{"id":"https://openalex.org/W7204199727","doi":"https://doi.org/10.3390/cells15171529","title":"Pulsed Electromagnetic Fields Modulate Inflammatory and Tenogenic Responses in Human Tenocytes: Insights from Acute and Prolonged Inflammation Models","display_name":"Pulsed Electromagnetic Fields Modulate Inflammatory and Tenogenic Responses in Human Tenocytes: Insights from Acute and Prolonged Inflammation Models","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204199727","doi":"https://doi.org/10.3390/cells15171529","pmid":"https://pubmed.ncbi.nlm.nih.gov/42738823"},"language":"en","primary_location":{"id":"doi:10.3390/cells15171529","doi":"https://doi.org/10.3390/cells15171529","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells15171529","pdf_url":null,"source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cells15171529","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055985759","display_name":"Michela Maria Taiana","orcid":"https://orcid.org/0000-0001-8257-8831","observed_orcids":["https://orcid.org/0000-0001-8257-8831"]},"institutions":[{"id":"https://openalex.org/I4210113215","display_name":"IRCCS Ospedale Galeazzi - Sant'Ambrogio","ror":"https://ror.org/01vyrje42","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113215","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michela Maria Taiana","raw_affiliation_strings":["IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, Laboratorio di Biotecnologie Applicate all\u2019Ortopedia, 20157 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8257-8831","affiliations":[{"raw_affiliation_string":"IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, Laboratorio di Biotecnologie Applicate all\u2019Ortopedia, 20157 Milan, Italy","institution_ids":["https://openalex.org/I4210113215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009533626","display_name":"Paola De Luca","orcid":"https://orcid.org/0000-0001-9810-8818","observed_orcids":["https://orcid.org/0000-0001-9810-8818","https://orcid.org/0009-0005-4079-7899","https://orcid.org/0000-0001-7212-1029"]},"institutions":[{"id":"https://openalex.org/I4210113215","display_name":"IRCCS Ospedale Galeazzi - Sant'Ambrogio","ror":"https://ror.org/01vyrje42","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113215","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Paola De Luca","raw_affiliation_strings":["IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, Laboratorio di Biotecnologie Applicate all\u2019Ortopedia, 20157 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9810-8818","affiliations":[{"raw_affiliation_string":"IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, Laboratorio di Biotecnologie Applicate all\u2019Ortopedia, 20157 Milan, Italy","institution_ids":["https://openalex.org/I4210113215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057559893","display_name":"Giulio Grieco","orcid":"https://orcid.org/0009-0004-4716-1984","observed_orcids":["https://orcid.org/0009-0004-4716-1984"]},"institutions":[{"id":"https://openalex.org/I4210113215","display_name":"IRCCS Ospedale Galeazzi - Sant'Ambrogio","ror":"https://ror.org/01vyrje42","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113215","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulio Grieco","raw_affiliation_strings":["IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, Laboratorio di Biotecnologie Applicate all\u2019Ortopedia, 20157 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, Laboratorio di Biotecnologie Applicate all\u2019Ortopedia, 20157 Milan, Italy","institution_ids":["https://openalex.org/I4210113215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089724795","display_name":"Enrico Ragni","orcid":"https://orcid.org/0000-0003-0272-7417","observed_orcids":["https://orcid.org/0000-0003-0272-7417"]},"institutions":[{"id":"https://openalex.org/I4210113215","display_name":"IRCCS Ospedale Galeazzi - Sant'Ambrogio","ror":"https://ror.org/01vyrje42","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113215","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Ragni","raw_affiliation_strings":["IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, Laboratorio di Biotecnologie Applicate all\u2019Ortopedia, 20157 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, Laboratorio di Biotecnologie Applicate all\u2019Ortopedia, 20157 Milan, Italy","institution_ids":["https://openalex.org/I4210113215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067684103","display_name":"Simona Salati","orcid":"https://orcid.org/0000-0002-8072-1128","observed_orcids":["https://orcid.org/0000-0002-8072-1128"]},"institutions":[{"id":"https://openalex.org/I4210106972","display_name":"IGEA Clinical Biophysics (Italy)","ror":"https://ror.org/01bws2668","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210106972"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona Salati","raw_affiliation_strings":["Medical Division, IGEA, 41012 Carpi, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8072-1128","affiliations":[{"raw_affiliation_string":"Medical Division, IGEA, 41012 Carpi, Italy","institution_ids":["https://openalex.org/I4210106972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067032690","display_name":"Antonio Marmotti","orcid":"https://orcid.org/0000-0002-1683-6094","observed_orcids":["https://orcid.org/0000-0002-1683-6094"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Marmotti","raw_affiliation_strings":["Department of Orthopaedics and Traumatology, University of Turin, 10100 Turin, Italy","Molecular Biotechnology Center \u201cGuido Tarone\u201d, Department Molecular Biotechnology and Health Sciences, University