{"id":"https://openalex.org/W7204229193","doi":"https://doi.org/10.3389/fmicb.2026.1854938","title":"Endogenous Amphiregulin promotes muscle repair and function through expansion of fibro-adipogenic progenitors during chronic Toxoplasma gondii infection in mice","display_name":"Endogenous Amphiregulin promotes muscle repair and function through expansion of fibro-adipogenic progenitors during chronic Toxoplasma gondii infection in mice","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204229193","doi":"https://doi.org/10.3389/fmicb.2026.1854938","pmid":"https://pubmed.ncbi.nlm.nih.gov/42718992","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13553749"},"language":"en","primary_location":{"id":"doi:10.3389/fmicb.2026.1854938","doi":"https://doi.org/10.3389/fmicb.2026.1854938","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1854938","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1854938/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1854938/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080259476","display_name":"Ronzon R. Shihab","orcid":"https://orcid.org/0000-0001-5356-5345","observed_orcids":["https://orcid.org/0000-0001-5356-5345"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronzon Shihab","raw_affiliation_strings":["Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028326984","display_name":"Andrea Alfaro-Chac\u00f3n","orcid":"https://orcid.org/0000-0001-8784-756X","observed_orcids":["https://orcid.org/0000-0001-8784-756X"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Alfaro-Chacon","raw_affiliation_strings":["Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033463438","display_name":"Monica S. Humby","orcid":"https://orcid.org/0000-0002-3252-7670","observed_orcids":["https://orcid.org/0000-0002-3252-7670"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Humby","raw_affiliation_strings":["Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148307827","display_name":"Caleb Buerger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caleb Buerger","raw_affiliation_strings":["Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009238458","display_name":"Elizabeth A. Wohlfert","orcid":"https://orcid.org/0000-0001-7936-8614","observed_orcids":["https://orcid.org/0000-0001-7936-8614"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth A. Wohlfert","raw_affiliation_strings":["Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009238458"],"corresponding_institution_ids":["https://openalex.org/I63190737"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.49237379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1854938","last_page":"1854938"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.06530000269412994,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amphiregulin","display_name":"amphiregulin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/toxoplasma-gondii","display_name":"Toxoplasma gondii","score":0.9309999942779541},{"id":"https://openalex.org/keywords/chronic-toxoplasmosis","display_name":"chronic toxoplasmosis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/skeletal-muscle-regeneration","display_name":"skeletal muscle regeneration","score":0.9760000109672546},{"id":"https://openalex.org/keywords/fibro-adipogenic-progenitors","display_name":"fibro-adipogenic progenitors","score":0.9599999785423279},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9470000267028809},{"id":"https://openalex.org/keywords/th1-response","display_name":"Th1 response","score":0.7120000123977661},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7509999871253967},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9570000171661377},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.871999979019165},{"id":"https://openalex.org/keywords/inflammatory-myopathies","display_name":"myositis","score":0.6690000295639038},{"id":"https://openalex.org/keywords/muscle-fibrosis","display_name":"muscle fibrosis","score":0.703000009059906},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9509999752044678}],"concepts":[{"id":"https://openalex.org/C2780806702","wikidata":"https://www.wikidata.org/wiki/Q14866198","display_name":"Amphiregulin","level":4,"score":0.9204000234603882},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7685999870300293},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6820999979972839},{"id":"https://openalex.org/C2778128430","wikidata":"https://www.wikidata.org/wiki/Q131003","display_name":"Toxoplasma