{"id":"https://openalex.org/W7204234382","doi":"https://doi.org/10.64898/2026.08.25.747035","title":"An Intronic SINE at Pou5f1 Links Hormone Signaling to Blastocyst Hatching","display_name":"An Intronic SINE at Pou5f1 Links Hormone Signaling to Blastocyst Hatching","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204234382","doi":"https://doi.org/10.64898/2026.08.25.747035"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.25.747035","doi":"https://doi.org/10.64898/2026.08.25.747035","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.25.747035","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.08.25.747035","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016221026","display_name":"Youjia Guo","orcid":"https://orcid.org/0000-0002-4837-9350","observed_orcids":["https://orcid.org/0000-0002-4837-9350"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youjia Zach Guo","raw_affiliation_strings":["University of Pennsylvania School of Veterinary Medicine;"],"raw_orcid":"https://orcid.org/0000-0002-4837-9350","affiliations":[{"raw_affiliation_string":"University of Pennsylvania School of Veterinary Medicine;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015844165","display_name":"Hyun Hyung An","orcid":"https://orcid.org/0000-0002-7070-8552","observed_orcids":["https://orcid.org/0000-0002-7070-8552"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyun Hyung An","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007319400","display_name":"Katelyn Toohill","orcid":"https://orcid.org/0009-0009-9706-2753","observed_orcids":["https://orcid.org/0009-0009-9706-2753"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelyn Toohill","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084515555","display_name":"Sneha Ramesh Mani","orcid":"https://orcid.org/0000-0002-5784-041X","observed_orcids":["https://orcid.org/0000-0002-5784-041X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sneha Ramesh Mani","raw_affiliation_strings":["Center for Research on Reproduction and Women Health, Perelman School of Medicine, University of Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research on Reproduction and Women Health, Perelman School of Medicine, University of Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087228244","display_name":"Ten D. Li","orcid":"https://orcid.org/0000-0003-3971-6463","observed_orcids":["https://orcid.org/0000-0003-3971-6463"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ten D Li","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036986479","display_name":"Chantal K. Diallo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chantal Diallo","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033693650","display_name":"Diego Antonio Jimenez","orcid":"https://orcid.org/0000-0002-7072-8449","observed_orcids":["https://orcid.org/0000-0002-7072-8449"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diego Antonio Jimenez","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016806568","display_name":"Alyssa Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alyssa Saito","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108819626","display_name":"Nicolae Adrian Leu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolae Adrian Leu","raw_affiliation_strings":["Center for Animal Transgenesis & Germ Cell Research, School of Veterinary Medicine, University of Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Animal Transgenesis & Germ Cell Research, School of Veterinary Medicine, University of Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148341809","display_name":"Beril Tore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beril Tore","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148334804","display_name":"Jamie Yoon Ha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie Yoon Ha","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104602581","display_name":"Vamshidhar C. Nallamala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vamshidhar Nallamala","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148373288","display_name":"Sarah Stanger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Stanger","raw_affiliation_strings":["Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046822275","display_name":"Piotr Tetlak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Piotr Tetlak","raw_affiliation_strings":["Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110422845","display_name":"Yanlin Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanlin Hou","raw_affiliation_strings":["Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148359656","display_name":"Ana Domingo-Meulas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Domingo-Meulas","raw_affiliation_strings":["Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054245422","display_name":"Nicolas Plachta","orcid":"https://orcid.org/0000-0002-5035-7425","observed_orcids":["https://orcid.org/0000-0002-5035-7425"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas D Plachta","raw_affiliation_strings":["Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017794876","display_name":"Monica Ailawadi Mainigi","orcid":"https://orcid.org/0000-0003-3306-4791","observed_orcids":["https://orcid.org/0000-0003-3306-4791"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Ailawadi Mainigi","raw_affiliation_strings":["Center for Research on Reproduction and Women Health, Perelman School of Medicine, University of Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research on Reproduction and Women Health, Perelman School of Medicine, University of Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023995887","display_name":"Andrew J. Modzelewski","orcid":"https://orcid.org/0000-0003-0698-957X","observed_orcids":["https://orcid.org/0000-0003-0698-957X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew J Modzelewski","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023995887"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.3928000032901764,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.3928000032901764,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.3345000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.18299999833106995,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blastocyst-hatching","display_name":"blastocyst