{"id":"https://openalex.org/W7204201502","doi":"https://doi.org/10.64898/2026.08.21.745777","title":"Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise","display_name":"Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204201502","doi":"https://doi.org/10.64898/2026.08.21.745777"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.21.745777","doi":"https://doi.org/10.64898/2026.08.21.745777","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.21.745777","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.08.21.745777","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038386548","display_name":"Roberto De Filippo","orcid":"https://orcid.org/0000-0002-4085-9114","observed_orcids":["https://orcid.org/0000-0002-4085-9114"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4210152641","display_name":"Bernstein Center for Computational Neuroscience Berlin","ror":"https://ror.org/05ewdps05","country_code":"DE","type":"government","lineage":["https://openalex.org/I39343248","https://openalex.org/I4210092532","https://openalex.org/I4210152641","https://openalex.org/I4577782","https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Roberto De Filippo","raw_affiliation_strings":["Allen Institute, Brain and Consciousness, Seattle, WA, USA","Humboldt-Universit\u00e4t zu Berlin, Bernstein Center for Computational Neuroscience Berlin and Institute of Biology, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4085-9114","affiliations":[{"raw_affiliation_string":"Allen Institute, Brain and Consciousness, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341"]},{"raw_affiliation_string":"Humboldt-Universit\u00e4t zu Berlin, Bernstein Center for Computational Neuroscience Berlin and Institute of Biology, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I4210152641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104119654","display_name":"Ryan Gillis","orcid":"https://orcid.org/0009-0000-1879-6519","observed_orcids":["https://orcid.org/0009-0000-1879-6519"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Gillis","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0009-0000-1879-6519","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043292927","display_name":"David G Wyrick","orcid":"https://orcid.org/0000-0001-8096-5766","observed_orcids":["https://orcid.org/0000-0001-8096-5766"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Wyrick","raw_affiliation_strings":["Allen Institute, Studio D3, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0001-8096-5766","affiliations":[{"raw_affiliation_string":"Allen Institute, Studio D3, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108322929","display_name":"Mikayla Carlson","orcid":"https://orcid.org/0009-0003-7019-2781","observed_orcids":["https://orcid.org/0009-0003-7019-2781"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikayla Carlson","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0009-0003-7019-2781","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044384795","display_name":"S\u00e9verine Durand","orcid":"https://orcid.org/0000-0001-7788-0200","observed_orcids":["https://orcid.org/0000-0001-7788-0200"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Severine Durand","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0001-7788-0200","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115959442","display_name":"Carter R. Peene","orcid":"https://orcid.org/0009-0000-6660-2264","observed_orcids":["https://orcid.org/0009-0000-6660-2264"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Carter Peene","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0009-0000-6660-2264","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092104718","display_name":"Ahad Bawany","orcid":"https://orcid.org/0009-0002-5495-5411","observed_orcids":["https://orcid.org/0009-0002-5495-5411"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahad Bawany","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0009-0002-5495-5411","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094196786","display_name":"Avalon M. Amaya","orcid":"https://orcid.org/0000-0003-2274-2892","observed_orcids":["https://orcid.org/0000-0003-2274-2892"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avalon Amaya","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0003-2274-2892","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079237080","display_name":"Hannah Belski","orcid":"https://orcid.org/0009-0001-5422-5964","observed_orcids":["https://orcid.org/0009-0001-5422-5964"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Belski","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088576477","display_name":"Conor Grasso","orcid":"https://orcid.org/0009-0003-6384-4075","observed_orcids":["https://orcid.org/0009-0003-6384-4075"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Conor Grasso","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0009-0003-6384-4075","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023013952","display_name":"Warren Han","orcid":"https://orcid.org/0009-0006-0104-0380","observed_orcids":["https://orcid.org/0009-0006-0104-0380"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warren Han","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0009-0006-0104-0380","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008512221","display_name":"Jaimie Kenney","orcid":"https://orcid.org/0009-0003-5308-2783","observed_orcids":["https://orcid.org/0009-0003-5308-2783"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaimie Kenney","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0009-0003-5308-2783","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061330249","display_name":"Carly