{"id":"https://openalex.org/W7204222129","doi":"https://doi.org/10.1371/journal.pone.0349155","title":"Systems pharmacology reveals type I interferon and myeloid-like B cell reprogramming as candidate druggable axes in antiphospholipid syndrome","display_name":"Systems pharmacology reveals type I interferon and myeloid-like B cell reprogramming as candidate druggable axes in antiphospholipid syndrome","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204222129","doi":"https://doi.org/10.1371/journal.pone.0349155","pmid":"https://pubmed.ncbi.nlm.nih.gov/42647509"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0349155","doi":"https://doi.org/10.1371/journal.pone.0349155","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0349155","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0349155&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0349155&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148409896","display_name":"Bin Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]},{"id":"https://openalex.org/I4210125177","display_name":"Wuxi No.2 People's Hospital","ror":"https://ror.org/0399zkh42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125177"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Sun","raw_affiliation_strings":["Wuxi No. 2 People's Hospital, Jiangnan University Medical Center, Wuxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuxi No. 2 People's Hospital, Jiangnan University Medical Center, Wuxi, China","institution_ids":["https://openalex.org/I111599522","https://openalex.org/I4210125177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135228862","display_name":"Yiqiao Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137217","display_name":"Women's Hospital, School of Medicine, Zhejiang University","ror":"https://ror.org/042t7yh44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137217"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiqiao Lu","raw_affiliation_strings":["Women's Hospital School of Medicine Zhejiang University, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Hospital School of Medicine Zhejiang University, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210137217","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148382395","display_name":"Wei Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Liu","raw_affiliation_strings":["Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086326894","display_name":"Chengze Wang","orcid":"https://orcid.org/0000-0003-2349-6427","observed_orcids":["https://orcid.org/0000-0003-2349-6427"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chengze Wang","raw_affiliation_strings":["Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0003-2349-6427","affiliations":[{"raw_affiliation_string":"Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5086326894","https://openalex.org/A5148382395"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.70749543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"8","first_page":"e0349155","last_page":"e0349155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiphospholipid-syndrome","display_name":"antiphospholipid syndrome","score":1.0},{"id":"https://openalex.org/keywords/type-i-interferon-signaling","display_name":"type I interferon signaling","score":0.9860000014305115},{"id":"https://openalex.org/keywords/neutrophil-degranulation","display_name":"neutrophil degranulation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/pu-1","display_name":"PU.1","score":0.6899999976158142},{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hydroxychloroquine","display_name":"hydroxychloroquine","score":0.9629999995231628},{"id":"https://openalex.org/keywords/candidate-therapeutic-targets","display_name":"candidate therapeutic targets","score":0.6240000128746033},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.7559999823570251},{"id":"https://openalex.org/keywords/ifitm1","display_name":"IFITM1","score":0.7390000224113464},{"id":"https://openalex.org/keywords/coronin-1a","display_name":"CORO1A","score":0.8799999952316284},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.6320000290870667},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.625}],"concepts":[{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.8083999752998352},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.6843000054359436},{"id":"https://openalex.org/C155261790","wikidata":"https://www.wikidata.org/wiki/Q1122544","display_name":"DrugBank","level":3,"score":0.609000027179718},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.53329998254776},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5192000269889832},{"id":"https://openalex.org/C2776874634","wikidata":"https://www.wikidata.org/wiki/Q582207","display_name":"Antiphospholipid