{"id":"https://openalex.org/W7204208351","doi":"https://doi.org/10.1002/advs.77358","title":"Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T\u2010Cell Immunity","display_name":"Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T\u2010Cell Immunity","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204208351","doi":"https://doi.org/10.1002/advs.77358","pmid":"https://pubmed.ncbi.nlm.nih.gov/42640144"},"language":"en","primary_location":{"id":"doi:10.1002/advs.77358","doi":"https://doi.org/10.1002/advs.77358","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.77358","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/advs.77358","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148133993","display_name":"Shaocong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaocong Wang","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148111661","display_name":"Zijian Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zijian Zhang","raw_affiliation_strings":["National Resource Center for Mutant Mice MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center Department of Oncology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Resource Center for Mutant Mice MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center Department of Oncology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4210130538","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085700511","display_name":"Fulin Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fulin Dai","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148103786","display_name":"Zhijie Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhijie Yin","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148070603","display_name":"Zhen Xing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Xing","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China","Wuxi Xishan Institute of Applied Biotechnology Nanjing University  Wuxi Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"raw_affiliation_string":"Wuxi Xishan Institute of Applied Biotechnology Nanjing University  Wuxi Jiangsu China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107935413","display_name":"Yurong Li","orcid":"https://orcid.org/0000-0001-7318-0784","observed_orcids":["https://orcid.org/0000-0001-7318-0784"]},"institutions":[{"id":"https://openalex.org/I4210096899","display_name":"Jiangsu University of Science and Technology","ror":"https://ror.org/00tyjp878","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210096899"]},{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yurong Li","raw_affiliation_strings":["Chemistry and Biomedicine Innovation Center (ChemBIC) ChemBioMed Interdisciplinary Research Center at Nanjing University  Nanjing Jiangsu China","Jiangsu Key Laboratory of Sericultural Biology and Biotechnology School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China","National Resource Center for Mutant Mice MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center Department of Oncology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China","State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China","Wuxi Xishan Institute of Applied Biotechnology Nanjing University  Wuxi Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Biomedicine Innovation Center (ChemBIC) ChemBioMed Interdisciplinary Research Center at Nanjing University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"Jiangsu Key Laboratory of Sericultural Biology and Biotechnology School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China","institution_ids":["https://openalex.org/I4210096899"]},{"raw_affiliation_string":"National Resource Center for Mutant Mice MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center Department of Oncology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4210130538","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"raw_affiliation_string":"Wuxi Xishan Institute of Applied Biotechnology Nanjing University  Wuxi Jiangsu China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107935413","display_name":"Yurong Li","orcid":"https://orcid.org/0000-0001-7318-0784","observed_orcids":["https://orcid.org/0000-0001-7318-0784"]},"institutions":[{"id":"https://openalex.org/I4210096899","display_name":"Jiangsu University of Science and Technology","ror":"https://ror.org/00tyjp878","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210096899"]},{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yurong Li","raw_affiliation_strings":["Chemistry and Biomedicine Innovation Center (ChemBIC) ChemBioMed Interdisciplinary Research Center at Nanjing University  Nanjing Jiangsu China","Jiangsu Key Laboratory of Sericultural Biology and Biotechnology School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China","National Resource Center for Mutant Mice MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center Department of Oncology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China","State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China","Wuxi Xishan Institute of Applied Biotechnology Nanjing University  Wuxi Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Biomedicine Innovation Center (ChemBIC) ChemBioMed Interdisciplinary Research Center at Nanjing