{"id":"https://openalex.org/W7204214328","doi":"https://doi.org/10.1016/j.bneo.2026.100293","title":"A comparison of overall survival and quality of life in patients with MDS treated with azacytidine vs decitabine","display_name":"A comparison of overall survival and quality of life in patients with MDS treated with azacytidine vs decitabine","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204214328","doi":"https://doi.org/10.1016/j.bneo.2026.100293","pmid":"https://pubmed.ncbi.nlm.nih.gov/42903632","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13681970"},"language":"en","primary_location":{"id":"doi:10.1016/j.bneo.2026.100293","doi":"https://doi.org/10.1016/j.bneo.2026.100293","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bneo.2026.100293","pdf_url":null,"source":{"id":"https://openalex.org/S5407037027","display_name":"Blood Neoplasia","issn_l":"2950-3280","issn":["2950-3280"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","ki-jl-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Neoplasia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.bneo.2026.100293","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007881437","display_name":"James T. England","orcid":"https://orcid.org/0000-0002-9692-1634","observed_orcids":["https://orcid.org/0000-0002-9692-1634"]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"James T. England","raw_affiliation_strings":["Sunnybrook Health Sciences Centre, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunnybrook Health Sciences Centre, Toronto, Canada","institution_ids":["https://openalex.org/I1323843004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357092","display_name":"Liying Zhang","orcid":"https://orcid.org/0000-0002-5882-6070","observed_orcids":["https://orcid.org/0000-0002-5882-6070"]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Liying Zhang","raw_affiliation_strings":["Sunnybrook Health Sciences Centre, Toronto, Canada"],"raw_orcid":"https://orcid.org/0000-0002-5882-6070","affiliations":[{"raw_affiliation_string":"Sunnybrook Health Sciences Centre, Toronto, Canada","institution_ids":["https://openalex.org/I1323843004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055906478","display_name":"Karen W L Yee","orcid":"https://orcid.org/0000-0002-2572-9952","observed_orcids":["https://orcid.org/0000-0002-2572-9952"]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Karen Yee","raw_affiliation_strings":["Princess Margaret Cancer Centre, Toronto, Canada"],"raw_orcid":"https://orcid.org/0000-0002-2572-9952","affiliations":[{"raw_affiliation_string":"Princess Margaret Cancer Centre, Toronto, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091623372","display_name":"Michelle N. Geddes","orcid":"https://orcid.org/0000-0003-1662-6000","observed_orcids":["https://orcid.org/0000-0003-1662-6000"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle Geddes","raw_affiliation_strings":["Tom Baker Cancer Center, Calgary, Canada"],"raw_orcid":"https://orcid.org/0000-0003-1662-6000","affiliations":[{"raw_affiliation_string":"Tom Baker Cancer Center, Calgary, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144191454","display_name":"Nancy Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800445679","display_name":"Alberta Hospital Edmonton","ror":"https://ror.org/03nw9hs25","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I126859394","https://openalex.org/I2800445679"]},{"id":"https://openalex.org/I2802925319","display_name":"University of Alberta Hospital","ror":"https://ror.org/013e81n30","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I126859394","https://openalex.org/I2802925319"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nancy Zhu","raw_affiliation_strings":["University of Alberta Hospital, Edmonton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alberta Hospital, Edmonton, Canada","institution_ids":["https://openalex.org/I2800445679","https://openalex.org/I2802925319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108235041","display_name":"April Shamy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"April Shamy","raw_affiliation_strings":["Jewish General Hospital, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jewish General Hospital, Montreal, Canada","institution_ids":["https://openalex.org/I2801824472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042821201","display_name":"Heather A. Leitch","orcid":"https://orcid.org/0000-0002-7899-2025","observed_orcids":["https://orcid.org/0000-0002-7899-2025"]},"institutions":[{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Heather Leitch","raw_affiliation_strings":["St. Paul's Hospital, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Paul's Hospital, Vancouver, Canada","institution_ids":["https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066224233","display_name":"Mitchell Sabloff","orcid":"https://orcid.org/0000-0002-0122-6138","observed_orcids":["https://orcid.org/0000-0002-0122-6138"]},"institutions":[{"id":"https://openalex.org/I2800722420","display_name":"Ottawa