{"id":"https://openalex.org/W7204209795","doi":"https://doi.org/10.1186/s40168-026-02490-x","title":"Resistant starch facilitates butyrate production by Bifidobacterium pseudolongum to mitigate colitis via Lgals4 upregulation","display_name":"Resistant starch facilitates butyrate production by Bifidobacterium pseudolongum to mitigate colitis via Lgals4 upregulation","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204209795","doi":"https://doi.org/10.1186/s40168-026-02490-x"},"language":"en","primary_location":{"id":"doi:10.1186/s40168-026-02490-x","doi":"https://doi.org/10.1186/s40168-026-02490-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40168-026-02490-x","pdf_url":null,"source":{"id":"https://openalex.org/S3004984423","display_name":"Microbiome","issn_l":"2049-2618","issn":["2049-2618"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiome","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s40168-026-02490-x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100677475","display_name":"Yalin Liu","orcid":"https://orcid.org/0000-0001-7266-7304","observed_orcids":["https://orcid.org/0000-0001-7266-7304","https://orcid.org/0000-0003-2870-4598","https://orcid.org/0009-0005-8252-9147"]},"institutions":[{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yalin Liu","raw_affiliation_strings":["College of Animal Science, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","National Engineering Research Center for Green Feed and Healthy Breeding, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210151987","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"National Engineering Research Center for Green Feed and Healthy Breeding, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110632060","display_name":"Xiaoxi Lu","orcid":"https://orcid.org/0009-0005-9224-7418","observed_orcids":["https://orcid.org/0009-0005-9224-7418"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoxi Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148099540","display_name":"Siyu Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siyu Wei","raw_affiliation_strings":["College of Animal Science, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","National Engineering Research Center for Green Feed and Healthy Breeding, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210151987","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"National Engineering Research Center for Green Feed and Healthy Breeding, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148050490","display_name":"Lei Qiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Qiao","raw_affiliation_strings":["College of Animal Science, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","National Engineering Research Center for Green Feed and Healthy Breeding, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210151987","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"National Engineering Research Center for Green Feed and Healthy Breeding, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148083510","display_name":"Rong Yan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rong Yan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070584521","display_name":"Jie Fu","orcid":"https://orcid.org/0000-0001-5054-571X","observed_orcids":["https://orcid.org/0000-0001-5054-571X","https://orcid.org/0009-0009-1149-2040"]},"institutions":[{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Fu","raw_affiliation_strings":["College of Animal Science, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","National Engineering Research Center for Green Feed and Healthy Breeding, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210151987","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"National Engineering Research Center for Green Feed and Healthy Breeding, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036294751","display_name":"Peiyuan Han","orcid":"https://orcid.org/0000-0001-6977-8038","observed_orcids":["https://orcid.org/0000-0001-6977-8038"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peiyuan Han","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148168280","display_name":"Bin Yao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bin Yao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136922242","display_name":"Yizhen Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yizhen Wang","raw_affiliation_strings":["College of Animal Science, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","National Engineering Research Center for Green Feed and Healthy Breeding, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210151987","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"National Engineering Research Center for Green Feed and Healthy Breeding, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076305419","display_name":"Mingliang Jin","orcid":"https://orcid.org/0000-0001-6358-5307","observed_orcids":["https://orcid.org/0000-0001-6358-5307"]},"institutions":[{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingliang Jin","raw_affiliation_strings":["College of Animal Science, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","National Engineering Research Center for Green Feed and Healthy Breeding, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-6358-5307","affiliations":[{"raw_affiliation_string":"College of Animal Science, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210151987","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"National Engineering Research Center for Green Feed and Healthy Breeding, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Zhejiang University, Hangzhou, 310058, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5076305419"],"corresponding_institution_ids":["https://openalex.org/I4210151987","https://openalex.org/I76130692"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60995826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resistant-starch","display_name":"resistant starch","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bifidobacterium-pseudolongum","display_name":"Bifidobacterium pseudolongum","score":0.9309999942779541},{"id":"https://openalex.org/keywords/butyrate-production","display_name":"butyrate production","score":0.8880000114440918},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.902999997138977},{"id":"https://openalex.org/keywords/dietary-fiber","display_name":"dietary fiber","score":0.7049999833106995},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.6819999814033508},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.6449999809265137},{"id":"https://openalex.org/keywords/mucosal-healing","display_name":"mucosal healing","score":0.777999997138977},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8050000071525574},{"id":"https://openalex.org/keywords/muc2","display_name":"MUC2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/bacteroides-acidifaciens","display_name":"Bacteroides