Pharmaceutical Sciences, Johnson City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Binghamton University School of Pharmacy & Pharmaceutical Sciences, Johnson City, NY, USA","institution_ids":["https://openalex.org/I123946342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081904718","display_name":"Gurpreet Singh Guliani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113162","display_name":"United Health Services","ror":"https://ror.org/024nhth42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210113162"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gurpreet S. Guliani","raw_affiliation_strings":["UHS Binghamton General Hospital, Binghamton, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UHS Binghamton General Hospital, Binghamton, NY, USA","institution_ids":["https://openalex.org/I4210113162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148328819","display_name":"Roisin Daly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roisin Daly","raw_affiliation_strings":["Binghamton University School of Pharmacy & Pharmaceutical Sciences, Johnson City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Binghamton University School of Pharmacy & Pharmaceutical Sciences, Johnson City, NY, USA","institution_ids":["https://openalex.org/I123946342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148267768","display_name":"Vaishvi S. Gandhi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vaishvi S. Gandhi","raw_affiliation_strings":["Binghamton University School of Pharmacy & Pharmaceutical Sciences, Johnson City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Binghamton University School of Pharmacy & Pharmaceutical Sciences, Johnson City, NY, USA","institution_ids":["https://openalex.org/I123946342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148234255","display_name":"Dev V. Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dev V. Patel","raw_affiliation_strings":["Binghamton University School of Pharmacy & Pharmaceutical Sciences, Johnson City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Binghamton University School of Pharmacy & Pharmaceutical Sciences, Johnson City, NY, USA","institution_ids":["https://openalex.org/I123946342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068788366","display_name":"Kenneth L. McCall","orcid":"https://orcid.org/0000-0003-2061-108X","observed_orcids":["https://orcid.org/0000-0003-2061-108X"]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth L. McCall","raw_affiliation_strings":["Binghamton University School of Pharmacy & Pharmaceutical Sciences, Johnson City, NY, USA. Electronic address: kmccall@binghamton.edu"],"raw_orcid":"https://orcid.org/0000-0003-2061-108X","affiliations":[{"raw_affiliation_string":"Binghamton University School of Pharmacy & Pharmaceutical Sciences, Johnson City, NY, USA. Electronic address: kmccall@binghamton.edu","institution_ids":["https://openalex.org/I123946342"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068788366"],"corresponding_institution_ids":["https://openalex.org/I123946342"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"4","first_page":"e01054","last_page":"e01054"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xanomeline","display_name":"xanomeline","score":0.9369999766349792},{"id":"https://openalex.org/keywords/trospium-chloride","display_name":"trospium chloride","score":1.0},{"id":"https://openalex.org/keywords/adverse-event-reporting","display_name":"adverse event reporting","score":0.5450000166893005},{"id":"https://openalex.org/keywords/pharmacovigilance","display_name":"pharmacovigilance","score":0.8709999918937683},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.597000002861023},{"id":"https://openalex.org/keywords/signal-detection","display_name":"signal detection","score":0.5509999990463257},{"id":"https://openalex.org/keywords/fda-adverse-event-reporting-system","display_name":"FDA Adverse Event Reporting System","score":0.5770000219345093},{"id":"https://openalex.org/keywords/case-definition","display_name":"case definition","score":0.4429999887943268},{"id":"https://openalex.org/keywords/reproducibility","display_name":"reproducibility","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7699000239372253},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45809999108314514},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.38989999890327454},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3772999942302704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37049999833106995},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3443000018596649},{"id":"https://openalex.org/C12770488","wikidata":"https://www.wikidata.org/wiki/Q188449","display_name":"Neurosurgery","level":2,"score":0.3264999985694885},{"id":"https://openalex.org/C2992477034","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Clinical neurology","level":2,"score":0.25780001282691956},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.24529999494552612},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.22470000386238098}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neurot.2026.e01054","doi":"https://doi.org/10.1016/j.neurot.2026.e01054","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neurot.2026.e01054","pdf_url":null,"source":{"id":"https://openalex.org/S75519821","display_name":"Neurotherapeutics","issn_l":"1878-7479","issn":["1878-7479","1933-7213"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics","raw_type":"journal-article"},{"id":"pmid:42648934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42648934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a5a0e683dd3648f7a457931881543f4c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a5a0e683dd3648f7a457931881543f4c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurotherapeutics, Vol 23, Iss 4, Pp e01054- (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13639622","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13639622/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurotherapeutics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.neurot.2026.e01054","doi":"https://doi.org/10.1016/j.neurot.2026.e01054","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neurot.2026.e01054","pdf_url":null,"source":{"id":"https://openalex.org/S75519821","display_name":"Neurotherapeutics","issn_l":"1878-7479","issn":["1878-7479","1933-7213"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W4389752902","https://openalex.org/W4396561837","https://openalex.org/W4396696202","https://openalex.org/W4407931623","https://openalex.org/W4410481172","https://openalex.org/W7152735554","https://openalex.org/W7162546991","https://openalex.org/W7164053788"],"related_works":[],"abstract_inverted_index":{"We":[0],"read":[1],"with":[2],"interest":[3],"the":[4,11,23,39,77],"study":[5],"by":[6],"Bao":[7],"et":[8],"al.":[9],"describing":[10],"early":[12],"postmarketing":[13],"safety":[14],"profile":[15,43],"of":[16,44,81],"xanomeline":[17],"and":[18,49,64,79],"trospium":[19],"chloride":[20],"(X/T)":[21],"using":[22,69],"FDA":[24],"Adverse":[25],"Event":[26],"Reporting":[27],"System":[28],"(FAERS)":[29],"[1].":[30],"Their":[31],"analysis":[32],"provides":[33],"timely,":[34],"real-world":[35],"pharmacovigilance":[36,55],"data":[37,56],"regarding":[38],"adverse":[40],"event":[41],"(AE)":[42],"this":[45],"novel,":[46],"first-in-class":[47],"therapy,":[48],"complements":[50],"recent":[51],"reports":[52],"[2,3].":[53],"Since":[54],"are":[57,73],"sensitive":[58],"to":[59],"preprocessing":[60],"decisions,":[61],"case":[62],"definitions,":[63],"signal-detection":[65],"methods,":[66],"analyses":[67],"conducted":[68],"independently":[70],"developed":[71],"methods":[72],"important":[74],"for":[75],"evaluating":[76],"consistency":[78],"reproducibility":[80],"newly":[82],"identified":[83],"reporting":[84],"signals":[85],"[4,5].":[86]},"counts_by_year":[],"updated_date":"2026-10-11T09:32:39.932853","created_date":"2026-08-27T00:00:00"}
