{"id":"https://openalex.org/W7204204238","doi":"https://doi.org/10.1002/sim.70710","title":"Dynamic Predictions and Predictimands for Salvage Therapy in Recurrent Prostate Cancer Using Joint Models","display_name":"Dynamic Predictions and Predictimands for Salvage Therapy in Recurrent Prostate Cancer Using Joint Models","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204204238","doi":"https://doi.org/10.1002/sim.70710","pmid":"https://pubmed.ncbi.nlm.nih.gov/42639747"},"language":"en","primary_location":{"id":"doi:10.1002/sim.70710","doi":"https://doi.org/10.1002/sim.70710","is_oa":true,"landing_page_url":"https://doi.org/10.1002/sim.70710","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sim.70710","source":{"id":"https://openalex.org/S55189604","display_name":"Statistics in Medicine","issn_l":"0277-6715","issn":["0277-6715","1097-0258"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sim.70710","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015883299","display_name":"Lukas Owens","orcid":"https://orcid.org/0000-0002-5149-5379","observed_orcids":["https://orcid.org/0000-0002-5149-5379"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lukas Owens","raw_affiliation_strings":["Division of Public Health Sciences Fred Hutchinson Cancer Center  Seattle Washington USA"],"raw_orcid":"https://orcid.org/0000-0002-5149-5379","affiliations":[{"raw_affiliation_string":"Division of Public Health Sciences Fred Hutchinson Cancer Center  Seattle Washington USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083133856","display_name":"Dimitris Rizopoulos","orcid":"https://orcid.org/0000-0001-9397-0900","observed_orcids":["https://orcid.org/0000-0001-9397-0900"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Dimitris Rizopoulos","raw_affiliation_strings":["Department of Biostatistics Erasmus University Medical Center  Rotterdam the Netherlands","Department of Epidemiology Erasmus University Medical Center  Rotterdam the Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-9397-0900","affiliations":[{"raw_affiliation_string":"Department of Biostatistics Erasmus University Medical Center  Rotterdam the Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Department of Epidemiology Erasmus University Medical Center  Rotterdam the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102991181","display_name":"Jonathan S. Fainberg","orcid":"https://orcid.org/0000-0002-7084-2743","observed_orcids":["https://orcid.org/0000-0002-7084-2743"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Fainberg","raw_affiliation_strings":["Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087481089","display_name":"Sigrid Carlsson","orcid":"https://orcid.org/0000-0003-3553-5710","observed_orcids":["https://orcid.org/0000-0003-3553-5710"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["DE","SE","US"],"is_corresponding":false,"raw_author_name":"Sigrid Carlsson","raw_affiliation_strings":["Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York New York USA","Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA","Department of Translational Medicine, Division of Urological Cancers Lund University  Lund Sweden","Division of Clinical Epidemiology of Early Cancer Detection German Cancer Research Center (DKFZ)  Heidelberg Germany"],"raw_orcid":"https://orcid.org/0000-0003-3553-5710","affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Translational Medicine, Division of Urological Cancers Lund University  Lund Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Division of Clinical Epidemiology of Early Cancer Detection German Cancer Research Center (DKFZ)  Heidelberg Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010511865","display_name":"Nicole Liso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Liso","raw_affiliation_strings":["Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077258060","display_name":"Sean M. McBride","orcid":"https://orcid.org/0000-0002-9676-1669","observed_orcids":["https://orcid.org/0000-0002-9676-1669"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean McBride","raw_affiliation_strings":["Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049771578","display_name":"Vincent Paul Laudone","orcid":"https://orcid.org/0000-0001-9263-9415","observed_orcids":["https://orcid.org/0000-0001-9263-9415"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent Laudone","raw_affiliation_strings":["Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136370956","display_name":"Ruth Etzioni","orcid":"https://orcid.org/0000-0002-9164-6370","observed_orcids":["https://orcid.org/0000-0002-9164-6370"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth Etzioni","raw_affiliation_strings":["Division of Public Health Sciences Fred Hutchinson Cancer Center  Seattle Washington USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Public Health Sciences Fred Hutchinson Cancer Center  Seattle Washington USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5123926284","display_name":"Jeremy M. G. Taylor","orcid":"https://orcid.org/0000-0003-2791-1229","observed_orcids":["https://orcid.org/0000-0003-2791-1229"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy M. G. Taylor","raw_affiliation_strings":["Department of Biostatistics University of Michigan  Ann Arbor Michigan USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics University of Michigan  Ann Arbor Michigan USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5015883299"],"corresponding_institution_ids":["https://openalex.org/I4210089486"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6848562,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"20-22","first_page":"e70710","last_page":"e70710"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.8213000297546387,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.8213000297546387,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.08259999752044678,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.041099999099969864,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/recurrent-prostate-cancer","display_name":"recurrent prostate cancer","score":0.9729999899864197},{"id":"https://openalex.org/keywords/biochemical-recurrence","display_name":"biochemical recurrence","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dynamic-prediction","display_name":"dynamic prediction","score":0.6930000185966492},{"id":"https://openalex.org/keywords/counterfactual-prediction","display_name":"counterfactual prediction","score":0.8119999766349792},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.7160000205039978},{"id":"https://openalex.org/keywords/time-varying-confounding","display_name":"time-varying confounding","score":0.9049999713897705},{"id":"https://openalex.org/keywords/treatment-timing","display_name":"treatment timing","score":0.7540000081062317},{"id":"https://openalex.org/keywords/metastasis-risk","display_name":"metastasis risk","score":0.8560000061988831},{"id":"https://openalex.org/keywords/monte-carlo-estimation","display_name":"Monte Carlo estimation","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6786999702453613},{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.5824000239372253},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5570999979972839},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5414999723434448},{"id":"https://openalex.org/C108650721","wikidata":"https://www.wikidata.org/wiki/Q1783253","display_name":"Counterfactual thinking","level":2,"score":0.535099983215332},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5146999955177307},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.47119998931884766},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4648999869823456},{"id":"https://openalex.org/C2780775027","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Salvage therapy","level":3,"score":0.45339998602867126},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.3747999966144562},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.3702000081539154},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.36079999804496765},{"id":"https://openalex.org/C2909113890","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Recurrent prostate cancer","level":5,"score":0.3573000133037567},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.351500004529953},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.34860000014305115},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.34769999980926514},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3458000123500824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33329999446868896},{"id":"https://openalex.org/C2777008409","wikidata":"https://www.wikidata.org/wiki/Q4914714","display_name":"Biochemical recurrence","level":5,"score":0.33219999074935913},{"id":"https://openalex.org/C18555067","wikidata":"https://www.wikidata.org/wiki/Q8375051","display_name":"Joint (building)","level":2,"score":0.3294000029563904},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.310699999332428},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.2957000136375427},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2912999987602234},{"id":"https://openalex.org/C2776141087","wikidata":"https://www.wikidata.org/wiki/Q2161551","display_name":"Watchful waiting","level":4,"score":0.2851000130176544},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.28459998965263367},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.2750000059604645},{"id":"https://openalex.org/C147168706","wikidata":"https://www.wikidata.org/wiki/Q1457734","display_name":"Recurrent neural network","level":3,"score":0.2687999904155731},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2578999996185303},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2556999921798706},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.2533999979496002},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.25279998779296875}],"mesh":[{"descriptor_ui":"D000098437","descriptor_name":"Prediction Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098437","descriptor_name":"Prediction Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098437","descriptor_name":"Prediction Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098437","descriptor_name":"Prediction Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016879","descriptor_name":"Salvage Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016879","descriptor_name":"Salvage Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016879","descriptor_name":"Salvage Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016879","descriptor_name":"Salvage Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/sim.70710","doi":"https://doi.org/10.1002/sim.70710","is_oa":true,"landing_page_url":"https://doi.org/10.1002/sim.70710","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sim.70710","source":{"id":"https://openalex.org/S55189604","display_name":"Statistics in Medicine","issn_l":"0277-6715","issn":["0277-6715","1097-0258"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in Medicine","raw_type":"journal-article"},{"id":"pmid:42639747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42639747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13504709","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13504709/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13504709/pdf/SIM-45-0.