{"id":"https://openalex.org/W7204202601","doi":"https://doi.org/10.1080/21688370.2026.2721715","title":"Decoding the multidimensional landscape of skin aging: molecular pathways and next-generation diagnostics & therapeutics","display_name":"Decoding the multidimensional landscape of skin aging: molecular pathways and next-generation diagnostics & therapeutics","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204202601","doi":"https://doi.org/10.1080/21688370.2026.2721715","pmid":"https://pubmed.ncbi.nlm.nih.gov/42640108"},"language":"en","primary_location":{"id":"doi:10.1080/21688370.2026.2721715","doi":"https://doi.org/10.1080/21688370.2026.2721715","is_oa":false,"landing_page_url":"https://doi.org/10.1080/21688370.2026.2721715","pdf_url":null,"source":{"id":"https://openalex.org/S2764733849","display_name":"Tissue Barriers","issn_l":"2168-8370","issn":["2168-8370","2168-8362"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Barriers","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7204202601"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010544497","display_name":"Megha Sharma","orcid":"https://orcid.org/0009-0005-4019-9223","observed_orcids":["https://orcid.org/0009-0005-4019-9223","https://orcid.org/0009-0006-8488-350X"]},"institutions":[{"id":"https://openalex.org/I154970844","display_name":"Jaypee Institute of Information Technology","ror":"https://ror.org/05sttyy11","country_code":"IN","type":"education","lineage":["https://openalex.org/I154970844"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Megha Sharma","raw_affiliation_strings":["Jaypee Institute of Information Technology (Main Campus)"],"raw_orcid":"https://orcid.org/0009-0005-4019-9223","affiliations":[{"raw_affiliation_string":"Jaypee Institute of Information Technology (Main Campus)","institution_ids":["https://openalex.org/I154970844"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089787200","display_name":"Sonam Chawla","orcid":"https://orcid.org/0000-0002-6187-4778","observed_orcids":["https://orcid.org/0000-0002-6187-4778"]},"institutions":[{"id":"https://openalex.org/I154970844","display_name":"Jaypee Institute of Information Technology","ror":"https://ror.org/05sttyy11","country_code":"IN","type":"education","lineage":["https://openalex.org/I154970844"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sonam Chawla","raw_affiliation_strings":["Jaypee Institute of Information Technology (Main Campus)"],"raw_orcid":"https://orcid.org/0000-0002-6187-4778","affiliations":[{"raw_affiliation_string":"Jaypee Institute of Information Technology (Main Campus)","institution_ids":["https://openalex.org/I154970844"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089787200"],"corresponding_institution_ids":["https://openalex.org/I154970844"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"2721715","last_page":"2721715"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-aging","display_name":"skin aging","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chronological-aging","display_name":"chronological aging","score":0.8080000281333923},{"id":"https://openalex.org/keywords/intrinsic-aging","display_name":"intrinsic aging","score":0.6840000152587891},{"id":"https://openalex.org/keywords/extrinsic-aging","display_name":"extrinsic aging","score":0.9879999756813049},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.8690000176429749},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9729999899864197},{"id":"https://openalex.org/keywords/fibroblast-senescence","display_name":"fibroblast senescence","score":0.9330000281333923},{"id":"https://openalex.org/keywords/epigenetic-drift","display_name":"epigenetic drift","score":0.8700000047683716},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.847000002861023},{"id":"https://openalex.org/keywords/uv-photo-oxidation","display_name":"UV photo-oxidation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/skin-barrier-dysfunction","display_name":"skin barrier dysfunction","score":0.5329999923706055},{"id":"https://openalex.org/keywords/collagen-degradation","display_name":"collagen degradation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/inflammaging","display_name":"inflammaging","score":0.8040000200271606},{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9049999713897705},{"id":"https://openalex.org/keywords/nf-kappab-mapk-signaling","display_name":"MAPK/NF-\u03baB signaling","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tgf-beta-smad-signaling-pathway","display_name":"TGF-\u03b2/Smad signaling","score":0.9819999933242798},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.996999979019165},{"id":"https://openalex.org/keywords/sirtuins","display_name":"sirtuins","score":0.9700000286102295},{"id":"https://openalex.org/keywords/skin-microbiome","display_name":"skin