{"id":"https://openalex.org/W7204227355","doi":"https://doi.org/10.58647/rexpo26000207.v1","title":"From Patient-Specific Networks to Actionable Drug Repurposing Strategies through Multi-Omics Data Integration","display_name":"From Patient-Specific Networks to Actionable Drug Repurposing Strategies through Multi-Omics Data Integration","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204227355","doi":"https://doi.org/10.58647/rexpo26000207.v1"},"language":"en","primary_location":{"id":"doi:10.58647/rexpo26000207.v1","doi":"https://doi.org/10.58647/rexpo26000207.v1","is_oa":true,"landing_page_url":"https://doi.org/10.58647/rexpo26000207.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"From Patient-Specific Networks to Actionable Drug Repurposing Strategies through Multi-Omics Data Integration","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.58647/rexpo26000207.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050761928","display_name":"Nurcan Tun\u00e7ba\u011f","orcid":"https://orcid.org/0000-0002-0389-9459","observed_orcids":["https://orcid.org/0000-0002-0389-9459"]},"institutions":[{"id":"https://openalex.org/I1351752","display_name":"Ko\u00e7 University","ror":"https://ror.org/00jzwgz36","country_code":"TR","type":"education","lineage":["https://openalex.org/I1351752"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Nurcan Tuncbag","raw_affiliation_strings":["Ko\u00e7 University"],"raw_orcid":"https://orcid.org/0000-0002-0389-9459","affiliations":[{"raw_affiliation_string":"Ko\u00e7 University","institution_ids":["https://openalex.org/I1351752"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050761928"],"corresponding_institution_ids":["https://openalex.org/I1351752"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65618404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/network-medicine","display_name":"network medicine","score":0.800000011920929},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.8489999771118164},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.9810000061988831},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9380000233650208},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9700000286102295},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.9129999876022339},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.9369999766349792},{"id":"https://openalex.org/keywords/olaparib","display_name":"olaparib","score":0.9810000061988831},{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.9800000190734863},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5400000214576721},{"id":"https://openalex.org/keywords/bet-inhibition","display_name":"BET inhibition","score":0.7710000276565552},{"id":"https://openalex.org/keywords/lenalidomide","display_name":"lenalidomide","score":0.9850000143051147},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.6549999713897705},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.6430000066757202},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5282999873161316},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.4325999915599823},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.41940000653266907},{"id":"https://openalex.org/C19527686","wikidata":"https://www.wikidata.org/wiki/Q1665453","display_name":"System integration","level":2,"score":0.3488999903202057},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3386000096797943},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.3066999912261963},{"id":"https://openalex.org/C75684735","wikidata":"https://www.wikidata.org/wiki/Q858810","display_name":"Big data","level":2,"score":0.30630001425743103},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.29350000619888306},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.2815000116825104},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.27649998664855957},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.2676999866962433},{"id":"https://openalex.org/C33326189","wikidata":"https://www.wikidata.org/wiki/Q17092450","display_name":"Information integration","level":2,"score":0.2651999890804291}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.58647/rexpo26000207.v1","doi":"https://doi.org/10.58647/rexpo26000207.v1","is_oa":true,"landing_page_url":"https://doi.org/10.58647/rexpo26000207.