{"id":"https://openalex.org/W7204209602","doi":"https://doi.org/10.1073/pnas.2606900123","title":"Ank3 loss in adult forebrain excitatory neurons disrupts behavior, neuronal activity, membrane proteome, and myelination","display_name":"Ank3 loss in adult forebrain excitatory neurons disrupts behavior, neuronal activity, membrane proteome, and myelination","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204209602","doi":"https://doi.org/10.1073/pnas.2606900123","pmid":"https://pubmed.ncbi.nlm.nih.gov/42640795"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2606900123","doi":"https://doi.org/10.1073/pnas.2606900123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2606900123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.2606900123","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031631465","display_name":"Sehyoun Yoon","orcid":"https://orcid.org/0000-0001-6545-3615","observed_orcids":["https://orcid.org/0000-0001-6545-3615"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sehyoun Yoon","raw_affiliation_strings":["Department of Neuroscience, Northwestern University Feinberg School of Medicine"],"raw_orcid":"https://orcid.org/0000-0001-6545-3615","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Northwestern University Feinberg School of Medicine","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063733869","display_name":"Marc Dos Santos","orcid":"https://orcid.org/0000-0002-6101-5631","observed_orcids":["https://orcid.org/0000-0002-6101-5631"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Dos Santos","raw_affiliation_strings":["Department of Neuroscience, Northwestern University Feinberg School of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-6101-5631","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Northwestern University Feinberg School of Medicine","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045515415","display_name":"Natalia Khalatyan","orcid":"https://orcid.org/0000-0002-2883-0589","observed_orcids":["https://orcid.org/0000-0002-2883-0589"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalia Khalatyan","raw_affiliation_strings":["Department of Neurology, Northwestern University Feinberg School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Northwestern University Feinberg School of Medicine","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053093737","display_name":"Jeffrey N. Savas","orcid":"https://orcid.org/0000-0002-8173-5580","observed_orcids":["https://orcid.org/0000-0002-8173-5580"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey N. Savas","raw_affiliation_strings":["Department of Neurology, Northwestern University Feinberg School of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-8173-5580","affiliations":[{"raw_affiliation_string":"Department of Neurology, Northwestern University Feinberg School of Medicine","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071692996","display_name":"Peter Penzes","orcid":"https://orcid.org/0000-0001-5449-1640","observed_orcids":["https://orcid.org/0000-0001-5449-1640"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter Penzes","raw_affiliation_strings":["Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine","Department of Neuroscience, Northwestern University Feinberg School of Medicine","Department of Pharmacology, Northwestern University Feinberg School of Medicine","Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine"],"raw_orcid":"https://orcid.org/0000-0001-5449-1640","affiliations":[{"raw_affiliation_string":"Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Neuroscience, Northwestern University Feinberg School of Medicine","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Pharmacology, Northwestern University Feinberg School of Medicine","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071692996"],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67737322,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"123","issue":"35","first_page":"e2606900123","last_page":"e2606900123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.5741999745368958,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.5741999745368958,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.28780001401901245,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.04690000042319298,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ankyrin-g","display_name":"ankyrin-G","score":0.9300000071525574},{"id":"https://openalex.org/keywords/ank3","display_name":"ANK3","score":0.7459999918937683},{"id":"https://openalex.org/keywords/hyperactivity","display_name":"hyperactivity","score":0.6949999928474426},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.9359999895095825},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neuronal-activity","display_name":"neuronal activity","score":0.7279999852180481},{"id":"https://openalex.org/keywords/synaptic-proteome","display_name":"synaptic proteome","score":0.9660000205039978},{"id":"https://openalex.org/keywords/taok2","display_name":"TAOK2","score":0.7419999837875366},{"id":"https://openalex.org/keywords/myelin-basic-protein","display_name":"myelin basic protein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.9039999842643738},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.9760000109672546},{"id":"https://openalex.org/keywords/lithium-treatment","display_name":"lithium therapy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.7960000038146973},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9539999961853027},{"id":"https://openalex.org/keywords/neuropsychiatric-disorders","display_name":"neuropsychiatric disorders","score":0.6949999928474426},{"id":"https://openalex.org/keywords/emx1-cre","display_name":"Emx1-Cre","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2779715522","wikidata":"https://www.wikidata.org/wiki/Q507027","display_name":"Forebrain","level":3,"score":0.7720000147819519},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.7091000080108643},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6675000190734863},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6353999972343445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4961000084877014},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.4672999978065491},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.3831000030040741},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.37860000133514404},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.3781999945640564},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.36880001425743103},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.349700003862381},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.3285999894142151},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.3249000012874603},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3215000033378601},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.299699991941452},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.298799991607666},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.29679998755455017},{"id":"https://openalex.org/C2776032975","wikidata":"https://www.wikidata.org/wiki/Q5018833","display_name":"Calcium