microbiome","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cutometer","display_name":"Cutometer","score":0.6150000095367432},{"id":"https://openalex.org/keywords/nanoformulations","display_name":"nanoformulations","score":0.6480000019073486},{"id":"https://openalex.org/keywords/epigenetic-reprogramming","display_name":"epigenetic reprogramming","score":0.9039999842643738},{"id":"https://openalex.org/keywords/senolytics","display_name":"senolytics","score":0.9959999918937683},{"id":"https://openalex.org/keywords/anti-aging-therapeutics","display_name":"anti-aging therapeutics","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6209999918937683},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5835000276565552},{"id":"https://openalex.org/C2909910311","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Skin Aging","level":2,"score":0.5792999863624573},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47690001130104065},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.41760000586509705},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41429999470710754},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4075999855995178},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4034000039100647},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3882000148296356},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3871000111103058},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.37689998745918274},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.37560001015663147},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.367900013923645},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3515999913215637},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3474000096321106},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.3160000145435333},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.3012999892234802},{"id":"https://openalex.org/C165932988","wikidata":"https://www.wikidata.org/wiki/Q7101746","display_name":"Organ-on-a-chip","level":3,"score":0.3001999855041504},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.29089999198913574},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.28839999437332153},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.2872999906539917},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.2854999899864197},{"id":"https://openalex.org/C2991981033","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Skin barrier","level":2,"score":0.2554999887943268},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.2502000033855438}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/21688370.2026.2721715","doi":"https://doi.org/10.1080/21688370.2026.2721715","is_oa":false,"landing_page_url":"https://doi.org/10.1080/21688370.2026.2721715","pdf_url":null,"source":{"id":"https://openalex.org/S2764733849","display_name":"Tissue Barriers","issn_l":"2168-8370","issn":["2168-8370","2168-8362"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Barriers","raw_type":"journal-article"},{"id":"pmid:42640108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42640108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue barriers","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328353","display_name":"Jaypee Institute of Information Technology","ror":"https://ror.org/05sttyy11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":196,"referenced_works":["https://openalex.org/W1528231423","https://openalex.org/W1669527760","https://openalex.org/W2039248729","https://openalex.org/W2052813747","https://openalex.org/W2069628967","https://openalex.org/W2093361740","https://openalex.org/W2162996266","https://openalex.org/W2185134274","https://openalex.org/W2308711581","https://openalex.org/W2427895239","https://openalex.org/W2629996009","https://openalex.org/W2765525576","https://openalex.org/W2784164089","https://openalex.org/W2888940174","https://openalex.org/W2891006520","https://openalex.org/W2910608361","https://openalex.org/W2911342375","https://openalex.org/W2912583419","https://openalex.org/W2926445293","https://openalex.org/W2940564657","https://openalex.org/W2951872997","https://openalex.org/W2952937900","https://openalex.org/W2965081252","https://openalex.org/W2967114091","https://openalex.org/W2969429304","https://openalex.org/W2971314327","https://openalex.org/W2971363373","https://openalex.org/W2972626908","https://openalex.org/W2974461575","https://openalex.org/W2979051140","https://openalex.org/W2980875709","https://openalex.org/W2982198406","https://openalex.org/W2990428470","https://openalex.org/W2998362383","https://openalex.org/W2999465434","https://openalex.org/W2999655917","https://openalex.org/W3001702071","https://openalex.org/W3006133913","https://openalex.org/W3007