{"id":"https://openalex.org/W7204202174","doi":"https://doi.org/10.5281/zenodo.22099294","title":"CLINICAL PROTOCOL MANAGEMENT OF BIOCHEMICAL PREGNANCY AND EVIDENCE-BASED APPROACH TO PLANNING THE NEXT PREGNANCY with Integration of the RPS-SCORE\u2122 Assessment System and Master Lock\u2122 Know-How","display_name":"CLINICAL PROTOCOL MANAGEMENT OF BIOCHEMICAL PREGNANCY AND EVIDENCE-BASED APPROACH TO PLANNING THE NEXT PREGNANCY with Integration of the RPS-SCORE\u2122 Assessment System and Master Lock\u2122 Know-How","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204202174","doi":"https://doi.org/10.5281/zenodo.22099294"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.22099294","doi":"https://doi.org/10.5281/zenodo.22099294","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22099294","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Report"},"volume":null,"type":"report","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.22099294","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5137312532","display_name":"Viktoriya Hudziak","orcid":"https://orcid.org/0009-0000-4863-2750","observed_orcids":["https://orcid.org/0009-0000-4863-2750"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hudziak, Viktoriya","raw_affiliation_strings":["Hudziak Academy","HUDZIAK FERTILITY MANAGEMENT CENTER","Viktoriya Hudziak Reproductive clinic"],"raw_orcid":"https://orcid.org/0009-0000-4863-2750","affiliations":[{"raw_affiliation_string":"Hudziak Academy","institution_ids":[]},{"raw_affiliation_string":"HUDZIAK FERTILITY MANAGEMENT CENTER","institution_ids":[]},{"raw_affiliation_string":"Viktoriya Hudziak Reproductive clinic","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5137312532"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.5586000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.5586000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.3508000075817108,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.033399999141693115,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biochemical-pregnancy","display_name":"biochemical pregnancy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/chemical-pregnancy","display_name":"chemical pregnancy","score":0.6740000247955322},{"id":"https://openalex.org/keywords/miscarriage","display_name":"miscarriage","score":0.6240000128746033},{"id":"https://openalex.org/keywords/preimplantation-genetic-testing-for-aneuploidy","display_name":"preimplantation genetic testing for aneuploidy","score":0.8460000157356262},{"id":"https://openalex.org/keywords/endometrial-microbiota","display_name":"endometrial microbiota","score":0.859000027179718},{"id":"https://openalex.org/keywords/endometrial-receptivity","display_name":"endometrial receptivity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/window-of-implantation","display_name":"implantation window","score":0.6769999861717224},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6850000023841858},{"id":"https://openalex.org/keywords/recurrent-pregnancy-loss","display_name":"recurrent pregnancy loss","score":0.5569999814033508},{"id":"https://openalex.org/keywords/immunological-screening","display_name":"immunological screening","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.8805999755859375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6916999816894531},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6019999980926514},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.4950000047683716},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.4677000045776367},{"id":"https://openalex.org/C518429986","wikidata":"https://www.wikidata.org/wiki/Q964401","display_name":"Fertility","level":3,"score":0.4334000051021576},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.4133000075817108},{"id":"https://openalex.org/C2779245376","wikidata":"https://www.wikidata.org/wiki/Q28693","display_name":"Miscarriage","level":3,"score":0.4092999994754791},{"id":"https://openalex.org/C2776537878","wikidata":"https://www.wikidata.org/wiki/Q7239894","display_name":"Pregnancy