{"id":"https://openalex.org/W7204222954","doi":"https://doi.org/10.5281/zenodo.23219654","title":"Evaluation of commercially available low molecular mass heparin products: an internal market surveillance study","display_name":"Evaluation of commercially available low molecular mass heparin products: an internal market surveillance study","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7204222954","doi":"https://doi.org/10.5281/zenodo.23219654"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:aac8f0284df446e9b8ae4265904d0be8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/aac8f0284df446e9b8ae4265904d0be8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Makedonsko Farmacevtski Bilten, Vol 72, Iss 3, Pp 331-332 (2026)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite","doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.23219654","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148247865","display_name":"Ina Baru\u010dija","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barucija, Ina","raw_affiliation_strings":["Agency for Medicinal Products and Medical Devices of Bosnia and Herzegovina, Banja Luka-Sarajevo, Bosnia and Herzegovina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agency for Medicinal Products and Medical Devices of Bosnia and Herzegovina, Banja Luka-Sarajevo, Bosnia and Herzegovina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103439920","display_name":"Amar Elezovi\u0107","orcid":"https://orcid.org/0000-0001-9832-9135","observed_orcids":["https://orcid.org/0000-0001-9832-9135"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elezovic, Amar","raw_affiliation_strings":["Agency for Medicinal Products and Medical Devices of Bosnia and Herzegovina, Banja Luka-Sarajevo, Bosnia and Herzegovina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agency for Medicinal Products and Medical Devices of Bosnia and Herzegovina, Banja Luka-Sarajevo, Bosnia and Herzegovina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091044448","display_name":"Alija Uzunovi\u0107","orcid":"https://orcid.org/0000-0002-3582-9893","observed_orcids":["https://orcid.org/0000-0002-3582-9893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uzunovic, Alija","raw_affiliation_strings":["Agency for Medicinal Products and Medical Devices of Bosnia and Herzegovina, Banja Luka-Sarajevo, Bosnia and Herzegovina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agency for Medicinal Products and Medical Devices of Bosnia and Herzegovina, Banja Luka-Sarajevo, Bosnia and Herzegovina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148341815","display_name":"Sabina Be\u0161lagi\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beslagic, Sabina","raw_affiliation_strings":["Agency for Medicinal Products and Medical Devices of Bosnia and Herzegovina, Banja Luka-Sarajevo, Bosnia and Herzegovina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agency for Medicinal Products and Medical Devices of Bosnia and Herzegovina, Banja Luka-Sarajevo, Bosnia and Herzegovina","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110439017","display_name":"D\u017eenita Softi\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Softic, Dzenita","raw_affiliation_strings":["Agency for Medicinal Products and Medical Devices of Bosnia and Herzegovina, Banja Luka-Sarajevo, Bosnia and Herzegovina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agency for Medicinal Products and Medical Devices of Bosnia and Herzegovina, Banja Luka-Sarajevo, Bosnia and Herzegovina","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.6503999829292297,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.6503999829292297,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.1348000019788742,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12878","display_name":"Pharmaceutical Quality and Counterfeiting","score":0.10409999638795853,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enoxaparin","display_name":"enoxaparin","score":0.8460000157356262},{"id":"https://openalex.org/keywords/dalteparin","display_name":"dalteparin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nadroparin","display_name":"nadroparin","score":1.0},{"id":"https://openalex.org/keywords/antithrombin-activity","display_name":"antithrombin activity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/anti-xa-activity","display_name":"anti-Xa activity","score":0.9150000214576721},{"id":"https://openalex.org/keywords/anti-factor-iia-activity","display_name":"anti-factor IIa activity","score":0.8069999814033508},{"id":"https://openalex.org/keywords/relative-potency","display_name":"relative potency","score":0.7609999775886536},{"id":"https://openalex.org/keywords/post-marketing-surveillance","display_name":"post-marketing surveillance","score":0.7580000162124634},{"id":"https://openalex.org/keywords/market-surveillance","display_name":"market surveillance","score":0.5920000076293945},{"id":"https://openalex.org/keywords/bacterial-endotoxin","display_name":"bacterial endotoxin","score":0.7630000114440918},{"id":"https://openalex.org/keywords/sterility","display_name":"sterility","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45210000872612},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.3564000129699707},{"id":"https://openalex.org/C2776884760","wikidata":"https://www.wikidata.org/wiki/Q2750727","display_name":"Low