syndrome","level":3,"score":0.4440000057220459},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.4194999933242798},{"id":"https://openalex.org/C2779836521","wikidata":"https://www.wikidata.org/wiki/Q14914081","display_name":"TLR7","level":5,"score":0.39879998564720154},{"id":"https://openalex.org/C2778420691","wikidata":"https://www.wikidata.org/wiki/Q14866230","display_name":"TLR3","level":5,"score":0.3912999927997589},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.38760000467300415},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.3856000006198883},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38019999861717224},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.37369999289512634},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3538999855518341},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3465000092983246},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.34380000829696655},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.3310000002384186},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.3206999897956848},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.3206000030040741},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32030001282691956},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.302700012922287},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.2964000105857849},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.26499998569488525},{"id":"https://openalex.org/C2777178219","wikidata":"https://www.wikidata.org/wiki/Q425154","display_name":"Tocilizumab","level":3,"score":0.26420000195503235},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.2619999945163727},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26159998774528503},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2596000134944916},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.25679999589920044},{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.25380000472068787},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2513999938964844},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.25110000371932983}],"mesh":[{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002738","descriptor_name":"Chloroquine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002738","descriptor_name":"Chloroquine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002738","descriptor_name":"Chloroquine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002738","descriptor_name":"Chloroquine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006886","descriptor_name":"Hydroxychloroquine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006886","descriptor_name":"Hydroxychloroquine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006886","descriptor_name":"Hydroxychloroquine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006886","descriptor_name":"Hydroxychloroquine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016736","descriptor_name":"Antiphospholipid Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016736","descriptor_name":"Antiphospholipid Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016736","descriptor_name":"Antiphospholipid Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016736","descriptor_name":"Antiphospholipid Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016736","descriptor_name":"Antiphospholipid Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016736","descriptor_name":"Antiphospholipid Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016736","descriptor_name":"Antiphospholipid Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016736","descriptor_name":"Antiphospholipid Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016736","descriptor_name":"Antiphospholipid Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016736","descriptor_name":"Antiphospholipid Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1371/journal.pone.0349155","doi":"https://doi.org/10.1371/journal.pone.0349155","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0349155","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0349155&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},{"id":"pmid:42647509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42647509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13514046","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13514046/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13514046/pdf/pone.0349155.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0349155","doi":"https://doi.org/10.1371/journal.pone.0349155","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0349155","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0349155&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.500130832195282,"display_name":"Life on land","id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204222129.pdf","grobid_xml":"https://content.openalex.org/works/W7204222129.