rate","level":3,"score":0.40869998931884766},{"id":"https://openalex.org/C500014431","wikidata":"https://www.wikidata.org/wiki/Q25862","display_name":"Assisted reproductive technology","level":4,"score":0.39640000462532043},{"id":"https://openalex.org/C2776210078","wikidata":"https://www.wikidata.org/wiki/Q351870","display_name":"Reproductive medicine","level":3,"score":0.3955000042915344},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.39480000734329224},{"id":"https://openalex.org/C2777904497","wikidata":"https://www.wikidata.org/wiki/Q5445580","display_name":"Fertility preservation","level":4,"score":0.3646000027656555},{"id":"https://openalex.org/C2994380379","wikidata":"https://www.wikidata.org/wiki/Q1135142","display_name":"Pregnancy test","level":3,"score":0.3547999858856201},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3395000100135803},{"id":"https://openalex.org/C2909731803","wikidata":"https://www.wikidata.org/wiki/Q28693","display_name":"Early Pregnancy Loss","level":4,"score":0.3075999915599823},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.2870999872684479},{"id":"https://openalex.org/C2994278967","wikidata":"https://www.wikidata.org/wiki/Q7314318","display_name":"Reproductive technology","level":4,"score":0.2782000005245209},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2777000069618225},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2687000036239624},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.2549000084400177}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.22099294","doi":"https://doi.org/10.5281/zenodo.22099294","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22099294","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Report"},{"id":"doi:10.5281/zenodo.22099295","doi":"https://doi.org/10.5281/zenodo.22099295","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22099295","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Report"}],"best_oa_location":{"id":"doi:10.5281/zenodo.22099294","doi":"https://doi.org/10.5281/zenodo.22099294","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22099294","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Report"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4412585882","https://openalex.org/W4413949240","https://openalex.org/W2005601419","https://openalex.org/W4407102445","https://openalex.org/W1983547069","https://openalex.org/W1972170331","https://openalex.org/W3022489777","https://openalex.org/W2046694412","https://openalex.org/W1991673016","https://openalex.org/W4283730942"],"abstract_inverted_index":{"Biochemical":[0,372],"pregnancy":[1,27,50,75,95,107,115,185,234,254,350,373],"(BP;":[2],"Chemical":[3],"Pregnancy,":[4],"CP)":[5],"is":[6,121,155,261,315,346,354],"defined":[7],"as":[8,180,377],"a":[9,18,70,104,157,181,188,197,228,286,356,360,378],"serum":[10],"\u03b2-hCG":[11,87],"elevation":[12],">5IU/L":[13],"without":[14,187],"ultrasound":[15],"confirmation":[16],"of":[17,26,33,44,61,162,184,202,265,362,387,395,406],"gestational":[19],"sac.":[20],"It":[21,345],"represents":[22],"the":[23,42,73,78,98,149,163,205,237,244,295,390,404],"earliest":[24],"clinicalphenotype":[25],"loss,":[28],"occurring":[29],"before":[30],"5":[31],"weeks":[32],"amenorrhea,":[34],"and":[35,216,223,243,279,335,402],"frequently":[36],"remainsundiagnosed":[37],"in":[38,77,85,101,129,321,382,398],"spontaneous":[39],"conception":[40],"cycles.In":[41],"context":[43],"assisted":[45],"reproductive":[46,384],"technologies":[47],"(ART),":[48],"biochemical":[49,58,106,114,233,349],"acquiresparticular":[51],"prognostic":[52,380],"significance.":[53],"Studies":[54],"demonstrate":[55],"that":[56,128,151,348],"after":[57,97,116,153,325],"pregnancy,":[59],"theoutcomes":[60],"subsequent":[62,399],"clinical":[63,74,172,230,313,391],"pregnancies