{"id":"https://openalex.org/W7204229581","doi":"https://doi.org/10.2147/dmso.s606697","title":"Wnt/\u03b2-Catenin Signaling in Diabetic Complications: Mechanisms and Therapeutic Potential","display_name":"Wnt/\u03b2-Catenin Signaling in Diabetic Complications: Mechanisms and Therapeutic Potential","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7204229581","doi":"https://doi.org/10.2147/dmso.s606697","pmid":"https://pubmed.ncbi.nlm.nih.gov/42677203"},"language":"en","primary_location":{"id":"doi:10.2147/dmso.s606697","doi":"https://doi.org/10.2147/dmso.s606697","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dmso.s606697","pdf_url":"https://www.dovepress.com/article/download/118806","source":{"id":"https://openalex.org/S176615914","display_name":"Diabetes Metabolic Syndrome and Obesity","issn_l":"1178-7007","issn":["1178-7007"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Metabolic Syndrome and Obesity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/118806","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101677401","display_name":"Xuelian Liu","orcid":"https://orcid.org/0000-0003-1676-4593","observed_orcids":["https://orcid.org/0000-0003-1676-4593","https://orcid.org/0009-0002-7345-7004"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuelian Liu","raw_affiliation_strings":["Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148185049","display_name":"Yuefen Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuefen Liu","raw_affiliation_strings":["Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100356791","display_name":"Yun Zhang","orcid":"https://orcid.org/0000-0002-0554-9102","observed_orcids":["https://orcid.org/0000-0002-0554-9102"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Zhang","raw_affiliation_strings":["Department of Social Medicine and Health Service Management, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Social Medicine and Health Service Management, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148197919","display_name":"Zhanqi Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhanqi Cao","raw_affiliation_strings":["Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148341236","display_name":"Qie Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qie Guo","raw_affiliation_strings":["Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148223154","display_name":"Hongyan Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyan Ji","raw_affiliation_strings":["Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023659584","display_name":"Donghua Liu","orcid":"https://orcid.org/0000-0002-5506-8366","observed_orcids":["https://orcid.org/0000-0002-5506-8366"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Donghua Liu","raw_affiliation_strings":["Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-5506-8366","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China","institution_ids":["https://openalex.org/I4210116869"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210116869"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.61107191,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 19","issue":null,"first_page":"1","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diabetes-complications","display_name":"diabetes complications","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9660000205039978},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":1.0},{"id":"https://openalex.org/keywords/diabetic-cardiomyopathy","display_name":"diabetic cardiomyopathy","score":1.0},{"id":"https://openalex.org/keywords/diabetic-neuropathy","display_name":"diabetic neuropathy","score":0.972000002861023},{"id":"https://openalex.org/keywords/diabetic-osteoporosis","display_name":"diabetic osteoporosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9599999785423279},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9879999756813049},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pathological-angiogenesis","display_name":"pathological angiogenesis","score":0.796999990940094},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9200000166893005},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/nerve-regeneration","display_name":"nerve regeneration","score":0.9520000219345093},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8629999756813049},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":1.0},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.847000002861023},{"id":"https://openalex.org/keywords/lrp6","display_name":"LRP6","score":0.9089999794960022},{"id":"https://openalex.org/keywords/small-molecule-modulators","display_name":"small molecule modulators","score":0.8270000219345093},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.8709999918937683},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5498999953269958},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.40450000762939453},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3828999996185303},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3271999955177307},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31119999289512634},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2696000039577484},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2605000138282776},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.25920000672340393},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.2425999939441681},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.24169999361038208}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/dmso.s606697","doi":"https://doi.org/10.2147/dmso.s606697","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dmso.s606697","pdf_url":"https://www.dovepress.com/article/download/118806","source":{"id":"https://openalex.org/S176615914","display_name":"Diabetes