{"id":"https://openalex.org/W7204201450","doi":"https://doi.org/10.1016/j.xhgg.2026.100664","title":"Multi-omic characterization of the Hispanic/Latino blood lipidome reveals an additional locus and attenuated genetic prediction","display_name":"Multi-omic characterization of the Hispanic/Latino blood lipidome reveals an additional locus and attenuated genetic prediction","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204201450","doi":"https://doi.org/10.1016/j.xhgg.2026.100664","pmid":"https://pubmed.ncbi.nlm.nih.gov/42642928"},"language":"en","primary_location":{"id":"doi:10.1016/j.xhgg.2026.100664","doi":"https://doi.org/10.1016/j.xhgg.2026.100664","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xhgg.2026.100664","pdf_url":null,"source":{"id":"https://openalex.org/S4210200806","display_name":"Human Genetics and Genomics Advances","issn_l":"2666-2477","issn":["2666-2477"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Genetics and Genomics Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.xhgg.2026.100664","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102908997","display_name":"Wanying Zhu","orcid":"https://orcid.org/0000-0002-2673-3048","observed_orcids":["https://orcid.org/0000-0002-2673-3048"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wanying Zhu","raw_affiliation_strings":["Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084182903","display_name":"Hung\u2010Hsin Chen","orcid":"https://orcid.org/0000-0002-1921-2797","observed_orcids":["https://orcid.org/0000-0002-1921-2797","https://orcid.org/0000-0003-4171-7991"]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hung-hsin Chen","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei City, Taiwan","institution_ids":["https://openalex.org/I4210096666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086859091","display_name":"Heather M. Highland","orcid":"https://orcid.org/0000-0002-3583-8239","observed_orcids":["https://orcid.org/0000-0002-3583-8239"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather M. Highland","raw_affiliation_strings":["Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27517, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27517, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038367542","display_name":"Corey Giles","orcid":"https://orcid.org/0000-0002-6050-1259","observed_orcids":["https://orcid.org/0000-0002-6050-1259"]},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]},{"id":"https://openalex.org/I196829312","display_name":"La Trobe University","ror":"https://ror.org/01rxfrp27","country_code":"AU","type":"education","lineage":["https://openalex.org/I196829312"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Corey Giles","raw_affiliation_strings":["Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Baker Department of Cardiovascular Research, Translation and Implementation, La Trobe University, Bundoora, VIC 3086, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Baker Department of Cardiovascular Research, Translation and Implementation, La Trobe University, Bundoora, VIC 3086, Australia","institution_ids":["https://openalex.org/I142471025","https://openalex.org/I196829312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010188514","display_name":"Peter J. Meikle","orcid":"https://orcid.org/0000-0002-2593-4665","observed_orcids":["https://orcid.org/0000-0002-2593-4665"]},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]},{"id":"https://openalex.org/I196829312","display_name":"La Trobe University","ror":"https://ror.org/01rxfrp27","country_code":"AU","type":"education","lineage":["https://openalex.org/I196829312"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Peter J. Meikle","raw_affiliation_strings":["Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Baker Department of Cardiovascular Research, Translation and Implementation, La Trobe University, Bundoora, VIC 3086, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Baker Department of Cardiovascular Research, Translation and Implementation, La Trobe University, Bundoora, VIC 3086, Australia","institution_ids":["https://openalex.org/I142471025","https://openalex.org/I196829312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102621828","display_name":"Phillip Lin","orcid":"https://orcid.org/0009-0003-6988-0237","observed_orcids":["https://orcid.org/0009-0003-6988-0237"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip Lin","raw_affiliation_strings":["Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022981309","display_name":"Lauren E. Petty","orcid":"https://orcid.org/0000-0003-1619-6303","observed_orcids":["https://orcid.org/0000-0003-1619-6303"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren E. Petty","raw_affiliation_strings":["Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014043233","display_name":"Hannah G. Polikowsky","orcid":"https://orcid.org/0000-0001-7226-9752","observed_orcids":["https://orcid.org/0000-0001-7226-9752"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah G. Polikowsky","raw_affiliation_strings":["Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090069128","display_name":"Alexander S Petty","orcid":"https://orcid.org/0009-0008-9366-7897","observed_orcids":["https://orcid.org/0009-0008-9366-7897"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex S. Petty","raw_affiliation_strings":["Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138694363","display_name":"Mohammad Y. Anwar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Y. Anwar","raw_affiliation_strings":["Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27517, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27517, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103142484","display_name":"Xinruo Zhang","orcid":"https://orcid.org/0000-0001-5789-4592","observed_orcids":["https://orcid.org/0000-0001-5789-4592"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinruo Zhang","raw_affiliation_strings":["Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27517, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27517, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088365248","display_name":"Joanne E. Curran","orcid":"https://orcid.org/0000-0002-6898-155X","observed_orcids":["https://orcid.org/0000-0002-6898-155X"]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne E. Curran","raw_affiliation_strings":["Department of Human Genetics, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA","institution_ids":["https://openalex.org/I2802326326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157927462","display_name":"Elizabeth G. Frankel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth G. Frankel","raw_affiliation_strings":["Department of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093578906","display_name":"Rashedeh Roshani","orcid":"https://orcid.org/0009-0001-2696-2852","observed_orcids":["https://orcid.org/0009-0001-2696-2852"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rashedeh Roshani","raw_affiliation_strings":["Department of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039527927","display_name":"Joshua M. Landman","orcid":"https://orcid.org/0000-0003-2431-6053","observed_orcids":["https://orcid.org/0000-0003-2431-6053"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua M. Landman","raw_affiliation_strings":["Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140296862","display_name":"Gabriela Castrodad-Rivera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriela S. Castrodad-Rivera","raw_affiliation_strings":["Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140274316","display_name":"Caroline Herndon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Herndon","raw_affiliation_strings":["Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050832426","display_name":"Joseph B. McCormick","orcid":"https://orcid.org/0000-0002-5844-8102","observed_orcids":["https://orcid.org/0000-0002-5844-8102"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph B. McCormick","raw_affiliation_strings":["Department of Epidemiology, UT Health Houston School of Public Health, Brownsville Campus, Brownsville, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, UT Health Houston School of Public Health, Brownsville Campus, Brownsville, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023188513","display_name":"Susan P. Fisher\u2010Hoch","orcid":"https://orcid.org/0000-0002-7894-5114","observed_orcids":["https://orcid.org/0000-0002-7894-5114"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan P. Fisher-Hoch","raw_affiliation_strings":["Department of Epidemiology, UT Health Houston School of Public Health, Brownsville Campus, Brownsville, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, UT Health Houston School of Public Health, Brownsville Campus, Brownsville, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028657341","display_name":"Penny Gordon\u2010Larsen","orcid":"https://orcid.org/0000-0001-5322-4188","observed_orcids":["https://orcid.org/0000-0001-5322-4188"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Penny Gordon-Larsen","raw_affiliation_strings":["Department of Nutrition, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091036407","display_name":"Eric R. Gamazon","orcid":"https://orcid.org/0000-0003-4204-8734","observed_orcids":["https://orcid.org/0000-0003-4204-8734"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric R. Gamazon","raw_affiliation_strings":["Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062296084","display_name":"Kari E. North","orcid":"https://orcid.org/0000-0002-8903-0366","observed_orcids":["https://orcid.org/0000-0002-8903-0366"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kari E. North","raw_affiliation_strings":["Department of Epidemiology, UT Health Houston School of Public Health, Brownsville Campus, Brownsville, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, UT Health Houston School of Public Health, Brownsville Campus, Brownsville, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028714205","display_name":"Jennifer Elizabeth Below","orcid":"https://orcid.org/0000-0002-1346-1872","observed_orcids":["https://orcid.org/0000-0002-1346-1872","https://orcid.org/0000-0002-6372-6402"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer E. Below","raw_affiliation_strings":["Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: jennifer.e.below@vumc.org"],"raw_orcid":"https://orcid.org/0000-0002-1346-1872","affiliations":[{"raw_affiliation_string":"Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: jennifer.e.below@vumc.org","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":{"value":3300,"currency":"USD","value_usd":3300},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66354226,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"4","first_page":"100664","last_page":"100664"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hispanic-latino-populations","display_name":"Hispanic/Latino