{"id":"https://openalex.org/W7204190190","doi":"https://doi.org/10.3389/fcvm.2026.1912257","title":"A novel composite inflammatory\u2013metabolic index for long-term prognosis after TAVR: the modifying role of left ventricular ejection fraction","display_name":"A novel composite inflammatory\u2013metabolic index for long-term prognosis after TAVR: the modifying role of left ventricular ejection fraction","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204190190","doi":"https://doi.org/10.3389/fcvm.2026.1912257","pmid":"https://pubmed.ncbi.nlm.nih.gov/42712487","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13550165"},"language":"en","primary_location":{"id":"doi:10.3389/fcvm.2026.1912257","doi":"https://doi.org/10.3389/fcvm.2026.1912257","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1912257","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1912257/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1912257/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068513451","display_name":"Haitham Abu Khadija","orcid":"https://orcid.org/0000-0002-2336-3125","observed_orcids":["https://orcid.org/0000-0002-2336-3125"]},"institutions":[{"id":"https://openalex.org/I2800052317","display_name":"Kaplan Medical Center","ror":"https://ror.org/00t0n9020","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800052317","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Haitham Abu Khadija","raw_affiliation_strings":["Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University","institution_ids":["https://openalex.org/I2800052317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099434075","display_name":"Nizar Abu Hamdeh","orcid":"https://orcid.org/0009-0000-4209-0137","observed_orcids":["https://orcid.org/0009-0000-4209-0137","https://orcid.org/0000-0001-5675-1346"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2800052317","display_name":"Kaplan Medical Center","ror":"https://ror.org/00t0n9020","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800052317","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Nizar Abu Hamdeh","raw_affiliation_strings":["Department of Internal Medicine B, Kaplan Medical Center and Faculty of Medicine, Hebrew University of Jerusalem"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine B, Kaplan Medical Center and Faculty of Medicine, Hebrew University of Jerusalem","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2800052317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093079901","display_name":"Duha Najajra","orcid":"https://orcid.org/0009-0007-3561-2380","observed_orcids":["https://orcid.org/0009-0007-3561-2380"]},"institutions":[{"id":"https://openalex.org/I4405262615","display_name":"Palestinian Clinical Research Center","ror":"https://ror.org/049raxa23","country_code":"PS","type":"nonprofit","lineage":["https://openalex.org/I4405262615"]}],"countries":["PS"],"is_corresponding":false,"raw_author_name":"Duha Najajra","raw_affiliation_strings":["Palestinian Clinical Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Palestinian Clinical Research Center","institution_ids":["https://openalex.org/I4405262615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103097335","display_name":"Kareem Ibraheem","orcid":"https://orcid.org/0009-0007-1852-6819","observed_orcids":["https://orcid.org/0009-0007-1852-6819"]},"institutions":[{"id":"https://openalex.org/I4405262615","display_name":"Palestinian Clinical Research Center","ror":"https://ror.org/049raxa23","country_code":"PS","type":"nonprofit","lineage":["https://openalex.org/I4405262615"]}],"countries":["PS"],"is_corresponding":false,"raw_author_name":"Kareem Ibraheem","raw_affiliation_strings":["Palestinian Clinical Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Palestinian Clinical Research Center","institution_ids":["https://openalex.org/I4405262615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120705834","display_name":"Jebrin Alkrinawi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800052317","display_name":"Kaplan Medical Center","ror":"https://ror.org/00t0n9020","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800052317","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Jebrin Alkrinawi","raw_affiliation_strings":["Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University","institution_ids":["https://openalex.org/I2800052317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025397753","display_name":"Osama