{"id":"https://openalex.org/W7204233634","doi":"https://doi.org/10.1016/j.aohep.2026.102326","title":"#51 - IMPACT OF RAPID RESPONSE TO IMMUNOSUPPRESSIVE TREATMENT ON THE CLINICAL COURSE OF PATIENTS WITH AUTOIMMUNE HEPATITIS.","display_name":"#51 - IMPACT OF RAPID RESPONSE TO IMMUNOSUPPRESSIVE TREATMENT ON THE CLINICAL COURSE OF PATIENTS WITH AUTOIMMUNE HEPATITIS.","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7204233634","doi":"https://doi.org/10.1016/j.aohep.2026.102326"},"language":"en","primary_location":{"id":"doi:10.1016/j.aohep.2026.102326","doi":"https://doi.org/10.1016/j.aohep.2026.102326","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.aohep.2026.102326","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1665268126001468/pdf","source":{"id":"https://openalex.org/S32516778","display_name":"Annals of Hepatology","issn_l":"1665-2681","issn":["1665-2681","2659-5982"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1665268126001468/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148373185","display_name":"Hstlim Rodr\u00edguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134311","display_name":"Instituto de Gastroenterolog\u00eda","ror":"https://ror.org/049kj1302","country_code":"CU","type":"healthcare","lineage":["https://openalex.org/I4210134311"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Hstlim Rodr\u00edguez","raw_affiliation_strings":["Institute Of Gastroenterology, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute Of Gastroenterology, Cuba","institution_ids":["https://openalex.org/I4210134311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111453704","display_name":"Danay Guerrero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134311","display_name":"Instituto de Gastroenterolog\u00eda","ror":"https://ror.org/049kj1302","country_code":"CU","type":"healthcare","lineage":["https://openalex.org/I4210134311"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Danay Guerrero","raw_affiliation_strings":["Institute Of Gastroenterology, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute Of Gastroenterology, Cuba","institution_ids":["https://openalex.org/I4210134311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026681570","display_name":"Yusimik Rom\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134311","display_name":"Instituto de Gastroenterolog\u00eda","ror":"https://ror.org/049kj1302","country_code":"CU","type":"healthcare","lineage":["https://openalex.org/I4210134311"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Yusimik Rom\u00e1n","raw_affiliation_strings":["Institute Of Gastroenterology, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute Of Gastroenterology, Cuba","institution_ids":["https://openalex.org/I4210134311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037493930","display_name":"Kenia Valenzuela","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenia Valenzuela","raw_affiliation_strings":["Medical Surgical Research Center, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Surgical Research Center, Cuba","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046208577","display_name":"Marcia Samada","orcid":"https://orcid.org/0000-0003-3795-3801","observed_orcids":["https://orcid.org/0000-0003-3795-3801"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcia Samada","raw_affiliation_strings":["Medical Surgical Research Center, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Surgical Research Center, Cuba","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103348045","display_name":"Ludmila Martinez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ludmila Mart\u00ednez","raw_affiliation_strings":["Hospital Carlos J Finlay, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Carlos J Finlay, Cuba","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000278573","display_name":"Mirta Infante Vel\u00e1zquez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134311","display_name":"Instituto de Gastroenterolog\u00eda","ror":"https://ror.org/049kj1302","country_code":"CU","type":"healthcare","lineage":["https://openalex.org/I4210134311"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Mirta Infante","raw_affiliation_strings":["Institute Of Gastroenterology, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute Of Gastroenterology, Cuba","institution_ids":["https://openalex.org/I4210134311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110620422","display_name":"Marlen Castellanos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134311","display_name":"Instituto de Gastroenterolog\u00eda","ror":"https://ror.org/049kj1302","country_code":"CU","type":"healthcare","lineage":["https://openalex.org/I4210134311"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Marl\u00e9n Castellanos","raw_affiliation_strings":["Institute Of Gastroenterology, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute Of Gastroenterology, Cuba","institution_ids":["https://openalex.org/I4210134311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.56346376,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":null,"first_page":"102326","last_page":"102326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoimmune-hepatitis","display_name":"autoimmune hepatitis","score":1.0},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/biochemical-response","display_name":"biochemical response","score":0.6800000071525574},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8450000286102295},{"id":"https://openalex.org/keywords/complications","display_name":"complications","score":0.5699999928474426},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9710000157356262},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9872999787330627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7142999768257141},{"id":"https://openalex.org/C2777203481","wikidata":"https://www.wikidata.org/wiki/Q786844","display_name":"Autoimmune