populations","score":0.9089999794960022},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.7850000262260437},{"id":"https://openalex.org/keywords/long-range-linkage-disequilibrium","display_name":"long-range linkage disequilibrium","score":0.8199999928474426},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"expression quantitative trait loci","score":0.7820000052452087},{"id":"https://openalex.org/keywords/native-american-populations","display_name":"Native American populations","score":0.6389999985694885},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.48399999737739563},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2780241833","wikidata":"https://www.wikidata.org/wiki/Q6556375","display_name":"Lipidome","level":3,"score":0.718500018119812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6554999947547913},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.642300009727478},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5720999836921692},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31709998846054077},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.31220000982284546},{"id":"https://openalex.org/C23085057","wikidata":"https://www.wikidata.org/wiki/Q5532877","display_name":"Genetic analysis","level":3,"score":0.23330000042915344},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2282000035047531},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.22540000081062317},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.21160000562667847}],"mesh":[{"descriptor_ui":"D000081362","descriptor_name":"Lipidomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000090943","descriptor_name":"Delta-5 Fatty Acid Desaturase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006630","descriptor_name":"Hispanic or Latino","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.xhgg.2026.100664","doi":"https://doi.org/10.1016/j.xhgg.2026.100664","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xhgg.2026.100664","pdf_url":null,"source":{"id":"https://openalex.org/S4210200806","display_name":"Human Genetics and Genomics Advances","issn_l":"2666-2477","issn":["2666-2477"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Genetics and Genomics Advances","raw_type":"journal-article"},{"id":"pmid:42642928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42642928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HGG advances","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.utrgv.edu:hg_pub-1044","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.utrgv.edu/hg_pub/45","pdf_url":"https://scholarworks.utrgv.edu/context/hg_pub/article/1044/viewcontent/1_s2.0_S2666247726001041_main.pdf","source":{"id":"https://openalex.org/S4306402611","display_name":"ScholarWorks @ UTRGV (The University of Texas Rio Grande Valley)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802326326","host_organization_name":"The University of Texas Rio Grande Valley","host_organization_lineage":["https://openalex.org/I2802326326"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Genetics Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:4ed1790371494249b0f2e9dbaab54ad5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4ed1790371494249b0f2e9dbaab54ad5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HGG Advances, Vol 7, Iss 4, Pp 100664- (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13594937","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42642928/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HGG Adv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.xhgg.2026.100664","doi":"https://doi.org/10.1016/j.xhgg.2026.100664","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xhgg.2026.100664","pdf_url":null,"source":{"id":"https://openalex.org/S4210200806","display_name":"Human Genetics and Genomics Advances","issn_l":"2666-2477","issn":["2666-2477"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Genetics and Genomics Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.4524729251861572,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1620252213","display_name":"Center for Clinical and Translational Sciences (CCTS)","funder_award_id":"4ul1tr000371-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G267556863","display_name":"Genomic, transcriptomic, and metabolic effects on skeletal health in Mexican Americans","funder_award_id":"5r01ag078452-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7096488574","display_name":"Whole Genome DNA Methylation Markers for Tracking and Predicting Advanced Liver Fibrosis as a Precursor of Liver Cancer in NAFLD.","funder_award_id":"RP230063","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G9000114515","display_name":null,"funder_award_id":"R01 HL142302-05A1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000143680","display_name":null,"funder_award_id":"R01AG078452-01A1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000295144","display_name":null,"funder_award_id":"UL1 TR00371","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000910403","display_name":"Pharmacogenetics of the Response to GLP-1 in Mexican-Americans with