Hospital","ror":"https://ror.org/03c62dg59","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800722420"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mitchell Sabloff","raw_affiliation_strings":["The Ottawa Hospital, Ottawa, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ottawa Hospital, Ottawa, Canada","institution_ids":["https://openalex.org/I2800722420"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060728482","display_name":"Grace Christou","orcid":"https://orcid.org/0000-0003-0453-8046","observed_orcids":["https://orcid.org/0000-0003-0453-8046"]},"institutions":[{"id":"https://openalex.org/I2800722420","display_name":"Ottawa Hospital","ror":"https://ror.org/03c62dg59","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800722420"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Grace Christou","raw_affiliation_strings":["The Ottawa Hospital, Ottawa, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ottawa Hospital, Ottawa, Canada","institution_ids":["https://openalex.org/I2800722420"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025028312","display_name":"Brett L. Houston","orcid":"https://orcid.org/0000-0002-8776-4083","observed_orcids":["https://orcid.org/0000-0002-8776-4083"]},"institutions":[{"id":"https://openalex.org/I2799698466","display_name":"Juravinski Cancer Centre","ror":"https://ror.org/02cwjh447","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799698466","https://openalex.org/I76442945"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Brett L. Houston","raw_affiliation_strings":["Juravinski Cancer Centre, Hamilton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Juravinski Cancer Centre, Hamilton, Canada","institution_ids":["https://openalex.org/I2799698466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033021913","display_name":"Ivan Landego","orcid":"https://orcid.org/0009-0005-3628-4695","observed_orcids":["https://orcid.org/0009-0005-3628-4695"]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ivan Landego","raw_affiliation_strings":["Division of Medical Oncology and Hematology, University of Manitoba, Winnipeg, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology and Hematology, University of Manitoba, Winnipeg, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023965566","display_name":"Brian F. Leber","orcid":"https://orcid.org/0000-0001-5502-1480","observed_orcids":["https://orcid.org/0000-0001-5502-1480"]},"institutions":[{"id":"https://openalex.org/I2799698466","display_name":"Juravinski Cancer Centre","ror":"https://ror.org/02cwjh447","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799698466","https://openalex.org/I76442945"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Brian Leber","raw_affiliation_strings":["Juravinski Cancer Centre, Hamilton, Canada"],"raw_orcid":"https://orcid.org/0000-0001-5502-1480","affiliations":[{"raw_affiliation_string":"Juravinski Cancer Centre, Hamilton, Canada","institution_ids":["https://openalex.org/I2799698466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044016966","display_name":"Dina Khalaf","orcid":"https://orcid.org/0000-0002-2119-6626","observed_orcids":["https://orcid.org/0000-0002-2119-6626"]},"institutions":[{"id":"https://openalex.org/I2799698466","display_name":"Juravinski Cancer Centre","ror":"https://ror.org/02cwjh447","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799698466","https://openalex.org/I76442945"]},{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Dina Khalaf","raw_affiliation_strings":["Division of Medical Oncology and Hematology, University of Florida, Gainesville, FL","Juravinski Cancer Centre, Hamilton, Canada"],"raw_orcid":"https://orcid.org/0000-0002-2119-6626","affiliations":[{"raw_affiliation_string":"Division of Medical Oncology and Hematology, University of Florida, Gainesville, FL","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"raw_affiliation_string":"Juravinski Cancer Centre, Hamilton, Canada","institution_ids":["https://openalex.org/I2799698466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052133567","display_name":"Alejandro Garcia\u2010Horton","orcid":"https://orcid.org/0000-0003-0579-6709","observed_orcids":["https://orcid.org/0000-0003-0579-6709"]},"institutions":[{"id":"https://openalex.org/I2799698466","display_name":"Juravinski Cancer Centre","ror":"https://ror.org/02cwjh447","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799698466","https://openalex.org/I76442945"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alejandro Garcia-Horton","raw_affiliation_strings":["Juravinski Cancer Centre, Hamilton, Canada"],"raw_orcid":"https://orcid.org/0000-0003-0579-6709","affiliations":[{"raw_affiliation_string":"Juravinski Cancer Centre, Hamilton, Canada","institution_ids":["https://openalex.org/I2799698466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057445007","display_name":"\u00c8ve St\u2010Hilaire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153374","display_name":"Dr. Georges-L.