792051","https://openalex.org/W3009761771","https://openalex.org/W3010429611","https://openalex.org/W3013946215","https://openalex.org/W3014384057","https://openalex.org/W3015264051","https://openalex.org/W3022615893","https://openalex.org/W3024687736","https://openalex.org/W3032854954","https://openalex.org/W3033656382","https://openalex.org/W3036524281","https://openalex.org/W3044606504","https://openalex.org/W3044938674","https://openalex.org/W3047910909","https://openalex.org/W3087929852","https://openalex.org/W3089994865","https://openalex.org/W3090114299","https://openalex.org/W3092422466","https://openalex.org/W3094257751","https://openalex.org/W3108736543","https://openalex.org/W3108849603","https://openalex.org/W3111280890","https://openalex.org/W3113013277","https://openalex.org/W3115895814","https://openalex.org/W3117437033","https://openalex.org/W3122971209","https://openalex.org/W3125907883","https://openalex.org/W3129841130","https://openalex.org/W3132129564","https://openalex.org/W3134557556","https://openalex.org/W3139226133","https://openalex.org/W3146384614","https://openalex.org/W3155726245","https://openalex.org/W3157638995","https://openalex.org/W3163095124","https://openalex.org/W3168869046","https://openalex.org/W3189546038","https://openalex.org/W3197920949","https://openalex.org/W3199592381","https://openalex.org/W3201712279","https://openalex.org/W3207668987","https://openalex.org/W3210597398","https://openalex.org/W3214922888","https://openalex.org/W3215010548","https://openalex.org/W3215035283","https://openalex.org/W3215528319","https://openalex.org/W3216044194","https://openalex.org/W3216242846","https://openalex.org/W3217122146","https://openalex.org/W4205730966","https://openalex.org/W4210719890","https://openalex.org/W4214483686","https://openalex.org/W4220657298","https://openalex.org/W4220973307","https://openalex.org/W4223916500","https://openalex.org/W4280593523","https://openalex.org/W4281669426","https://openalex.org/W4281805377","https://openalex.org/W4283380016","https://openalex.org/W4286447743","https://openalex.org/W4289028880","https://openalex.org/W4289521098","https://openalex.org/W4292236939","https://openalex.org/W4294767481","https://openalex.org/W4296035972","https://openalex.org/W4296771181","https://openalex.org/W4298087062","https://openalex.org/W4298089151","https://openalex.org/W4304146106","https://openalex.org/W4308061206","https://openalex.org/W4309220848","https://openalex.org/W4309297893","https://openalex.org/W4309472908","https://openalex.org/W4310211357","https://openalex.org/W4311510624","https://openalex.org/W4311793476","https://openalex.org/W4312117542","https://openalex.org/W4312194518","https://openalex.org/W4313326608","https://openalex.org/W4315795729","https://openalex.org/W4318818972","https://openalex.org/W4319599402","https://openalex.org/W4319970176","https://openalex.org/W4321097255","https://openalex.org/W4321373033","https://openalex.org/W4322770093","https://openalex.org/W4323050489","https://openalex.org/W4361287294","https://openalex.org/W4362637328","https://openalex.org/W4362657067","https://openalex.org/W4366083711","https://openalex.org/W4367461136","https://openalex.org/W4376504211","https://openalex.org/W4378515677","https://openalex.org/W4378805857","https://openalex.org/W4378983094","https://openalex.org/W4385226081","https://openalex.org/W4385729684","https://openalex.org/W4385994512","https://openalex.org/W4386079340","https://openalex.org/W4386258787","https://openalex.org/W4386409353","https://openalex.org/W4387022561","https://openalex.org/W4387772637","https://openalex.org/W4387949317","https://openalex.org/W4387950586","https://openalex.org/W4388034964","https://openalex.org/W4388482895","https://openalex.org/W4388701376","https://openalex.org/W4388977595","https://openalex.org/W4389475364","https://openalex.org/W4389976758","https://openalex.org/W4391033828","https://openalex.org/W4391685416","https://openalex.org/W4391690569","https://openalex.org/W4391987161","https://openalex.org/W4392357250","https://openalex.org/W4393192731","https://openalex.org/W4394583900","https://openalex.org/W4396849534","https://openalex.org/W4397022525","https://openalex.org/W4397033838","https://openalex.org/W4399363628","https://openalex.org/W4399982487","https://openalex.org/W4401962532","https://openalex.org/W4402857796","https://openalex.org/W4403287357","https://openalex.org/W4403552875","https://openalex.org/W4403762310","https://openalex.org/W4403947998","https://openalex.org/W4404711810","https://openalex.org/W4404884757","https://openalex.org/W4405239525","https://openalex.org/W4405547418","https://openalex.org/W4405833556","https://openalex.org/W4406027886","https://openalex.org/W4406069071","https://openalex.