Prediabetes","funder_award_id":"R01DK127084","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W873417055","https://openalex.org/W1544906050","https://openalex.org/W1964284218","https://openalex.org/W1964598131","https://openalex.org/W1978929392","https://openalex.org/W1984217297","https://openalex.org/W1986911601","https://openalex.org/W1999574084","https://openalex.org/W2016676797","https://openalex.org/W2017333447","https://openalex.org/W2018838463","https://openalex.org/W2024822227","https://openalex.org/W2033151532","https://openalex.org/W2037320975","https://openalex.org/W2048612325","https://openalex.org/W2073836327","https://openalex.org/W2087246553","https://openalex.org/W2087644320","https://openalex.org/W2089555306","https://openalex.org/W2094768566","https://openalex.org/W2099294505","https://openalex.org/W2105673666","https://openalex.org/W2107018762","https://openalex.org/W2112759585","https://openalex.org/W2115801316","https://openalex.org/W2116687544","https://openalex.org/W2118648486","https://openalex.org/W2122825543","https://openalex.org/W2127427274","https://openalex.org/W2128371599","https://openalex.org/W2132495615","https://openalex.org/W2138207763","https://openalex.org/W2138956168","https://openalex.org/W2139763955","https://openalex.org/W2152885121","https://openalex.org/W2153118028","https://openalex.org/W2155496693","https://openalex.org/W2159268255","https://openalex.org/W2161633633","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2209106767","https://openalex.org/W2241686927","https://openalex.org/W2292687608","https://openalex.org/W2433325820","https://openalex.org/W2471370314","https://openalex.org/W2516224023","https://openalex.org/W2596258020","https://openalex.org/W2596624061","https://openalex.org/W2761275051","https://openalex.org/W2899328785","https://openalex.org/W2951912016","https://openalex.org/W2962931338","https://openalex.org/W2976913454","https://openalex.org/W2991212521","https://openalex.org/W3006663297","https://openalex.org/W3029661147","https://openalex.org/W3042068575","https://openalex.org/W3083786426","https://openalex.org/W3087677418","https://openalex.org/W3089716446","https://openalex.org/W3091953196","https://openalex.org/W3092119378","https://openalex.org/W3104088357","https://openalex.org/W3119787852","https://openalex.org/W3133997201","https://openalex.org/W3198747389","https://openalex.org/W3202209876","https://openalex.org/W3205644245","https://openalex.org/W3210601686","https://openalex.org/W4214506665","https://openalex.org/W4220802070","https://openalex.org/W4281713853","https://openalex.org/W4286218496","https://openalex.org/W4292607816","https://openalex.org/W4301391759","https://openalex.org/W4308771989","https://openalex.org/W4308990258","https://openalex.org/W4315779240","https://openalex.org/W4361199852","https://openalex.org/W4367294547","https://openalex.org/W4378781655","https://openalex.org/W4382894701","https://openalex.org/W4387764752","https://openalex.org/W4388080313","https://openalex.org/W4392500048","https://openalex.org/W4400770247","https://openalex.org/W4402713313","https://openalex.org/W4404283194","https://openalex.org/W4409320181"],"related_works":[],"abstract_inverted_index":{"While":[0],"lipids":[1,84],"have":[2],"been":[3],"extensively":[4],"investigated,":[5],"genetic":[6,80,140],"regulation":[7],"of":[8,26,142],"the":[9,54,60,70,133,152],"circulating":[10,75],"lipidome":[11],"in":[12,30,145,154],"diverse":[13],"populations":[14],"remains":[15],"poorly":[16],"understood.":[17],"We":[18,41],"conducted":[19],"a":[20,74,98,139,146],"lipidome-wide":[21],"genome-wide":[22,44],"association":[23,68],"study":[24,137],"(GWAS)":[25],"830":[27],"lipid":[28,143,156],"species":[29],"2,287":[31],"Hispanic/Latino":[32],"participants":[33],"and":[34,150],"performed":[35],"predictive":[36,115],"modeling":[37],"across":[38],"omics":[39],"layers.":[40],"identified":[42],"7,593":[43],"significant":[45],"SNPs":[46],"mapping":[47],"to":[48,122,124],"208":[49],"genes.":[50],"Conditional":[51],"analysis":[52],"disentangled":[53],"long-range":[55],"linkage":[56],"disequilibrium":[57],"artifacts":[58],"from":[59,120,129],"pleiotropic":[61],"FADS1/2/3":[62],"cluster.":[63],"Separately,":[64],"we":[65],"discovered":[66],"an":[67],"at":[69],"GPLD1":[71],"locus":[72],"for":[73],"ceramide.":[76],"Colocalization":[77],"revealed":[78],"shared":[79],"architecture":[81],"with":[82],"conventional":[83],"alongside":[85],"distinct,":[86],"species-specific":[87],"pathways.":[88],"Incorporating":[89],"Native/Indigenous":[90],"American":[91],"expression":[92,110],"quantitative":[93],"trait":[94],"loci":[95],"(eQTLs)":[96],"within":[97],"multi-omic":[99],"framework":[100],"uncovered":[101],"62":[102],"likely":[103],"regulatory":[104],"genes":[105],"missed":[106],"by":[107],"European-centric":[108],"gene":[109,130],"models.":[111],"Finally,":[112],"genetically":[113],"regulated":[114],"models":[116],"demonstrated":[117],"performance":[118],"declining":[119],"transcriptomics":[121],"proteomics":[123],"lipidomics,":[125],"reflecting":[126],"increased":[127],"distance":[128],"action":[131],"along":[132],"molecular":[134],"cascade.":[135],"Our":[136],"provides":[138],"landscape":[141],"metabolism":[144],"highly":[147],"burdened":[148],"population":[149],"highlights":[151],"challenges":[153],"predicting":[155],"abundance.":[157]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-08-26T00:00:00"}