Metabolic Syndrome and Obesity","issn_l":"1178-7007","issn":["1178-7007"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Metabolic Syndrome and Obesity","raw_type":"journal-article"},{"id":"pmid:42677203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42677203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, metabolic syndrome and obesity : targets and therapy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3a71137e56ab4dbd98c8126099212f4a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3a71137e56ab4dbd98c8126099212f4a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Diabetes, Metabolic Syndrome and Obesity, Vol Volume 19, Iss Issue 1, Pp 1-22 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13528675","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13528675/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13528675/pdf/DMSO-19-606697.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes Metab Syndr Obes","raw_type":"Text"},{"id":"pmh:oai:dovepress.com/118806","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/wnt-catenin-signaling-in-diabetic-complications-mechanisms-and-therape-peer-reviewed-fulltext-article-DMSO","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Review"}],"best_oa_location":{"id":"doi:10.2147/dmso.s606697","doi":"https://doi.org/10.2147/dmso.s606697","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dmso.s606697","pdf_url":"https://www.dovepress.com/article/download/118806","source":{"id":"https://openalex.org/S176615914","display_name":"Diabetes Metabolic Syndrome and Obesity","issn_l":"1178-7007","issn":["1178-7007"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Metabolic Syndrome and Obesity","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204229581.pdf","grobid_xml":"https://content.openalex.org/works/W7204229581.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Diabetic":[0],"complications,":[1,36],"driven":[2],"by":[3,59],"chronic":[4],"hyperglycemia":[5,117],"and":[6,22,68,95,106,128,140,159,174,184,199,218,241,259,274],"complex":[7],"pathogenic":[8],"mechanisms,":[9],"are":[10],"a":[11,205],"major":[12,77,103],"global":[13],"health":[14],"challenge,":[15],"yet":[16],"the":[17,66,102,113,181,196,250,262],"basis":[18],"of":[19,62,72,109,122,164,208,235,265],"tissue-specific":[20,273],"injury":[21],"repair":[23,52],"remains":[24],"unclear.":[25],"Wnt/\u03b2-catenin":[26,73,151,236,254],"signaling":[27,74,152,255],"has":[28],"emerged":[29],"as":[30,213],"an":[31],"important":[32],"regulator":[33],"in":[34,47,53,125,149,156],"these":[35,188],"but":[37],"its":[38,60,272],"role":[39],"is":[40,57,153,246],"highly":[41],"context":[42],"dependent,":[43],"promoting":[44],"pathological":[45,104,141,240],"remodeling":[46],"some":[48],"tissues":[49],"while":[50],"impairing":[51],"others.":[54],"This":[55,244],"review":[56,245],"distinguished":[58],"integration":[61],"current":[63],"evidence":[64,228],"on":[65],"dual":[67],"often":[69,118],"opposing":[70],"roles":[71],"across":[75],"six":[76],"diabetic":[78,80,83,86,90,93,96,257],"complications:":[79],"nephropathy":[81],"(DN),":[82],"retinopathy":[84],"(DR),":[85],"cutaneous":[87],"ulcers":[88],"(DCU),":[89],"cardiomyopathy":[91],"(DCM),":[92],"neuropathy,":[94],"osteoporosis":[97],"(DOP).":[98],"We":[99,178],"first":[100],"outline":[101],"features":[105],"clinical":[107],"significance":[108],"each":[110],"complication,":[111],"highlighting":[112],"recurring":[114],"observation":[115],"that":[116,230,268],"causes":[119],"aberrant":[120],"activation":[121],"this":[123],"pathway":[124],"DN,":[126],"DR,":[127],"DCM,":[129],"where":[130],"it":[131],"promotes":[132],"epithelial-to-mesenchymal":[133],"transition,":[134],"extracellular":[135],"matrix":[136],"accumulation,":[137],"fibrosis,":[138],"inflammation,":[139],"angiogenesis.":[142],"In":[143],"contrast,":[144],"we":[145,225],"then":[146],"examine":[147],"conditions":[148],"which":[150],"suppressed,":[154],"particularly":[155],"DCU,":[157],"DOP,":[158],"certain":[160],"forms":[161],"or":[162],"stages":[163],"DPN,":[165],"leading":[166],"to":[167,248,256,260],"impaired":[168],"wound":[169],"healing,":[170],"reduced":[171],"bone":[172],"formation,":[173],"defective":[175],"nerve":[176],"regeneration.":[177],"subsequently":[179],"analyze":[180],"cell":[182],"type-":[183],"stage-specific":[185,275],"mechanisms":[186,252],"underlying":[187],"divergent":[189],"effects,":[190],"including":[191],"cross-talk":[192],"with":[193],"oxidative":[194],"stress,":[195],"renin-angiotensin":[197],"system,":[198],"transforming":[200],"growth":[201],"factor-\u03b2":[202],"signaling.":[203],"Following":[204],"detailed":[206],"discussion":[207],"emerging":[209],"therapeutic":[210],"strategies,":[211],"such":[212],"LRP6-targeting":[214],"biologics,":[215],"small-molecule":[216],"modulators,":[217],"agents":[219],"derived":[220],"from":[221],"traditional":[222],"Chinese":[223],"medicine,":[224],"summarize":[226],"preclinical":[227],"showing":[229],"carefully":[231],"tuned,":[232],"context-specific":[233],"modulation":[234],"can":[237],"improve":[238],"both":[239],"functional":[242],"outcomes.":[243],"intended":[247],"clarify":[249],"potential":[251],"linking":[253],"complications":[258],"guide":[261],"rational":[263],"development":[264],"new":[266],"therapies":[267],"take":[269],"into":[270],"account":[271],"effects.":[276]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2026-08-27T00:00:00"}
