{"id":"https://openalex.org/W7204229376","doi":"https://doi.org/10.51891/rease.v12i8.29777","title":"OSTEOSSARCOMA MAXILOFACIAL E BIOMARCADORES MOLECULARES: AVAN\u00c7OS NO DIAGN\u00d3STICO PRECOCE, ASPECTOS CL\u00cdNICOS, RADIOGR\u00c1FICOS, HISTOPATOL\u00d3GICOS E TERAP\u00caUTICOS \u2014 REVIS\u00c3O DE LITERATURA","display_name":"OSTEOSSARCOMA MAXILOFACIAL E BIOMARCADORES MOLECULARES: AVAN\u00c7OS NO DIAGN\u00d3STICO PRECOCE, ASPECTOS CL\u00cdNICOS, RADIOGR\u00c1FICOS, HISTOPATOL\u00d3GICOS E TERAP\u00caUTICOS \u2014 REVIS\u00c3O DE LITERATURA","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204229376","doi":"https://doi.org/10.51891/rease.v12i8.29777"},"language":"pt","primary_location":{"id":"doi:10.51891/rease.v12i8.29777","doi":"https://doi.org/10.51891/rease.v12i8.29777","is_oa":true,"landing_page_url":"https://doi.org/10.51891/rease.v12i8.29777","pdf_url":"https://periodicorease.pro.br/rease/article/download/29777/19228","source":{"id":"https://openalex.org/S4210238184","display_name":"Revista Ibero-Americana de Humanidades, Ci\u00eancias e Educa\u00e7\u00e3o","issn_l":"2675-3375","issn":["2675-3375"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4365394759","host_organization_name":"Arche Scientific and Editorial Consultancy","host_organization_lineage":["https://openalex.org/P4365394759"],"host_organization_lineage_names":["Arche Scientific and Editorial Consultancy"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Ibero-Americana de Humanidades, Ci\u00eancias e Educa\u00e7\u00e3o","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://periodicorease.pro.br/rease/article/download/29777/19228","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117533488","display_name":"Bruna Mabilly Dias","orcid":"https://orcid.org/0009-0009-5807-3388","observed_orcids":["https://orcid.org/0009-0009-5807-3388"]},"institutions":[{"id":"https://openalex.org/I187576290","display_name":"Universidade Paranaense","ror":"https://ror.org/0084z7g54","country_code":"BR","type":"education","lineage":["https://openalex.org/I187576290"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bruna Mabilly Dias","raw_affiliation_strings":["UNIPAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIPAR","institution_ids":["https://openalex.org/I187576290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083580263","display_name":"Adeline Limberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282333","display_name":"Centro Universit\u00e1rio Univel","ror":"https://ror.org/05pgdev72","country_code":"BR","type":"education","lineage":["https://openalex.org/I4405282333"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adeline Limberger","raw_affiliation_strings":["Centro Universit\u00e1rio Univel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Universit\u00e1rio Univel","institution_ids":["https://openalex.org/I4405282333"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148201133","display_name":"Amanda Ithaides Crespi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282333","display_name":"Centro Universit\u00e1rio Univel","ror":"https://ror.org/05pgdev72","country_code":"BR","type":"education","lineage":["https://openalex.org/I4405282333"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Amanda Ithaides Crespi","raw_affiliation_strings":["Centro Universit\u00e1rio Univel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Universit\u00e1rio Univel","institution_ids":["https://openalex.org/I4405282333"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148223892","display_name":"Matheus Francener","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282333","display_name":"Centro Universit\u00e1rio Univel","ror":"https://ror.org/05pgdev72","country_code":"BR","type":"education","lineage":["https://openalex.org/I4405282333"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Matheus Francener","raw_affiliation_strings":["Centro Universit\u00e1rio Univel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Universit\u00e1rio Univel","institution_ids":["https://openalex.org/I4405282333"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067126596","display_name":"Katiuscia Zago","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193876067","display_name":"Universidade Estadual do Oeste do Paran\u00e1","ror":"https://ror.org/05ne20t07","country_code":"BR","type":"education","lineage":["https://openalex.org/I193876067"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Katiuscia Zago","raw_affiliation_strings":["Unioeste"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unioeste","institution_ids":["https://openalex.org/I193876067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5135821171","display_name":"Ana Karolina