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stat Med","raw_type":"Text"},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/782ab6b7-6547-430b-b0f8-f85cbdc6f4d8","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/782ab6b7-6547-430b-b0f8-f85cbdc6f4d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Owens, L, Rizopoulos, D, Fainberg, J, Carlsson, S, Liso, N, McBride, S, Laudone, V, Etzioni, R & Taylor, J M G 2026, 'Dynamic Predictions and Predictimands for Salvage Therapy in Recurrent Prostate Cancer Using Joint Models', Statistics in Medicine, vol. 45, no. 20-22, e70710. https://doi.org/10.1002/sim.70710","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/sim.70710","doi":"https://doi.org/10.1002/sim.70710","is_oa":true,"landing_page_url":"https://doi.org/10.1002/sim.70710","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sim.70710","source":{"id":"https://openalex.org/S55189604","display_name":"Statistics in Medicine","issn_l":"0277-6715","issn":["0277-6715","1097-0258"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5973482728004456,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2472941002","display_name":null,"funder_award_id":"CA253915","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5667720541","display_name":null,"funder_award_id":"U01 CA253915","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G836263805","display_name":null,"funder_award_id":"#R35 CA274442","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204204238.pdf","grobid_xml":"https://content.openalex.org/works/W7204204238.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W2023126708","https://openalex.org/W2141976715","https://openalex.org/W2159790321","https://openalex.org/W2323487608","https://openalex.org/W2505625229","https://openalex.org/W2510755861","https://openalex.org/W2962811743","https://openalex.org/W2987006811","https://openalex.org/W4240400659","https://openalex.org/W4302770418","https://openalex.org/W4392951589"],"related_works":[],"abstract_inverted_index":{"Prostate":[0],"cancer":[1],"patients":[2,139],"with":[3,140],"biochemical":[4,98],"recurrence":[5],"(BCR)":[6],"face":[7],"a":[8,74,118,135,147,162,175,180,213,222],"decision":[9,34],"of":[10,22,28,54,77,80,92,95,107,126,132,137,225,233],"whether":[11],"to":[12,35,63,83,89,113,173,197,206,221,239],"start":[13,36],"salvage":[14],"therapy":[15],"(ST),":[16],"which":[17],"may":[18],"reduce":[19],"the":[20,26,33,67,78,90,105,130,231,246],"probability":[21],"metastatic":[23],"progression":[24],"at":[25,38],"cost":[27],"side":[29],"effects.":[30],"To":[31],"inform":[32],"ST":[37,166],"or":[39],"after":[40,97,150],"BCR,":[41],"models":[42,56,112,196],"that":[43,128],"make":[44],"counterfactual":[45,228],"predictions":[46,193,229],"incorporating":[47],"treatment":[48,96,160,200],"are":[49],"highly":[50],"desirable.":[51],"However,":[52],"estimation":[53],"such":[55,241],"using":[57],"observational":[58],"data":[59],"requires":[60],"care":[61],"due":[62,88],"time-varying":[64,234],"confounding":[65],"by":[66],"longitudinal":[68,109],"biomarker":[69],"prostate-specific":[70],"antigen":[71],"(PSA).":[72],"Moreover,":[73],"careful":[75],"definition":[76],"estimands":[79],"interest,":[81],"referred":[82],"as":[84],"\"predictimands\",":[85],"is":[86,167,171,204,243],"required":[87],"possibility":[91],"delayed":[93],"initiation":[94],"recurrence.":[99],"In":[100],"this":[101],"study,":[102],"we":[103],"utilize":[104],"framework":[106],"joint":[108,195],"and":[110,124,159,210,236],"survival":[111],"tackle":[114],"these":[115,186],"issues,":[116],"estimating":[117],"model":[119],"for":[120,146,184,199],"pre-ST":[121],"PSA":[122,170],"trajectories":[123],"risk":[125],"metastasis":[127],"incorporates":[129],"effect":[131],"ST,":[133],"from":[134,194],"dataset":[136],"2075":[138],"BCR.":[141],"We":[142,178],"define":[143],"relevant":[144],"predictimands":[145],"new":[148],"patient":[149,209],"BCR":[151],"under":[152,161],"three":[153],"scenarios:":[154],"Immediately":[155],"treated,":[156,158],"never":[157],"dynamic":[163,192],"regime,":[164],"where":[165],"started":[168],"when":[169],"observed":[172],"exceed":[174],"pre-specified":[176],"threshold.":[177],"propose":[179],"Monte":[181],"Carlo":[182],"scheme":[183],"computing":[185],"predictimands,":[187],"adapting":[188],"previous":[189],"work":[190],"on":[191],"account":[198],"timing.":[201],"This":[202,216],"methodology":[203,217],"applied":[205],"an":[207],"example":[208],"validated":[211],"in":[212,230,245],"simulation":[214],"study.":[215],"could":[218],"be":[219],"adapted":[220],"wide":[223],"variety":[224],"applications":[226],"requiring":[227],"presence":[232],"treatments":[235],"biomarkers.":[237],"Code":[238],"implement":[240],"analyses":[242],"available":[244],"R":[247],"package":[248],"JMbayes2.":[249]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2026-08-26T00:00:00"}