University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"Jiangsu Key Laboratory of Sericultural Biology and Biotechnology School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China","institution_ids":["https://openalex.org/I4210096899"]},{"raw_affiliation_string":"National Resource Center for Mutant Mice MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center Department of Oncology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4210130538","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"raw_affiliation_string":"Wuxi Xishan Institute of Applied Biotechnology Nanjing University  Wuxi Jiangsu China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143682182","display_name":"Haochong Lei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Haochong Lei","raw_affiliation_strings":["Faculty of Life Sciences &amp; Medicine King's College London  London UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences &amp; Medicine King's College London  London UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148129186","display_name":"Junfeng Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junfeng Zhang","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148156616","display_name":"Chunyan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunyan Liu","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148045542","display_name":"Yan Li","orcid":"https://orcid.org/0000-0001-7612-3953","observed_orcids":["https://orcid.org/0000-0001-7612-3953"]},"institutions":[{"id":"https://openalex.org/I4210096899","display_name":"Jiangsu University of Science and Technology","ror":"https://ror.org/00tyjp878","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210096899"]},{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Li","raw_affiliation_strings":["Chemistry and Biomedicine Innovation Center (ChemBIC) ChemBioMed Interdisciplinary Research Center at Nanjing University  Nanjing Jiangsu China","Jiangsu Key Laboratory of Sericultural Biology and Biotechnology School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China","National Resource Center for Mutant Mice MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center Department of Oncology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China","State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China","Wuxi Xishan Institute of Applied Biotechnology Nanjing University  Wuxi Jiangsu China"],"raw_orcid":"https://orcid.org/0000-0001-7612-3953","affiliations":[{"raw_affiliation_string":"Chemistry and Biomedicine Innovation Center (ChemBIC) ChemBioMed Interdisciplinary Research Center at Nanjing University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"Jiangsu Key Laboratory of Sericultural Biology and Biotechnology School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China","institution_ids":["https://openalex.org/I4210096899"]},{"raw_affiliation_string":"National Resource Center for Mutant Mice MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center Department of Oncology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4210130538","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"raw_affiliation_string":"Wuxi Xishan Institute of Applied Biotechnology Nanjing University  Wuxi Jiangsu China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148045542","display_name":"Yan Li","orcid":"https://orcid.org/0000-0001-7612-3953","observed_orcids":["https://orcid.org/0000-0001-7612-3953"]},"institutions":[{"id":"https://openalex.org/I4210096899","display_name":"Jiangsu University of Science and Technology","ror":"https://ror.org/00tyjp878","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210096899"]},{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Li","raw_affiliation_strings":["Chemistry and Biomedicine Innovation Center (ChemBIC) ChemBioMed Interdisciplinary Research Center at Nanjing University  Nanjing Jiangsu China","Jiangsu Key Laboratory of Sericultural Biology and Biotechnology School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China","National Resource Center for Mutant Mice MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center Department of Oncology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China","State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China","Wuxi Xishan Institute of Applied Biotechnology Nanjing University  Wuxi Jiangsu China"],"raw_orcid":"https://orcid.org/0000-0001-7612-3953","affiliations":[{"raw_affiliation_string":"Chemistry and Biomedicine Innovation Center (ChemBIC) ChemBioMed Interdisciplinary Research Center at Nanjing University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"Jiangsu Key Laboratory of Sericultural Biology and Biotechnology School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China","institution_ids":["https://openalex.org/I4210096899"]},{"raw_affiliation_string":"National Resource Center for Mutant Mice MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center Department of Oncology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4210130538","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"raw_affiliation_string":"Wuxi Xishan Institute of Applied Biotechnology Nanjing University  Wuxi Jiangsu China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074415258","display_name":"Lei