Matos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193876067","display_name":"Universidade Estadual do Oeste do Paran\u00e1","ror":"https://ror.org/05ne20t07","country_code":"BR","type":"education","lineage":["https://openalex.org/I193876067"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana karolina Matos","raw_affiliation_strings":["UNIOESTE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIOESTE","institution_ids":["https://openalex.org/I193876067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"8","first_page":"1","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11787","display_name":"Oral and Maxillofacial Pathology","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-biomarkers","display_name":"molecular biomarkers","score":0.8119999766349792},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/maxilla","display_name":"maxilla","score":0.5989999771118164},{"id":"https://openalex.org/keywords/mandible","display_name":"mandible","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-cycle-genes","display_name":"cell cycle genes","score":0.7549999952316284},{"id":"https://openalex.org/keywords/dna-repair-genes","display_name":"DNA repair genes","score":0.8970000147819519},{"id":"https://openalex.org/keywords/angiogenic-factors","display_name":"angiogenic factors","score":0.8379999995231628},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8899999856948853},{"id":"https://openalex.org/keywords/circulating-biomarkers","display_name":"circulating biomarkers","score":0.8999999761581421},{"id":"https://openalex.org/keywords/prognostic-stratification","display_name":"prognostic stratification","score":0.9599999785423279},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5440000295639038},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.6890000104904175},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.6850000023841858},{"id":"https://openalex.org/keywords/radiological-features","display_name":"radiological features","score":0.7720000147819519},{"id":"https://openalex.org/keywords/treatment-strategy","display_name":"treatment options","score":0.3440000116825104},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.5059999823570251},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.6240000128746033},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4758000075817108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4122999906539917},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40549999475479126},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.36250001192092896},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3610999882221222},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3052999973297119},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2800000011920929},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2605000138282776},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.25839999318122864},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.25290000438690186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.51891/rease.v12i8.29777","doi":"https://doi.org/10.51891/rease.v12i8.29777","is_oa":true,"landing_page_url":"https://doi.org/10.51891/rease.v12i8.29777","pdf_url":"https://periodicorease.pro.br/rease/article/download/29777/19228","source":{"id":"https://openalex.org/S4210238184","display_name":"Revista Ibero-Americana de Humanidades, Ci\u00eancias e Educa\u00e7\u00e3o","issn_l":"2675-3375","issn":["2675-3375"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4365394759","host_organization_name":"Arche Scientific and Editorial Consultancy","host_organization_lineage":["https://openalex.org/P4365394759"],"host_organization_lineage_names":["Arche Scientific and Editorial Consultancy"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Ibero-Americana de Humanidades, Ci\u00eancias e Educa\u00e7\u00e3o","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.51891/rease.v12i8.29777","doi":"https://doi.org/10.51891/rease.v12i8.29777","is_oa":true,"landing_page_url":"https://doi.org/10.51891/rease.v12i8.29777","pdf_url":"https://periodicorease.pro.br/rease/article/download/29777/19228","source":{"id":"https://openalex.org/S4210238184","display_name":"Revista Ibero-Americana de Humanidades, Ci\u00eancias e Educa\u00e7\u00e3o","issn_l":"2675-3375","issn":["2675-3375"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4365394759","host_organization_name":"Arche Scientific and Editorial Consultancy","host_organization_lineage":["https://openalex.org/P4365394759"],"host_organization_lineage_names":["Arche Scientific and Editorial Consultancy"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Ibero-Americana de Humanidades, Ci\u00eancias e Educa\u00e7\u00e3o","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204229376.pdf","grobid_xml":"https://content.openalex.org/works/W7204229376.