acidifaciens","score":0.9800000190734863},{"id":"https://openalex.org/keywords/synbiotics","display_name":"synbiotics","score":0.7250000238418579},{"id":"https://openalex.org/keywords/microcrystalline-cellulose","display_name":"microcrystalline cellulose","score":0.8410000205039978},{"id":"https://openalex.org/keywords/inulin","display_name":"inulin","score":0.953000009059906},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7498000264167786},{"id":"https://openalex.org/C2776633847","wikidata":"https://www.wikidata.org/wiki/Q574416","display_name":"Resistant starch","level":3,"score":0.7240999937057495},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6008999943733215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5827000141143799},{"id":"https://openalex.org/C2776979534","wikidata":"https://www.wikidata.org/wiki/Q193213","display_name":"Butyrate","level":3,"score":0.5522000193595886},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.46309998631477356},{"id":"https://openalex.org/C2780305828","wikidata":"https://www.wikidata.org/wiki/Q132656","display_name":"Bifidobacterium","level":4,"score":0.4490000009536743},{"id":"https://openalex.org/C529335014","wikidata":"https://www.wikidata.org/wiki/Q41534","display_name":"Starch","level":2,"score":0.4165000021457672},{"id":"https://openalex.org/C2780675110","wikidata":"https://www.wikidata.org/wiki/Q3738294","display_name":"Faecalibacterium prausnitzii","level":3,"score":0.3962000012397766},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.34709998965263367},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.33320000767707825},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.3260999917984009},{"id":"https://openalex.org/C193176779","wikidata":"https://www.wikidata.org/wiki/Q5016050","display_name":"Caco-2","level":3,"score":0.3133000135421753},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3043999969959259},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3001999855041504},{"id":"https://openalex.org/C2776996202","wikidata":"https://www.wikidata.org/wiki/Q4904768","display_name":"Bifidobacterium longum","level":5,"score":0.2892000079154968},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.2784999907016754},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.2718000113964081},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.26820001006126404},{"id":"https://openalex.org/C2910153003","wikidata":"https://www.wikidata.org/wiki/Q5380200","display_name":"Enteric bacteria","level":4,"score":0.2669999897480011},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.2547000050544739},{"id":"https://openalex.org/C2776280935","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Large intestine","level":2,"score":0.2538999915122986},{"id":"https://openalex.org/C190139176","wikidata":"https://www.wikidata.org/wiki/Q598976","display_name":"Medical microbiology","level":2,"score":0.2531000077724457}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s40168-026-02490-x","doi":"https://doi.org/10.1186/s40168-026-02490-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40168-026-02490-x","pdf_url":null,"source":{"id":"https://openalex.org/S3004984423","display_name":"Microbiome","issn_l":"2049-2618","issn":["2049-2618"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiome","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s40168-026-02490-x","doi":"https://doi.org/10.1186/s40168-026-02490-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40168-026-02490-x","pdf_url":null,"source":{"id":"https://openalex.org/S3004984423","display_name":"Microbiome","issn_l":"2049-2618","issn":["2049-2618"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiome","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3169124790","display_name":null,"funder_award_id":"226-2024-00080","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G5474314794","display_name":null,"funder_award_id":"32372889","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Dietary":[0],"fiber\u2019s":[1],"capacity":[2],"to":[3,26,28,112],"support":[4],"intestinal":[5,30,238],"microbial":[6],"homeostasis":[7],"in":[8,46,62,187,217,230],"mitigating":[9],"disorders":[10],"is":[11],"well":[12],"established.":[13],"However,":[14],"comparative":[15],"studies":[16],"on":[17],"the":[18,35,38,47,53,104,113,188,210,222,232],"mechanisms":[19,55],"by":[20,130,154],"which":[21],"different":[22],"dietary":[23,44,60,205,228],"fibers":[24,72],"bind":[25],"microbiota":[27,42,58],"alleviate":[29],"inflammation":[31,129],"remain":[32],"insufficient.":[33],"Therefore,":[34],"study":[36],"investigated":[37],"association":[39],"between":[40,213],"gut":[41],"and":[43,51,59,84,93,108,116,124,133,136,141,171,215,227,236],"fiber":[45,61,206,229],"DSS-induced":[48,90,191],"colitis":[49,91,192,235],"model,":[50],"evaluated":[52],"potential":[54,223],"of":[56,69,169,190,225,234],"specific":[57],"managing":[63],"this":[64],"condition.":[65],"The":[66],"anti-inflammatory":[67],"effects":[68],"three":[70],"classical":[71],"with":[73,194,207],"distinct":[74],"digestive":[75],"properties,":[76],"including":[77],"microcrystalline":[78],"cellulose":[79],"(MCC),":[80],"resistant":[81],"starch":[82],"(RS),":[83],"inulin,":[85],"were":[86],"compared":[87],"using":[88],"a":[89,159,184],"model":[92],"single-cell":[94],"RNA":[95],"sequencing.":[96],"Among":[97],"them,":[98],"RS":[99,127,150,170,216],"showed":[100],"superior":[101],"efficacy,":[102],"reducing":[103],"disease":[105],"activity":[106],"index":[107],"histopathological":[109],"score":[110],"relative":[111],"fiber-free":[114],"diet,":[115],"better":[117],"restoring":[118],"colonic":[119],"crypts":[120],"morphology":[121],"than":[122],"MCC":[123],"inulin.":[125],"Mechanistically,":[126],"alleviated":[128],"modulating":[131],"IL-1\u03b2":[132],"Muc2":[134],"expression":[135],"markedly":[137],"increasing":[138],"Bifidobacterium":[139,214],"pseudolongum":[140,173,182],"Bacteroides":[142],"acidifaciens":[143],".":[144],"Single-cell":[145],"sequencing":[146],"further":[147],"revealed":[148],"that":[149,162,180],"promotes":[151],"mucosal":[152],"repair":[153],"upregulating":[155],"epithelial":[156],"Lgals4":[157],",":[158],"carbohydrate-binding":[160],"gene":[161],"activates":[163],"intercellular":[164],"junction":[165],"pathways.":[166],"Notably,":[167],"co-supplementation":[168],"B.":[172,181],"provided":[174],"additional":[175],"protection.":[176],"These":[177],"findings":[178],"indicate":[179],"plays":[183],"pivotal":[185],"role":[186],"pathogenesis":[189],"treated":[193],"RS,":[195],"offering":[196],"significant":[197],"insights":[198],"for":[199],"developing":[200],"novel":[201],"synbiotic":[202],"strategies":[203],"combining":[204],"probiotics.":[208],"Furthermore,":[209],"synergistic":[211],"effect":[212],"producing":[218],"increased":[219],"butyrate":[220],"highlights":[221],"impact":[224],"probiotics":[226],"suppressing":[231],"progression":[233],"other":[237],"inflammations.":[239],"Video":[240],"Abstract":[241]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2026-08-26T00:00:00"}