{"id":"https://openalex.org/W7204202895","doi":"https://doi.org/10.1016/j.ymthe.2026.08.035","title":"C-terminal CD28 phosphorylation, pY218, modulates IL-2 secretion and therapeutic effect of CAR-T cells","display_name":"C-terminal CD28 phosphorylation, pY218, modulates IL-2 secretion and therapeutic effect of CAR-T cells","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7204202895","doi":"https://doi.org/10.1016/j.ymthe.2026.08.035","pmid":"https://pubmed.ncbi.nlm.nih.gov/41659581","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12874040"},"language":"en","primary_location":{"id":"doi:10.1016/j.ymthe.2026.08.035","doi":"https://doi.org/10.1016/j.ymthe.2026.08.035","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2026.08.035","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.ymthe.2026.08.035","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013941982","display_name":"Elena Martinez Planes","orcid":"https://orcid.org/0009-0006-3220-5395","observed_orcids":["https://orcid.org/0009-0006-3220-5395"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena Martinez-Planes","raw_affiliation_strings":["Department of Immunology, H. Lee Moffitt Cancer Center and Research Center Institute, Tampa, FL 33612, USA"],"raw_orcid":"https://orcid.org/0009-0006-3220-5395","affiliations":[{"raw_affiliation_string":"Department of Immunology, H. Lee Moffitt Cancer Center and Research Center Institute, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068475093","display_name":"Maria Cecilia Ramello","orcid":"https://orcid.org/0000-0001-8108-141X","observed_orcids":["https://orcid.org/0000-0001-8108-141X"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Cecilia Ramello","raw_affiliation_strings":["Department of Immunology, H. Lee Moffitt Cancer Center and Research Center Institute, Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, H. Lee Moffitt Cancer Center and Research Center Institute, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056301950","display_name":"Miguel Gomez Fontela","orcid":"https://orcid.org/0000-0002-7563-3350","observed_orcids":["https://orcid.org/0000-0002-7563-3350"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miguel G. Fontela","raw_affiliation_strings":["Department of Immunology, H. Lee Moffitt Cancer Center and Research Center Institute, Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, H. Lee Moffitt Cancer Center and Research Center Institute, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013358334","display_name":"Mohammad-Reza Shokri","orcid":"https://orcid.org/0000-0001-8037-8940","observed_orcids":["https://orcid.org/0000-0001-8037-8940"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad-Reza Shokri","raw_affiliation_strings":["Department of Immunology, H. Lee Moffitt Cancer Center and Research Center Institute, Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, H. Lee Moffitt Cancer Center and Research Center Institute, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023097444","display_name":"Timothy H. Tran","orcid":"https://orcid.org/0000-0003-1342-7620","observed_orcids":["https://orcid.org/0000-0003-1342-7620"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy H. Tran","raw_affiliation_strings":["Chemical Biology Core, Structural Biology Division, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"],"raw_orcid":"https://orcid.org/0000-0003-1342-7620","affiliations":[{"raw_affiliation_string":"Chemical Biology Core, Structural Biology Division, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087517890","display_name":"Lancia N. F. Darville","orcid":"https://orcid.org/0000-0002-9793-3741","observed_orcids":["https://orcid.org/0000-0002-9793-3741"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lancia Darville","raw_affiliation_strings":["Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124725531","display_name":"John Koomen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Koomen","raw_affiliation_strings":["Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124735595","display_name":"Youngchul Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youngchul Kim","raw_affiliation_strings":["Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Center Institute, Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Center Institute, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028956946","display_name":"Daniel Abate\u2010Daga","orcid":"https://orcid.org/0000-0002-2571-0215","observed_orcids":["https://orcid.org/0000-0002-2571-0215"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel Abate-Daga","raw_affiliation_strings":["Department of Immunology, H. Lee Moffitt Cancer Center and Research Center Institute, Tampa, FL 33612, USA. Electronic address: daniel.abate-daga@moffitt.