{"id":"https://openalex.org/W7204205554","doi":"https://doi.org/10.1186/s13567-026-01829-4","title":"Pseudorabies virus pUL40 drives inflammatory signaling through competitive hijacking of EphA2 from the Akt\u2013EphA2 interaction","display_name":"Pseudorabies virus pUL40 drives inflammatory signaling through competitive hijacking of EphA2 from the Akt\u2013EphA2 interaction","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204205554","doi":"https://doi.org/10.1186/s13567-026-01829-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/42642744"},"language":"en","primary_location":{"id":"doi:10.1186/s13567-026-01829-4","doi":"https://doi.org/10.1186/s13567-026-01829-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13567-026-01829-4","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13567-026-01829-4.pdf","source":{"id":"https://openalex.org/S134003780","display_name":"Veterinary Research","issn_l":"0928-4249","issn":["0928-4249","1297-9716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s13567-026-01829-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054845523","display_name":"Yutong Tian","orcid":"https://orcid.org/0000-0001-9395-5049","observed_orcids":["https://orcid.org/0000-0001-9395-5049"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yutong Tian","raw_affiliation_strings":["Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070203150","display_name":"Hang Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hang Yin","raw_affiliation_strings":["Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148113605","display_name":"Jiaxiang Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxiang Fu","raw_affiliation_strings":["Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101958730","display_name":"Qingqing Yang","orcid":"https://orcid.org/0000-0002-7560-295X","observed_orcids":["https://orcid.org/0000-0002-7560-295X"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingqing Yang","raw_affiliation_strings":["Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108114369","display_name":"Ru Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ru Yan","raw_affiliation_strings":["Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148224465","display_name":"Yuqing Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqing Li","raw_affiliation_strings":["Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100683274","display_name":"Chao Ye","orcid":"https://orcid.org/0000-0001-6255-9684","observed_orcids":["https://orcid.org/0000-0001-6255-9684","https://orcid.org/0000-0003-3827-1597"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chao Ye","raw_affiliation_strings":["Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China. yechao123@swu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China. yechao123@swu.edu.cn","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081429630","display_name":"Rendong Fang","orcid":"https://orcid.org/0000-0003-3094-5059","observed_orcids":["https://orcid.org/0000-0003-3094-5059","https://orcid.org/0000-0001-9313-3088"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rendong Fang","raw_affiliation_strings":["Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China. rdfang@swu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0003-3094-5059","affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, China. rdfang@swu.edu.cn","institution_ids":["https://openalex.org/I142108993"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081429630","https://openalex.org/A5100683274"],"corresponding_institution_ids":["https://openalex.org/I142108993"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.69261708,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"57","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudorabies-virus","display_name":"pseudorabies virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epha2","display_name":"EphA2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8420000076293945},{"id":"https://openalex.org/keywords/viral-induced-inflammation","display_name":"viral-induced inflammation","score":0.5249999761581421},{"id":"https://openalex.org/keywords/alphaherpesvirus","display_name":"alphaherpesvirus","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9789999723434448},{"id":"https://openalex.org/keywords/competitive-protein-binding","display_name":"competitive protein binding","score":0.5640000104904175},{"id":"https://openalex.org/keywords/tegument-proteins","display_name":"tegument proteins","score":0.6470000147819519},{"id":"https://openalex.org/keywords/immunopathology","display_name":"immunopathology","score":0.621999979019165},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C2781092067","wikidata":"https://www.wikidata.org/wiki/Q316180","display_name":"Pseudorabies","level":3,"score":0.8547999858856201},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.832099974155426},{"id":"https://openalex.org/C150582083","wikidata":"https://www.wikidata.org/wiki/Q18250395","display_name":"EPH receptor