{"id":"https://openalex.org/W7204207683","doi":"https://doi.org/10.1002/pmf2.70363","title":"Xenobiotic transfer of onabotulinumtoxinA using an ex vivo human placental perfusion model: A pilot study","display_name":"Xenobiotic transfer of onabotulinumtoxinA using an ex vivo human placental perfusion model: A pilot study","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204207683","doi":"https://doi.org/10.1002/pmf2.70363","pmid":"https://pubmed.ncbi.nlm.nih.gov/42643799"},"language":"en","primary_location":{"id":"doi:10.1002/pmf2.70363","doi":"https://doi.org/10.1002/pmf2.70363","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pmf2.70363","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pmf2.70363","source":{"id":"https://openalex.org/S5407042707","display_name":"Pregnancy","issn_l":"2997-9684","issn":["2997-9684"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pregnancy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pmf2.70363","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108259878","display_name":"Alexandra Loza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Loza","raw_affiliation_strings":["Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology University of Connecticut Health Center  Farmington Connecticut USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology University of Connecticut Health Center  Farmington Connecticut USA","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135336173","display_name":"Ali Lotfi","orcid":"https://orcid.org/0000-0001-6124-3338","observed_orcids":["https://orcid.org/0000-0001-6124-3338"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Lotfi","raw_affiliation_strings":["Department of Chemistry University of Connecticut  Storrs Connecticut USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry University of Connecticut  Storrs Connecticut USA","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019367442","display_name":"Richard Wagner","orcid":"https://orcid.org/0000-0002-3035-2619","observed_orcids":["https://orcid.org/0000-0002-3035-2619"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Wagner","raw_affiliation_strings":["Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology University of Connecticut Health Center  Farmington Connecticut USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology University of Connecticut Health Center  Farmington Connecticut USA","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135317168","display_name":"Alexander Aksenov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I4210165057","display_name":"ProNAi Therapeutics (United States)","ror":"https://ror.org/05rzyfd75","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165057"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Aksenov","raw_affiliation_strings":["Arome Science Inc.  Farmington Connecticut USA","Department of Chemistry University of Connecticut  Storrs Connecticut USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arome Science Inc.  Farmington Connecticut USA","institution_ids":["https://openalex.org/I4210165057"]},{"raw_affiliation_string":"Department of Chemistry University of Connecticut  Storrs Connecticut USA","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5128877577","display_name":"Andrea Shields","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrea Shields","raw_affiliation_strings":["Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology University of Connecticut Health Center  Farmington Connecticut USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology University of Connecticut Health Center  Farmington Connecticut USA","institution_ids":["https://openalex.org/I75929689"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5128877577"],"corresponding_institution_ids":["https://openalex.org/I75929689"],"apc_list":{"value":2225,"currency":"USD","value_usd":2225},"apc_paid":{"value":2225,"currency":"USD","value_usd":2225},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.68071804,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"5","first_page":"e70363","last_page":"e70363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.07779999822378159,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/onabotulinumtoxina","display_name":"onabotulinumtoxinA","score":1.0},{"id":"https://openalex.org/keywords/transplacental-transfer","display_name":"transplacental transfer","score":0.949999988079071},{"id":"https://openalex.org/keywords/prenatal-exposure","display_name":"prenatal exposure","score":0.6690000295639038},{"id":"https://openalex.org/keywords/antipyrine","display_name":"antipyrine","score":0.7599999904632568},{"id":"https://openalex.org/keywords/maternal-fetal-pharmacokinetics","display_name":"maternal-fetal pharmacokinetics","score":0.9520000219345093},{"id":"https://openalex.org/keywords/chronic-migraine","display_name":"chronic migraine","score":0.625},{"id":"https://openalex.org/keywords/botulinum-toxin","display_name":"botulinum toxin","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C2779906218","wikidata":"https://www.wikidata.org/wiki/Q7834818","display_name":"Transplacental","level":5,"score":0.9484000205993652},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.7940000295639038},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6967999935150146},{"id":"https://openalex.org/C2779753670","wikidata":"https://www.wikidata.org/wiki/Q2657962","display_name":"Fetal