Hroub","orcid":"https://orcid.org/0009-0006-6889-2932","observed_orcids":["https://orcid.org/0009-0006-6889-2932"]},"institutions":[{"id":"https://openalex.org/I4405262615","display_name":"Palestinian Clinical Research Center","ror":"https://ror.org/049raxa23","country_code":"PS","type":"nonprofit","lineage":["https://openalex.org/I4405262615"]}],"countries":["PS"],"is_corresponding":false,"raw_author_name":"Osama Hroub","raw_affiliation_strings":["Palestinian Clinical Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Palestinian Clinical Research Center","institution_ids":["https://openalex.org/I4405262615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119816976","display_name":"Yahya Z. Fraitekh","orcid":"https://orcid.org/0009-0009-9804-9753","observed_orcids":["https://orcid.org/0009-0009-9804-9753"]},"institutions":[{"id":"https://openalex.org/I4405262615","display_name":"Palestinian Clinical Research Center","ror":"https://ror.org/049raxa23","country_code":"PS","type":"nonprofit","lineage":["https://openalex.org/I4405262615"]}],"countries":["PS"],"is_corresponding":false,"raw_author_name":"Yahya Z. Fraitekh","raw_affiliation_strings":["Palestinian Clinical Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Palestinian Clinical Research Center","institution_ids":["https://openalex.org/I4405262615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121058020","display_name":"Mohammad Masu'd","orcid":"https://orcid.org/0009-0003-1359-6982","observed_orcids":["https://orcid.org/0009-0003-1359-6982"]},"institutions":[{"id":"https://openalex.org/I4405262615","display_name":"Palestinian Clinical Research Center","ror":"https://ror.org/049raxa23","country_code":"PS","type":"nonprofit","lineage":["https://openalex.org/I4405262615"]}],"countries":["PS"],"is_corresponding":false,"raw_author_name":"Mohammad Masu'd","raw_affiliation_strings":["Palestinian Clinical Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Palestinian Clinical Research Center","institution_ids":["https://openalex.org/I4405262615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068557660","display_name":"Abdalaziz Darwish","orcid":"https://orcid.org/0000-0002-3231-3672","observed_orcids":["https://orcid.org/0000-0002-3231-3672"]},"institutions":[{"id":"https://openalex.org/I4405262615","display_name":"Palestinian Clinical Research Center","ror":"https://ror.org/049raxa23","country_code":"PS","type":"nonprofit","lineage":["https://openalex.org/I4405262615"]}],"countries":["PS"],"is_corresponding":false,"raw_author_name":"Abdalaziz Darwish","raw_affiliation_strings":["Palestinian Clinical Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Palestinian Clinical Research Center","institution_ids":["https://openalex.org/I4405262615"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5092456547","display_name":"Mohammad Alnees","orcid":"https://orcid.org/0000-0002-5577-8499","observed_orcids":["https://orcid.org/0000-0002-5577-8499"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2800052317","display_name":"Kaplan Medical Center","ror":"https://ror.org/00t0n9020","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800052317","https://openalex.org/I64767286"]},{"id":"https://openalex.org/I4405262615","display_name":"Palestinian Clinical Research Center","ror":"https://ror.org/049raxa23","country_code":"PS","type":"nonprofit","lineage":["https://openalex.org/I4405262615"]}],"countries":["IL","PS","US"],"is_corresponding":true,"raw_author_name":"Mohammad Alnees","raw_affiliation_strings":["Department of Internal Medicine B, Kaplan Medical Center and Faculty of Medicine, Hebrew University of Jerusalem","Palestinian Clinical Research Center","Postgraduate Medical Education, Global Clinical Scholar Research Training Program, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine B, Kaplan Medical Center and Faculty of Medicine, Hebrew University of Jerusalem","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2800052317"]},{"raw_affiliation_string":"Palestinian Clinical Research Center","institution_ids":["https://openalex.org/I4405262615"]},{"raw_affiliation_string":"Postgraduate Medical Education, Global Clinical Scholar Research Training Program, Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5092456547"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I197251160","https://openalex.org/I2800052317","https://openalex.org/I4405262615"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"1912257","last_page":"1912257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcatheter-aortic-valve-replacement","display_name":"transcatheter