of Turin, 10100 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics and Traumatology, University of Turin, 10100 Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Molecular Biotechnology Center \u201cGuido Tarone\u201d, Department Molecular Biotechnology and Health Sciences, University of Turin, 10100 Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072184375","display_name":"Valerio Pascale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210113215","display_name":"IRCCS Ospedale Galeazzi - Sant'Ambrogio","ror":"https://ror.org/01vyrje42","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113215","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valerio Pascale","raw_affiliation_strings":["IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, Ortopedia Clinicizzata, 20157 Milan, Italy","Medicina e Chirurgia, Scienze Biomediche per la Salute, Universit\u00e0 degli Studi di Milano, 20133 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, Ortopedia Clinicizzata, 20157 Milan, Italy","institution_ids":["https://openalex.org/I4210113215"]},{"raw_affiliation_string":"Medicina e Chirurgia, Scienze Biomediche per la Salute, Universit\u00e0 degli Studi di Milano, 20133 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023786049","display_name":"Laura de Girolamo","orcid":"https://orcid.org/0000-0002-9979-3092","observed_orcids":["https://orcid.org/0000-0002-9979-3092"]},"institutions":[{"id":"https://openalex.org/I4210113215","display_name":"IRCCS Ospedale Galeazzi - Sant'Ambrogio","ror":"https://ror.org/01vyrje42","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113215","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura de Girolamo","raw_affiliation_strings":["IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, Laboratorio di Biotecnologie Applicate all\u2019Ortopedia, 20157 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9979-3092","affiliations":[{"raw_affiliation_string":"IRCCS Ospedale Galeazzi Sant\u2019Ambrogio, Laboratorio di Biotecnologie Applicate all\u2019Ortopedia, 20157 Milan, Italy","institution_ids":["https://openalex.org/I4210113215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5009533626"],"corresponding_institution_ids":["https://openalex.org/I4210113215"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.68145903,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"17","first_page":"1529","last_page":"1529"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10874","display_name":"Electromagnetic Fields and Biological Effects","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulsed-electromagnetic-fields","display_name":"pulsed electromagnetic fields","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tendinopathy","display_name":"tendinopathy","score":0.9729999899864197},{"id":"https://openalex.org/keywords/tenocytes","display_name":"tenocytes","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tenogenesis","display_name":"tenogenesis","score":0.6919999718666077},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8830000162124634},{"id":"https://openalex.org/keywords/acute-and-chronic-inflammation","display_name":"acute and chronic inflammation","score":0.5569999814033508},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5490000247955322},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.8769999742507935},{"id":"https://openalex.org/keywords/secretome","display_name":"secretome","score":0.6759999990463257},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.7419999837875366},{"id":"https://openalex.org/keywords/ccl5","display_name":"RANTES","score":0.8820000290870667},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8320000171661377},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9589999914169312},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.8600000143051147},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6930999755859375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6600000262260437},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5774000287055969},{"id":"https://openalex.org/C101666144","wikidata":"https://www.wikidata.org/wiki/Q2587862","display_name":"CCL2","level":4,"score":0.5741999745368958},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.5095999836921692},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5001000165939331},{"id":"https://openalex.org/C2778911562","wikidata":"https://www.wikidata.org/wiki/Q1682583","display_name":"Tendinopathy","level":3,"score":0.49300000071525574},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4659000039100647},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4187999963760376},{"id":"https://openalex.org/C2993958860","wikidata":"https://www.wikidata.org/wiki/Q1064904","display_name":"Acute injury","level":2,"score":0.4002000093460083},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.35440000891685486},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.3441999852657318},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30889999866485596},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28870001435279846},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2840000092983246},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.2766999900341034},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.26499998569488525},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.2542000114917755}],"mesh":[{"descriptor_ui":"D000070916","descriptor_name":"Tenocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000070916","descriptor_name":"Tenocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000070916","descriptor_name":"Tenocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000070916","descriptor_name":"Tenocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000070916","descriptor_name":"Tenocytes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D000070916","descriptor_name":"Tenocytes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D004574","descriptor_name":"Electromagnetic