{"id":"https://openalex.org/W7204200889","doi":"https://doi.org/10.1016/j.biopha.2026.119869","title":"Radiolabeled drug-delivery and controlled-release nanocarriers for arthritis: Clinical evidence, kinetic modeling, radiation-safety challenges, and precision nanotheranostics","display_name":"Radiolabeled drug-delivery and controlled-release nanocarriers for arthritis: Clinical evidence, kinetic modeling, radiation-safety challenges, and precision nanotheranostics","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204200889","doi":"https://doi.org/10.1016/j.biopha.2026.119869","pmid":"https://pubmed.ncbi.nlm.nih.gov/42641260"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2026.119869","doi":"https://doi.org/10.1016/j.biopha.2026.119869","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2026.119869","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.biopha.2026.119869","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002048460","display_name":"Tais Monteiro Magne","orcid":"https://orcid.org/0000-0003-3416-054X","observed_orcids":["https://orcid.org/0000-0003-3416-054X"]},"institutions":[{"id":"https://openalex.org/I4210142725","display_name":"Nuclear Engineering Institute","ror":"https://ror.org/040bdaa45","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210142725","https://openalex.org/I4210151455","https://openalex.org/I76248293"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Tais Magne Ramos","raw_affiliation_strings":["Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro, RJ 21941906, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-3416-054X","affiliations":[{"raw_affiliation_string":"Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro, RJ 21941906, Brazil","institution_ids":["https://openalex.org/I4210142725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034681854","display_name":"Luciana Magalh\u00e3es Reb\u00ealo Alencar","orcid":"https://orcid.org/0000-0001-8210-2016","observed_orcids":["https://orcid.org/0000-0001-8210-2016"]},"institutions":[{"id":"https://openalex.org/I47327664","display_name":"Universidade Federal do Maranh\u00e3o","ror":"https://ror.org/043fhe951","country_code":"BR","type":"education","lineage":["https://openalex.org/I47327664"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luciana Magalhaes Rebelo Alencar","raw_affiliation_strings":["Federal University of Maranh\u00e3o, Department of Physics, Biophysics Laboratory, Campus Bacanga, S\u00e3o Lu\u00eds, MA 65080-805, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Maranh\u00e3o, Department of Physics, Biophysics Laboratory, Campus Bacanga, S\u00e3o Lu\u00eds, MA 65080-805, Brazil","institution_ids":["https://openalex.org/I47327664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059411009","display_name":"Leandro Medeiros Motta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Leandro Medeiros Motta","raw_affiliation_strings":["LADEG, Laboratory of Pharmaceutical Nanotechnology, Faculty of Pharmacy, DEFARMED, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 2190000, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LADEG, Laboratory of Pharmaceutical Nanotechnology, Faculty of Pharmacy, DEFARMED, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 2190000, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045111623","display_name":"Pierre Bas\u00edlio Almeida Fechine","orcid":"https://orcid.org/0000-0002-7822-2354","observed_orcids":["https://orcid.org/0000-0002-7822-2354"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Pierre B.A. Fechine","raw_affiliation_strings":["Group of Chemistry of Advanced Materials (GQMat) - Department of Analytical Chemistry and Physical-Chemistry, Federal University of Cear\u00e1, Fortaleza, CE 451-970, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Group of Chemistry of Advanced Materials (GQMat) - Department of Analytical Chemistry and Physical-Chemistry, Federal University of Cear\u00e1, Fortaleza, CE 451-970, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079151433","display_name":"Eduardo Ricci\u2010J\u00fanior","orcid":"https://orcid.org/0000-0002-2550-696X","observed_orcids":["https://orcid.org/0000-0002-2550-696X"]},"institutions":[{"id":"https://openalex.org/I36001604","display_name":"University of Peshawar","ror":"https://ror.org/02t2qwf81","country_code":"PK","type":"education","lineage":["https://openalex.org/I36001604"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Eduardo Ricci-Junior","raw_affiliation_strings":["6 Nuclear Medicine Research Laboratory, Institute of