{"id":"https://openalex.org/W7204196673","doi":"https://doi.org/10.7150/thno.131793","title":"An integrated SOX4-driven transcriptional and metabolic program governs tumor-infiltrating regulatory T cells in ovarian cancer","display_name":"An integrated SOX4-driven transcriptional and metabolic program governs tumor-infiltrating regulatory T cells in ovarian cancer","publication_year":2026,"publication_date":"2026-08-12","ids":{"openalex":"https://openalex.org/W7204196673","doi":"https://doi.org/10.7150/thno.131793","pmid":"https://pubmed.ncbi.nlm.nih.gov/42707988","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13549143"},"language":"en","primary_location":{"id":"doi:10.7150/thno.131793","doi":"https://doi.org/10.7150/thno.131793","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.131793","pdf_url":"https://www.thno.org/v16p8611.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.thno.org/v16p8611.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148043498","display_name":"Lei Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Wu","raw_affiliation_strings":["Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","institution_ids":[]},{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133265726","display_name":"Ziqi Tao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ziqi Tao","raw_affiliation_strings":["Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","institution_ids":[]},{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004095648","display_name":"Yuelu Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuelu Zhang","raw_affiliation_strings":["Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","institution_ids":[]},{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111072634","display_name":"Yepeng Mao","orcid":"https://orcid.org/0009-0003-0924-5143","observed_orcids":["https://orcid.org/0009-0003-0924-5143"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yepeng Mao","raw_affiliation_strings":["Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","institution_ids":[]},{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148079842","display_name":"Lei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097726","display_name":"Huaian First People\u2019s Hospital","ror":"https://ror.org/00xpfw690","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097726"]},{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Zhang","raw_affiliation_strings":["Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","Department of Gynecology, The Affiliated Huaian NO.1 People's Hospital of Nanjing Medical University, Huaian, 223300, China","Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","institution_ids":[]},{"raw_affiliation_string":"Department of Gynecology, The Affiliated Huaian NO.1 People's Hospital of Nanjing Medical University, Huaian, 223300, China","institution_ids":["https://openalex.org/I4210097726"]},{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148091917","display_name":"Lina Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lina Yan","raw_affiliation_strings":["Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","Department of Gynecology, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China","Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","institution_ids":[]},{"raw_affiliation_string":"Department of Gynecology, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148164531","display_name":"Rong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Li","raw_affiliation_strings":["Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","Department of Gynecology, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China","Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","institution_ids":[]},{"raw_affiliation_string":"Department of Gynecology, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133278259","display_name":"Lingfei Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingfei Zhou","raw_affiliation_strings":["Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","institution_ids":[]},{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140514145","display_name":"Zhijie Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhijie Liu","raw_affiliation_strings":["Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","institution_ids":[]},{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103806554","display_name":"Wenwen Shang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenwen Shang","raw_affiliation_strings":["Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","institution_ids":[]},{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031139469","display_name":"Shuna Liu","orcid":"https://orcid.org/0000-0003-0417-5732","observed_orcids":["https://orcid.org/0000-0003-0417-5732","https://orcid.org/0000-0002-9852-0455"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuna Liu","raw_affiliation_strings":["Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","institution_ids":[]},{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033220213","display_name":"\u5a04\u9274\u82b3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianfang Lou","raw_affiliation_strings":["Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","institution_ids":[]},{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148126127","display_name":"Xi Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Huang","raw_affiliation_strings":["Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","institution_ids":[]},{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148156368","display_name":"Ting Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ting Wang","raw_affiliation_strings":["Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","institution_ids":[]},{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5148140986","display_name":"Fang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fang Wang","raw_affiliation_strings":["Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, 210029, China","institution_ids":[]},{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004095648","https://openalex.org/A5111072634","https://openalex.org/A5133265726","https://openalex.org/A5148043498","https://openalex.org/A5148140986","https://openalex.org/A5148156368"],"corresponding_institution_ids":["https://openalex.org/I4210152119"],"apc_list":{"value":2500,"currency":"AUD","value_usd":1671},"apc_paid":{"value":2500,"currency":"AUD","value_usd":1671},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.55524148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"15","first_page":"8611","last_page":"8632"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0608999989926815,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sox4","display_name":"SOX4","score":0.8870000243186951},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/tumor-infiltrating-t-cells","display_name":"tumor-infiltrating T cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":1.0},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8140000104904175},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.6520000100135803},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hypoxic-tumor-microenvironment","display_name":"hypoxic tumor microenvironment","score":0.8100000023841858},{"id":"https://openalex.org/keywords/t-cell-receptor-activation","display_name":"T cell receptor stimulation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.9160000085830688},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5950000286102295},{"id":"https://openalex.org/keywords/immunotherapy-targets","display_name":"immunotherapy targets","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6870999932289124},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5389999747276306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4016999900341034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3578000068664551},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30649998784065247},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2856000065803528},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.27320000529289246},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.271699994802475},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2687999904155731},{"id":"https://openalex.org/C2908651487","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian carcinomas","level":5,"score":0.2669999897480011},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.25999999046325684},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2590999901294708},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2549999952316284},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.25450000166893005},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2515999972820282},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2506999969482422}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055751","descriptor_name":"SOXC Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055751","descriptor_name":"SOXC Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.7150/thno.131793","doi":"https://doi.org/10.7150/thno.131793","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.131793","pdf_url":"https://www.thno.org/v16p8611.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13549143","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13549143/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13549143/pdf/thnov16p8611.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"Text"},{"id":"pmid:42707988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42707988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7150/thno.131793","doi":"https://doi.org/10.7150/thno.131793","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.131793","pdf_url":"https://www.thno.org/v16p8611.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1847947455","display_name":null,"funder_award_id":"82273199","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G2804270925","display_name":null,"funder_award_id":"BK20221417","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G2861756885","display_name":null,"funder_award_id":"82502175","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3802453471","display_name":null,"funder_award_id":"BK20221417","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8869107313","display_name":null,"funder_award_id":"82273199","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204196673.pdf","grobid_xml":"https://content.openalex.org/works/W7204196673.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2885788384","https://openalex.org/W4413757349","https://openalex.org/W2472140658","https://openalex.org/W2781565776","https://openalex.org/W7132840533","https://openalex.org/W7220898593","https://openalex.org/W2405590190","https://openalex.org/W2945428273","https://openalex.org/W4412140322","https://openalex.org/W7165792334"],"abstract_inverted_index":{"Background:":[0],"Regulatory":[1],"T":[2],"cells":[3],"(Tregs)":[4],"suppress":[5],"antitumor":[6],"immunity":[7],"in":[8,141,188],"ovarian":[9],"cancer":[10],"(OC)":[11],"and":[12,21,50,59,69,85,92,138,155,178,210],"are":[13],"promising":[14,215],"targets":[15],"for":[16,218],"immunotherapy.":[17],"However,":[18],"the":[19,109,135],"heterogeneity":[20],"regulatory":[22,63],"mechanisms":[23],"of":[24,72,173,195,206],"tumor-infiltrating":[25],"Tregs":[26,45,120],"(TI-Tregs)":[27],"remain":[28],"poorly":[29],"defined.":[30],"Here,":[31],"we":[32],"aim":[33],"to":[34,38,151],"delineate":[35],"TI-Treg":[36,113,207],"programs":[37],"identify":[39],"potential":[40],"therapeutic":[41,216],"targets.":[42],"Methods:":[43],"CD4\u207aCD25\u207aCD127\u207b":[44],"from":[46],"OC,":[47],"adjacent":[48],"tissues,":[49],"peripheral":[51],"blood":[52],"were":[53,74],"profiled":[54],"by":[55,134],"single-cell":[56],"RNA":[57],"sequencing":[58],"spatial":[60,116],"transcriptomics,":[61],"with":[62,100,115],"networks":[64],"inferred":[65],"using":[66,76],"SCENIC.":[67],"Functional":[68],"mechanistic":[70],"studies":[71],"SOX4":[73,107,148,168,174,183,201],"performed":[75],"hypoxic/tumor-conditioned":[77],"models,":[78],"CRISPR-Cas9":[79],"perturbation,":[80],"ectopic":[81],"overexpression,":[82],"Cut&Tag":[83,158],"profiling,":[84],"oxidative":[86],"phosphorylation":[87],"(OXPHOS)":[88],"inhibition.":[89],"Results:":[90],",":[91],"their":[93],"increased":[94],"intratumoral":[95],"abundance":[96],"was":[97,131],"independently":[98],"associated":[99],"poorer":[101],"overall":[102],"survival.":[103],"SCENIC":[104],"analysis":[105],"identified":[106],"as":[108],"top":[110],"regulon":[111],"defining":[112],"identity,":[114],"transcriptomics":[117],"revealing":[118],"SOX4\u207a":[119],"forming":[121],"an":[122,189],"immunoregulatory":[123],"barrier":[124],"at":[125,164],"tumor":[126],"margins.":[127],"This":[128],"phenotypic":[129],"identity":[130],"robustly":[132],"induced":[133],"hypoxic":[136],"microenvironment":[137],"TCR":[139],"stimulation":[140],"a":[142,203,214],"well-established":[143],"murine":[144],"OC":[145],"model.":[146],"Mechanistically,":[147],"transactivated":[149],"MT1X":[150],"promote":[152],"mitochondrial":[153],"fitness":[154],"OXPHOS.":[156],"Consistently,":[157],"profiling":[159],"showed":[160],"reduced":[161,175],"chromatin":[162],"accessibility":[163],"OXPHOS-related":[165],"loci":[166],"following":[167],"depletion.":[169],"Furthermore,":[170],"CRISPR-Cas9-mediated":[171],"disruption":[172],"FOXP3":[176,186],"expression":[177,187],"other":[179],"suppressive":[180,208],"markers,":[181],"whereas":[182],"overexpression":[184],"enhanced":[185],"OXPHOS-dependent":[190],"manner.":[191],"Notably,":[192],"pharmacological":[193],"inhibition":[194],"OXPHOS":[196],"abolished":[197],"this":[198],"effect.":[199],"Conclusions:":[200],"is":[202],"central":[204],"regulator":[205],"function":[209],"metabolic":[211],"fitness,":[212],"representing":[213],"target":[217],"OC.":[219]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-26T00:00:00"}