gondii","level":3,"score":0.6628000140190125},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6388999819755554},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5931000113487244},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5802000164985657},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4544999897480011},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4519999921321869},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42250001430511475},{"id":"https://openalex.org/C3019392825","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic infection","level":3,"score":0.4106999933719635},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3928000032901764},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.3659999966621399},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.33980000019073486},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.3086000084877014},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.299699991941452},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2896000146865845},{"id":"https://openalex.org/C2777619251","wikidata":"https://www.wikidata.org/wiki/Q7312279","display_name":"Remyelination","level":4,"score":0.27570000290870667},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.274399995803833},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.26460000872612},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.25870001316070557},{"id":"https://openalex.org/C2777700362","wikidata":"https://www.wikidata.org/wiki/Q107647","display_name":"Phagocyte","level":3,"score":0.25600001215934753},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.25130000710487366}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fmicb.2026.1854938","doi":"https://doi.org/10.3389/fmicb.2026.1854938","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1854938","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1854938/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13553749","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13553749/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13553749/pdf/fmicb-17-1854938.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Microbiol","raw_type":"Text"},{"id":"pmid:42718992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42718992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:db1285d4ce2d4ab488dacc8fb7a26e42","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/db1285d4ce2d4ab488dacc8fb7a26e42","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Microbiology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmicb.2026.1854938","doi":"https://doi.org/10.3389/fmicb.2026.1854938","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1854938","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1854938/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6468761843","display_name":"Antibody Fragments as Biochemical Tools to Interrogate CD9 Function in Inflammatory Diseases","funder_award_id":"R21GM135853","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000867724","display_name":"T Regulatory cell responses in Toxoplasma-infected muscle","funder_award_id":"R01AI162756","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000877109","display_name":"Associate-Director Flow and Image Cytometry Roswell Park ComprehensiveCancer Center","funder_award_id":"R50CA211108","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000888465","display_name":"Roswell Park Cancer Center Support Grant","funder_award_id":"P30CA016056","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G908282731","display_name":"Dysregulation of regulatory T cells during chronic infection in muscle","funder_award_id":"R21AI128284","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306497","display_name":"Roswell Park Cancer Institute","ror":"https://ror.org/0499dwk57"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204229193.pdf","grobid_xml":"https://content.openalex.org/works/W7204229193.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1574278422","https://openalex.org/W1888830013","https://openalex.org/W1927296860","https://openalex.org/W1945156854","https://openalex.org/W1964124818","https://openalex.org/W1974207421","https://openalex.org/W1976911916","https://openalex.org/W1984706770","https://openalex.org/W1995612509","https://openalex.org/W1998047654","https://openalex.org/W1999902156","https://openalex.org/W2001505007","https://openalex.org/W2006786116","https://openalex.org/W2008264147","https://openalex.org/W2010253303","https://openalex.org/W2012628829","https://openalex.org/W2019631420","https://openalex.org/W2026576172","https://openalex.org/W2035748790","https://openalex.org/W2039686723","https://openalex.org/W2060025481","https://openalex.org/W2062467557","https://openalex.org/W2081360252","https://openalex.org/W2106409745","https://openalex.org/W2108723188","https://openalex.org/W2112039060","https://openalex.org/W2122059149","https://openalex.org/W2130307536","https://openalex.org/