{"id":"https://openalex.org/W7204222343","doi":"https://doi.org/10.3390/biomedicines14091901","title":"Safety Profile of Thread-Embedding Acupuncture: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","display_name":"Safety Profile of Thread-Embedding Acupuncture: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204222343","doi":"https://doi.org/10.3390/biomedicines14091901","pmid":"https://pubmed.ncbi.nlm.nih.gov/42792644","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13604257"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines14091901","doi":"https://doi.org/10.3390/biomedicines14091901","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14091901","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biomedicines14091901","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029562775","display_name":"J.C. Hong","orcid":"https://orcid.org/0009-0004-8421-3296","observed_orcids":["https://orcid.org/0009-0004-8421-3296"]},"institutions":[{"id":"https://openalex.org/I9507","display_name":"Sangji University","ror":"https://ror.org/01gqe3t73","country_code":"KR","type":"education","lineage":["https://openalex.org/I9507"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jinyeong Hong","raw_affiliation_strings":["Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Sangji University, Wonju 26339, Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0004-8421-3296","affiliations":[{"raw_affiliation_string":"Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Sangji University, Wonju 26339, Republic of Korea","institution_ids":["https://openalex.org/I9507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092207047","display_name":"Woo-hyeon Noh","orcid":"https://orcid.org/0009-0001-6109-6662","observed_orcids":["https://orcid.org/0009-0001-6109-6662"]},"institutions":[{"id":"https://openalex.org/I9507","display_name":"Sangji University","ror":"https://ror.org/01gqe3t73","country_code":"KR","type":"education","lineage":["https://openalex.org/I9507"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Woo-Hyeon Noh","raw_affiliation_strings":["Department of Neuropsychiatry of Korean Medicine, College of Korean Medicine, Sangji University, Wonju 26339, Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0001-6109-6662","affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry of Korean Medicine, College of Korean Medicine, Sangji University, Wonju 26339, Republic of Korea","institution_ids":["https://openalex.org/I9507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091087504","display_name":"Jin-woo Suh","orcid":"https://orcid.org/0000-0002-9048-0962","observed_orcids":["https://orcid.org/0000-0002-9048-0962"]},"institutions":[{"id":"https://openalex.org/I9507","display_name":"Sangji University","ror":"https://ror.org/01gqe3t73","country_code":"KR","type":"education","lineage":["https://openalex.org/I9507"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin-woo Suh","raw_affiliation_strings":["Department of Neuropsychiatry of Korean Medicine, College of Korean Medicine, Sangji University, Wonju 26339, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-9048-0962","affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry of Korean Medicine, College of Korean Medicine, Sangji University, Wonju 26339, Republic of Korea","institution_ids":["https://openalex.org/I9507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062475231","display_name":"Yeonju Woo","orcid":"https://orcid.org/0000-0002-9028-9981","observed_orcids":["https://orcid.org/0000-0002-9028-9981"]},"institutions":[{"id":"https://openalex.org/I9507","display_name":"Sangji University","ror":"https://ror.org/01gqe3t73","country_code":"KR","type":"education","lineage":["https://openalex.org/I9507"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeonju Woo","raw_affiliation_strings":["Department of Physiology, College of Korean Medicine, Sangji University, Wonju 26339, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Korean Medicine, Sangji University, Wonju 26339, Republic of Korea","institution_ids":["https://openalex.org/I9507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062615661","display_name":"Felipe Fregni","orcid":"https://orcid.org/0000-0002-1703-7526","observed_orcids":["https://orcid.org/0000-0002-1703-7526","https://orcid.org/0000-0003-1307-9355","https://orcid.org/0000-0001-9359-8643"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2799748957","display_name":"Spaulding Rehabilitation Hospital","ror":"https://ror.org/011dvr318","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799748957","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Felipe Fregni","raw_affiliation_strings":["Spaulding Neuromodulation Center, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spaulding Neuromodulation Center, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2799748957","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101923710","display_name":"Joo\u2010Hee Kim","orcid":"https://orcid.org/0000-0003-1435-5649","observed_orcids":["https://orcid.org/0000-0003-1435-5649"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I9507","display_name":"Sangji University","ror":"https://ror.org/01gqe3t73","country_code":"KR","type":"education","lineage":["https://openalex.org/I9507"]}],"countries":["KR","US"],"is_corresponding":true,"raw_author_name":"Joo-Hee Kim","raw_affiliation_strings":["Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Sangji University, Wonju 26339, Republic of Korea","Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA"],"raw_orcid":"https://orcid.org/0000-0003-1435-5649","affiliations":[{"raw_affiliation_string":"Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Sangji