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"From Patient-Specific Networks to Actionable Drug Repurposing Strategies through Multi-Omics Data Integration","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.58647/rexpo26000207.v1","doi":"https://doi.org/10.58647/rexpo26000207.v1","is_oa":true,"landing_page_url":"https://doi.org/10.58647/rexpo26000207.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"From Patient-Specific Networks to Actionable Drug Repurposing Strategies through Multi-Omics Data Integration","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3207245180","https://openalex.org/W4380871351","https://openalex.org/W7110569635","https://openalex.org/W7066636613","https://openalex.org/W7111937805","https://openalex.org/W7204229164","https://openalex.org/W3048965072","https://openalex.org/W2901775822","https://openalex.org/W4296480486","https://openalex.org/W7153093531"],"abstract_inverted_index":{"The":[0],"increasing":[1],"availability":[2],"of":[3,47,112,195],"multi-omic":[4,79,171],"data":[5],"offers":[6],"unprecedented":[7],"opportunities":[8],"to":[9,250],"characterize":[10],"disease":[11,41],"mechanisms":[12,194],"at":[13],"molecular":[14,49,177,248],"resolution.":[15],"However,":[16],"translating":[17],"these":[18,138,237],"heterogeneous":[19],"datasets":[20],"into":[21],"clinically":[22],"actionable":[23],"knowledge":[24],"remains":[25],"a":[26,32,153],"major":[27],"challenge.":[28],"Network":[29],"medicine":[30],"provides":[31],"systems-level":[33],"framework":[34,94],"for":[35,258],"addressing":[36],"this":[37,58],"complexity":[38],"by":[39,169],"representing":[40,148],"and":[42,74,104,115,176,197,205,221,233,242,253],"therapeutic":[43,75,251],"response":[44,252],"as":[45,128,208],"perturbations":[46],"interconnected":[48],"processes":[50],"rather":[51],"than":[52],"isolated":[53],"genes":[54],"or":[55],"proteins.":[56],"In":[57,152],"talk,":[59],"I":[60],"will":[61],"present":[62],"two":[63],"examples":[64],"illustrating":[65],"how":[66,240],"network-based":[67],"multi-omics":[68],"integration":[69],"can":[70,246],"support":[71],"patient":[72],"stratification":[73,93],"prioritization.":[76],"First,":[77],"using":[78],"profiles":[80],"from":[81,191],"101":[82],"patients":[83],"with":[84,100,173,216,226],"lung":[85,145],"adenocarcinoma,":[86],"we":[87,156],"developed":[88],"an":[89,129,135],"extracellular":[90],"matrix":[91],"(ECM)-guided":[92],"that":[95],"identified":[96],"four":[97],"ECM":[98,121,150],"grades":[99],"distinct":[101,149],"clinical,":[102],"mutational,":[103],"cellular":[105],"characteristics.":[106],"Patient-specific":[107],"network":[108,219,244],"models":[109,147,245],"revealed":[110,182],"enrichment":[111],"epithelial\u2013mesenchymal":[113],"transition":[114],"cancer":[116,146,166],"stemness":[117],"programs":[118],"in":[119,144,212],"higher":[120],"grades.":[122],"Network-proximity":[123],"analysis":[124],"further":[125],"predicted":[126],"olaparib":[127],"ECM-dependent":[130],"therapeutic,":[131],"whereas":[132],"erlotinib":[133],"showed":[134],"ECM-insensitive":[136],"response;":[137],"predictions":[139],"were":[140],"subsequently":[141],"validated":[142],"experimentally":[143],"microenvironments.":[151],"complementary":[154,222],"study,":[155],"reconstructed":[157],"236":[158],"drug-modulated":[159],"networks":[160],"covering":[161],"70":[162],"drugs":[163,188],"across":[164],"five":[165],"cell":[167],"lines":[168],"integrating":[170],"responses":[172],"drug":[174,200,259],"targets":[175],"interaction":[178],"networks.":[179],"Network-level":[180],"comparisons":[181],"context-specific":[183],"pathway":[184,223],"perturbations,":[185,224],"similarities":[186],"between":[187],"not":[189],"apparent":[190],"their":[192],"annotated":[193],"action,":[196],"evidence-supported":[198],"candidate":[199],"combinations.":[201],"For":[202],"example,":[203],"I-BET-762":[204],"lenalidomide":[206,234],"emerged":[207],"the":[209],"top-ranked":[210],"combination":[211],"A375":[213],"melanoma":[214],"cells,":[215],"topologically":[217],"separated":[218],"effects":[220],"consistent":[225],"prior":[227],"evidence":[228],"supporting":[229],"combined":[230],"BET":[231],"inhibition":[232],"treatment.":[235],"Together,":[236],"studies":[238],"show":[239],"patient-specific":[241],"drug-specific":[243],"link":[247],"heterogeneity":[249],"help":[254],"prioritize":[255],"context-dependent":[256],"strategies":[257],"repurposing.":[260]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-27T00:00:00"}