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1733102599","https://openalex.org/W1966327575","https://openalex.org/W1974033269","https://openalex.org/W1981403111","https://openalex.org/W1994309500","https://openalex.org/W1999517476","https://openalex.org/W1999555834","https://openalex.org/W2014677321","https://openalex.org/W2017341404","https://openalex.org/W2023929943","https://openalex.org/W2035618305","https://openalex.org/W2042958596","https://openalex.org/W2046517086","https://openalex.org/W2054330426","https://openalex.org/W2060705109","https://openalex.org/W2072196555","https://openalex.org/W2095726706","https://openalex.org/W2106273198","https://openalex.org/W2119266650","https://openalex.org/W2121604817","https://openalex.org/W2132173287","https://openalex.org/W2133402546","https://openalex.org/W2133779525","https://openalex.org/W2134967712","https://openalex.org/W2139657244","https://openalex.org/W2141089307","https://openalex.org/W2165608602","https://openalex.org/W2168888135","https://openalex.org/W2169678694","https://openalex.org/W2179438025","https://openalex.org/W2529397270","https://openalex.org/W2530335997","https://openalex.org/W2556737993","https://openalex.org/W2588044396","https://openalex.org/W2594879804","https://openalex.org/W2612467560","https://openalex.org/W2756032138","https://openalex.org/W2767891136","https://openalex.org/W2790466592","https://openalex.org/W2799711263","https://openalex.org/W2803799996","https://openalex.org/W2896002881","https://openalex.org/W2896465879","https://openalex.org/W2912390237","https://openalex.org/W2920903673","https://openalex.org/W2946160313","https://openalex.org/W2984472267","https://openalex.org/W2997280954","https://openalex.org/W3113196149","https://openalex.org/W3115157454","https://openalex.org/W3177828909","https://openalex.org/W4396700529","https://openalex.org/W4400775433","https://openalex.org/W4402050365","https://openalex.org/W4408959767","https://openalex.org/W4410632869","https://openalex.org/W4411659187","https://openalex.org/W4413807097","https://openalex.org/W4414414838","https://openalex.org/W4416153402","https://openalex.org/W7134008203"],"related_works":[],"abstract_inverted_index":{"Antiphospholipid":[0],"syndrome":[1],"(APS)":[2],"lacks":[3],"disease-modifying":[4],"targeted":[5],"therapies,":[6],"and":[7,35,75,98,150,174,202,214],"its":[8],"molecular":[9,36,187],"heterogeneity":[10],"remains":[11],"poorly":[12],"characterized.":[13],"We":[14],"employed":[15],"an":[16],"integrative":[17],"systems":[18],"pharmacology":[19],"approach":[20],"combining":[21],"weighted":[22],"gene":[23],"co-expression":[24],"network":[25],"analysis":[26,85,107],"(WGCNA),":[27],"single-cell":[28],"RNA":[29],"sequencing,":[30],"Connectivity":[31],"Map":[32],"(CMap)":[33],"screening,":[34],"docking":[37],"to":[38,116],"prioritize":[39],"candidate":[40,197],"therapeutic":[41,209],"targets":[42,198],"in":[43,57,124,178],"APS.":[44],"WGCNA":[45],"of":[46,86,138,163],"purified-neutrophil":[47],"bulk":[48],"RNA-seq":[49],"(n":[50,60],"=":[51,61,71,80,132],"18),":[52],"with":[53,94,189],"module":[54,148,176],"preservation":[55],"confirmed":[56],"whole":[58],"blood":[59],"88),":[62],"identified":[63,143],"two":[64],"disease-associated":[65],"modules:":[66],"ME10":[67,181],"(176":[68],"genes,":[69,78,149],"r":[70,79],"0.77,":[72],"interferon-I":[73],"signaling)":[74],"ME2":[76,96,129,168,183],"(3409":[77],"0.79,":[81],"degranulation/innate":[82],"activation).":[83],"Single-cell":[84],"26,936":[87],"B":[88,92],"cells":[89,93],"revealed":[90,185],"transitional":[91],"elevated":[95],"scores":[97],"aberrant":[99],"SPI1":[100],"expression,":[101],"suggesting":[102],"myeloid-like":[103],"transcriptional":[104],"reprogramming.":[105],"CMap":[106],"ranked":[108],"chloroquine":[109],"-":[110,126],"a":[111,151],"4-aminoquinoline":[112],"antimalarial":[113],"closely":[114],"related":[115],"hydroxychloroquine,":[117],"which":[118],"is":[119],"recommended":[120],"as":[121],"adjunctive":[122],"therapy":[123],"APS":[125],"among":[127],"top":[128],"candidates":[130],"(NCS":[131],"-2.07),":[133],"supporting":[134],"the":[135,139],"biological":[136],"relevance":[137],"screen.":[140],"DrugBank":[141],"mapping":[142],"14":[144],"FDA-approved":[145],"drugs":[146],"targeting":[147],"3-gene":[152],"machine":[153],"learning":[154],"signature":[155],"(CORO1A,":[156],"ANKRD22,":[157],"IFITM1)":[158],"achieved":[159],"cross-tissue":[160,175],"validation":[161],"AUC":[162],"0.802.":[164],"External":[165],"datasets":[166],"supported":[167],"pathway":[169,191],"modulation":[170],"by":[171],"NAPc2":[172],"intervention":[173],"conservation":[177],"platelets.":[179],"Patient-level":[180],"x":[182],"stratification":[184],"four":[186],"subtypes":[188],"distinct":[190],"activation":[192],"profiles.":[193],"This":[194],"framework":[195],"prioritizes":[196],"across":[199],"both":[200],"IFN-I":[201],"degranulation":[203],"pathways,":[204],"generating":[205],"hypotheses":[206],"for":[207],"pathway-guided":[208],"development":[210],"that":[211],"require":[212],"experimental":[213],"clinical":[215],"validation.":[216]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2026-08-27T00:00:00"}