-Dumont University Hospital Centre","ror":"https://ror.org/04gqmrb58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210153374","https://openalex.org/I4210153458"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Eve St-Hilaire","raw_affiliation_strings":["Centre Hospitalier Universitaire Dr-Georges-L.-Dumont, Moncton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire Dr-Georges-L.-Dumont, Moncton, Canada","institution_ids":["https://openalex.org/I4210153374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038685198","display_name":"Nicholas Finn","orcid":"https://orcid.org/0000-0002-4908-6824","observed_orcids":["https://orcid.org/0000-0002-4908-6824"]},"institutions":[{"id":"https://openalex.org/I4210153374","display_name":"Dr. Georges-L.-Dumont University Hospital Centre","ror":"https://ror.org/04gqmrb58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210153374","https://openalex.org/I4210153458"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nicholas Finn","raw_affiliation_strings":["Centre Hospitalier Universitaire Dr-Georges-L.-Dumont, Moncton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire Dr-Georges-L.-Dumont, Moncton, Canada","institution_ids":["https://openalex.org/I4210153374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034812867","display_name":"Thomas J. Nevill","orcid":"https://orcid.org/0000-0002-3124-541X","observed_orcids":["https://orcid.org/0000-0002-3124-541X"]},"institutions":[{"id":"https://openalex.org/I2802832906","display_name":"Vancouver General Hospital","ror":"https://ror.org/02zg69r60","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I141074466","https://openalex.org/I2799475292","https://openalex.org/I2802832906"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Thomas Nevill","raw_affiliation_strings":["Vancouver General Hospital, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vancouver General Hospital, Vancouver, Canada","institution_ids":["https://openalex.org/I2802832906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083165674","display_name":"Amy M. Trottier","orcid":"https://orcid.org/0000-0001-9922-9232","observed_orcids":["https://orcid.org/0000-0001-9922-9232"]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Amy Trottier","raw_affiliation_strings":["Division of Hematology, Dalhousie University, Halifax, Canada"],"raw_orcid":"https://orcid.org/0000-0001-9922-9232","affiliations":[{"raw_affiliation_string":"Division of Hematology, Dalhousie University, Halifax, Canada","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060462360","display_name":"John M. Storring","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John Storring","raw_affiliation_strings":["Division of Hematology, McGill University, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045042696","display_name":"Mohamed Elemary","orcid":"https://orcid.org/0000-0002-7622-4065","observed_orcids":["https://orcid.org/0000-0002-7622-4065"]},"institutions":[{"id":"https://openalex.org/I4405267691","display_name":"Saskatoon Cancer Centre","ror":"https://ror.org/03x513f48","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405267691"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mohamed Elemary","raw_affiliation_strings":["Saskatchewan Cancer Centre, Saskatoon, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saskatchewan Cancer Centre, Saskatoon, Canada","institution_ids":["https://openalex.org/I4405267691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035484977","display_name":"Robert Delage","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133239","display_name":"H\u00f4pital de l'Enfant-J\u00e9sus","ror":"https://ror.org/02p1gpn45","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210133239","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Robert Delage","raw_affiliation_strings":["H\u00f4pital de l'Enfant-J\u00e9sus, Laval, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital de l'Enfant-J\u00e9sus, Laval, Canada","institution_ids":["https://openalex.org/I4210133239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070557410","display_name":"Laura Anne Habib","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Laura Habib","raw_affiliation_strings":["Division of Hematology, McGill University, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090873686","display_name":"Lisa Chodirker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lisa Chodirker","raw_affiliation_strings":["Sunnybrook Health Sciences Centre, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunnybrook Health Sciences Centre, Toronto, Canada","institution_ids":["https://openalex.org/I1323843004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086571729","display_name":"Signy Chow","orcid":"https://orcid.org/0000-0002-6303-1774","observed_orcids":["https://orcid.org/0000-0002-6303-1774"]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Signy