W2143633028","https://openalex.org/W2143940677","https://openalex.org/W2145399303","https://openalex.org/W2150508221","https://openalex.org/W2151328705","https://openalex.org/W2156937928","https://openalex.org/W2160515243","https://openalex.org/W2165272574","https://openalex.org/W2235205471","https://openalex.org/W2337609700","https://openalex.org/W2467628122","https://openalex.org/W2536389260","https://openalex.org/W2557733681","https://openalex.org/W2587398364","https://openalex.org/W2800766398","https://openalex.org/W2889889927","https://openalex.org/W2892240428","https://openalex.org/W2910310212","https://openalex.org/W2914818051","https://openalex.org/W2928403250","https://openalex.org/W2952566600","https://openalex.org/W2965455118","https://openalex.org/W2979424267","https://openalex.org/W2996262293","https://openalex.org/W2999482784","https://openalex.org/W3005794975","https://openalex.org/W3012349948","https://openalex.org/W3043732524","https://openalex.org/W3088341443","https://openalex.org/W3110661317","https://openalex.org/W3191323626","https://openalex.org/W4200522994","https://openalex.org/W4211162417","https://openalex.org/W4294961496","https://openalex.org/W4306182256","https://openalex.org/W4312093673","https://openalex.org/W4319308391","https://openalex.org/W4385163329","https://openalex.org/W4388425210","https://openalex.org/W4391609501","https://openalex.org/W4412757660"],"related_works":["https://openalex.org/W2800766398","https://openalex.org/W2557733681","https://openalex.org/W4313385691","https://openalex.org/W7167342349","https://openalex.org/W2989973499","https://openalex.org/W1962551563","https://openalex.org/W2151328705","https://openalex.org/W2078389270","https://openalex.org/W2483905437","https://openalex.org/W1994452055"],"abstract_inverted_index":{"Skeletal":[0],"muscle":[1,28,45,58,134,158,233],"regeneration":[2,200,234],"relies":[3],"on":[4,20,27],"coordinated":[5],"interactions":[6],"between":[7],"immune":[8],"cells":[9,85],"and":[10,46,55,78,100,126,182,207,226,231],"resident":[11],"stem":[12],"cell":[13,229],"populations.":[14],"While":[15,130],"most":[16],"studies":[17],"have":[18],"focused":[19],"sterile":[21],"injury,":[22,193],"the":[23,48,108,141,184,236],"impact":[24],"of":[25,57,91,107,143,186,238],"infections":[26],"repair":[29,118,159],"remains":[30,146],"less":[31],"understood.":[32],"Toxoplasma":[33],"gondii":[34,139,241],",":[35],"a":[36,62,69,95,105,214],"widespread":[37],"parasite":[38],"that":[39,165],"establishes":[40],"chronic":[41,66,137,161,239],"infection":[42,67],"in":[43,116,220,235],"skeletal":[44],"also":[47],"central":[49],"nervous":[50],"system,":[51],"induces":[52],"myositis,":[53],"fibrosis,":[54],"loss":[56],"function.":[59],"In":[60],"mice,":[61,195],"natural":[63],"intermediate":[64],"host,":[65],"sustains":[68],"robust":[70],"Th1":[71],"response":[72],"dominated":[73],"by":[74,119,202],"IFN\u03b3-producing":[75,177],"CD4":[76],"+":[77,80,179,188],"CD8":[79,178],"T":[81,84,180,228],"cells.":[82],"Regulatory":[83],"(Tregs),":[86],"which":[87],"normally":[88],"promote":[89],"resolution":[90],"inflammation,":[92],"instead":[93],"adopt":[94],"pathogenic":[96],"phenotype,":[97],"increasing":[98],"inflammation":[99],"impairing":[101],"repair.":[102],"Amphiregulin":[103],"(Areg),":[104],"ligand":[106],"epidermal":[109],"growth":[110],"factor":[111],"receptor,":[112],"has":[113],"been":[114],"implicated":[115],"tissue":[117],"enhancing":[120],"Treg":[121],"function,":[122],"promoting":[123],"macrophage":[124],"polarization,":[125,230],"supporting":[127],"mesenchymal":[128],"differentiation.":[129],"exogenous":[131],"Areg":[132,145,166,169,219],"improves":[133],"function":[135],"during":[136,160],"T.":[138,240],"infection,":[140],"role":[142,216],"endogenous":[144,218],"unknown.":[147],"Here,":[148],"we":[149],"used":[150],"Areg-deficient":[151,194],"mice":[152],"to":[153,157],"investigate":[154],"its":[155],"contribution":[156],"infection.":[162,242],"We":[163],"show":[164],"deficiency":[167,170],"impaired":[168,171,199],"fibro-adipogenic":[172],"progenitor":[173],"(FAP)":[174],"expansion,":[175,223],"reduced":[176],"cells,":[181],"diminished":[183],"frequency":[185],"Tbet":[187],"Tregs.":[189],"Additionally,":[190],"following":[191],"CTX":[192],"particularly":[196],"females,":[197],"exhibited":[198],"characterized":[201],"smaller,":[203],"more":[204],"heterogeneous":[205],"myofibers,":[206],"increased":[208],"damaged":[209],"area.":[210],"These":[211],"findings":[212],"reveal":[213],"critical":[215],"for":[217],"timely":[221],"FAP":[222],"proper":[224],"effector":[225],"regulatory":[227],"efficient":[232],"setting":[237]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-08-27T00:00:00"}