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, H. Lee Moffitt Cancer Center and Research Center Institute, Tampa, FL 33612, USA. Electronic address: daniel.abate-daga@moffitt.org","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028956946"],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58500944,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd28","display_name":"CD28","score":0.9760000109672546},{"id":"https://openalex.org/keywords/il-2-secretion","display_name":"IL-2 secretion","score":0.8619999885559082},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/itk","display_name":"ITK","score":0.925000011920929},{"id":"https://openalex.org/keywords/il-17a","display_name":"IL-17A","score":0.7170000076293945},{"id":"https://openalex.org/keywords/il-17f","display_name":"IL-17F","score":0.9629999995231628},{"id":"https://openalex.org/keywords/costimulation","display_name":"costimulation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/antitumor-efficacy","display_name":"antitumor efficacy","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.7389000058174133},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.657800018787384},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.6205999851226807},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48500001430511475},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.47200000286102295},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4659999907016754},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3050000071525574},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29580000042915344},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28839999437332153},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2551000118255615}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.ymthe.2026.08.035","doi":"https://doi.org/10.1016/j.ymthe.2026.08.035","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2026.08.035","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},{"id":"doi:10.64898/2026.01.28.701378","doi":"https://doi.org/10.64898/2026.01.28.701378","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.01.28.701378","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41659581","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41659581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42642932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42642932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy : the journal of the American Society of Gene Therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13670897","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13670897/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11681576","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12874040","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.ymthe.2026.08.035","doi":"https://doi.org/10.1016/j.ymthe.2026.08.035","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2026.08.035","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3949532679","display_name":"KIR2DL2 Immune Checkpoint as Modulator of T-Cell Effector Function","funder_award_id":"5r21ca280233-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000876523","display_name":"Moffitt Cancer Center Support Grant","funder_award_id":"P30CA076292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320312058","display_name":"\u201cla Caixa\u201d Foundation","ror":"https://ror.org/03zhx9h04"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1566606277","https://openalex.org/W1619537825","https://openalex.org/W1804861156","https://openalex.org/W1926597952","https://openalex.org/W1964399995","https://openalex.org/W1971519497","https://openalex.org/W1976933694","https://openalex.org/W1981593008","https://openalex.org/W1982795546","https://openalex.org/W1991623174","https://openalex.org/W1993778590","https://openalex.org/W1995976925","https://openalex.org/W1997025161","https://openalex.org/W2006428939","https://openalex.org/W2026465178","https://openalex.org/W2030728145","https://openalex.org/W2052561585","https://openalex.org/W2053968039","https://openalex.org/W2070113813","https://openalex.org/W2071131149","https://openalex.org/W2074067501","https://openalex.org/W2081236127","https://openalex.org/W2109495864","https://openalex.org/W2133544019","https://openalex.org/W2134526812","https://openalex.org/W2141091417","https://openalex.org/W2142017607","https://openalex.org/W2144491853","https://openalex.org/W2144796561","https://openalex.org/W2145115817","https://openalex.org/W2153983456","https://openalex.org/W2158947557","https://openalex.org/W2160717085","https://openalex.org/W2162143298","https://openalex.org/W2169456326","https://openalex.org/W2169936410","https://openalex.org/W2173132728","https://openalex.org/W2179438025","https://openalex.org/W2237146032","https://openalex.org/W2395845086","https://openalex.org/W2771398071","https://openalex.org/W2773804840","https://openalex.org/W2774812597","https://openalex.org/W2787301955","https://openalex.org/W2787578932","https://openalex.org/W2789780246","https://openalex.org/W2790362095","https://openalex.org/W2792889166","https://openalex.org/W2801032953","https://openalex.org/W2801680389","https://openalex.org/W2888019042","https://openalex.org/W2903062212","https://openalex.org/W2912983001","https://openalex.org/W2940767284","https://openalex.org/W2944669426","https://openalex.org/W2971364607","https://openalex.org/W2972117761","https://openalex.org/W3005178769","https://openalex.org/W3008558475","https://openalex.org/W3099784960","https://openalex.org/W3182446092","https://openalex.org/W4284693043","https://openalex.org/W4393001462","https://openalex.org/W4394009626","https://openalex.org/W4394810127","https://openalex.org/W4396721167","https://openalex.org/W4399389890","https://openalex.org/W4399731408"],"related_works":["https://openalex.org/W7127054808","https://openalex.org/W4404064092","https://openalex.org/W4362596865","https://openalex.org/W4308377058","https://openalex.org/W4416449650","https://openalex.org/W2057739983","https://openalex.org/W2991829535","https://openalex.org/W2910372856","https://openalex.org/W2969242730","https://openalex.org/W7132923957"],"abstract_inverted_index":{"CD28":[0,30,48],"is":[1,61],"a":[2,52,69,104,107,140,144,183],"costimulatory":[3],"component":[4],"of":[5,28,76,90,97,173],"several":[6],"second-generation":[7],"chimeric":[8],"antigen":[9],"receptor":[10],"(CAR)-T":[11],"cells,":[12],"providing":[13],"signals":[14],"essential":[15,62],"for":[16,63],"T":[17,122],"cell":[18,35,66,123,179],"proliferation,":[19],"survival,":[20],"and":[21,56,84,100,161,181],"cytokine":[22],"secretion.":[23],"However,":[24],"the":[25,47,120,170],"specific":[26],"contribution":[27],"individual":[29],"intracellular":[31],"motifs":[32],"to":[33,80,114,185,193],"CAR-T":[34,65,92,178],"function":[36],"remains":[37],"incompletely":[38],"understood.":[39],"Here,":[40],"we":[41,72,117,138],"identify":[42],"tyrosine":[43],"218":[44],"(Y218)":[45],"in":[46,165,176],"cytoplasmic":[49],"domain":[50],"as":[51],"critical":[53],"regulatory":[54],"site":[55],"demonstrate":[57,118],"that":[58,74,111,119],"its":[59],"phosphorylation":[60,78,175],"optimal":[64],"activity.":[67],"Using":[68],"218F":[70,91],"mutant,":[71],"show":[73],"loss":[75],"Y218":[77,127,156,174],"leads":[79],"impaired":[81],"IL-2":[82,159],"production":[83],"abrogates":[85],"antitumor":[86,163],"efficacy.":[87,196],"Transcriptomic":[88],"profiling":[89],"cells":[93],"revealed":[94],"increased":[95],"expression":[96],"IL-17A,":[98],"IL-17F,":[99],"related":[101],"cytokines,":[102],"suggesting":[103],"shift":[105],"toward":[106],"pro-inflammatory":[108],"Th17-like":[109],"phenotype":[110],"may":[112],"contribute":[113],"dysfunction.":[115],"Mechanistically,":[116],"interleukin-2-inducible":[121],"kinase,":[124],"ITK,":[125],"mediates":[126],"phosphorylation.":[128],"To":[129],"translate":[130],"this":[131],"mechanistic":[132],"insight":[133],"into":[134],"improving":[135],"CAR":[136,142,187],"design,":[137],"engineered":[139],"novel":[141,150],"incorporating":[143],"synthetic":[145],"ITK-binding":[146],"motif":[147],"(PYRP).":[148],"This":[149],"design":[151],"enhances":[152],"ITK":[153],"recruitment,":[154],"increases":[155],"phosphorylation,":[157],"boosts":[158],"secretion,":[160],"improves":[162],"efficacy":[164],"vivo.":[166],"Our":[167],"findings":[168],"underscore":[169],"functional":[171],"relevance":[172],"modulating":[177],"fate":[180],"reveal":[182],"strategy":[184],"fine-tune":[186],"signaling":[188],"through":[189],"targeted":[190],"kinase":[191],"recruitment":[192],"enhance":[194],"therapeutic":[195]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-26T00:00:00"}
