{"id":"https://openalex.org/W7204229119","doi":"https://doi.org/10.1016/j.jaccas.2026.110006","title":"Cardiopulmonary Exercise Testing Identifies Treatable ATTR Cardiac Amyloidosis","display_name":"Cardiopulmonary Exercise Testing Identifies Treatable ATTR Cardiac Amyloidosis","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204229119","doi":"https://doi.org/10.1016/j.jaccas.2026.110006","pmid":"https://pubmed.ncbi.nlm.nih.gov/42644794","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13698931"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaccas.2026.110006","doi":"https://doi.org/10.1016/j.jaccas.2026.110006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaccas.2026.110006","pdf_url":"https://www.jacc.org/doi/pdf/10.1016/j.jaccas.2026.110006?download=true","source":{"id":"https://openalex.org/S4210180918","display_name":"JACC Case Reports","issn_l":"2666-0849","issn":["2666-0849"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jacc.org/doi/pdf/10.1016/j.jaccas.2026.110006?download=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5133040833","display_name":"Sara Rioja Abad","orcid":"https://orcid.org/0009-0004-9396-1341","observed_orcids":["https://orcid.org/0009-0004-9396-1341"]},"institutions":[{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Sara Rioja-Abad","raw_affiliation_strings":["Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain. Electronic address: sarariojaabad@gmail.com"],"raw_orcid":"https://orcid.org/0009-0004-9396-1341","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain. Electronic address: sarariojaabad@gmail.com","institution_ids":["https://openalex.org/I4210158107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148198290","display_name":"Ramon Andion-Ogando","orcid":"https://orcid.org/0000-0001-9744-780X","observed_orcids":["https://orcid.org/0000-0001-9744-780X"]},"institutions":[{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ramon Andion-Ogando","raw_affiliation_strings":["Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain"],"raw_orcid":"https://orcid.org/0000-0001-9744-780X","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148331022","display_name":"Maria Perez-Diaz","orcid":"https://orcid.org/0009-0007-4839-8934","observed_orcids":["https://orcid.org/0009-0007-4839-8934"]},"institutions":[{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Perez-Diaz","raw_affiliation_strings":["Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain"],"raw_orcid":"https://orcid.org/0009-0007-4839-8934","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075283316","display_name":"Cristina Barinaga-Mart\u00edn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Barinaga-Martin","raw_affiliation_strings":["Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111015667","display_name":"Jordi Candela Ferre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jordi Candela-Ferre","raw_affiliation_strings":["Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029149975","display_name":"Mar\u00eda Jes\u00fas Roll\u00e1n-G\u00f3mez","orcid":"https://orcid.org/0000-0002-7976-3507","observed_orcids":["https://orcid.org/0000-0002-7976-3507"]},"institutions":[{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Jesus Rollan-Gomez","raw_affiliation_strings":["Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019258889","display_name":"Ignacio Hern\u00e1ndez\u2010Gonz\u00e1lez","orcid":"https://orcid.org/0000-0001-7636-9988","observed_orcids":["https://orcid.org/0000-0001-7636-9988"]},"institutions":[{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ignacio Hernandez-Gonzalez","raw_affiliation_strings":["Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009314682","display_name":"Maria M. de la Torre\u2010Carpente","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria del Mar de la Torre-Carpente","raw_affiliation_strings":["Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054254186","display_name":"H\u00e9ctor Garc\u00eda\u2010Pardo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Hector Garcia-Pardo","raw_affiliation_strings":["Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5148256105","display_name":"Juan Carlos Mu\u00f1oz-San Jose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Carlos Mu\u00f1oz-San Jose","raw_affiliation_strings":["Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Rio Hortega University Hospital, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5133040833"],"corresponding_institution_ids":["https://openalex.org/I4210158107"],"apc_list":{"value":850,"currency":"USD","value_usd":850},"apc_paid":{"value":850,"currency":"USD","value_usd":850},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.61141304,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"42","first_page":"110006","last_page":"110006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transthyretin-amyloid-cardiomyopathy","display_name":"transthyretin amyloid cardiomyopathy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cardiopulmonary-exercise-testing","display_name":"cardiopulmonary exercise testing","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tafamidis","display_name":"tafamidis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/acoramidis","display_name":"acoramidis","score":0.7390000224113464},{"id":"https://openalex.org/keywords/transthyretin-stabilizers","display_name":"transthyretin stabilizers","score":0.8460000157356262},{"id":"https://openalex.org/keywords/n-terminal-pro-b-type-natriuretic-peptide","display_name":"N-terminal pro-brain natriuretic peptide","score":0.9649999737739563},{"id":"https://openalex.org/keywords/treatment-eligibility","display_name":"treatment eligibility","score":0.6740000247955322},{"id":"https://openalex.org/keywords/functional-capacity","display_name":"functional capacity","score":0.7120000123977661},{"id":"https://openalex.org/keywords/exertional-dyspnea","display_name":"exertional dyspnea","score":0.8289999961853027},{"id":"https://openalex.org/keywords/expanded-access","display_name":"compassionate