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W4389104295","https://openalex.org/W4390806437","https://openalex.org/W4391295253","https://openalex.org/W4398233072","https://openalex.org/W4401219131","https://openalex.org/W4402626634","https://openalex.org/W4404023725","https://openalex.org/W4406274630","https://openalex.org/W4417292443"],"related_works":["https://openalex.org/W7166861576","https://openalex.org/W7008303493","https://openalex.org/W4415600689","https://openalex.org/W4307651544","https://openalex.org/W4417292443","https://openalex.org/W2347771010","https://openalex.org/W3044151415","https://openalex.org/W7163322849","https://openalex.org/W7033057964","https://openalex.org/W1991358615"],"abstract_inverted_index":{"O":[0],"osteossarcoma":[1,225],"maxilofacial":[2],"\u00e9":[3,185],"uma":[4,28],"neoplasia":[5],"maligna":[6],"\u00f3ssea":[7],"rara":[8],"e":[9,21,37,44,77,109,128,140,163,199,222,235,244],"biologicamente":[10],"heterog\u00eanea,":[11],"caracterizada":[12],"pela":[13,187,200],"produ\u00e7\u00e3o":[14],"de":[15,71,91,100,142,166,193,202,210,246],"matriz":[16],"osteoide":[17],"por":[18,22,73],"c\u00e9lulas":[19],"tumorais":[20],"significativa":[23],"complexidade":[24],"diagn\u00f3stica.":[25],"Embora":[26],"represente":[27],"pequena":[29],"parcela":[30],"dos":[31,170],"osteossarcomas,":[32],"quando":[33],"acomete":[34],"a":[35,38,65,98,177],"maxila":[36],"mand\u00edbula":[39],"apresenta":[40],"caracter\u00edsticas":[41],"cl\u00ednicas,":[42],"radiogr\u00e1ficas":[43],"evolutivas":[45],"distintas":[46],"daquelas":[47],"observadas":[48],"nos":[49],"ossos":[50],"longos.":[51],"A":[52],"apresenta\u00e7\u00e3o":[53],"cl\u00ednica":[54,183],"pouco":[55],"espec\u00edfica":[56],"pode":[57],"contribuir":[58],"para":[59,158,239],"atrasos":[60],"no":[61,164],"diagn\u00f3stico,":[62],"tornando":[63],"necess\u00e1ria":[64],"integra\u00e7\u00e3o":[66],"entre":[67],"avalia\u00e7\u00e3o":[68],"cl\u00ednica,":[69],"m\u00e9todos":[70,94],"diagn\u00f3stico":[72,241],"imagem,":[74],"exame":[75],"histopatol\u00f3gico":[76],"investiga\u00e7\u00e3o":[78],"molecular.":[79],"Nesse":[80],"contexto,":[81],"os":[82,93,114,147,216],"biomarcadores":[83,153,233],"moleculares":[84,234],"v\u00eam":[85],"sendo":[86],"estudados":[87],"como":[88,213],"ferramentas":[89],"capazes":[90],"complementar":[92],"diagn\u00f3sticos":[95],"convencionais,":[96],"possibilitando":[97],"identifica\u00e7\u00e3o":[99],"altera\u00e7\u00f5es":[101,119],"relacionadas":[102],"\u00e0":[103,129,135],"carcinog\u00eanese,":[104],"progress\u00e3o":[105],"tumoral,":[106,189],"invasividade,":[107],"met\u00e1stase":[108],"resposta":[110],"ao":[111,123],"tratamento.":[112],"Entre":[113],"potenciais":[115],"marcadores":[116,180],"investigados":[117],"destacam-se":[118],"em":[120,204],"genes":[121],"relacionados":[122],"controle":[124],"do":[125,131,175,224],"ciclo":[126],"celular":[127],"repara\u00e7\u00e3o":[130],"DNA,":[132],"prote\u00ednas":[133],"associadas":[134],"prolifera\u00e7\u00e3o":[136],"celular,":[137],"fatores":[138],"angiog\u00eanicos":[139],"mol\u00e9culas":[141],"RNA":[143],"n\u00e3o":[144],"codificante,":[145],"especialmente":[146],"microRNAs.":[148],"Estudos":[149],"tamb\u00e9m":[150],"sugerem":[151],"que":[152],"circulantes":[154],"podem":[155],"apresentar":[156],"potencial":[157],"auxiliar":[159],"na":[160,172,181],"estratifica\u00e7\u00e3o":[161],"progn\u00f3stica":[162],"acompanhamento":[165],"pacientes.":[167],"Entretanto,":[168],"apesar":[169],"avan\u00e7os":[171],"caracteriza\u00e7\u00e3o":[173],"molecular":[174],"osteossarcoma,":[176],"utiliza\u00e7\u00e3o":[178],"desses":[179],"pr\u00e1tica":[182],"ainda":[184],"limitada":[186],"heterogeneidade":[188],"pelo":[190],"pequeno":[191],"n\u00famero":[192],"estudos":[194],"espec\u00edficos":[195],"envolvendo":[196],"les\u00f5es":[197],"maxilofaciais":[198],"necessidade":[201],"valida\u00e7\u00e3o":[203],"popula\u00e7\u00f5es":[205],"maiores.":[206],"Assim,":[207],"esta":[208],"revis\u00e3o":[209],"literatura":[211],"tem":[212],"objetivo":[214],"analisar":[215],"principais":[217],"aspectos":[218],"cl\u00ednicos,":[219],"radiogr\u00e1ficos,":[220],"histopatol\u00f3gicos":[221],"terap\u00eauticos":[223],"maxilofacial,":[226],"com":[227],"\u00eanfase":[228],"nas":[229],"evid\u00eancias":[230],"atuais":[231],"sobre":[232],"sua":[236],"poss\u00edvel":[237],"contribui\u00e7\u00e3o":[238],"o":[240],"precoce,":[242],"progn\u00f3stico":[243],"desenvolvimento":[245],"estrat\u00e9gias":[247],"terap\u00eauticas":[248],"individualizadas.":[249]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-27T00:00:00"}