Kiselycznyk","orcid":"https://orcid.org/0009-0006-8410-1192","observed_orcids":["https://orcid.org/0009-0006-8410-1192"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carly Kiselycznyk","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0009-0006-8410-1192","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092104717","display_name":"Henry Loeffler","orcid":"https://orcid.org/0009-0007-3935-6863","observed_orcids":["https://orcid.org/0009-0007-3935-6863"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry Loeffler","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0009-0007-3935-6863","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005221962","display_name":"Lydia C. Marks","orcid":"https://orcid.org/0000-0002-7270-2680","observed_orcids":["https://orcid.org/0000-0002-7270-2680"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lydia C. Marks","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0002-7270-2680","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084230077","display_name":"Robyn Naidoo","orcid":"https://orcid.org/0009-0004-0996-8808","observed_orcids":["https://orcid.org/0009-0004-0996-8808"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robyn Naidoo","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0009-0004-0996-8808","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061802285","display_name":"Ben Ouellette","orcid":"https://orcid.org/0000-0003-4913-554X","observed_orcids":["https://orcid.org/0000-0003-4913-554X"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Ouellette","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0003-4913-554X","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113285337","display_name":"Lucas Suarez","orcid":"https://orcid.org/0009-0002-0121-3334","observed_orcids":["https://orcid.org/0009-0002-0121-3334"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucas Suarez","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0009-0002-0121-3334","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039062478","display_name":"Jackie Swapp","orcid":"https://orcid.org/0009-0008-4965-6242","observed_orcids":["https://orcid.org/0009-0008-4965-6242"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jackie Swapp","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0009-0008-4965-6242","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148170482","display_name":"Tye Johnson","orcid":"https://orcid.org/0009-0006-7239-7571","observed_orcids":["https://orcid.org/0009-0006-7239-7571"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tye Johnson","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0009-0006-7239-7571","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148159771","display_name":"Julie Weber","orcid":"https://orcid.org/0009-0002-1060-3828","observed_orcids":["https://orcid.org/0009-0002-1060-3828"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Weber","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0009-0002-1060-3828","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017280735","display_name":"Joshua Wilkes","orcid":"https://orcid.org/0009-0001-1383-2960","observed_orcids":["https://orcid.org/0009-0001-1383-2960","https://orcid.org/0009-0005-4858-2219"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Wilkes","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0009-0005-4858-2219","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082682484","display_name":"Peter A. Groblewski","orcid":"https://orcid.org/0000-0002-8415-1118","observed_orcids":["https://orcid.org/0000-0002-8415-1118"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Groblewski","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0002-8415-1118","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011452583","display_name":"Allison Williford","orcid":"https://orcid.org/0009-0000-7282-7515","observed_orcids":["https://orcid.org/0009-0000-7282-7515"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison Williford","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0009-0000-7282-7515","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086928889","display_name":"Michael A. Buice","orcid":"https://orcid.org/0000-0002-2196-1498","observed_orcids":["https://orcid.org/0000-0002-2196-1498"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Buice","raw_affiliation_strings":["Allen Institute, Studio D3, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0002-2196-1498","affiliations":[{"raw_affiliation_string":"Allen Institute, Studio D3, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084822308","display_name":"Christof Koch","orcid":"https://orcid.org/0000-0001-6482-8067","observed_orcids":["https://orcid.org/0000-0001-6482-8067"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153645","display_name":"Tiny Blue Dot Foundation","ror":"https://ror.org/01a4es322","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4387153645"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christof Koch","raw_affiliation_strings":["Allen Institute, Brain and Consciousness, Seattle, WA, USA","Tiny Blue Dot Foundation, Santa Monica, CA, USA"],"raw_orcid":"https://orcid.org/0000-0001-6482-8067","affiliations":[{"raw_affiliation_string":"Allen Institute, Brain and Consciousness, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341"]},{"raw_affiliation_string":"Tiny Blue Dot Foundation, Santa Monica, CA, USA","institution_ids":["https://openalex.org/I4387153645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008918526","display_name":"Irene Rembado","orcid":"https://orcid.org/0000-0001-7121-4442","observed_orcids":["https://orcid.org/0000-0001-7121-4442"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene Rembado","raw_affiliation_strings":["Allen Institute, Brain and Consciousness, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0001-7121-4442","affiliations":[{"raw_affiliation_string":"Allen Institute, Brain and Consciousness, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016337396","display_name":"J\u00e9r\u00f4me A. Lecoq","orcid":"https://orcid.org/0000-0002-0131-0938","observed_orcids":["https://orcid.org/0000-0002-0131-0938"]},"institutions":[{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4387153123","display_name":"Allen Institute for Neural Dynamics","ror":"https://ror.org/04szwah67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J\u00e9r\u00f4me A. Lecoq","raw_affiliation_strings":["Allen Institute, Neural Dynamics, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0002-0131-0938","affiliations":[{"raw_affiliation_string":"Allen Institute, Neural Dynamics, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I4387153123"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078455227","display_name":"Torben Ott","orcid":"https://orcid.org/0000-0002-4168-2832","observed_orcids":["https://orcid.org/0000-0002-4168-2832"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210152641","display_name":"Bernstein Center for Computational Neuroscience Berlin","ror":"https://ror.org/05ewdps05","country_code":"DE","type":"government","lineage":["https://openalex.org/I39343248","https://openalex.org/I4210092532","https://openalex.org/I4210152641","https://openalex.org/I4577782","https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Torben Ott","raw_affiliation_strings":["Humboldt-Universit\u00e4t zu Berlin, Bernstein Center for Computational Neuroscience Berlin and Institute of Biology, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4168-2832","affiliations":[{"raw_affiliation_string":"Humboldt-Universit\u00e4t zu Berlin, Bernstein Center for Computational Neuroscience Berlin and Institute of Biology, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I4210152641"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5078455227"],"corresponding_institution_ids":["https://openalex.org/I39343248","https://openalex.org/I4210152641"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10427","display_name":"Visual perception and processing mechanisms","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psilocybin","display_name":"psilocybin","score":1.0},{"id":"https://openalex.org/keywords/psychedelics","display_name":"psychedelics","score":0.6710000038146973},{"id":"https://openalex.org/keywords/visual-change-detection","display_name":"visual change detection","score":0.9789999723434448},{"id":"https://openalex.org/keywords/surprise","display_name":"surprise","score":0.4429999887943268},{"id":"https://openalex.org/keywords/somatostatin-interneurons","display_name":"somatostatin interneurons","score":0.9399999976158142},{"id":"https://openalex.org/keywords/layer-5-neurons","display_name":"layer 5 neurons","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C2776502132","wikidata":"https://www.wikidata.org/wiki/Q208118","display_name":"Psilocybin","level":3,"score":0.9187999963760376},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7476999759674072},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.6233999729156494},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.6019999980926514},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.5630999803543091},{"id":"https://openalex.org/C178253425","wikidata":"https://www.wikidata.org/wiki/Q162668","display_name":"Visual perception","level":3,"score":0.5537999868392944},{"id":"https://openalex.org/C2780343955","wikidata":"https://www.wikidata.org/wiki/Q333173","display_name":"Surprise","level":2,"score":0.5453000068664551},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5123000144958496},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4796999990940094},{"id":"https://openalex.org/C2908832724","wikidata":"https://www.wikidata.org/wiki/Q7187600","display_name":"Photic Stimulation","level":4,"score":0.45179998874664307},{"id":"https://openalex.org/C2779345533","wikidata":"https://www.wikidata.org/wiki/Q75785","display_name":"Visual cortex","level":2,"score":0.42260000109672546},{"id":"https://openalex.org/C2778251979","wikidata":"https://www.wikidata.org/wiki/Q7936617","display_name":"Visual processing","level":3,"score":0.40230000019073486},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.3756999969482422},{"id":"https://openalex.org/C142812007","wikidata":"https://www.wikidata.org/wiki/Q6675553","display_name":"Looming","level":2,"score":0.36970001459121704},{"id":"https://openalex.org/C195221683","wikidata":"https://www.wikidata.org/wiki/Q5000649","display_name":"Bursting","level":2,"score":0.36739999055862427},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.3370000123977661},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.33000001311302185},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.32919999957084656},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.328000009059906},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.28610000014305115},{"id":"https://openalex.org/C2778439541","wikidata":"https://www.wikidata.org/wiki/Q7106412","display_name":"Oscillation (cell