aortic valve implantation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.6119999885559082},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/metabolic-dysfunction","display_name":"metabolic dysfunction","score":0.7519999742507935},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.9869999885559082},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.9369999766349792},{"id":"https://openalex.org/keywords/long-term-prognosis","display_name":"long-term prognosis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8289999961853027},{"id":"https://openalex.org/keywords/aortic-stenosis","display_name":"aortic stenosis","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.9161999821662903},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8877999782562256},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7732999920845032},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7434999942779541},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5785999894142151},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5764999985694885},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5151000022888184},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.4401000142097473},{"id":"https://openalex.org/C2993376042","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricular function","level":2,"score":0.4235000014305115},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4115000069141388},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.40799999237060547},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.4004000127315521},{"id":"https://openalex.org/C2780026749","wikidata":"https://www.wikidata.org/wiki/Q7912830","display_name":"Valve replacement","level":3,"score":0.3862000107765198},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.37439998984336853},{"id":"https://openalex.org/C2780714102","wikidata":"https://www.wikidata.org/wiki/Q616071","display_name":"Aortic valve","level":2,"score":0.3472999930381775},{"id":"https://openalex.org/C2776570981","wikidata":"https://www.wikidata.org/wiki/Q4413093","display_name":"Aortic valve replacement","level":3,"score":0.32120001316070557},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.28610000014305115},{"id":"https://openalex.org/C2781414266","wikidata":"https://www.wikidata.org/wiki/Q531019","display_name":"Aortic valve stenosis","level":3,"score":0.2547999918460846}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcvm.2026.1912257","doi":"https://doi.org/10.3389/fcvm.2026.1912257","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1912257","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1912257/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13550165","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13550165/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13550165/pdf/fcvm-13-1912257.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cardiovasc Med","raw_type":"Text"},{"id":"pmid:42712487","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42712487","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cardiovascular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7919c8e3d2c3494baf25e9f11f7909af","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7919c8e3d2c3494baf25e9f11f7909af","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cardiovascular Medicine, Vol 13 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcvm.2026.1912257","doi":"https://doi.org/10.3389/fcvm.2026.1912257","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1912257","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1912257/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204190190.pdf","grobid_xml":"https://content.openalex.org/works/W7204190190.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W2162255581","https://openalex.org/W2765621914","https://openalex.org/W2908277307","https://openalex.org/W3044596489","https://openalex.org/W3153799187","https://openalex.org/W3156434758","https://openalex.org/W3169726997","https://openalex.org/W3199499701","https://openalex.org/W4206066213","https://openalex.org/W4288051009","https://openalex.org/W4294844322","https://openalex.org/W4318833910","https://openalex.org/W4383532047","https://openalex.org/W4385568258","https://openalex.org/W4391315627","https://openalex.org/W4399873197","https://openalex.org/W4399884542","https://openalex.org/W4400763964","https://openalex.org/W4401843526","https://openalex.org/W4402406665","https://