imaging","level":3,"score":0.29649999737739563},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.2797999978065491},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.2775000035762787},{"id":"https://openalex.org/C53645450","wikidata":"https://www.wikidata.org/wiki/Q907093","display_name":"Scaffold protein","level":3,"score":0.2653999924659729}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004676","descriptor_name":"Myelin Basic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004676","descriptor_name":"Myelin Basic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004676","descriptor_name":"Myelin Basic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017487","descriptor_name":"Ankyrins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D017487","descriptor_name":"Ankyrins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D017487","descriptor_name":"Ankyrins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D017487","descriptor_name":"Ankyrins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017487","descriptor_name":"Ankyrins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017487","descriptor_name":"Ankyrins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017487","descriptor_name":"Ankyrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017487","descriptor_name":"Ankyrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017487","descriptor_name":"Ankyrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.2606900123","doi":"https://doi.org/10.1073/pnas.2606900123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2606900123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:42640795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42640795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13535106","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13535106/pdf/pnas.202606900.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1073/pnas.2606900123","doi":"https://doi.org/10.1073/pnas.2606900123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2606900123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7604897618293762,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2167612718","display_name":null,"funder_award_id":"R01MH107182","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6357003619","display_name":null,"funder_award_id":"1S10OD032270-01","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000891045","display_name":"The Robert H. Lurie Comprehensive Cancer Center","funder_award_id":"P30CA060553","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1942239965","https://openalex.org/W1963600261","https://openalex.org/W1999775510","https://openalex.org/W2012961395","https://openalex.org/W2014596688","https://openalex.org/W2023456394","https://openalex.org/W2028281706","https://openalex.org/W2048004270","https://openalex.org/W2058623711","https://openalex.org/W2076736456","https://openalex.org/W2078035790","https://openalex.org/W2121626412","https://openalex.org/W2127442418","https://openalex.org/W2132561979","https://openalex.org/W2137348407","https://openalex.org/W2141923548","https://openalex.org/W2162423225","https://openalex.org/W2180449937","https://openalex.org/W2273816628","https://openalex.org/W2562253178","https://openalex.org/W2577977549","https://openalex.org/W2734391724","https://openalex.org/W2749513260","https://openalex.org/W2754722101","https://openalex.org/W2755780856","https://openalex.org/W2767050687","https://openalex.org/W2789447616","https://openalex.org/W2798508824","https://openalex.org/W2800330668","https://openalex.org/W2895445208","https://openalex.org/W2948949781","https://openalex.org/W2962820578","https://openalex.org/W2976240417","https://openalex.org/W2989787606","https://openalex.org/W3004223337","https://openalex.org/W3011948446","https://openalex.org/W3093292403","https://openalex.org/W3141591362","https://openalex.org/W4283836141","https://openalex.org/W4293068416","https://openalex.org/W4293068820","https://openalex.org/W4303628053","https://openalex.org/W4308997373","https://openalex.org/W4378772065","https://openalex.org/W4383682990","https://openalex.org/W4388592717","https://openalex.org/W4389001924","https://openalex.org/W4391386005","https://openalex.org/W4403098432","https://openalex.org/W4408206697"],"related_works":[],"abstract_inverted_index":{"ANK3":[0,164],",":[1],"encoding":[2],"the":[3,100,106],"scaffolding":[4],"protein":[5,115,157],"ankyrin-G,":[6],"is":[7],"a":[8,117,146,160],"major":[9],"risk":[10],"gene":[11],"for":[12],"bipolar":[13],"disorder":[14],"and":[15,20,65,74,85,109,155],"schizophrenia,":[16],"but":[17],"its":[18],"cellular":[19],"circuit-level":[21],"mechanisms":[22],"remain":[23],"poorly":[24],"defined.":[25],"Here,":[26],"we":[27],"demonstrate":[28],"that":[29,79],"deletion":[30],"of":[31,92,99,105,112,120],"Ank3":[32,39,48,133],"in":[33,45,58,71,132],"forebrain":[34],"excitatory":[35,150],"neurons-either":[36],"prenatally":[37],"(":[38,47],"\u2013/":[40,49],"\u2212":[41],":Emx1-Cre":[42],")":[43,52],"or":[44],"adolescence":[46],"\u2013":[50],":CaMKII\u03b1-Cre":[51],"leads":[53],"to":[54,128,168],"convergent":[55],"behavioral":[56,130],"phenotypes":[57],"adulthood,":[59],"including":[60,103],"hyperactivity,":[61],"reduced":[62],"anxiety-like":[63],"behavior,":[64],"decreased":[66],"depression-like":[67],"responses.":[68],"Calcium":[69],"imaging":[70],"cultured":[72],"neurons":[73],"acute":[75],"brain":[76],"slices":[77],"revealed":[78],"ankyrin-G":[80,144],"loss":[81],"reduces":[82],"both":[83],"spontaneous":[84],"evoked":[86],"neuronal":[87,151],"activity.":[88],"Quantitative":[89],"proteomic":[90],"profiling":[91],"membrane-enriched":[93],"cortical":[94],"fractions":[95],"uncovered":[96],"widespread":[97],"remodeling":[98],"synaptic":[101,153],"proteome,":[102],"upregulation":[104],"kinase":[107],"Taok2":[108],"unexpected":[110],"downregulation":[111],"myelin":[113],"basic":[114],"(Mbp),":[116],"structural":[118],"component":[119],"oligodendrocyte-derived":[121],"myelin.":[122],"Importantly,":[123],"chronic":[124],"lithium":[125],"treatment,":[126],"known":[127],"reverse":[129],"abnormalities":[131],"-deficient":[134],"mice,":[135],"also":[136],"restored":[137],"Mbp":[138],"expression.":[139],"Together,":[140],"our":[141],"findings":[142],"identify":[143],"as":[145],"molecular":[147],"bridge":[148],"between":[149],"activity,":[152],"structure,":[154],"myelin-associated":[156],"expression,":[158],"revealing":[159],"pathway":[161],"by":[162],"which":[163],"variants":[165],"may":[166],"contribute":[167],"neuropsychiatric":[169],"disease.":[170]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2026-08-26T00:00:00"}