University, Wonju 26339, Republic of Korea","institution_ids":["https://openalex.org/I9507"]},{"raw_affiliation_string":"Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5062615661","https://openalex.org/A5101923710"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2799748957","https://openalex.org/I4210087915","https://openalex.org/I9507"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.53694818,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"9","first_page":"1901","last_page":"1901"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thread-embedding-acupuncture","display_name":"thread embedding acupuncture","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acupuncture-safety","display_name":"acupuncture safety","score":0.7540000081062317},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.9900000095367432},{"id":"https://openalex.org/keywords/local-adverse-events","display_name":"local adverse events","score":0.8289999961853027},{"id":"https://openalex.org/keywords/sham-acupuncture","display_name":"sham acupuncture","score":0.6980000138282776},{"id":"https://openalex.org/keywords/serious-adverse-events","display_name":"serious adverse events","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8745999932289124},{"id":"https://openalex.org/C199475168","wikidata":"https://www.wikidata.org/wiki/Q1539689","display_name":"MedDRA","level":4,"score":0.7121999859809875},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6420999765396118},{"id":"https://openalex.org/C3018359032","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Safety profile","level":3,"score":0.618399977684021},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.597599983215332},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5266000032424927},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5217000246047974},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.46869999170303345},{"id":"https://openalex.org/C167704817","wikidata":"https://www.wikidata.org/wiki/Q7295548","display_name":"Rate ratio","level":3,"score":0.38909998536109924},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.38499999046325684},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.3691999912261963},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36500000953674316},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3598000109195709},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.336899995803833},{"id":"https://openalex.org/C56837625","wikidata":"https://www.wikidata.org/wiki/Q121713","display_name":"Acupuncture","level":3,"score":0.3361000120639801},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.31040000915527344},{"id":"https://openalex.org/C3017906399","wikidata":"https://www.wikidata.org/wiki/Q48973845","display_name":"Pooled analysis","level":3,"score":0.2985999882221222},{"id":"https://openalex.org/C57658597","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Pharmacovigilance","level":3,"score":0.2752000093460083},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.2669000029563904},{"id":"https://openalex.org/C2777793932","wikidata":"https://www.wikidata.org/wiki/Q1116229","display_name":"Common Terminology Criteria for Adverse Events","level":3,"score":0.26179999113082886},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2612000107765198}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biomedicines14091901","doi":"https://doi.org/10.3390/biomedicines14091901","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14091901","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13604257","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13604257/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13604257/pdf/biomedicines-14-01901.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmid:42792644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42792644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ab2ba40c718942fab6993af95c584e67","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ab2ba40c718942fab6993af95c584e67","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 14, Iss 9, p 1901 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines14091901","doi":"https://doi.org/10.3390/biomedicines14091901","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14091901","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[{"id":"https://openalex.org/G2450846705","display_name":null,"funder_award_id":"RS-2021-KH109727","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G7015095615","display_name":null,"funder_award_id":"2026-ANCHOR-10-005","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"}],"funders":[{"id":"https://openalex.org/F4320320751","display_name":"Ministry of Education - Singapore","ror":"https://ror.org/01kcva023"},{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W1492192767","https://openalex.org/W1509156154","https://openalex.org/W1588729362","https://openalex.org/W1968229577","https://openalex.org/W1992698943","https://openalex.org/W1995063875","https://openalex.org/W1996290308","https://openalex.org/W2008605063","https://openalex.org/W2009600994","https://openalex.org/W2012498683","https://openalex.org/W2051413352","https://openalex.org/W2053154970","https://openalex.org/W2061002930","https://openalex.org/W2069578781","https://openalex.org/W2070727775","https://openalex.org/W2074901946","https://openalex.org/W2100224535","https://openalex.org/W2111985824","https://openalex.org/W2130599772","https://openalex.org/W2164777277","https://openalex.org/W2169090881","https://openalex.org/W2263572070","https://openalex.org/W2461165364","https://openalex.org/W2549451092","https://openalex.org/W2554019942","https://openalex.org/W2595915881","https://openalex.org/W2598476089","https://openalex.org/W2728279631","https://openalex.org/W2803030417","https://openalex.org/W2803823565","https://openalex.org/W2885344991","https://openalex.org/W2886135476","https://openalex.org/W2886806459","https://openalex.org/W2888297055","https://openalex.org/W2902277242","https://openalex.org/W2903655835","https://openalex.org/W2904087236","https://openalex.org/W2941250829","https://openalex.org/W2966801977","https://openalex.org/W2974804688","https://openalex.org/W2991253675","https://openalex.org/W3043017551","https://openalex.org/W3048947522","https://openalex.org/W3100641724","https://openalex.org/W3104325437","https://openalex.org/W3113249491","https://openalex.org/W3121271048","https://openalex.org/W3153715163","https://openalex.org/W3193610792","https://openalex.org/W3196641786","https://openalex.org/W3215998879","https://openalex.org/W4210306220","https://openalex.org/W4210421762","https://openalex.org/W4288074438","https://openalex.org/W4297394496","https://openalex.org/W4297855246","https://openalex.org/W4319334200","https://openalex.org/W4386258707","https://openalex.org/W4386272480","https://openalex.org/W4386695341","https://openalex.org/W4386853639","https://openalex.org/W4388466927","https://openalex.org/W4389580956","https://openalex.org/W4389839690","https://openalex.org/W4399646276","https://openalex.org/W4402680246","https://openalex.org/W4403268709","https://openalex.org/W4404853829","https://openalex.org/W4405229767","https://openalex.org/W4406216082","https://openalex.org/W4408561216","https://openalex.org/W4410362794","https://openalex.org/W4412951230","https://openalex.org/W4414022820","https://openalex.org/W4414083456","https://openalex.org/W4416863197","https://openalex.org/W7119096847","https://openalex.org/W7128511311","https://openalex.org/W7143606510"],"related_works":["https://openalex.org/W4297394496","https://openalex.org/W3153715163","https://openalex.org/W4404853829","https://openalex.org/W7171831609","https://openalex.org/W4213316597","https://openalex.org/W4406334365","https://openalex.org/W6887657824","https://openalex.org/W2789436384","https://openalex.org/W4309824007","https://openalex.org/W7165089046"],"abstract_inverted_index":{"Background/Objectives:":[0],"Thread-embedding":[1],"acupuncture":[2,181],"(TEA)":[3],"involves":[4],"the":[5,96,206,245],"implantation":[6],"of":[7,54],"suture":[8],"threads":[9],"into":[10],"therapeutic":[11],"points":[12],"for":[13,49,247],"sustained":[14],"stimulation;":[15],"however,":[16],"its":[17,36],"safety":[18,37,221,253],"evidence":[19],"remains":[20],"limited.":[21],"This":[22],"systematic":[23],"review":[24],"and":[25,66,80,134,157,235,242,250],"meta-analysis":[26],"evaluated":[27],"adverse":[28],"events":[29],"(AEs)":[30],"associated":[31],"with":[32,89,142,152,231],"TEA":[33,108,165,175,217],"to":[34,45,210],"establish":[35],"profile.":[38],"Methods:":[39],"Ten":[40],"databases":[41],"were":[42,58,73,84,101,124,145],"searched":[43],"up":[44],"April":[46],"5,":[47],"2026":[48],"randomized":[50],"controlled":[51],"trials":[52],"(RCTs)":[53],"TEA.":[55],"Reported":[56],"AEs":[57,123,136,212,233],"standardized":[59,248],"using":[60,75,86],"MedDRA":[61],"terminology,":[62],"WHO-UMC":[63],"causality":[64],"criteria,":[65],"CTCAE":[67],"version":[68],"5.0.":[69],"Pooled":[70],"incidence":[71,112],"proportions":[72],"estimated":[74],"generalized":[76],"linear":[77],"mixed":[78],"models,":[79],"risk":[81,172],"ratios":[82],"(RRs)":[83],"pooled":[85,110],"random-effects":[87],"models":[88],"95%":[90,178,184,192],"confidence":[91],"intervals":[92],"(CIs).":[93],"Results:":[94],"Of":[95],"90":[97],"RCTs":[98],"included,":[99],"most":[100,125,144,232],"conducted":[102],"in":[103,170,239,255],"China":[104],"(81,":[105],"90.0%).":[106],"For":[107],"monotherapy,":[109],"AE":[111,171,199,240],"proportion":[113],"was":[114,200,213],"3%":[115],"(95%":[116],"CI:":[117,179,185,193],"2\u20137%;":[118],"I2":[119],"=":[120],"53.7%).":[121],"Local":[122],"common":[126],"(111,":[127],"5.9%),":[128],"followed":[129],"by":[130],"systemic":[131],"(5,":[132],"0.3%)":[133],"other":[135],"(2,":[137],"0.1%).":[138],"Among":[139],"118":[140],"participants":[141,204],"AEs,":[143],"classified":[146],"as":[147,227],"Grade":[148,153],"1":[149],"(95,":[150],"80.5%),":[151],"2":[154],"(8,":[155],"6.8%)":[156],"unassessable":[158],"cases":[159],"(15,":[160],"12.7%).":[161],"In":[162],"comparative":[163],"analyses,":[164],"showed":[166],"no":[167],"significant":[168],"increase":[169],"versus":[173],"sham":[174],"(RR:":[176,182,190],"1.15,":[177],"0.83\u20131.60),":[180],"0.97,":[183],"0.64\u20131.49),":[186],"or":[187,226],"conventional":[188],"medicine":[189],"0.28,":[191],"0.18\u20130.45).":[194],"Only":[195],"one":[196],"serious":[197],"TEA-related":[198,211],"reported":[201],"among":[202],"1697":[203],"(0.06%);":[205],"withdrawal":[207],"rate":[208],"due":[209],"0.36%":[214],"(9/2524).":[215],"Conclusions:":[216],"demonstrated":[218],"a":[219],"favorable":[220],"profile":[222],"when":[223],"used":[224],"alone":[225],"an":[228],"add-on":[229],"therapy,":[230],"mild":[234],"transient.":[236],"However,":[237],"inconsistencies":[238],"definitions":[241],"reporting":[243],"highlight":[244],"need":[246],"terminology":[249],"more":[251],"rigorous":[252],"evaluation":[254],"future":[256],"studies.":[257]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-08-27T00:00:00"}