Dong","orcid":"https://orcid.org/0000-0002-2013-4191","observed_orcids":["https://orcid.org/0000-0002-2013-4191"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Dong","raw_affiliation_strings":["Chemistry and Biomedicine Innovation Center (ChemBIC) ChemBioMed Interdisciplinary Research Center at Nanjing University  Nanjing Jiangsu China","National Resource Center for Mutant Mice MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center Department of Oncology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China","State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China","Wuxi Xishan Institute of Applied Biotechnology Nanjing University  Wuxi Jiangsu China"],"raw_orcid":"https://orcid.org/0000-0002-2013-4191","affiliations":[{"raw_affiliation_string":"Chemistry and Biomedicine Innovation Center (ChemBIC) ChemBioMed Interdisciplinary Research Center at Nanjing University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"National Resource Center for Mutant Mice MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center Department of Oncology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4210130538","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"raw_affiliation_string":"Wuxi Xishan Institute of Applied Biotechnology Nanjing University  Wuxi Jiangsu China","institution_ids":["https://openalex.org/I881766915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5074415258","https://openalex.org/A5107935413","https://openalex.org/A5148045542","https://openalex.org/A5148156616"],"corresponding_institution_ids":["https://openalex.org/I4210096899","https://openalex.org/I4210111013","https://openalex.org/I4210130538","https://openalex.org/I4391768045","https://openalex.org/I881766915"],"apc_list":{"value":6730,"currency":"USD","value_usd":6730},"apc_paid":{"value":6730,"currency":"USD","value_usd":6730},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60783338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"e77358","last_page":"e77358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.08640000224113464,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymus-development","display_name":"thymus development","score":0.8709999918937683},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.6930000185966492},{"id":"https://openalex.org/keywords/humanized-mouse-model","display_name":"humanized mice","score":0.781000018119812},{"id":"https://openalex.org/keywords/aged-mice","display_name":"aged mice","score":0.5830000042915344},{"id":"https://openalex.org/keywords/thymectomy","display_name":"thymectomy","score":0.7559999823570251},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6771000027656555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.666100025177002},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6018999814987183},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5631999969482422},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5543000102043152},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.552299976348877},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5123999714851379},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5120999813079834},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.49390000104904175},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4300999939441681},{"id":"https://openalex.org/C2777380497","wikidata":"https://www.wikidata.org/wiki/Q2051174","display_name":"Parabiosis","level":2,"score":0.42570000886917114},{"id":"https://openalex.org/C30503417","wikidata":"https://www.wikidata.org/wiki/Q958938","display_name":"Organogenesis","level":3,"score":0.4120999872684479},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4032000005245209},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.3961000144481659},{"id":"https://openalex.org/C2779615886","wikidata":"https://www.wikidata.org/wiki/Q3090790","display_name":"Thymectomy","level":3,"score":0.39329999685287476},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.38019999861717224},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3797999918460846},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35929998755455017},{"id":"https://openalex.org/C2776156784","wikidata":"https://www.wikidata.org/wiki/Q3491954","display_name":"Humanized mouse","level":3,"score":0.335999995470047},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.32350000739097595},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.3098999857902527},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3025999963283539},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.29089999198913574},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28029999136924744},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.2676999866962433},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25209999084472656}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/advs.77358","doi":"https://doi.org/10.1002/advs.77358","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.77358","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},{"id":"pmid:42640144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42640144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13505467","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13505467/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Adv