use","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9157000184059143},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6915000081062317},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6687999963760376},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.656000018119812},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.6363999843597412},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5485000014305115},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.5164999961853027},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.4618000090122223},{"id":"https://openalex.org/C121157162","wikidata":"https://www.wikidata.org/wiki/Q419999","display_name":"Transthyretin","level":2,"score":0.4449999928474426},{"id":"https://openalex.org/C2777607188","wikidata":"https://www.wikidata.org/wiki/Q5038315","display_name":"Cardiac amyloidosis","level":3,"score":0.3862000107765198},{"id":"https://openalex.org/C2775846464","wikidata":"https://www.wikidata.org/wiki/Q66360952","display_name":"Brain natriuretic peptide","level":3,"score":0.35600000619888306},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.29809999465942383},{"id":"https://openalex.org/C2779962030","wikidata":"https://www.wikidata.org/wiki/Q2151267","display_name":"Restrictive cardiomyopathy","level":4,"score":0.2962999939918518},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.27869999408721924},{"id":"https://openalex.org/C2779551797","wikidata":"https://www.wikidata.org/wiki/Q4652470","display_name":"AL amyloidosis","level":4,"score":0.26919999718666077},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.26649999618530273}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jaccas.2026.110006","doi":"https://doi.org/10.1016/j.jaccas.2026.110006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaccas.2026.110006","pdf_url":"https://www.jacc.org/doi/pdf/10.1016/j.jaccas.2026.110006?download=true","source":{"id":"https://openalex.org/S4210180918","display_name":"JACC Case Reports","issn_l":"2666-0849","issn":["2666-0849"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Case Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13698931","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13698931/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13698931/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC Case Rep","raw_type":"Text"},{"id":"pmid:42644794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42644794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC. Case reports","raw_type":"Case Reports"},{"id":"pmh:oai:doaj.org/article:189d007282af44c29650ca48626f4c56","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/189d007282af44c29650ca48626f4c56","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JACC: Case Reports, Vol 31, Iss 42, Pp 110006- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jaccas.2026.110006","doi":"https://doi.org/10.1016/j.jaccas.2026.110006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaccas.2026.110006","pdf_url":"https://www.jacc.org/doi/pdf/10.1016/j.jaccas.2026.110006?download=true","source":{"id":"https://openalex.org/S4210180918","display_name":"JACC Case Reports","issn_l":"2666-0849","issn":["2666-0849"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204229119.pdf","grobid_xml":"https://content.openalex.org/works/W7204229119.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2607896223","https://openalex.org/W3091354871","https://openalex.org/W3093386527","https://openalex.org/W3145296972","https://openalex.org/W4281655933","https://openalex.org/W4392509018","https://openalex.org/W4396855320","https://openalex.org/W4404958687","https://openalex.org/W4414684312","https://openalex.org/W4415773338"],"related_works":["https://openalex.org/W7223548566","https://openalex.org/W4309368425","https://openalex.org/W3186668188","https://openalex.org/W4392509018","https://openalex.org/W4410500228","https://openalex.org/W4387252526","https://openalex.org/W4311753791","https://openalex.org/W4377985037","https://openalex.org/W4323519306","https://openalex.org/W7001308596"],"abstract_inverted_index":{"BACKGROUND:":[0],"Transthyretin":[1],"cardiac":[2],"amyloidosis":[3],"(ATTR-CM)":[4],"is":[5],"a":[6],"progressive":[7],"infiltrative":[8],"cardiomyopathy":[9],"where":[10],"early":[11],"disease-modifying":[12],"therapy":[13,114],"improves":[14],"outcomes.":[15],"However,":[16],"treatment":[17,144],"access":[18],"may":[19,99],"be":[20],"restricted":[21],"by":[22],"biomarker":[23,117],"thresholds":[24],"not":[25,47],"reflecting":[26],"true":[27],"functional":[28,39,67,123,138,148],"impairment.":[29],"CASE":[30],"SUMMARY:":[31],"A":[32],"73-year-old":[33],"man":[34],"with":[35,102],"exertional":[36],"dyspnea":[37],"(NYHA":[38],"class":[40,139],"II)":[41],"and":[42,88],"confirmed":[43],"wild-type":[44],"ATTR-CM":[45,126],"did":[46],"meet":[48],"reimbursement":[49],"criteria":[50],"for":[51],"tafamidis":[52],"because":[53],"N-terminal":[54,94],"pro-B-type":[55,95],"natriuretic":[56,96,129],"peptide":[57,97],"was":[58,75],"below":[59,116],"the":[60,83],"required":[61],"threshold":[62],"(\u2265600":[63],"pg/mL),":[64],"despite":[65],"impaired":[66],"capacity":[68],"on":[69],"cardiopulmonary":[70],"exercise":[71,90],"testing":[72],"(CPET).":[73],"Acoramidis":[74],"obtained":[76],"through":[77],"expanded":[78],"access.":[79],"At":[80],"6-month":[81],"follow-up,":[82],"patient":[84],"showed":[85],"clinical":[86],"stability":[87],"improved":[89],"capacity.":[91],"DISCUSSION:":[92],"Fixed":[93],"cutoffs":[98],"exclude":[100],"patients":[101],"early-stage":[103],"heart":[104],"failure":[105],"who":[106],"would":[107],"benefit":[108],"from":[109],"treatment.":[110],"CPET":[111,121],"helps":[112],"identify":[113],"candidates":[115],"thresholds.":[118],"TAKE-HOME":[119],"MESSAGES:":[120],"detects":[122],"impairment":[124],"in":[125,136],"even":[127],"when":[128],"peptides":[130],"remain":[131],"low.":[132],"Early":[133],"transthyretin-stabilizer":[134],"initiation":[135],"NYHA":[137],"I-II":[140],"yields":[141],"better":[142],"outcomes;":[143],"eligibility":[145],"should":[146],"integrate":[147],"assessment":[149],"beyond":[150],"biomarkers":[151],"alone.":[152]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-08-27T00:00:00"}