Chemical Sciences, University of Peshawar, Peshawar, Khyber Pakhtunkhwa 25120, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6 Nuclear Medicine Research Laboratory, Institute of Chemical Sciences, University of Peshawar, Peshawar, Khyber Pakhtunkhwa 25120, Pakistan","institution_ids":["https://openalex.org/I36001604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148096578","display_name":"Syed Qaiser Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Syed Qaiser Shah","raw_affiliation_strings":["State University of Rio de Janeiro, Laboratory of Nanoradiopharmacy and Strategic Biomaterials, Rio de Janeiro, RJ 220000, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of Rio de Janeiro, Laboratory of Nanoradiopharmacy and Strategic Biomaterials, Rio de Janeiro, RJ 220000, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075467933","display_name":"Ralph Santos\u2010Oliveira","orcid":"https://orcid.org/0000-0002-0905-481X","observed_orcids":["https://orcid.org/0000-0002-0905-481X"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I4210142725","display_name":"Nuclear Engineering Institute","ror":"https://ror.org/040bdaa45","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210142725","https://openalex.org/I4210151455","https://openalex.org/I76248293"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Ralph Santos-Oliveira","raw_affiliation_strings":["Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro, RJ 21941906, Brazil; LADEG, Laboratory of Pharmaceutical Nanotechnology, Faculty of Pharmacy, DEFARMED, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 2190000, Brazil. Electronic address: roliveira@ien.gov.br"],"raw_orcid":"https://orcid.org/0000-0002-0905-481X","affiliations":[{"raw_affiliation_string":"Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro, RJ 21941906, Brazil; LADEG, Laboratory of Pharmaceutical Nanotechnology, Faculty of Pharmacy, DEFARMED, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 2190000, Brazil. Electronic address: roliveira@ien.gov.br","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4210142725"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5075467933"],"corresponding_institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4210142725"],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":{"value":3610,"currency":"USD","value_usd":3610},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67304834,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"203","issue":null,"first_page":"119869","last_page":"119869"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.6161999702453613,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.6161999702453613,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.3546999990940094,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arthritis","display_name":"arthritis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/controlled-drug-delivery","display_name":"controlled drug delivery","score":0.9340000152587891},{"id":"https://openalex.org/keywords/radiosynoviorthesis","display_name":"radiosynoviorthesis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/nanotheranostics","display_name":"nanotheranostics","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.5249999761581421},{"id":"https://openalex.org/keywords/dosimetry","display_name":"dosimetry","score":0.8069999814033508},{"id":"https://openalex.org/keywords/radiation-protection","display_name":"radiation protection","score":0.7440000176429749},{"id":"https://openalex.org/keywords/intra-articular-drug-delivery","display_name":"intra-articular drug delivery","score":0.6909999847412109},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.6399999856948853},{"id":"https://openalex.org/keywords/polymeric-nanoparticles","display_name":"polymeric nanoparticles","score":0.9150000214576721},{"id":"https://openalex.org/keywords/micelles","display_name":"micelles","score":0.7360000014305115},{"id":"https://openalex.org/keywords/hydrogels","display_name":"hydrogels","score":0.7379999756813049},{"id":"https://openalex.org/keywords/hydroxyapatite-particles","display_name":"hydroxyapatite particles","score":0.8309999704360962},{"id":"https://openalex.org/keywords/radiocolloid","display_name":"radiocolloid","score":0.7699999809265137},{"id":"https://openalex.org/keywords/radiolabel-stability","display_name":"radiolabel stability","score":0.6309999823570251},{"id":"https://openalex.org/keywords/nanomaterial-safety","display_name":"nanomaterial safety","score":0.45899999141693115},{"id":"https://openalex.org/keywords/pharmacokinetic-modeling","display_name":"pharmacokinetic