signaling)","level":2,"score":0.28290000557899475},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.27320000529289246},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2669999897480011},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.26460000872612},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.2639000117778778},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.26010000705718994},{"id":"https://openalex.org/C124315065","wikidata":"https://www.wikidata.org/wiki/Q194270","display_name":"Hallucinogen","level":2,"score":0.25189998745918274}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.21.745777","doi":"https://doi.org/10.64898/2026.08.21.745777","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.21.745777","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.21.745777","doi":"https://doi.org/10.64898/2026.08.21.745777","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.21.745777","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W1965322047","https://openalex.org/W2039145827","https://openalex.org/W2086297411","https://openalex.org/W2094304788","https://openalex.org/W2177522049","https://openalex.org/W2434010258","https://openalex.org/W2461298255","https://openalex.org/W2531083186","https://openalex.org/W2556544290","https://openalex.org/W2558180774","https://openalex.org/W2558430488","https://openalex.org/W2586123043","https://openalex.org/W2622461305","https://openalex.org/W2623559747","https://openalex.org/W2767493192","https://openalex.org/W2770636944","https://openalex.org/W2808301300","https://openalex.org/W2809461452","https://openalex.org/W2887114371","https://openalex.org/W2905702364","https://openalex.org/W2923100148","https://openalex.org/W2949457836","https://openalex.org/W2965796360","https://openalex.org/W2982557070","https://openalex.org/W2999364864","https://openalex.org/W3018689408","https://openalex.org/W3026259034","https://openalex.org/W3036791464","https://openalex.org/W3087152370","https://openalex.org/W3104213443","https://openalex.org/W3124792448","https://openalex.org/W3155379073","https://openalex.org/W3179469168","https://openalex.org/W3180355975","https://openalex.org/W3210539052","https://openalex.org/W4214649547","https://openalex.org/W4225773355","https://openalex.org/W4311116298","https://openalex.org/W4311778131","https://openalex.org/W4319734849","https://openalex.org/W4321033185","https://openalex.org/W4321377299","https://openalex.org/W4384820554","https://openalex.org/W4386757590","https://openalex.org/W4387664540","https://openalex.org/W4387866883","https://openalex.org/W4388823868","https://openalex.org/W4389670373","https://openalex.org/W4389670555","https://openalex.org/W4390875269","https://openalex.org/W4394577481","https://openalex.org/W4399141100","https://openalex.org/W4400383201","https://openalex.org/W4400386882","https://openalex.org/W4400537457","https://openalex.org/W4400580347","https://openalex.org/W4401947187","https://openalex.org/W4401992776","https://openalex.org/W4405850617","https://openalex.org/W4407199634","https://openalex.org/W4409147414","https://openalex.org/W4409155833","https://openalex.org/W4409310214","https://openalex.org/W4413683528","https://openalex.org/W4414845973","https://openalex.org/W4415219138","https://openalex.org/W4415366347","https://openalex.org/W7122520569","https://openalex.org/W7126181625","https://openalex.org/W7154685724","https://openalex.org/W7167514027","https://openalex.org/W7203789443"],"related_works":["https://openalex.org/W4391051065","https://openalex.org/W4416466349","https://openalex.org/W4415219138","https://openalex.org/W4408574959","https://openalex.org/W4399528691","https://openalex.org/W1976576985","https://openalex.org/W4412459077","https://openalex.org/W2033134445","https://openalex.org/W2020974659","https://openalex.org/W2413949863"],"abstract_inverted_index":{"Abstract":[0],"Psilocybin":[1,32],"profoundly":[2],"alters":[3],"visual":[4,29,111],"perception,":[5],"yet":[6],"the":[7,43,155],"neuronal":[8],"mechanisms":[9],"underlying":[10],"these":[11],"effects":[12,103],"remain":[13],"unclear.":[14],"Here":[15],"we":[16],"combined":[17],"large-scale":[18],"Neuropixels":[19],"recordings":[20],"with":[21,127],"cell-type-specific":[22],"optogenetics":[23],"in":[24,106,110,154],"head-fixed":[25],"mice":[26],"performing":[27],"a":[28,62,148],"change-detection":[30],"task.":[31],"severely":[33],"impaired":[34],"task":[35],"performance":[36],"without":[37],"overt":[38],"motor":[39],"deficits.":[40],"In":[41],"cortex,":[42],"drug":[44],"modestly":[45],"suppressed":[46],"activity":[47,68],"of":[48,55,115],"layer":[49],"5":[50],"neurons":[51,72],"while":[52],"preserving":[53],"representations":[54],"image":[56,74,78,83,120],"identity.":[57,79],"By":[58],"contrast,":[59],"psilocybin":[60,140],"imposed":[61],"4-Hz":[63],"oscillation":[64],"on":[65,119],"visually":[66],"evoked":[67,97],"that":[69,139],"preferentially":[70,132],"affected":[71],"encoding":[73],"change":[75],"rather":[76],"than":[77],"Under":[80],"psilocybin,":[81],"expected":[82],"repetitions":[84],"aberrantly":[85],"recruited":[86,133],"change-encoding":[87,134],"ensembles":[88],"and":[89,122],"shifted":[90],"cortical":[91,144],"population":[92],"dynamics":[93],"towards":[94],"trajectories":[95],"normally":[96],"by":[98],"genuine":[99],"stimulus":[100],"changes.":[101],"These":[102,136],"were":[104],"strongest":[105],"somatostatin-expressing":[107],"(SST)":[108],"interneurons":[109],"cortex.":[112],"The":[113],"strength":[114],"this":[116],"modulation":[117],"depended":[118],"structure":[121],"was":[123],"greatest":[124],"for":[125,151],"images":[126],"clear,":[128],"continuous":[129],"contours,":[130],"which":[131],"ensembles.":[135],"findings":[137],"demonstrate":[138],"drives":[141],"internally":[142],"generated":[143],"surprise":[145],"signals,":[146],"providing":[147],"circuit":[149],"mechanism":[150],"altered":[152],"perception":[153],"acute":[156],"psychedelic":[157],"state.":[158]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-08-26T00:00:00"}