Sci (Weinh)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/advs.77358","doi":"https://doi.org/10.1002/advs.77358","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.77358","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8405905961990356}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3224058285","display_name":null,"funder_award_id":"32471000","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3960262573","display_name":null,"funder_award_id":"32230056","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4104943155","display_name":null,"funder_award_id":"KG202511","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G4153126464","display_name":null,"funder_award_id":"U24A20378","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4260394701","display_name":null,"funder_award_id":"32230058","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6663203099","display_name":null,"funder_award_id":"XJ2024003602","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G6722593191","display_name":null,"funder_award_id":"32361163656","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7701139004","display_name":null,"funder_award_id":"2024300408","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W832862346","https://openalex.org/W1526209767","https://openalex.org/W1558801857","https://openalex.org/W1596806896","https://openalex.org/W1913095327","https://openalex.org/W1982643265","https://openalex.org/W1985711700","https://openalex.org/W1995236521","https://openalex.org/W1999966048","https://openalex.org/W2031822312","https://openalex.org/W2035519735","https://openalex.org/W2074960482","https://openalex.org/W2077166543","https://openalex.org/W2079852453","https://openalex.org/W2144177716","https://openalex.org/W2177185177","https://openalex.org/W2604610929","https://openalex.org/W2795226066","https://openalex.org/W2901857916","https://openalex.org/W2918621261","https://openalex.org/W3025696538","https://openalex.org/W3034426277","https://openalex.org/W3046747175","https://openalex.org/W3161426443","https://openalex.org/W3187373040","https://openalex.org/W4206830978","https://openalex.org/W4214826293","https://openalex.org/W4308914942","https://openalex.org/W4320857128","https://openalex.org/W4322618969","https://openalex.org/W4324073254","https://openalex.org/W4327923955","https://openalex.org/W4327940554","https://openalex.org/W4376256338","https://openalex.org/W4377290765","https://openalex.org/W4385476149","https://openalex.org/W4387329553","https://openalex.org/W4387692765","https://openalex.org/W4389452771","https://openalex.org/W4390145972","https://openalex.org/W4390929320","https://openalex.org/W4391264508","https://openalex.org/W4403528269","https://openalex.org/W4404061635","https://openalex.org/W4408315761","https://openalex.org/W4408367643","https://openalex.org/W4409831930","https://openalex.org/W4410553547"],"related_works":[],"abstract_inverted_index":{"Thymic":[0],"hypofunction":[1],"due":[2],"to":[3,92,107,113],"primary":[4],"defects,":[5],"aging,":[6],"infection,":[7],"or":[8],"cytoreductive":[9],"therapies":[10],"causes":[11],"profound":[12],"restriction":[13],"of":[14,23,44,62,95,135,149],"the":[15,34,38,42,60,93,146,157],"T-cell":[16,100,126],"receptor":[17],"(TCR)":[18],"repertoire":[19],"and":[20,25,76,83,98,109,119,128,167,176],"increases":[21],"rates":[22],"morbidity":[24],"mortality.":[26],"Restoring":[27],"thymic":[28,54,89,122],"function":[29],"is":[30,129],"therefore":[31],"critical.":[32],"Here,":[33],"distinctive":[35],"niche":[36,163],"within":[37],"spleen":[39,158],"has":[40],"inspired":[41],"development":[43],"intrasplenic":[45,141],"thymus":[46,142,165],"regeneration":[47,166],"(ISTR),":[48],"an":[49,160],"approach":[50],"in":[51],"which":[52],"cultured":[53],"tissue":[55],"fragments":[56],"are":[57],"implanted":[58],"into":[59],"spleens":[61],"athymic":[63],"nude":[64],"mice,":[65,67],"aged":[66],"thymectomized":[68],"mice":[69],"undergoing":[70],"hematopoietic":[71],"stem":[72],"cell":[73],"transplantation":[74],"(HSCT),":[75],"humanized":[77,139],"mice.":[78],"The":[79],"spleen's":[80],"abundant":[81],"vasculature":[82],"supportive":[84],"stromal":[85],"milieu":[86],"enable":[87],"rapid":[88,147],"organogenesis,":[90],"leading":[91],"reconstitution":[94,175],"phenotypically":[96],"diverse":[97],"functional":[99,150],"compartments,":[101],"as":[102,104,159],"well":[103],"protective":[105],"responses":[106],"viral":[108],"tumor":[110],"challenges.":[111],"Relative":[112],"intramuscular":[114],"implantation,":[115],"ISTR":[116],"drives":[117],"faster":[118],"more":[120],"complete":[121],"development,":[123],"generates":[124],"greater":[125],"output,":[127],"associated":[130],"with":[131],"a":[132,169],"lower":[133],"incidence":[134],"graft-vs.-host":[136],"disease.":[137],"In":[138],"animals,":[140],"grafts":[143],"also":[144],"promote":[145],"emergence":[148],"human":[151],"T":[152],"cells.":[153],"These":[154],"results":[155],"identify":[156],"optimal":[161],"ectopic":[162],"for":[164,172],"provide":[168],"promising":[170],"strategy":[171],"clinical":[173],"immune":[174],"regenerative":[177],"immunology.":[178]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-08-26T00:00:00"}
