{"id":"https://openalex.org/W7204199236","doi":"https://doi.org/10.1212/wn9.0000000000000150","title":"Adiposity and the Alzheimer Disease\u2013Related Blood Biomarker, p-Tau217, in Community-Dwelling Midlife Women","display_name":"Adiposity and the Alzheimer Disease\u2013Related Blood Biomarker, p-Tau217, in Community-Dwelling Midlife Women","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204199236","doi":"https://doi.org/10.1212/wn9.0000000000000150"},"language":"en","primary_location":{"id":"doi:10.1212/wn9.0000000000000150","doi":"https://doi.org/10.1212/wn9.0000000000000150","is_oa":true,"landing_page_url":"https://doi.org/10.1212/wn9.0000000000000150","pdf_url":"https://www.neurology.org/doi/pdf/10.1212/WN9.0000000000000150","source":{"id":"https://openalex.org/S5407042784","display_name":"Neurology Open Access","issn_l":"2998-7601","issn":["2998-7601"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology Open Access","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.neurology.org/doi/pdf/10.1212/WN9.0000000000000150","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5139873926","display_name":"Rui-Kyi Ng","orcid":"https://orcid.org/0009-0005-7561-1951","observed_orcids":["https://orcid.org/0009-0005-7561-1951"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Rui Kyi Ng","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore;"],"raw_orcid":"https://orcid.org/0009-0005-7561-1951","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore;","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111354415","display_name":"Darren Y. Z. Tan","orcid":"https://orcid.org/0009-0001-2015-0247","observed_orcids":["https://orcid.org/0009-0001-2015-0247"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Darren Y.Z. Tan","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore;"],"raw_orcid":"https://orcid.org/0009-0001-2015-0247","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore;","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114109307","display_name":"Beverly Wen Xin Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Beverly W.X. Wong","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore;","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026318854","display_name":"Liang Shen","orcid":"https://orcid.org/0000-0001-7976-668X","observed_orcids":["https://orcid.org/0000-0001-7976-668X","https://orcid.org/0000-0002-1818-1271"]},"institutions":[{"id":"https://openalex.org/I4210162116","display_name":"Singapore Clinical Research Institute","ror":"https://ror.org/05c27bs83","country_code":"SG","type":"other","lineage":["https://openalex.org/I4210162116"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Liang Shen","raw_affiliation_strings":["Biostatistics, Singapore Clinical Research Institute, CRIS, Singapore;"],"raw_orcid":"https://orcid.org/0000-0001-7976-668X","affiliations":[{"raw_affiliation_string":"Biostatistics, Singapore Clinical Research Institute, CRIS, Singapore;","institution_ids":["https://openalex.org/I4210162116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062361182","display_name":"Young\u2010Bin Cho","orcid":"https://orcid.org/0009-0003-2532-2348","observed_orcids":["https://orcid.org/0009-0003-2532-2348"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Bin Cho","raw_affiliation_strings":["Department of Medicine, Graduate School of Konkuk University, Korea; and"],"raw_orcid":"https://orcid.org/0009-0003-2532-2348","affiliations":[{"raw_affiliation_string":"Department of Medicine, Graduate School of Konkuk University, Korea; and","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121256449","display_name":"Christopher Li\u2010Hsian Chen","orcid":"https://orcid.org/0000-0002-1047-9225","observed_orcids":["https://orcid.org/0000-0002-1047-9225"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Christopher Li-Hsian Chen","raw_affiliation_strings":["Memory Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memory Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026246320","display_name":"Eu\u2010Leong Yong","orcid":"https://orcid.org/0000-0001-6511-770X","observed_orcids":["https://orcid.org/0000-0001-6511-770X"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Eu-Leong Yong","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore;"],"raw_orcid":"https://orcid.org/0000-0001-6511-770X","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore;","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111354415","https://openalex.org/A5139873926"],"corresponding_institution_ids":["https://openalex.org/I165932596"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.69161132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.10589999705553055,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adiposity","display_name":"adiposity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6980000138282776},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9089999794960022},{"id":"https://openalex.org/keywords/p-tau217","display_name":"p-tau217","score":0.9100000262260437},{"id":"https://openalex.org/keywords/phosphorylated-tau","display_name":"phosphorylated