{"id":"https://openalex.org/W7204233273","doi":"https://doi.org/10.1016/j.isci.2026.117357","title":"Pentachlorophenol enhances bladder cancer cell invasion through altered protein stability","display_name":"Pentachlorophenol enhances bladder cancer cell invasion through altered protein stability","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204233273","doi":"https://doi.org/10.1016/j.isci.2026.117357","pmid":"https://pubmed.ncbi.nlm.nih.gov/42699065"},"language":"en","primary_location":{"id":"doi:10.1016/j.isci.2026.117357","doi":"https://doi.org/10.1016/j.isci.2026.117357","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2026.117357","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.isci.2026.117357","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077869520","display_name":"Ranran Zhou","orcid":"https://orcid.org/0000-0003-2464-0646","observed_orcids":["https://orcid.org/0000-0003-2464-0646"]},"institutions":[{"id":"https://openalex.org/I4210088873","display_name":"Third Affiliated Hospital of Southern Medical University","ror":"https://ror.org/0050r1b65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088873"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ranran Zhou","raw_affiliation_strings":["Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province 510630, China","The Third Clinical School of Southern Medical University, Guangzhou, Guangdong Province 510630, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province 510630, China","institution_ids":["https://openalex.org/I4210088873","https://openalex.org/I58200834"]},{"raw_affiliation_string":"The Third Clinical School of Southern Medical University, Guangzhou, Guangdong Province 510630, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148290471","display_name":"Wansong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wansong Zhang","raw_affiliation_strings":["Department of Urology, The Seventh Affiliated Hospital, Southern Medical University, Foshan, Guangdong Province 528244, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Seventh Affiliated Hospital, Southern Medical University, Foshan, Guangdong Province 528244, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091714843","display_name":"Ming Xia","orcid":"https://orcid.org/0000-0003-3926-2350","observed_orcids":["https://orcid.org/0000-0003-3926-2350"]},"institutions":[{"id":"https://openalex.org/I4210088873","display_name":"Third Affiliated Hospital of Southern Medical University","ror":"https://ror.org/0050r1b65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088873"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Xia","raw_affiliation_strings":["Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province 510630, China","The Third Clinical School of Southern Medical University, Guangzhou, Guangdong Province 510630, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province 510630, China","institution_ids":["https://openalex.org/I4210088873","https://openalex.org/I58200834"]},{"raw_affiliation_string":"The Third Clinical School of Southern Medical University, Guangzhou, Guangdong Province 510630, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148219373","display_name":"Ker Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088873","display_name":"Third Affiliated Hospital of Southern Medical University","ror":"https://ror.org/0050r1b65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088873"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ker Zhang","raw_affiliation_strings":["Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province 510630, China","The Third Clinical School of Southern Medical University, Guangzhou, Guangdong Province 510630, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province 510630, China","institution_ids":["https://openalex.org/I4210088873","https://openalex.org/I58200834"]},{"raw_affiliation_string":"The Third Clinical School of Southern Medical University, Guangzhou, Guangdong Province 510630, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148221849","display_name":"Wei Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088873","display_name":"Third Affiliated Hospital of Southern Medical University","ror":"https://ror.org/0050r1b65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088873"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Luo","raw_affiliation_strings":["Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province 510630, China","The Third Clinical School of Southern Medical University, Guangzhou, Guangdong Province 510630, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province 510630, China","institution_ids":["https://openalex.org/I4210088873","https://openalex.org/I58200834"]},{"raw_affiliation_string":"The Third Clinical School of Southern Medical University, Guangzhou, Guangdong Province 510630, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111138043","display_name":"Tianhang Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088873","display_name":"Third Affiliated Hospital of Southern Medical University","ror":"https://ror.org/0050r1b65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088873"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianhang Zhu","raw_affiliation_strings":["Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province 510630, China","The Third Clinical School of Southern Medical University, Guangzhou, Guangdong Province 510630, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province 510630, China","institution_ids":["https://openalex.org/I4210088873","https://openalex.org/I58200834"]},{"raw_affiliation_string":"The Third Clinical School of Southern Medical University, Guangzhou, Guangdong Province 510630, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100349979","display_name":"Cheng Yang","orcid":"https://orcid.org/0000-0002-5836-3723","observed_orcids":["https://orcid.org/0000-0002-5836-3723","https://orcid.org/0000-0002-6236-610X","https://orcid.org/0009-0008-2224-7510"]},"institutions":[{"id":"https://openalex.org/I4210088873","display_name":"Third Affiliated Hospital of Southern Medical University","ror":"https://ror.org/0050r1b65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088873"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cheng Yang","raw_affiliation_strings":["Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province 510630, China","The Third Clinical School of Southern Medical University, Guangzhou, Guangdong Province 510630, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province 510630, China","institution_ids":["https://openalex.org/I4210088873","https://openalex.org/I58200834"]},{"raw_affiliation_string":"The Third Clinical School of Southern Medical University, Guangzhou, Guangdong Province 510630, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077472823","display_name":"Cundong Liu","orcid":"https://orcid.org/0000-0002-2098-1139","observed_orcids":["https://orcid.org/0000-0002-2098-1139"]},"institutions":[{"id":"https://openalex.org/I4210088873","display_name":"Third Affiliated Hospital of Southern Medical University","ror":"https://ror.org/0050r1b65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088873"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cundong Liu","raw_affiliation_strings":["Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province 510630, China","The Third Clinical School of Southern Medical University, Guangzhou, Guangdong Province 