hatching","score":0.9409999847412109},{"id":"https://openalex.org/keywords/hormone-signaling","display_name":"hormone signaling","score":0.625},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.8059999942779541},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.972000002861023},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.9359999895095825},{"id":"https://openalex.org/keywords/estrogen-related-receptor-alpha","display_name":"estrogen-related receptor alpha","score":0.9129999876022339},{"id":"https://openalex.org/keywords/endometrial-receptivity","display_name":"endometrial receptivity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/implantation","display_name":"implantation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/alu-elements","display_name":"Alu elements","score":0.7459999918937683},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.6230000257492065},{"id":"https://openalex.org/keywords/mouse-embryonic-development","display_name":"mouse embryo development","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.8950999975204468},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7838000059127808},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6051999926567078},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5476999878883362},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4805000126361847},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4072999954223633},{"id":"https://openalex.org/C2776010925","wikidata":"https://www.wikidata.org/wiki/Q219841","display_name":"Zona pellucida","level":4,"score":0.3928000032901764},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.3449000120162964},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.328900009393692},{"id":"https://openalex.org/C2777744765","wikidata":"https://www.wikidata.org/wiki/Q2734755","display_name":"Hatching","level":2,"score":0.3043000102043152},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.2851000130176544},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2849999964237213},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.26989999413490295},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.26750001311302185},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.2653999924659729},{"id":"https://openalex.org/C159399396","wikidata":"https://www.wikidata.org/wiki/Q1335221","display_name":"Inner cell mass","level":5,"score":0.2646999955177307},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.2599000036716461},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.257999986410141},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.25270000100135803}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.25.747035","doi":"https://doi.org/10.64898/2026.08.25.747035","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.25.747035","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.25.747035","doi":"https://doi.org/10.64898/2026.08.25.747035","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.25.747035","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1995315605","https://openalex.org/W4381620031","https://openalex.org/W2121695084","https://openalex.org/W2144759797","https://openalex.org/W2241142218","https://openalex.org/W3108064094","https://openalex.org/W1973844575","https://openalex.org/W2201717650","https://openalex.org/W83428078","https://openalex.org/W2331988547"],"abstract_inverted_index":{"Before":[0],"implantation,":[1],"mammalian":[2],"embryos":[3,62],"must":[4],"escape":[5],"from":[6],"the":[7,16,69,127],"zona":[8,41,95],"pellucida,":[9],"a":[10,34,72],"protective":[11],"glycoprotein":[12],"coat":[13],"that":[14,57,125,138,169],"surrounds":[15],"blastocyst.":[17],"This":[18],"process,":[19],"known":[20],"as":[21,33,165],"hatching,":[22],"is":[23,45],"essential":[24],"for":[25],"uterine":[26],"attachment":[27],"and":[28,40,86,104,112,115,157,177],"has":[29],"been":[30],"viewed":[31],"largely":[32],"mechanical":[35],"consequence":[36],"of":[37,60,66],"blastocyst":[38,84],"expansion":[39],"weakening.":[42],"Whether":[43],"hatching":[44,59],"actively":[46],"timed":[47],"by":[48,71],"embryo-intrinsic":[49],"gene":[50,146],"regulation":[51],"remains":[52],"unclear.":[53],"Here":[54],"we":[55],"show":[56,137],"timely":[58],"mouse":[61],"requires":[63,126],"signal-responsive":[64],"repression":[65],"Pou5f1/OCT4":[67],"in":[68,144],"trophectoderm":[70,132],"single":[73],"intronic":[74,140,151,163],"B2":[75,128],"short":[76],"interspersed":[77],"nuclear":[78],"element.":[79],"Deleting":[80],"this":[81],"element":[82,129],"preserves":[83],"formation":[85],"stem-cell":[87],"competence,":[88],"but":[89],"disrupts":[90],"trophectodermal":[91],"OCT4":[92],"repression,":[93],"delays":[94],"escape,":[96],"causes":[97],"hatching-uterine":[98],"receptivity":[99],"mismatch,":[100],"perturbs":[101],"implantation-site":[102],"organization":[103],"reduces":[105],"peri-implantation":[106],"fitness.":[107],"CRISPR":[108],"activation":[109],"screening,":[110],"siRNA":[111],"pharmacological":[113],"perturbation,":[114],"defined":[116],"progesterone/estradiol/EGF":[117],"culture":[118],"conditions":[119],"identify":[120,162],"an":[121],"ESRRA-linked":[122],"endocrine/growth-factor":[123],"response":[124],"to":[130,173],"consolidate":[131],"maturation.":[133],"Comparative":[134],"analyses":[135],"further":[136],"young":[139],"SINEs":[141,164],"are":[142],"enriched":[143],"developmental":[145],"programs,":[147],"whereas":[148],"human":[149],"POU5F1":[150],"Alu":[152],"elements":[153],"exhibit":[154],"genetic":[155],"constraint":[156],"repressive":[158],"potential.":[159],"These":[160],"findings":[161],"molecular":[166],"entry":[167],"points":[168],"couple":[170],"extracellular":[171],"cues":[172],"lineage-restricted":[174],"transcriptional":[175],"control":[176],"morphogenic":[178],"transition.":[179]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-27T00:00:00"}