openalex.org/W4403533896","https://openalex.org/W4403897260","https://openalex.org/W4404590035","https://openalex.org/W4406314310","https://openalex.org/W4408300432","https://openalex.org/W4411866741","https://openalex.org/W4413035236","https://openalex.org/W4416583772","https://openalex.org/W4416642370","https://openalex.org/W4416743816","https://openalex.org/W4417277556"],"related_works":["https://openalex.org/W2037301127","https://openalex.org/W3095058697","https://openalex.org/W2762816634","https://openalex.org/W7127601481","https://openalex.org/W4402669364","https://openalex.org/W4282918816","https://openalex.org/W2942487979","https://openalex.org/W3207663787","https://openalex.org/W4400102411","https://openalex.org/W2412995169"],"abstract_inverted_index":{"Background":[0],"Metabolic":[1],"dysfunction":[2],"and":[3,49,54,82,114,128,169,189],"systemic":[4],"inflammation":[5],"are":[6],"increasingly":[7],"recognized":[8],"as":[9,130,294],"important":[10],"determinants":[11],"of":[12,74,112,271,319],"outcomes":[13,51],"after":[14,52],"transcatheter":[15],"aortic":[16],"valve":[17,115,172],"replacement":[18],"(TAVR).":[19],"However,":[20],"whether":[21,57],"their":[22],"prognostic":[23],"impact":[24],"differs":[25],"according":[26,88,105],"to":[27,55,89,106,163],"baseline":[28,58,90],"left":[29,59],"ventricular":[30,60],"systolic":[31],"function":[32],"remains":[33],"unclear.":[34],"Objectives":[35],"To":[36,95],"evaluate":[37,164],"the":[38,41,165],"association":[39,166],"between":[40,79,167,207],"TyG\u2013SII":[42],"composite":[43],"index":[44],"(TSI),":[45],"an":[46],"inflammatory\u2013metabolic":[47,292],"biomarker,":[48],"long-term":[50,170,269,302,317],"TAVR":[53,78],"determine":[56],"ejection":[61],"fraction":[62],"(LVEF)":[63],"modifies":[64],"this":[65,322],"association.":[66],"Methods":[67],"We":[68],"conducted":[69],"a":[70,98,131,267,315],"retrospective":[71],"cohort":[72,102,156],"study":[73],"patients":[75,183,230,288],"who":[76],"underwent":[77],"December":[80],"2015":[81],"March":[83],"2025.":[84],"Patients":[85,261],"were":[86],"stratified":[87,148],"LVEF":[91,168,185,194,208,232,249,264,310],"(\u226440%":[92],"vs.":[93],">40%).":[94],"reduce":[96],"confounding,":[97],"1:4":[99,153],"exact":[100],"matched":[101,155,275],"was":[103,122,141,161,223,298,311],"constructed":[104],"sex,":[107],"age":[108],"category,":[109],"calendar":[110],"period":[111],"TAVR,":[113,290],"type":[116],"(":[117,157],"n":[118,158],"=":[119,159,212,242,259,284],"646).":[120],"TSI":[121,222],"calculated":[123],"from":[124],"pre-procedural":[125],"laboratory":[126],"values":[127],"analyzed":[129],"continuous":[132],"standardized":[133,221],"variable":[134],"(per":[135],"1-SD":[136,218],"increase).":[137],"Long-term":[138],"all-cause":[139],"mortality":[140,228,303],"assessed":[142],"using":[143],"Cox":[144],"proportional":[145],"hazards":[146],"models":[147],"by":[149,296],"LVEF.":[150,308],"A":[151],"separate":[152],"time-dependent":[154],"224)":[160],"used":[162],"hemodynamic":[171],"deterioration":[173],"(HVD).":[174],"Results":[175],"During":[176],"follow-up,":[177],"187":[178],"deaths":[179],"occurred:":[180],"51":[181],"among":[182,191,229,246,304],"with":[184,193,226,231,248,262,274,301,306,314],"\u2264":[186,233],"40%":[187,196,234,251],"(33.3%)":[188],"136":[190],"those":[192,247,305],">":[195,250],"(27.6%).":[197],"Kaplan\u2013Meier":[198],"analysis":[199],"showed":[200],"no":[201],"significant":[202],"difference":[203],"in":[204,220,327],"overall":[205],"survival":[206],"groups":[209],"(log-rank":[210],"p":[211,283],"0.225).":[213],"In":[214,287],"multivariable":[215],"analyses,":[216],"each":[217],"increase":[219],"independently":[224,299],"associated":[225,300,313],"higher":[227,268,316],"(adjusted":[235,252,277],"HR,":[236,253,278],"1.38;":[237],"95%":[238,255,280],"CI,":[239,256,281],"1.10\u20131.73;":[240],"P":[241,258],"0.005),":[243],"but":[244],"not":[245],"1.02;":[254],"0.84\u20131.24;":[257],"0.818).":[260],"reduced":[263,307],"also":[265,312],"exhibited":[266],"risk":[270,318],"HVD":[272],"compared":[273],"controls":[276],"1.71,":[279],"1.00\u20132.91,":[282],"0.048).":[285],"Conclusions":[286],"undergoing":[289],"greater":[291],"burden,":[293],"reflected":[295],"TSI,":[297],"Reduced":[309],"HVD;":[320],"however,":[321],"exploratory":[323],"finding":[324],"requires":[325],"confirmation":[326],"larger":[328],"prospective":[329],"studies.":[330]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-26T00:00:00"}