molecular weight heparin","level":3,"score":0.3172000050544739},{"id":"https://openalex.org/C197636746","wikidata":"https://www.wikidata.org/wiki/Q7234359","display_name":"Postmarketing surveillance","level":3,"score":0.2694999873638153},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.2646999955177307},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.2606000006198883},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.2524999976158142},{"id":"https://openalex.org/C2780009758","wikidata":"https://www.wikidata.org/wiki/Q6804172","display_name":"Measure (data warehouse)","level":2,"score":0.25189998745918274},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.23399999737739563},{"id":"https://openalex.org/C2776480101","wikidata":"https://www.wikidata.org/wiki/Q3555250","display_name":"Disease surveillance","level":3,"score":0.22429999709129333}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:doaj.org/article:aac8f0284df446e9b8ae4265904d0be8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/aac8f0284df446e9b8ae4265904d0be8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Makedonsko Farmacevtski Bilten, Vol 72, Iss 3, Pp 331-332 (2026)","raw_type":"article"},{"id":"doi:10.5281/zenodo.23219654","doi":"https://doi.org/10.5281/zenodo.23219654","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23219654","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.5281/zenodo.23219655","doi":"https://doi.org/10.5281/zenodo.23219655","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23219655","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23219654","doi":"https://doi.org/10.5281/zenodo.23219654","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23219654","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2046282557","https://openalex.org/W2088777755","https://openalex.org/W7167267070","https://openalex.org/W2349841930","https://openalex.org/W1535172423","https://openalex.org/W3215637716","https://openalex.org/W4396554365","https://openalex.org/W4401645129","https://openalex.org/W7067470998","https://openalex.org/W2088159974"],"abstract_inverted_index":{"Introduction.":[0],"Low":[1],"molecular":[2],"mass":[3],"heparins":[4],"(LMWHs)":[5],"are":[6],"complex":[7],"biological":[8,100],"products":[9,64,151],"with":[10,84,117,141,152,164],"activity":[11,74,155],"profiles":[12,156],"dependent":[13],"on":[14],"source":[15],"material":[16],"and":[17,26,104,137],"manufacturing.":[18],"Differences":[19],"exist":[20],"within":[21],"the":[22,27,32],"same":[23],"therapeutic":[24],"class,":[25],"2007-2008":[28],"contamination":[29],"crisis":[30],"highlighted":[31],"need":[33],"for":[34,119,130,134,139,148,168],"robust":[35],"analytical":[36],"control.":[37],"Post-marketing":[38],"surveillance":[39,173,205],"complements":[40],"pre-authorization":[41],"quality":[42,50,96,124,169,176],"assessment":[43],"by":[44],"providing":[45],"direct":[46],"evidence":[47],"of":[48,178],"product":[49],"available":[51,62],"to":[52,91,107],"patients.":[53],"Mat\u00e9riels":[54],"et":[55],"m\u00e9thodes.":[56],"The":[57],"study":[58],"evaluated":[59],"22":[60,160],"commercially":[61],"LMWH":[63,161,179],"(Enoxaparin,":[65],"Dalteparin,":[66],"Nadroparin)":[67],"using":[68],"a":[69,88],"chromogenic":[70],"assay":[71],"measuring":[72],"antithrombin":[73],"against":[75],"factor":[76],"Xa":[77,121],"or":[78],"IIa.":[79],"Absorbance":[80],"data":[81],"were":[82],"analyzed":[83],"CombiStats":[85],"software":[86],"applying":[87],"parallel-line":[89],"model":[90],"estimate":[92],"relative":[93],"potency.":[94],"Additional":[95,123],"attributes":[97,125],"assessed":[98],"included":[99],"activity,":[101,132],"bacterial":[102,135],"endotoxins,":[103,136],"sterility":[105,140],"according":[106],"European":[108],"Pharmacopoeia":[109],"methods.":[110],"R\u00e9sultats.":[111],"All":[112,159],"14":[113],"tested":[114,150],"samples":[115,162],"complied":[116,163],"specifications":[118],"anti-factor":[120],"activity.":[122],"showed":[126],"full":[127],"compliance:":[128],"14/14":[129],"anti-Xa":[131],"4/4":[133,138],"no":[142,153],"microbial":[143],"growth.":[144],"Potency":[145],"was":[146],"confirmed":[147],"all":[149],"atypical":[154],"observed.":[157],"Conclusion.":[158],"applicable":[165],"pharmacopoeial":[166],"requirements":[167],"parameters":[170],"evaluated.":[171],"Market":[172],"supports":[174],"continued":[175],"assurance":[177],"products.":[180],"Messages":[181],"cl\u00e9s.":[182],"Tous":[183],"les":[184,188,201],"\u00e9chantillons":[185],"test\u00e9s":[186],"respectent":[187],"sp\u00e9cifications":[189],"pharmacop\u00e9iales":[190],"pour":[191,210],"l'activit\u00e9":[192],"anti-Xa.":[193],"Aucune":[194],"activit\u00e9":[195],"atypique":[196],"n'a":[197],"\u00e9t\u00e9":[198],"observ\u00e9e":[199],"parmi":[200],"produits":[202,215],"\u00e9valu\u00e9s.":[203],"La":[204],"du":[206],"march\u00e9":[207],"est":[208],"essentielle":[209],"garantir":[211],"la":[212],"qualit\u00e9":[213],"des":[214],"LMWH.":[216]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-08-27T00:00:00"}