Chow","raw_affiliation_strings":["Sunnybrook Health Sciences Centre, Toronto, Canada"],"raw_orcid":"https://orcid.org/0000-0002-6303-1774","affiliations":[{"raw_affiliation_string":"Sunnybrook Health Sciences Centre, Toronto, Canada","institution_ids":["https://openalex.org/I1323843004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140184566","display_name":"Matthew Cheung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Matthew Cheung","raw_affiliation_strings":["Sunnybrook Health Sciences Centre, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunnybrook Health Sciences Centre, Toronto, Canada","institution_ids":["https://openalex.org/I1323843004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076995401","display_name":"Lee Mozessohn","orcid":"https://orcid.org/0000-0003-3436-3849","observed_orcids":["https://orcid.org/0000-0003-3436-3849"]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lee Mozessohn","raw_affiliation_strings":["Sunnybrook Health Sciences Centre, Toronto, Canada"],"raw_orcid":"https://orcid.org/0000-0003-3436-3849","affiliations":[{"raw_affiliation_string":"Sunnybrook Health Sciences Centre, Toronto, Canada","institution_ids":["https://openalex.org/I1323843004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148139636","display_name":"James A. Kennedy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"James A. Kennedy","raw_affiliation_strings":["Sunnybrook Health Sciences Centre, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunnybrook Health Sciences Centre, Toronto, Canada","institution_ids":["https://openalex.org/I1323843004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044632878","display_name":"Rena J. Buckstein","orcid":"https://orcid.org/0000-0001-9520-7386","observed_orcids":["https://orcid.org/0000-0001-9520-7386"]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rena Buckstein","raw_affiliation_strings":["Sunnybrook Health Sciences Centre, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunnybrook Health Sciences Centre, Toronto, Canada","institution_ids":["https://openalex.org/I1323843004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5007881437"],"corresponding_institution_ids":["https://openalex.org/I1323843004"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.55873356,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"4","first_page":"100293","last_page":"100293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9679999947547913},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.9649999737739563},{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":1.0},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.9990000128746033},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8840000033378601},{"id":"https://openalex.org/keywords/leukemia-free-survival","display_name":"leukemia-free survival","score":0.9300000071525574},{"id":"https://openalex.org/keywords/transfusion-dependence","display_name":"transfusion dependence","score":0.9620000123977661},{"id":"https://openalex.org/keywords/ipss-r-risk-stratification","display_name":"IPSS-R risk stratification","score":0.9150000214576721},{"id":"https://openalex.org/keywords/propensity-score-matching","display_name":"propensity score matching","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8442999720573425},{"id":"https://openalex.org/C2780235182","wikidata":"https://www.wikidata.org/wiki/Q1181878","display_name":"Decitabine","level":5,"score":0.7073000073432922},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6931999921798706},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6407999992370605},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.640500009059906},{"id":"https://openalex.org/C2776239401","wikidata":"https://www.wikidata.org/wiki/Q416451","display_name":"Azacitidine","level":5,"score":0.59170001745224},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5314000248908997},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2913999855518341},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.27149999141693115},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.2671999931335449},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.25940001010894775},{"id":"https://openalex.org/C2780790343","wikidata":"https://www.wikidata.org/wiki/Q5090610","display_name":"Chemoimmunotherapy","level":4,"score":0.25360000133514404},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.25040000677108765}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.bneo.2026.100293","doi":"https://doi.org/10.1016/j.bneo.2026.100293","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bneo.2026.100293","pdf_url":null,"source":{"id":"https://openalex.org/S5407037027","display_name":"Blood Neoplasia","issn_l":"2950-3280","issn":["2950-3280"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","ki-jl-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Neoplasia","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13681970","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13681970/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13681970/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Neoplasia","raw_type":"Text"},{"id":"pmid:42903632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42903632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood neoplasia","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a4ad77cc10ef45e79582ef9a61b504e9","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a4ad77cc10ef45e79582ef9a61b504e9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood Neoplasia, Vol 3, Iss 4, Pp 100293- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.bneo.2026.100293","doi":"https://doi.org/10.1016/j.bneo.2026.100293","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bneo.2026.100293","pdf_url":null,"source":{"id":"https://openalex.org/S5407037027","display_name":"Blood Neoplasia","issn_l":"2950-3280","issn":["2950-3280"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","ki-jl-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Neoplasia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204214328.pdf","grobid_xml":"https://content.openalex.org/works/W7204214328.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1982946927","https://openalex.org/W2005289703","https://openalex.org/W2106082819","https://openalex.org/W2107942053","https://openalex.org/W2118771330","https://openalex.org/W2169007954","https://openalex.org/W2521557372","https://openalex.org/W2549898496","https://openalex.org/W2555514872","https://openalex.org/W2900418013","https://openalex.org/W2986575254","https://openalex.org/W3028372384","https://openalex.org/W3133237233","https://openalex.org/W3158587435","https://openalex.org/W4225299329","https://openalex.org/W4229018428","https://openalex.org/W4292428196","https://openalex.org/W4295194215","https://openalex.org/W4320718011","https://openalex.org/W4390021910","https://openalex.org/W4413036059"],"related_works":["https://openalex.org/W4417007331","https://openalex.org/W2521557372","https://openalex.org/W2980190727","https://openalex.org/W2005289703","https://openalex.org/W2891824084","https://openalex.org/W4389246792","https://openalex.org/W4405092629","https://openalex.org/W2910656974","https://openalex.org/W2076579366","https://openalex.org/W3193455869"],"abstract_inverted_index":{":":[0],"Patients":[1],"with":[2,9,83,111,150,158,228],"higher-risk":[3,184],"MDS":[4,99],"are":[5,53],"considered":[6],"for":[7,80,88,115,183],"therapy":[8],"hypomethylating":[10],"agents":[11],"(HMAs),":[12],"to":[13,19],"help":[14],"restore":[15],"hematopoiesis,":[16],"delay":[17],"progression":[18],"AML,":[20],"and":[21,27,60,68,91,108,119,139,156],"improve":[22],"overall-survival":[23],"(OS).":[24],"Azacytidine":[25],"(AZA)":[26],"decitabine":[28],"(DEC)":[29],"have":[30,44],"commonly":[31],"been":[32],"used":[33],"without":[34],"direct":[35],"clinical":[36,78],"trial":[37],"comparison":[38],"between":[39,210,225],"these":[40,51],"agents.":[41],"Prior":[42],"studies":[43],"observed":[45],"no":[46,204,215],"difference":[47,205,217],"in":[48,77,133,141,171,197,206,218],"OS;":[49],"but":[50],"analyses":[52],"limited":[54],"by":[55,122,187],"the":[56,75,97,116,172],"lack":[57],"of":[58,153,161],"patient-level":[59],"disease":[61,89,124],"risk":[62],"factors":[63,93],"that":[64],"may":[65],"influence":[66],"efficacy":[67],"tolerability.":[69],"The":[70,103],"current":[71],"study":[72],"retrospectively":[73],"evaluated":[74,114],"differences":[76,140],"outcomes":[79,127],"patients":[81,147,174,185,226],"treated":[82,149,227],"AZA":[84,151],"or":[85,208,221],"DEC":[86,159],"adjusted":[87],"risk-category":[90],"patient-specific":[92],"using":[94],"data":[95],"from":[96],"Canadian":[98],"Registry":[100],"(MDS-CAN;":[101],"NCT02537990).":[102],"primary":[104],"outcome":[105],"was":[106,109,169,203,214],"OS":[107,168,207],"compared":[110],"log-rank":[112],"test;":[113],"whole":[117],"cohort":[118],"then":[120],"stratified":[121],"IPSS-R":[123,188],"risk.":[125],"Secondary":[126],"included":[128],"Leukemia-Free":[129],"Survival":[130],"(LFS),":[131],"change":[132],"transfusion":[134],"dependence":[135],"(TD)/independence":[136],"(TI)":[137],"status,":[138],"QoL":[142,223],"measurements.":[143],"In":[144,164],"total":[145],"424":[146],"were":[148],"(median":[152,160],"10":[154],"cycles)":[155],"85":[157],"5":[162],"cycles).":[163],"unadjusted":[165],"analysis,":[166],"median":[167],"longer":[170],"DEC-treated":[173],"(37.0":[175],"vs.":[176,192],"21.4":[177],"months,":[178,194],"p=0.001)":[179],"which":[180],"remained":[181],"significant":[182,216],"defined":[186],"score":[189],">3.5":[190],"(34.4":[191],"19.6":[193],"P=0.01).":[195],"However,":[196],"a":[198],"propensity-score":[199],"matched":[200],"analysis":[201],"there":[202],"LFS":[209],"HMA":[211],"therapies.":[212],"There":[213],"global,":[219],"physical,":[220],"social":[222],"scores":[224],"either":[229],"HMA.":[230]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-26T00:00:00"}