tau","score":0.8569999933242798},{"id":"https://openalex.org/keywords/blood-biomarkers","display_name":"blood biomarkers","score":0.9620000123977661},{"id":"https://openalex.org/keywords/middle-aged-women","display_name":"middle-aged women","score":0.9139999747276306},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.8140000104904175},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.765999972820282},{"id":"https://openalex.org/keywords/community-dwelling-women","display_name":"community-dwelling women","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.699999988079071},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.382999986410141},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3409000039100647},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3273000121116638},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3181000053882599},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.3158000111579895},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2782999873161316},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.25270000100135803},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2313999980688095},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.2295999974012375}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wn9.0000000000000150","doi":"https://doi.org/10.1212/wn9.0000000000000150","is_oa":true,"landing_page_url":"https://doi.org/10.1212/wn9.0000000000000150","pdf_url":"https://www.neurology.org/doi/pdf/10.1212/WN9.0000000000000150","source":{"id":"https://openalex.org/S5407042784","display_name":"Neurology Open Access","issn_l":"2998-7601","issn":["2998-7601"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology Open Access","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1212/wn9.0000000000000150","doi":"https://doi.org/10.1212/wn9.0000000000000150","is_oa":true,"landing_page_url":"https://doi.org/10.1212/wn9.0000000000000150","pdf_url":"https://www.neurology.org/doi/pdf/10.1212/WN9.0000000000000150","source":{"id":"https://openalex.org/S5407042784","display_name":"Neurology Open Access","issn_l":"2998-7601","issn":["2998-7601"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology Open Access","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/5","display_name":"Gender equality","score":0.5857399702072144}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204199236.pdf","grobid_xml":"https://content.openalex.org/works/W7204199236.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1941112507","https://openalex.org/W1966556007","https://openalex.org/W2013033239","https://openalex.org/W2063695226","https://openalex.org/W2064859339","https://openalex.org/W2087281430","https://openalex.org/W2096657471","https://openalex.org/W2129709499","https://openalex.org/W2162429408","https://openalex.org/W2195791173","https://openalex.org/W2206502647","https://openalex.org/W2467227824","https://openalex.org/W2613930978","https://openalex.org/W2793648003","https://openalex.org/W2800324981","https://openalex.org/W2900756240","https://openalex.org/W2963969303","https://openalex.org/W2976230514","https://openalex.org/W2977682063","https://openalex.org/W3009496837","https://openalex.org/W3017051753","https://openalex.org/W3048382545","https://openalex.org/W3119309452","https://openalex.org/W3126187484","https://openalex.org/W3153621800","https://openalex.org/W3201595862","https://openalex.org/W4200088684","https://openalex.org/W4206046172","https://openalex.org/W4206661596","https://openalex.org/W4210406803","https://openalex.org/W4229030955","https://openalex.org/W4229439744","https://openalex.org/W4241883936","https://openalex.org/W4307342303","https://openalex.org/W4315648038","https://openalex.org/W4327912638","https://openalex.org/W4382777619","https://openalex.org/W4385620073","https://openalex.org/W4388410342","https://openalex.org/W4388414096","https://openalex.org/W4388589365","https://openalex.org/W4391101037","https://openalex.org/W4392197305","https://openalex.org/W4393156531","https://openalex.org/W4400089962","https://openalex.org/W4400388912","https://openalex.org/W4400814815","https://openalex.org/W4401164724","https://openalex.org/W4404506969","https://openalex.org/W4405187546","https://openalex.org/W4406371559","https://openalex.org/W4406757736","https://openalex.org/W4407240952","https://openalex.org/W4407987233","https://openalex.org/W4408387793","https://openalex.org/W4409279344","https://openalex.org/W4412118194","https://openalex.org/W4412660439","https://openalex.org/W7151589412"],"related_works":[],"abstract_inverted_index":{"Women":[0],"have":[1],"twice":[2],"the":[3,12],"dementia":[4],"risk":[5,25],"compared":[6],"with":[7],"men.":[8],"Obesity":[9],"contributes":[10],"to":[11],"cardiovascular":[13],"component":[14],"of":[15],"Alzheimer":[16,28],"disease":[17],"(AD).":[18],"We":[19],"hypothesize":[20],"that":[21],"adiposity":[22],"would":[23],"increase":[24],"for":[26],"raised":[27],"disease\u2013related":[29],"blood":[30],"biomarker,":[31],"p-tau217,":[32],"in":[33],"community-dwelling":[34],"midlife":[35],"women.":[36]},"counts_by_year":[],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2026-08-26T00:00:00"}