hepatitis","level":3,"score":0.676800012588501},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5855000019073486},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.5206999778747559},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.4627000093460083},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.4009000062942505},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.37689998745918274},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.3693000078201294},{"id":"https://openalex.org/C2776760755","wikidata":"https://www.wikidata.org/wiki/Q18939","display_name":"Azathioprine","level":3,"score":0.34439998865127563},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.33739998936653137},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.31310001015663147},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.30320000648498535},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.30059999227523804},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2971000075340271},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2809999883174896},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.2766999900341034},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.26919999718666077},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26600000262260437}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.aohep.2026.102326","doi":"https://doi.org/10.1016/j.aohep.2026.102326","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.aohep.2026.102326","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1665268126001468/pdf","source":{"id":"https://openalex.org/S32516778","display_name":"Annals of Hepatology","issn_l":"1665-2681","issn":["1665-2681","2659-5982"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hepatology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.aohep.2026.102326","doi":"https://doi.org/10.1016/j.aohep.2026.102326","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.aohep.2026.102326","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1665268126001468/pdf","source":{"id":"https://openalex.org/S32516778","display_name":"Annals of Hepatology","issn_l":"1665-2681","issn":["1665-2681","2659-5982"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204233634.pdf","grobid_xml":"https://content.openalex.org/works/W7204233634.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7219397444","https://openalex.org/W4291272571","https://openalex.org/W7119300275","https://openalex.org/W2531162824","https://openalex.org/W4401426037","https://openalex.org/W4286256329","https://openalex.org/W998585907","https://openalex.org/W4392560441","https://openalex.org/W4399079507","https://openalex.org/W7215367317"],"abstract_inverted_index":{"Introduction":[0],"and":[1,17,57,82,110,115,127,157],"Objectives":[2],"Autoimmune":[3],"hepatitis":[4,72],"(AIH)":[5,73],"is":[6],"a":[7,42,96,144,196],"chronic":[8],"inflammatory":[9],"liver":[10],"disease":[11],"that":[12],"can":[13],"progress":[14],"to":[15,24,37,45,165],"cirrhosis":[16],"its":[18],"complications.":[19],"The":[20,34,84],"speed":[21],"of":[22,41,52,78,104,147,182],"response":[23,44,92,107,134,149,198],"immunosuppressive":[25,46],"therapy":[26,47],"has":[27],"emerged":[28],"as":[29,95,178],"an":[30],"important":[31],"prognostic":[32],"predictor.":[33],"objective":[35],"was":[36,64,87,93,135,169,179,191],"evaluate":[38],"the":[39,49,76,128,180],"impact":[40],"rapid":[43,91,133,197],"on":[48],"clinical":[50],"course":[51],"patients":[53,68,139,194],"with":[54,70,195],"AIH.":[55],"Materials":[56],"Methods":[58],"A":[59,90,132],"retrospective,":[60],"real-world":[61],"longitudinal":[62],"study":[63],"conducted":[65],"in":[66,99,137,171,193],"85":[67],"diagnosed":[69],"autoimmune":[71],"treated":[74],"at":[75,101,108,150],"Institute":[77],"Gastroenterology":[79],"between":[80],"2010":[81],"2025.":[83],"median":[85],"follow-up":[86],"107":[88],"months.":[89],"defined":[94],"80%":[97],"decrease":[98],"AST":[100],"8":[102],"weeks":[103,152,159],"treatment.":[105],"Biochemical":[106],"24":[109,151],"48":[111,158],"weeks,":[112],"progression,":[113],"complications,":[114],"overall":[116],"survival":[117,190],"were":[118],"evaluated.":[119],"Statistical":[120],"analysis":[121],"included":[122],"chi-square":[123],"tests,":[124],"Kaplan-Meier":[125],"curves,":[126],"log-rank":[129],"test.":[130],"Results":[131],"observed":[136],"46":[138],"(54%).":[140],"Rapid":[141],"responders":[142],"had":[143],"higher":[145,192],"rate":[146],"complete":[148],"(78.3%":[153],"vs":[154,161,175,186,200],"20.5%;":[155],"p<0.01)":[156],"(69.6%":[160],"17.9%;":[162],"p<0.01).":[163,188],"Progression":[164],"more":[166],"advanced":[167],"stages":[168],"lower":[170],"this":[172],"group":[173],"(52.2%":[174],"89.7%;":[176],"p<0.01),":[177],"occurrence":[181],"multiple":[183],"complications":[184],"(13%":[185],"46.1%;":[187],"Overall":[189],"(97.8%":[199],"82.1%;":[201],"p=0.02).":[202],"Conclusions":[203],"La":[204],"respuesta":[205,227],"r\u00e1pida":[206],"al":[207],"tratamiento":[208],"inmunosupresor":[209],"mostr\u00f3":[210],"un":[211],"impacto":[212],"positivo":[213],"en":[214],"la":[215,233],"evoluci\u00f3n":[216],"de":[217,232],"pacientes":[218],"con":[219,225],"HAI.":[220],"Su":[221],"presencia":[222],"se":[223],"asocia":[224],"mayor":[226,236],"bioqu\u00edmica":[228],"sostenida,":[229],"menor":[230],"progresi\u00f3n":[231],"enfermedad":[234],"y":[235],"supervivencia":[237],"global.":[238]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-08-27T00:00:00"}
