{"id":"https://openalex.org/W7204189255","doi":"https://doi.org/10.1158/2767-9764.crc-26-0322","title":"Patient-Level KRAS G12C Prevalence among Hispanic/Latino and Non-Hispanic White Patients in Real-world Clinicogenomic Cohorts","display_name":"Patient-Level KRAS G12C Prevalence among Hispanic/Latino and Non-Hispanic White Patients in Real-world Clinicogenomic Cohorts","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204189255","doi":"https://doi.org/10.1158/2767-9764.crc-26-0322","pmid":"https://pubmed.ncbi.nlm.nih.gov/42641173"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.crc-26-0322","doi":"https://doi.org/10.1158/2767-9764.crc-26-0322","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.crc-26-0322","pdf_url":null,"source":{"id":"https://openalex.org/S4210217028","display_name":"Cancer Research Communications","issn_l":"2767-9764","issn":["2767-9764"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.crc-26-0322","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024476933","display_name":"Daniel F. Pilco\u2010Janeta","orcid":"https://orcid.org/0000-0003-3640-0498","observed_orcids":["https://orcid.org/0000-0003-3640-0498"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel F. Pilco-Janeta","raw_affiliation_strings":["1Latin American Institute of Precision Oncology (CancerLat), Quito, Ecuador","2Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0003-3640-0498","affiliations":[{"raw_affiliation_string":"1Latin American Institute of Precision Oncology (CancerLat), Quito, Ecuador","institution_ids":[]},{"raw_affiliation_string":"2Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028046017","display_name":"Myriam De la Cruz Puebla","orcid":"https://orcid.org/0000-0002-8878-0974","observed_orcids":["https://orcid.org/0000-0002-8878-0974"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210144088","display_name":"Universidad T\u00e9cnica de Ambato","ror":"https://ror.org/048nctr92","country_code":"EC","type":"education","lineage":["https://openalex.org/I4210144088"]}],"countries":["EC","US"],"is_corresponding":false,"raw_author_name":"Myriam De la Cruz-Puebla","raw_affiliation_strings":["1Latin American Institute of Precision Oncology (CancerLat), Quito, Ecuador","3Department of Internal Medicine, Health Sciences Faculty, Technical University of Ambato, Ambato, Ecuador","University of California, San Francisco (UCSF) 4 Atlantic Fellows for Equity in Brain Health, , San Francisco, California"],"raw_orcid":"https://orcid.org/0000-0002-8878-0974","affiliations":[{"raw_affiliation_string":"1Latin American Institute of Precision Oncology (CancerLat), Quito, Ecuador","institution_ids":[]},{"raw_affiliation_string":"3Department of Internal Medicine, Health Sciences Faculty, Technical University of Ambato, Ambato, Ecuador","institution_ids":["https://openalex.org/I4210144088"]},{"raw_affiliation_string":"University of California, San Francisco (UCSF) 4 Atlantic Fellows for Equity in Brain Health, , San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093219046","display_name":"Daisy R. Guam\u00e1n-Pilco","orcid":"https://orcid.org/0000-0002-9212-0872","observed_orcids":["https://orcid.org/0000-0002-9212-0872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daisy R. Guam\u00e1n-Pilco","raw_affiliation_strings":["1Latin American Institute of Precision Oncology (CancerLat), Quito, Ecuador"],"raw_orcid":"https://orcid.org/0000-0002-9212-0872","affiliations":[{"raw_affiliation_string":"1Latin American Institute of Precision Oncology (CancerLat), Quito, Ecuador","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148097189","display_name":"Diego Montenegro","orcid":"https://orcid.org/0009-0007-5656-6061","observed_orcids":["https://orcid.org/0009-0007-5656-6061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diego Montenegro","raw_affiliation_strings":["1Latin American Institute of Precision Oncology (CancerLat), Quito, Ecuador","5Department of Oncology, Oncology Institute of Eastern Bolivia, Santa Cruz, Bolivia"],"raw_orcid":"https://orcid.org/0009-0007-5656-6061","affiliations":[{"raw_affiliation_string":"1Latin American Institute of Precision Oncology (CancerLat), Quito, Ecuador","institution_ids":[]},{"raw_affiliation_string":"5Department of Oncology, Oncology Institute of Eastern Bolivia, Santa Cruz, Bolivia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5134412220","display_name":"William Miranda","orcid":"https://orcid.org/0009-0000-5342-4235","observed_orcids":["https://orcid.org/0009-0000-5342-4235"]},"institutions":[{"id":"https://openalex.org/I4210133564","display_name":"Ministerio de Salud","ror":"https://ror.org/03c09x508","country_code":"NI","type":"government","lineage":["https://openalex.org/I4210133564"]}],"countries":["NI"],"is_corresponding":true,"raw_author_name":"William Miranda","raw_affiliation_strings":["6Department of Health Services, Ministry of Public Health, Managua, Nicaragua"],"raw_orcid":"https://orcid.org/0009-0000-5342-4235","affiliations":[{"raw_affiliation_string":"6Department of Health Services, Ministry of Public Health, Managua, Nicaragua","institution_ids":["https://openalex.org/I4210133564"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5134412220"],"corresponding_institution_ids":["https://openalex.org/I4210133564"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67075021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"9","first_page":"2090","last_page":"2097"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kras-g12c","display_name":"KRAS G12C","score":0.9729999899864197},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8209999799728394},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hispanic-patients","display_name":"Hispanic