org/W4406217297","https://openalex.org/W4406607776","https://openalex.org/W4406884228","https://openalex.org/W4407240799","https://openalex.org/W4407905544","https://openalex.org/W4408339069","https://openalex.org/W4408548219","https://openalex.org/W4408821771","https://openalex.org/W4410055416","https://openalex.org/W4410160903","https://openalex.org/W4411285406","https://openalex.org/W4411394747","https://openalex.org/W4411540036","https://openalex.org/W4411593075","https://openalex.org/W4413788568","https://openalex.org/W4413824453","https://openalex.org/W4414797621","https://openalex.org/W4415059782","https://openalex.org/W4415151427","https://openalex.org/W4415850453","https://openalex.org/W4416009099"],"related_works":["https://openalex.org/W7162021645","https://openalex.org/W4412175010","https://openalex.org/W7158278682","https://openalex.org/W3215010548","https://openalex.org/W7157237541","https://openalex.org/W7223260200","https://openalex.org/W4412780063","https://openalex.org/W2507940711","https://openalex.org/W7165795884","https://openalex.org/W2025725196"],"abstract_inverted_index":{"Skin":[0],"aging":[1,24,218],"is":[2,25,219],"a":[3,220,225],"multifactorial,":[4],"dynamically":[5],"regulated":[6],"biological":[7,175],"process":[8],"modulated":[9],"by":[10,27],"the":[11,83,234],"synergistic":[12],"interplay":[13],"of":[14,90,107,178,182,204],"intrinsic":[15,61],"genetic":[16],"programming":[17],"and":[18,38,55,60,74,87,123,138,170,180,184,197,228,241],"extrinsic":[19],"environmental":[20],"stressors.":[21],"Chronological":[22],"skin":[23,91,133,217],"dominated":[26],"molecular":[28,226],"signatures":[29],"such":[30,43],"as":[31,44,127,143],"telomere":[32],"attrition,":[33],"mitochondrial":[34,125,198],"dysfunction,":[35,71],"epigenetic":[36,194],"drift,":[37],"fibroblast":[39],"senescence.":[40],"Extrinsic":[41,59],"factors":[42,145],"UV-induced":[45],"photooxidation,":[46],"pollution,":[47],"lifestyle":[48],"toxins":[49],"accelerate":[50],"ROS":[51],"surge,":[52],"DNA":[53],"photolesions,":[54],"extracellular":[56],"matrix":[57],"fragmentation.":[58],"pathways":[62],"converge":[63],"to":[64],"cause":[65],"epidermal":[66],"thinning,":[67],"collagen":[68],"degradation,":[69],"barrier":[70,136],"pigmentation":[72],"heterogeneity":[73],"inflammaging-driven":[75],"microenvironmental":[76],"collapse.":[77],"In":[78,215],"this":[79],"review,":[80],"we":[81],"decode":[82],"structural,":[84],"cellular,":[85],"molecular,":[86],"biomechanical":[88],"axes":[89],"aging,":[92],"highlighting":[93,210],"ROS-driven":[94],"MAPK":[95],"(Mitogen-activated":[96],"protein":[97],"kinase)/NF-\u03baB":[98],"(Nuclear":[99],"factor":[100],"kappa-B)":[101],"activation,":[102],"PI3K/Akt-mTOR":[103],"(Phosphoinositide":[104],"3-kinase/Mechanistic":[105],"target":[106],"rapamycin)":[108],"dysregulation,":[109],"TGF-\u03b2/Smad":[110],"(Transforming":[111],"growth":[112],"factor-\u03b2/SMAD":[113],"signaling)":[114],"impairment,":[115],"Wnt/\u03b2-catenin":[116],"(Wnt":[117],"signaling":[118],"pathway/\u03b2-catenin)":[119],"decline,":[120],"mechanotransduction":[121],"failure,":[122],"sirtuin-mediated":[124],"compromise":[126],"central":[128],"mediators.":[129],"We":[130],"also":[131],"discuss":[132],"dysbiosis\u2011driven":[134],"lipid":[135],"disruption,":[137],"senescence\u2011associated":[139],"secretory":[140],"phenotype\u2011driven":[141],"inflammaging":[142],"underlying":[144],"for":[146,167,213],"systemic":[147],"inflammatory":[148],"disorder-like":[149],"phenotype":[150],"in":[151,173,202,237],"aged":[152],"skin.":[153],"Cutting-edge":[154],"diagnostic":[155],"advances":[156],"-":[157,187],"Cutometer\u00ae-based":[158],"elasticity":[159],"mapping,":[160],"corneometry,":[161],"AI-assisted":[162],"histopathology":[163],"etc":[164],"are":[165,200],"discussed":[166,201],"aiding":[168],"rapid":[169],"objective":[171],"precision":[172,242],"quantifying":[174],"age.":[176],"Mechanism":[177],"action":[179],"application":[181],"emerging":[183],"innovative":[185],"dermato-therapeutics":[186],"probiotic/postbiotic-based":[188],"microbiome":[189],"modulation,":[190],"nanoformulation-driven":[191],"targeted":[192],"delivery,":[193],"reprogramming,":[195],"senolytics,":[196],"revitalization":[199],"terms":[203],"their":[205],"current":[206],"limitations":[207],"(specificity,":[208],"stability),":[209],"future":[211],"scope":[212],"action.":[214],"summary,":[216],"multidimensional":[221],"process,":[222],"orchestrated":[223],"at":[224],"level,":[227],"clinically":[229],"actionable-one":[230],"that":[231],"will":[232],"enable":[233],"next":[235],"leap":[236],"personalized":[238],"anti-aging":[239],"innovation":[240],"dermatology":[243],"frameworks.":[244]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-26T00:00:00"}