modeling","score":0.44999998807907104},{"id":"https://openalex.org/keywords/target-engagement","display_name":"target engagement","score":0.375},{"id":"https://openalex.org/keywords/reticuloendothelial-system","display_name":"reticuloendothelial system","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.7846999764442444},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7128999829292297},{"id":"https://openalex.org/C135889238","wikidata":"https://www.wikidata.org/wiki/Q46276","display_name":"Kinetic energy","level":2,"score":0.4544999897480011},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4226999878883362},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.31940001249313354},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2883000075817108},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.1949000060558319},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19169999659061432},{"id":"https://openalex.org/C2993277463","wikidata":"https://www.wikidata.org/wiki/Q209082","display_name":"Chemical reaction kinetics","level":4,"score":0.18140000104904175},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.18119999766349792}],"mesh":[{"descriptor_ui":"D000068936","descriptor_name":"Theranostic Nanomedicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001168","descriptor_name":"Arthritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biopha.2026.119869","doi":"https://doi.org/10.1016/j.biopha.2026.119869","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2026.119869","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:42641260","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42641260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.biopha.2026.119869","doi":"https://doi.org/10.1016/j.biopha.2026.119869","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2026.119869","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7152761220932007}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1060491976","display_name":null,"funder_award_id":"E-26/010.000981/2019","funder_id":"https://openalex.org/F4320322749","funder_display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro"},{"id":"https://openalex.org/G2083983036","display_name":null,"funder_award_id":"301069/ 2018-2","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G3667194655","display_name":null,"funder_award_id":"401692/2023-0","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G4139392850","display_name":null,"funder_award_id":"E-26/200.815/2021","funder_id":"https://openalex.org/F4320322749","funder_display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro"},{"id":"https://openalex.org/G6908145910","display_name":null,"funder_award_id":"444089/2023-3","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G8700058705","display_name":null,"funder_award_id":"440852/2023-4","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322749","display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","ror":"https://ror.org/03kk0s825"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":143,"referenced_works":["https://openalex.org/W1038569680","https://openalex.org/W1812298537","https://openalex.org/W1947808021","https://openalex.org/W1965063429","https://openalex.org/W1969603156","https://openalex.org/W1979233582","https://openalex.org/W1986312882","https://openalex.org/W1993523958","https://openalex.org/W1995600944","https://openalex.org/W2006638208","https://openalex.org/W2014828564","https://openalex.org/W2021367421","https://openalex.org/W2036981237","https://openalex.org/W2045086952","https://openalex.org/W2052511353","https://openalex.org/W2056306723","https://openalex.org/W2057910069","https://openalex.org/W2058139986","https://openalex.org/W2072897177","https://openalex.org/W2076226743","https://openalex.org/W2092282157","https://openalex.org/W2095187713","https://openalex.org/W2098047948","https://openalex.org/W2100225360","https://openalex.org/W2101312385","https://openalex.org/W2104669609","https://openalex.org/W2118994799","https://openalex.org/W2130662409","https://openalex.org/W2137109674","https://openalex.org/W2139508918","https://openalex.org/W2143208806","https://openalex.org/W2143463421","https://openalex.org/W2158558808","https://openalex.org/W2188908588","https://openalex.org/W2302405003","https://openalex.org/W2328417245","https://openalex.org/W2344644350","https://openalex.org/W2415720263","https://openalex.org/W2464441488","https://openalex.org/W2588922129","https://openalex.org/