Fields","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004574","descriptor_name":"Electromagnetic Fields","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052256","descriptor_name":"Tendinopathy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D052256","descriptor_name":"Tendinopathy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D052256","descriptor_name":"Tendinopathy","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D052256","descriptor_name":"Tendinopathy","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/cells15171529","doi":"https://doi.org/10.3390/cells15171529","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells15171529","pdf_url":null,"source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},{"id":"pmid:42738823","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42738823","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Journal Article"},{"id":"pmh:oai:air.unimi.it:2434/1268976","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2434/1268976","pdf_url":"https://air.unimi.it/bitstream/2434/1268976/2/cells-15-01529.pdf","source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13565733","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13565733/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13565733/pdf/cells-15-01529.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ac6634d9e8a84415992e148ddc02b2bc","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ac6634d9e8a84415992e148ddc02b2bc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells, Vol 15, Iss 17, p 1529 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cells15171529","doi":"https://doi.org/10.3390/cells15171529","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells15171529","pdf_url":null,"source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7664183974266052}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4799732037","display_name":null,"funder_award_id":"CUP C43C22002370001","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"}],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1977547435","https://openalex.org/W2126582098","https://openalex.org/W2580061807","https://openalex.org/W2767429408","https://openalex.org/W2943528267","https://openalex.org/W2980382240","https://openalex.org/W2990261946","https://openalex.org/W3088902574","https://openalex.org/W3089356945","https://openalex.org/W3133630572","https://openalex.org/W4211130574","https://openalex.org/W4386901370"],"related_works":[],"abstract_inverted_index":{"Tendinopathy":[0],"is":[1],"a":[2,18],"prevalent":[3],"musculoskeletal":[4],"condition":[5],"characterised":[6],"by":[7,128],"chronic":[8],"inflammatory":[9,28,214],"and":[10,51,67,81,90,104,112,115],"degenerative":[11],"changes.":[12],"Pulsed":[13],"electromagnetic":[14],"fields":[15],"(PEMFs)":[16],"represent":[17],"promising":[19],"biophysical":[20],"therapeutic":[21],"modality,":[22],"yet":[23],"their":[24],"effects":[25,39],"across":[26,138,162],"different":[27],"states":[29],"of":[30,216,227,234],"tendinopathy":[31],"remain":[32],"poorly":[33],"characterised.":[34],"To":[35],"evaluate":[36],"PEMF":[37,220,239],"biological":[38],"on":[40],"human":[41],"tenocytes,":[42],"three":[43],"in":[44,48,85,93,107,119,130,144,165,176,189,222,231],"vitro":[45],"models":[46],"differing":[47],"IL-1\u03b2":[49],"dose":[50],"duration":[52],"were":[53],"tested:":[54],"acute":[55,61,87,109,141,167,205],"low-dose":[56,88,168],"(0.1":[57,69],"ng/mL,":[58,64,70],"96":[59,65],"h),":[60,66],"high-dose":[62,110,193],"(1":[63],"prolonged":[68,95,121,195],"9":[71],"days).":[72],"At":[73,97],"the":[74,86,94,98,108,120,140,166,213,225,232],"transcriptional":[75],"level,":[76,100],"PEMFs":[77,101,129,133,152,170,197],"significantly":[78,154,172],"reduced":[79,102],"IL-6":[80],"IL-8":[82,105],"mRNA":[83],"overexpression":[84],"model":[89],"CCL2":[91,114],"upregulation":[92],"model.":[96,122],"secretome":[99],"GM-CSF":[103],"secretion":[106,118],"model,":[111,169],"suppressed":[113],"CCL5":[116],"protein":[117],"MMP":[123],"activity":[124],"was":[125,187],"not":[126],"modulated":[127],"any":[131],"condition.":[132],"consistently":[134],"increased":[135],"tenocyte":[136],"proliferation":[137],"both":[139],"models.":[142],"Finally,":[143],"wound":[145,156,174],"healing":[146,202],"assays,":[147],"non-inflamed":[148],"tenocytes":[149,217],"exposed":[150,191],"to":[151,159,192],"showed":[153],"enhanced":[155],"closure":[157,175],"compared":[158],"IL-1\u03b2-treated":[160,177],"cells":[161,178,190],"all":[163],"models;":[164],"also":[171],"improved":[173],"at":[179],"an":[180],"early":[181],"timepoint,":[182],"whereas":[183],"no":[184],"such":[185],"effect":[186],"observed":[188],"or":[194,206],"inflammation.":[196,208],"exert":[198],"context-dependent":[199],"effects,":[200],"promoting":[201],"primarily":[203],"during":[204],"mild":[207],"These":[209],"findings":[210],"suggest":[211],"that":[212],"stage":[215],"may":[218],"influence":[219],"responsiveness":[221],"vitro,":[223],"highlighting":[224],"importance":[226],"considering":[228],"this":[229],"variable":[230],"design":[233],"future":[235],"clinical":[236],"studies":[237],"evaluating":[238],"therapy":[240],"for":[241],"tendinopathy.":[242]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2026-08-26T00:00:00"}