":[64],"differ":[65],"substantially":[66],"from":[67],"patients":[68,102],"with":[69,103,256,311],"negativepregnancy":[71],"test:":[72],"rate":[76,96],"next":[79,253],"cycle":[80],"reaches":[81,108],"37.3\u201338.4%":[82],"versus":[83],"27.3%":[84],"thenegative":[86],"group":[88,112],"(Bates":[89],"et":[90],"al.,":[91],"modified).":[92],"The":[93,191,259,281],"cumulative":[94],"first":[99],"ARTattempt":[100],"previous":[105],"54.1%,":[109],"exceeding":[110],"thenegative-test":[111],"(46.5%).However,":[113],"euploid":[117,326],"embryo":[118,327,352],"transfer":[119,353],"(PGT-A)":[120],"an":[122,249],"especially":[123],"alarmingmarker.":[124],"Current":[125],"data":[126],"indicate":[127],"such":[130],"cases":[131],"BP":[132,152,203,303,308,320,324],"reflects":[133],"deep":[134,363],"endometrial":[135,276,331,364],"or":[136,365],"immunologicaldysfunctions":[137,366],"not":[138,156,355],"detected":[139],"by":[140,302],"standard":[141,369],"morphometric":[142,370],"assessment":[143,210],"(endometrial":[144],"thickness,":[145],"estradiollevels).":[146],"This":[147],"supports":[148],"hypothesis":[150],"PGT-A":[154],"random":[158,357],"event":[159,358],"but":[160,359],"signalspathology":[161],"implantation":[164],"window":[165],"and/or":[166],"maternal-placental":[167],"immune":[168],"dialogue.Competitive":[169],"Positioning.":[170],"Existing":[171],"protocols":[173],"(ESHRE,":[174],"ASRM,":[175],"RCOG)":[176],"treat":[177],"biochemicalpregnancy":[178],"primarily":[179],"statistical":[182],"category":[183],"loss":[186],"differentiated":[189,307],"therapeuticalgorithm.":[190],"Hudziak":[192],"Fertility":[193],"Management":[194],"Center":[195],"proposes":[196],"fundamentally":[198],"new":[199],"approach":[200,251],"\u2014integration":[201],"into":[204,389],"Reproductive":[206,238],"Pause":[207,239],"Syndrome":[208,240],"(RPS)":[209,241],"system":[211,291],"using":[212],"thepatented":[213],"RPS-SCORE\u2122":[214,245,297,342,388],"instrument":[215],"Master":[217,282],"Lock\u2122":[218,283],"know-how,":[219],"ensuring":[220,248],"personalized":[221,229],"riskstratification":[222],"individualized":[224],"therapy.":[225],"To":[226],"develop":[227],"protocol":[231,260,338,392],"for":[232,299],"(BP)":[235],"managementintegrating":[236],"concept":[242],"multifactorialassessment":[246],"system,":[247],"evidence-based":[250,266],"to":[252],"planning":[255],"minimizedrecurrence":[257],"risk.Methods:":[258],"based":[262],"on":[263],"synthesis":[264],"medicine":[267],"(EBM)":[268],"levels":[269],"I\u2013III,":[270],"cohort":[271],"studiesusing":[272],"PGT-A,":[273],"immunological":[274],"screening,":[275],"microbiome":[277],"diagnostics,":[278],"psychosomaticassessment.":[280],"know-how":[284],"\u2014":[285,292],"six-level":[287],"intellectual":[288],"property":[289],"protection":[290],"isintegrated,":[293],"including":[294],"unique":[296],"algorithm":[298,310],"patient":[300],"stratification":[301],"recurrence":[304],"risk.Results:":[305],"A":[306,329],"diagnostic":[309],"four":[312],"phenotypes":[314],"proposed":[316],"(isolated":[317],"BP,recurrent":[318],"BP,":[319],"RPL":[322],"context,":[323],"transfer).":[328],"staged":[330],"rehabilitationprogram":[332],"Endo-Restore":[333],"360\u2122":[334],"preconception":[336],"preparation":[337],"PreConception":[339],"Shield\u2122individualized":[340],"via":[341],"are":[343],"developed.":[344],"demonstrated":[347],"aftereuploid":[351],"marker":[361,381],"invisible":[367],"under":[368],"assessment.Conclusions:":[371],"should":[374],"be":[375],"regarded":[376],"significant":[379],"thepatient's":[383],"history.":[385],"Integration":[386],"increases":[393],"theaccuracy":[394],"predicting":[396],"outcomes":[397],"ART":[400],"cycles":[401],"reduces":[403],"frequency":[405],"recurrent":[407],"lossesby":[408],"34\u201342%":[409],"(p<0.05).":[410]},"counts_by_year":[],"updated_date":"2026-10-07T09:51:55.459714","created_date":"2026-08-26T00:00:00"}