W2589710212","https://openalex.org/W2619345603","https://openalex.org/W2728687929","https://openalex.org/W2781545991","https://openalex.org/W2797494384","https://openalex.org/W2800248573","https://openalex.org/W2905111812","https://openalex.org/W2913999676","https://openalex.org/W2920324197","https://openalex.org/W2920893744","https://openalex.org/W2927037977","https://openalex.org/W2944564829","https://openalex.org/W2946778965","https://openalex.org/W2948068236","https://openalex.org/W2963219746","https://openalex.org/W2970329262","https://openalex.org/W2976680862","https://openalex.org/W2995491971","https://openalex.org/W2996581137","https://openalex.org/W3009386304","https://openalex.org/W3012688995","https://openalex.org/W3102563980","https://openalex.org/W3109746568","https://openalex.org/W3111371165","https://openalex.org/W3115487027","https://openalex.org/W3128081302","https://openalex.org/W3132708206","https://openalex.org/W3163522298","https://openalex.org/W3171954900","https://openalex.org/W3184503168","https://openalex.org/W3184755963","https://openalex.org/W3200509227","https://openalex.org/W3205127776","https://openalex.org/W4200229606","https://openalex.org/W4210700905","https://openalex.org/W4211111012","https://openalex.org/W4211234983","https://openalex.org/W4220727761","https://openalex.org/W4221129344","https://openalex.org/W4223439423","https://openalex.org/W4224037358","https://openalex.org/W4224323614","https://openalex.org/W4225587998","https://openalex.org/W4231972505","https://openalex.org/W4238387725","https://openalex.org/W4281262855","https://openalex.org/W4281693819","https://openalex.org/W4283124207","https://openalex.org/W4287965040","https://openalex.org/W4297830374","https://openalex.org/W4309334162","https://openalex.org/W4310592041","https://openalex.org/W4311040882","https://openalex.org/W4313621221","https://openalex.org/W4317434639","https://openalex.org/W4317521197","https://openalex.org/W4322617918","https://openalex.org/W4327811642","https://openalex.org/W4366000421","https://openalex.org/W4367312039","https://openalex.org/W4376274581","https://openalex.org/W4384830282","https://openalex.org/W4387067171","https://openalex.org/W4388520781","https://openalex.org/W4389118741","https://openalex.org/W4389816494","https://openalex.org/W4389870833","https://openalex.org/W4390508148","https://openalex.org/W4390589730","https://openalex.org/W4390904353","https://openalex.org/W4391253274","https://openalex.org/W4391577947","https://openalex.org/W4393276396","https://openalex.org/W4394927116","https://openalex.org/W4396743026","https://openalex.org/W4396951481","https://openalex.org/W4399068355","https://openalex.org/W4399068358","https://openalex.org/W4399467649","https://openalex.org/W4400218642","https://openalex.org/W4401592229","https://openalex.org/W4403402994","https://openalex.org/W4403457839","https://openalex.org/W4403733122","https://openalex.org/W4404048550","https://openalex.org/W4404303039","https://openalex.org/W4404496694","https://openalex.org/W4404593618","https://openalex.org/W4404633639","https://openalex.org/W4404673651","https://openalex.org/W4405541011","https://openalex.org/W4407248631","https://openalex.org/W4408348581","https://openalex.org/W4409851649","https://openalex.org/W4411993466","https://openalex.org/W4412785448","https://openalex.org/W4413137380","https://openalex.org/W4413853751","https://openalex.org/W4414568237","https://openalex.org/W4415900010","https://openalex.org/W4416745984","https://openalex.org/W4417188053","https://openalex.org/W7117112009"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Arthritis":[1],"comprises":[2],"a":[3,27,336],"heterogeneous":[4,47],"group":[5],"of":[6,76,215,240,259],"inflammatory":[7],"and":[8,19,32,44,59,87,102,120,134,148,209,222,249,253,263,293,302,312,319,364],"degenerative":[9],"joint":[10,261],"disorders":[11],"characterized":[12,182],"by":[13,72],"distinct":[14,213],"pathological":[15],"mechanisms,":[16],"anatomical":[17],"targets,":[18],"therapeutic":[20,270],"requirements.":[21],"Although":[22],"arthritis":[23],"is":[24],"not":[25],"primarily":[26],"pharmacokinetic":[28,31,265],"disorder,":[29],"several":[30],"delivery":[33],"barriers":[34],"can":[35,68],"limit":[36],"treatment.":[37],"These":[38],"include":[39,282],"rapid":[40],"synovial-fluid":[41],"turnover,":[42],"vascular":[43],"lymphatic":[45],"clearance,":[46],"pannus":[48],"architecture,":[49],"restricted":[50],"cartilage":[51],"penetration,":[52],"protein-corona":[53],"remodeling,":[54],"mononuclear":[