510630, China"],"raw_orcid":"https://orcid.org/0000-0002-2098-1139","affiliations":[{"raw_affiliation_string":"Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province 510630, China","institution_ids":["https://openalex.org/I4210088873","https://openalex.org/I58200834"]},{"raw_affiliation_string":"The Third Clinical School of Southern Medical University, Guangzhou, Guangdong Province 510630, China","institution_ids":["https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077472823","https://openalex.org/A5100349979"],"corresponding_institution_ids":["https://openalex.org/I4210088873","https://openalex.org/I58200834"],"apc_list":{"value":3240,"currency":"USD","value_usd":3240},"apc_paid":{"value":3240,"currency":"USD","value_usd":3240},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72001855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"9","first_page":"117357","last_page":"117357"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.5356000065803528,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.5356000065803528,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.19789999723434448,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.06769999861717224,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pentachlorophenol","display_name":"pentachlorophenol","score":1.0},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8700000047683716},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.9779999852180481},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mek1","display_name":"MEK1","score":1.0},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":1.0},{"id":"https://openalex.org/keywords/environmental-contaminants","display_name":"environmental pollutants","score":0.7039999961853027},{"id":"https://openalex.org/keywords/prognostic-gene-signature","display_name":"prognostic gene signature","score":0.7689999938011169},{"id":"https://openalex.org/keywords/persistent-organic-pollutants","display_name":"persistent organic pollutants","score":0.6660000085830688},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6050000190734863},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C2779912340","wikidata":"https://www.wikidata.org/wiki/Q423922","display_name":"Pentachlorophenol","level":2,"score":0.9243000149726868},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.7735999822616577},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.73580002784729},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5976999998092651},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5648000240325928},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5440000295639038},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44589999318122864},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4002000093460083},{"id":"https://openalex.org/C3020745361","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Urothelial cancer","level":4,"score":0.3003000020980835},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.296099990606308},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28290000557899475},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2770000100135803},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.2678000032901764},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.262800008058548},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.25450000166893005},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25369998812675476},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.25189998745918274}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.isci.2026.117357","doi":"https://doi.org/10.1016/j.isci.2026.117357","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2026.117357","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},{"id":"pmid:42699065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42699065","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13543803","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42699065/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"iScience","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.isci.2026.117357","doi":"https://doi.org/10.1016/j.isci.2026.117357","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2026.117357","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1425268590","https://openalex.org/W1545718641","https://openalex.org/W1970110882","https://openalex.org/W1971509668","https://openalex.org/W2007937905","https://openalex.org/W2026378458","https://openalex.org/W2042891907","https://openalex.org/W2053538348","https://openalex.org/W2056571752","https://openalex.org/W2104027363","https://openalex.org/W2119096115","https://openalex.org/W2124050512","https://openalex.org/W2161511101","https://openalex.org/W2162573748","https://openalex.org/W2346554829","https://openalex.org/W2575095601","https://openalex.org/W2806041148","https://openalex.org/W2894728921","https://openalex.org/W2922537641","https://openalex.org/W2981526150","https://openalex.org/W3038503389","https://openalex.org/W3047447240","https://openalex.org/W3092598261","https://openalex.org/W3134929357","https://openalex.org/W3136769379","https://openalex.org/W4210530293","https://openalex.org/W4229449894","https://openalex.org/W4308253982","https://openalex.org/W4311649944","https://openalex.org/W4386010994","https://openalex.org/W4386049803","https://openalex.org/W4387809667","https://openalex.org/W4392763526","https://openalex.org/W4400532597","https://openalex.org/W4407205035","https://openalex.org/W4408430910","https://openalex.org/W4408478991","https://openalex.org/W4409563331","https://openalex.org/W4412391974","https://openalex.org/W4414009001","https://openalex.org/W4415924319"],"related_works":[],"abstract_inverted_index":{"Pentachlorophenol":[0],"(PCP)":[1],"is":[2,14],"a":[3],"persistent":[4],"environmental":[5],"contaminant,":[6],"but":[7],"its":[8],"effect":[9],"on":[10,36,79],"bladder":[11,30,89,123],"cancer":[12,31,90,124],"invasiveness":[13],"unclear.":[15],"Here,":[16],"we":[17],"show":[18],"that":[19],"environmentally":[20],"relevant":[21],"PCP":[22,55,96,109],"concentrations":[23],"enhance":[24],"invasion":[25,125],"of":[26,60],"T24":[27],"and":[28,44,50,63,101,110,126,130],"SW780":[29],"cells,":[32],"with":[33,84],"limited":[34],"effects":[35],"migration":[37],"or":[38,65,68],"proliferation.":[39],"Integrative":[40],"target":[41],"prediction,":[42],"transcriptomics,":[43],"machine":[45],"learning":[46],"identified":[47],"EGFR,":[48],"MAP2K1,":[49],"NFE2L2":[51,69],"as":[52],"candidate":[53,118],"contributors.":[54],"altered":[56],"the":[57,111],"protein":[58],"stability":[59],"these":[61,80,93,115],"factors,":[62],"EGFR":[64],"MAP2K1":[66],"knockdown":[67],"overexpression":[70],"partially":[71],"attenuated":[72],"PCP-induced":[73],"invasion.":[74],"A":[75],"three-gene":[76],"signature":[77],"based":[78],"factors":[81],"was":[82],"associated":[83],"poor":[85],"prognosis":[86],"across":[87],"five":[88],"cohorts,":[91],"although":[92],"datasets":[94],"lacked":[95],"exposure":[97],"information.":[98],"Molecular":[99],"docking":[100],"molecular":[102,119],"dynamics":[103],"simulations":[104],"predicted":[105],"compatible":[106],"interactions":[107],"between":[108],"three":[112],"proteins.":[113],"Together,":[114],"findings":[116],"identify":[117],"contributors":[120],"to":[121],"PCP-associated":[122],"support":[127],"further":[128],"chronic-exposure":[129],"in":[131],"vivo":[132],"studies.":[133]},"counts_by_year":[],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2026-08-27T00:00:00"}