A2","level":4,"score":0.7472000122070312},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6531999707221985},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6123999953269958},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.5428000092506409},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4345000088214874},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4343999922275543},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.43389999866485596},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.420199990272522},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.39100000262260437},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.384799987077713},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.37070000171661377},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.37040001153945923},{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.34529998898506165},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.335099995136261},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3276999890804291},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32690000534057617},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32190001010894775},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3109999895095825},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.31049999594688416},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C2778847070","wikidata":"https://www.wikidata.org/wiki/Q389837","display_name":"Gammaherpesvirinae","level":5,"score":0.29589998722076416},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.28760001063346863},{"id":"https://openalex.org/C2778852064","wikidata":"https://www.wikidata.org/wiki/Q4115619","display_name":"Virus latency","level":4,"score":0.28119999170303345},{"id":"https://openalex.org/C123233396","wikidata":"https://www.wikidata.org/wiki/Q14914361","display_name":"TRAF2","level":4,"score":0.2623000144958496},{"id":"https://openalex.org/C146998594","wikidata":"https://www.wikidata.org/wiki/Q7933625","display_name":"Viral tegument","level":2,"score":0.26019999384880066},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.25949999690055847},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.25760000944137573},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.2563000023365021},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.25450000166893005},{"id":"https://openalex.org/C89138240","wikidata":"https://www.wikidata.org/wiki/Q3066564","display_name":"Vero cell","level":3,"score":0.2506999969482422}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D011557","descriptor_name":"Pseudorabies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011557","descriptor_name":"Pseudorabies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011557","descriptor_name":"Pseudorabies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011557","descriptor_name":"Pseudorabies","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D011557","descriptor_name":"Pseudorabies","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D011557","descriptor_name":"Pseudorabies","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D011558","descriptor_name":"Herpesvirus 1, Suid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011558","descriptor_name":"Herpesvirus 1, Suid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011558","descriptor_name":"Herpesvirus 1, Suid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011558","descriptor_name":"Herpesvirus 1, Suid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011558","descriptor_name":"Herpesvirus 1, Suid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011558","descriptor_name":"Herpesvirus 1, Suid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036104","descriptor_name":"Receptor, EphA2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D036104","descriptor_name":"Receptor, EphA2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D036104","descriptor_name":"Receptor, EphA2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D036104","descriptor_name":"Receptor, EphA2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D036104","descriptor_name":"Receptor, EphA2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D036104","descriptor_name":"Receptor, EphA2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s13567-026-01829-4","doi":"https://doi.org/10.1186/s13567-026-01829-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13567-026-01829-4","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13567-026-01829-4.pdf","source":{"id":"https://openalex.org/S134003780","display_name":"Veterinary Research","issn_l":"0928-4249","issn":["0928-4249","1297-9716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Research","raw_type":"journal-article"},{"id":"pmid:42642744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42642744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary research","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05731885v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05731885","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Veterinary Research, 2026, 57 (1), pp.153. &#x27E8;10.1186/s13567-026-01829-4&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13508209","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13508209/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vet Res","raw_type":"Text"},{"id":"doi:10.6084/m9.figshare.c.8673886","doi":"https://doi.org/10.6084/m9.figshare.c.8673886","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.8673886","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Collection"},{"id":"doi:10.6084/m9.figshare.c.8673886.v1","doi":"https://doi.org/10.6084/m9.figshare.c.8673886.