55],"phagocyte":[56],"system":[57],"sequestration,":[58],"systemic":[60,83,370],"toxicity":[61],"after":[62],"prolonged":[63,260],"exposure.":[64],"Radiolabeled":[65],"controlled-release":[66,110,141,176,328],"systems":[67],"transform":[69],"drug-delivery":[70,97],"evaluation":[71],"enabling":[73],"quantitative":[74,317,355],"measurement":[75],"carrier":[77],"retention,":[78,217],"payload":[79],"disposition,":[80],"extra-articular":[81],"leakage,":[82],"biodistribution,":[84,146],"target":[85],"engagement,":[86],"absorbed":[88],"radiation":[89,118,287],"dose.":[90],"OBJECTIVE:":[91],"This":[92],"review":[93,127],"critically":[94],"evaluates":[95],"radiolabeled":[96,138,269],"systems,":[98,184,208],"particulate":[99,234],"radionuclide":[100,235,245,298],"therapies,":[101],"nanotheranostic":[103],"strategies":[104],"for":[105,233],"arthritis,":[106],"emphasizing":[107],"formulation":[108,329],"design,":[109],"kinetics,":[111,354],"molecular":[112,144,225],"targeting,":[113],"radiochemical":[114,183],"stability,":[115],"clinical":[116,231],"evidence,":[117],"safety,":[119,164,291],"translational":[121,254,278,343],"feasibility.":[122],"METHODS:":[123],"A":[124],"mechanistic":[125],"narrative":[126],"was":[128],"conducted":[129],"using":[130],"peer-reviewed":[131],"clinical,":[132],"translational,":[133],"preclinical":[135,275],"studies":[136],"addressing":[137],"nanocarriers,":[139],"intra-articular":[140,243,372],"platforms,":[142],"radiosynoviorthesis,":[143],"imaging,":[145,162,311,356],"dosimetry,":[147,358],"arthritis-targeted":[149],"nanomedicine.":[150],"Studies":[151,168],"were":[152,185],"prioritized":[153],"when":[154],"they":[155],"reported":[156],"experimentally":[157],"determined":[158],"physicochemical,":[159],"pharmaceutical,":[160],"pharmacokinetic,":[161],"dosimetric,":[163],"or":[165,175,224,276,371],"clinical-development":[166],"data.":[167],"lacking":[169],"an":[170],"identifiable":[171],"carrier,":[172],"particulate,":[173],"depot,":[174],"component,":[177],"as":[178,180,335],"well":[179],"inadequately":[181],"excluded":[186],"from":[187],"the":[188,229,238,257,274],"comparative":[189],"synthesis.":[190],"RESULTS:":[191],"Liposomes,":[192],"biodegradable":[193],"polymeric":[194],"nanoparticles,":[195],"micelles,":[196],"macromolecular":[197],"prodrugs,":[198],"hydrogels,":[199],"nanogels,":[200],"cartilage-binding":[201],"constructs,":[202],"hydroxyapatite":[203],"particles,":[204],"radiocolloids,":[205],"hybrid":[206],"inorganic":[207],"biomimetic":[210],"carriers":[211],"offer":[212],"combinations":[214],"synovial":[216],"drug-loading":[218],"capacity,":[219],"release":[220,353],"behavior,":[221],"cellular":[223],"targeting.":[226],"Radiosynoviorthesis":[227],"provides":[228],"strongest":[230],"precedent":[232],"therapy,":[236],"demonstrating":[237],"importance":[239],"particle":[241],"size,":[242],"distribution,":[244],"range,":[246],"leakage":[247],"control,":[248],"absorbed-dose":[250],"heterogeneity.":[251],"Human":[252],"evidence":[255],"supports":[256],"relevance":[258],"residence":[262],"image-guided":[264],"assessment,":[266,361],"whereas":[267],"most":[268,341],"nanocarriers":[271],"remain":[272],"at":[273],"early":[277],"stage.":[279],"Major":[280],"limitations":[281],"radiolabel":[283],"instability,":[284],"carrier-payload":[285],"dissociation,":[286],"exposure,":[288],"long-term":[289],"nanomaterial":[290],"hepatic":[292],"splenic":[294],"accumulation,":[295],"manufacturing":[296],"complexity,":[297],"availability,":[299],"regulatory":[300],"uncertainty,":[301],"limited":[303],"cost-effectiveness":[304],"evidence.":[305],"Artificial":[306],"intelligence-assisted":[307],"image":[308],"analysis,":[309],"multimodal":[310],"patient-specific":[313],"dosimetry":[314],"may":[315],"improve":[316],"assessment":[318],"accelerate":[320],"translation.":[321],"CONCLUSIONS:":[322],"Radiolabeling":[323],"should":[324],"be":[325],"incorporated":[326],"throughout":[327],"development":[330],"rather":[331],"than":[332],"used":[333],"only":[334],"final":[337],"diagnostic":[338],"component.":[339],"The":[340],"credible":[342],"strategy":[344],"involves":[345],"mechanism-matched":[346],"platforms":[347],"that":[348],"combine":[349],"stable":[350],"radiochemistry,":[351],"disease-relevant":[352],"personalized":[357],"rigorous":[359],"safety":[360],"reproducible":[362],"manufacturing,":[363],"clinically":[365],"meaningful":[366],"superiority":[367],"over":[368],"conventional":[369],"therapy.":[373]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-08-26T00:00:00"}