circulation","level":5,"score":0.6898000240325928},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.6710000038146973},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.5216000080108643},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5108000040054321},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4165000021457672},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38089999556541443},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3368000090122223},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.3294999897480011},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.3183000087738037},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.30059999227523804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3000999987125397},{"id":"https://openalex.org/C2778546801","wikidata":"https://www.wikidata.org/wiki/Q2918261","display_name":"Biophysical profile","level":4,"score":0.26030001044273376},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.2590999901294708},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.25279998779296875}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1002/pmf2.70363","doi":"https://doi.org/10.1002/pmf2.70363","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pmf2.70363","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pmf2.70363","source":{"id":"https://openalex.org/S5407042707","display_name":"Pregnancy","issn_l":"2997-9684","issn":["2997-9684"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pregnancy","raw_type":"journal-article"},{"id":"pmid:42643799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42643799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pregnancy (Hoboken, N.J.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13505339","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13505339/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13505339/pdf/PMF2-2-e70363.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pregnancy (Hoboken)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:60ce15692ca64c089925792abf5dd2af","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/60ce15692ca64c089925792abf5dd2af","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pregnancy, Vol 2, Iss 5, Pp n/a-n/a (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/pmf2.70363","doi":"https://doi.org/10.1002/pmf2.70363","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pmf2.70363","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pmf2.70363","source":{"id":"https://openalex.org/S5407042707","display_name":"Pregnancy","issn_l":"2997-9684","issn":["2997-9684"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pregnancy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7700717449188232}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204207683.pdf","grobid_xml":"https://content.openalex.org/works/W7204207683.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1979728686","https://openalex.org/W2043338573","https://openalex.org/W2069428016","https://openalex.org/W2167719770","https://openalex.org/W2188714738","https://openalex.org/W2517000680","https://openalex.org/W2615322902","https://openalex.org/W2895868360","https://openalex.org/W3007415664","https://openalex.org/W3092849554","https://openalex.org/W3174080190","https://openalex.org/W4410131835"],"related_works":[],"abstract_inverted_index":{"Objective:":[0],"OnabotulinumtoxinA":[1,54,121,148],"is":[2],"an":[3,28],"effective":[4],"preventive":[5],"therapy":[6],"for":[7,91],"chronic":[8],"migraine;":[9],"however,":[10,172],"data":[11],"on":[12],"fetal":[13,84,126,154],"exposure":[14],"during":[15],"pregnancy":[16],"are":[17,176],"limited.":[18],"We":[19],"aimed":[20],"to":[21,101,178],"evaluate":[22],"transplacental":[23,135,161],"transfer":[24,80],"of":[25],"onabotulinumtoxinA":[26,115,141],"using":[27,48,108,116],"ex":[29,51],"vivo":[30,52,174],"human":[31],"placental":[32],"perfusion":[33],"model.":[34,53],"Study":[35],"design:":[36],"Five":[37],"term":[38],"placentas":[39],"from":[40],"uncomplicated":[41],"singleton":[42],"pregnancies":[43],"were":[44,86,99],"cannulated":[45],"and":[46,60,83,97,114],"perfused":[47],"a":[49,78],"validated":[50],"(100":[55],"units":[56,63],"in":[57,64,125,152,170,173],"Trials":[58,65],"1":[59],"2;":[61],"200":[62],"3-5)":[66],"was":[67,106,122,149],"introduced":[68],"into":[69],"the":[70,153],"maternal":[71],"circuit":[72],"with":[73],"antipyrine":[74],"(1":[75],"g/L)":[76],"as":[77],"positive":[79],"control.":[81],"Maternal":[82,140],"samples":[85,127],"collected":[87],"every":[88],"30":[89],"min":[90],"3":[92],"h.":[93],"Fetal":[94],"artery":[95],"pressure":[96],"pH":[98],"monitored":[100],"ensure":[102],"system":[103],"integrity.":[104],"Antipyrine":[105,132],"measured":[107],"ultra-high":[109],"performance":[110],"liquid":[111],"chromatography-mass":[112],"spectrometry,":[113],"enzyme-linked":[117],"immunosorbent":[118],"assay.":[119],"Results:":[120],"not":[123,150],"detected":[124,151],"at":[128],"any":[129],"time":[130],"point.":[131],"demonstrated":[133],"expected":[134],"transfer,":[136],"confirming":[137],"model":[138],"validity.":[139],"concentrations":[142],"decreased":[143],"slightly":[144],"over":[145],"time.":[146],"Conclusion:":[147],"circulation":[155],"under":[156],"study":[157],"conditions,":[158],"suggesting":[159],"minimal":[160],"transfer.":[162],"These":[163],"preliminary":[164],"findings":[165],"support":[166],"its":[167],"potential":[168],"use":[169],"pregnancy;":[171],"studies":[175],"needed":[177],"confirm":[179],"maternal-fetal":[180],"pharmacokinetics.":[181]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-08-26T00:00:00"}