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.8673886.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Collection"}],"best_oa_location":{"id":"doi:10.1186/s13567-026-01829-4","doi":"https://doi.org/10.1186/s13567-026-01829-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13567-026-01829-4","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13567-026-01829-4.pdf","source":{"id":"https://openalex.org/S134003780","display_name":"Veterinary Research","issn_l":"0928-4249","issn":["0928-4249","1297-9716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6516429781913757,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4580110408","display_name":null,"funder_award_id":"32372982","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323711","display_name":"Southwest University","ror":"https://ror.org/01kj4z117"},{"id":"https://openalex.org/F4320336332","display_name":"Modern Agricultural Technology Industry System of Shandong province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204205554.pdf","grobid_xml":"https://content.openalex.org/works/W7204205554.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1972331061","https://openalex.org/W2042828514","https://openalex.org/W2089297912","https://openalex.org/W2126038087","https://openalex.org/W2169760197","https://openalex.org/W2802483635","https://openalex.org/W2910512414","https://openalex.org/W2951827312","https://openalex.org/W2954511535","https://openalex.org/W3029483728","https://openalex.org/W3077428160","https://openalex.org/W3080273770","https://openalex.org/W3081041850","https://openalex.org/W3084452902","https://openalex.org/W3109985685","https://openalex.org/W3150835161","https://openalex.org/W3164532544","https://openalex.org/W4220655639","https://openalex.org/W4286487985","https://openalex.org/W4323295119","https://openalex.org/W4367835182","https://openalex.org/W4372333409","https://openalex.org/W4376640987","https://openalex.org/W4388726254","https://openalex.org/W4395664800","https://openalex.org/W4400317890","https://openalex.org/W4402690576","https://openalex.org/W4404909442","https://openalex.org/W4408304576","https://openalex.org/W4408960177","https://openalex.org/W4410554163","https://openalex.org/W4411413395","https://openalex.org/W4413094381","https://openalex.org/W4413115445","https://openalex.org/W4414037245","https://openalex.org/W4416256782","https://openalex.org/W4416553055"],"related_works":[],"abstract_inverted_index":{"Herpesvirus":[0],"infection":[1,57],"triggers":[2],"excessive":[3],"inflammation,":[4,101,174],"contributing":[5],"to":[6,69,132,158],"tissue":[7],"injury":[8],"and":[9,44,48,51,66,140,175],"disease":[10],"severity,":[11],"but":[12],"the":[13,80,111],"underlying":[14],"drivers":[15],"remain":[16],"unclear.":[17],"Here":[18],"we":[19],"identify":[20],"EphA2":[21,37,59,81,123,157,176],"as":[22,96,102],"a":[23,86,97,116,127,150,169,179],"critical":[24,170],"mediator":[25],"of":[26,36,100,172],"pseudorabies":[27],"virus":[28],"(PRV)-induced":[29],"inflammatory":[30,138],"response.":[31],"Genetic":[32],"or":[33],"pharmacological":[34],"inhibition":[35],"reduced":[38],"TNF-\u03b1":[39,71],"production":[40],"in":[41,115,144],"PRV-infected":[42],"cells":[43],"mice,":[45],"alleviated":[46],"liver":[47],"lung":[49],"damage,":[50],"improved":[52],"mice":[53],"survival.":[54],"Mechanistically,":[55],"PRV":[56,74,129,154],"promoted":[58],"phosphorylation":[60],"at":[61],"Ser-897,":[62],"which":[63],"activated":[64],"NF-\u03baB":[65],"MAPK":[67],"pathways":[68],"drive":[70],"production.":[72,107],"The":[73],"tegument":[75],"protein":[76],"UL40":[77,108,155],"directly":[78],"bound":[79],"kinase":[82],"domain":[83],"(residues":[84],"697-901),":[85],"region":[87],"that":[88],"also":[89],"interacts":[90],"with":[91],"Akt.":[92],"Unexpectedly,":[93],"Akt":[94],"acted":[95],"negative":[98],"regulator":[99],"its":[103],"knockdown":[104],"exacerbated":[105],"cytokine":[106],"competitively":[109],"disrupted":[110],"constitutive":[112],"EphA2-Akt":[113],"complex":[114],"time-dependent":[117],"manner,":[118],"relieving":[119],"Akt-mediated":[120],"restraint":[121],"on":[122],"S897":[124,134,177],"phosphorylation.":[125],"Accordingly,":[126],"UL40-deficient":[128],"mutant":[130],"failed":[131],"enhance":[133],"phosphorylation,":[135],"elicited":[136],"lower":[137],"responses,":[139],"showed":[141],"attenuated":[142],"virulence":[143],"mice.":[145],"Collectively,":[146],"our":[147],"findings":[148],"reveal":[149],"proviral":[151],"strategy":[152],"whereby":[153],"hijacks":[156],"counteract":[159],"an":[160],"intrinsic":[161],"Akt-dependent":[162],"inhibitory":[163],"pathway.":[164],"This":[165],"UL40-EphA2-Akt":[166],"cascade":[167],"is":[168],"determinant":[171],"virus-induced":[173],"represents":[178],"potential":[180],"therapeutic":[181],"target":[182],"for":[183],"mitigating":[184],"alphaherpesvirus":[185],"immunopathology.":[186]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2026-08-26T00:00:00"}