patients","score":0.9929999709129333},{"id":"https://openalex.org/keywords/racial-and-ethnic-disparities","display_name":"racial and ethnic disparities","score":0.7710000276565552},{"id":"https://openalex.org/keywords/biomarker-prevalence","display_name":"biomarker prevalence","score":0.8019999861717224},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.7260000109672546},{"id":"https://openalex.org/keywords/smoking-adjustment","display_name":"smoking adjustment","score":0.7419999837875366},{"id":"https://openalex.org/keywords/real-world-data","display_name":"real-world data","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8718000054359436},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8305000066757202},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5667999982833862},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5178999900817871},{"id":"https://openalex.org/C56273599","wikidata":"https://www.wikidata.org/wiki/Q3122841","display_name":"White (mutation)","level":3,"score":0.503600001335144},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4941999912261963},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48969998955726624},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.38670000433921814},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.3165000081062317},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3052999973297119},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2524000108242035}],"mesh":[{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000095223","descriptor_name":"White","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000095223","descriptor_name":"White","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006630","descriptor_name":"Hispanic or Latino","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006630","descriptor_name":"Hispanic or Latino","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006630","descriptor_name":"Hispanic or Latino","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006630","descriptor_name":"Hispanic or Latino","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1158/2767-9764.crc-26-0322","doi":"https://doi.org/10.1158/2767-9764.crc-26-0322","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.crc-26-0322","pdf_url":null,"source":{"id":"https://openalex.org/S4210217028","display_name":"Cancer Research Communications","issn_l":"2767-9764","issn":["2767-9764"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research Communications","raw_type":"journal-article"},{"id":"pmid:42641173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42641173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13548115","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13548115/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13548115/pdf/crc-26-0322.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Res Commun","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.crc-26-0322","doi":"https://doi.org/10.1158/2767-9764.crc-26-0322","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.crc-26-0322","pdf_url":null,"source":{"id":"https://openalex.org/S4210217028","display_name":"Cancer Research Communications","issn_l":"2767-9764","issn":["2767-9764"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Reduced inequalities","score":0.5676000118255615,"id":"https://metadata.un.org/sdg/10"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8410620093345642,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322526","display_name":"Secretar\u00eda de Educaci\u00f3n Superior, Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","ror":"https://ror.org/056c6e777"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W2128339707","https://openalex.org/W2139940827","https://openalex.org/W2149441684","https://openalex.org/W2736963305","https://openalex.org/W2767162493","https://openalex.org/W2804812017","https://openalex.org/W2982321167","https://openalex.org/W3109420156","https://openalex.org/W3120172300","https://openalex.org/W3127560436","https://openalex.org/W3135378412","https://openalex.org/W3172081492","https://openalex.org/W3216593905","https://openalex.org/W3217485783","https://openalex.org/W4200034683","https://openalex.org/W4281650778","https://openalex.org/W4285077014","https://openalex.org/W4297329383","https://openalex.org/W4319826818","https://openalex.org/W4384023329","https://openalex.org/W4386787976","https://openalex.org/W4399803133","https://openalex.org/W4400882553","https://openalex.org/W4404105438","https://openalex.org/W7117148233"],"related_works":[],"abstract_inverted_index":{"KRAS":[0,26,83,98,187,232],"G12C":[1,27,84,99,188,233],"is":[2],"a":[3,212],"treatment-defining":[4],"biomarker":[5,254],"in":[6,20,86,103,108,148,220,257,269],"non-small":[7],"cell":[8],"lung":[9,13,89,96,170,194,258],"cancer":[10],"(NSCLC),":[11],"particularly":[12],"adenocarcinoma.":[14],"Hispanic/Latino":[15],"(H/L)":[16],"patients":[17,107,183,192,217,239],"remain":[18,218],"undercharacterized":[19,219],"precision":[21,222],"oncology":[22,223,271],"datasets,":[23],"and":[24,46,91,125,145,206,237,246,260],"patient-level":[25,82,186],"prevalence":[28,85,100,189,234],"has":[29],"not":[30,146],"been":[31],"consistently":[32],"quantified":[33],"using":[34,240],"strict":[35,241],"ethnicity":[36],"definitions.":[37],"We":[38],"analyzed":[39],"MSK-CHORD":[40,109,149,169],"as":[41],"the":[42,56,176],"initial":[43],"reference":[44],"cohort":[45],"American":[47],"Association":[48],"for":[49,173],"Cancer":[50,60],"Research":[51],"(AACR)":[52],"GENIE":[53,126,159],"after":[54,208],"excluding":[55],"Memorial":[57],"Sloan":[58],"Kattering":[59],"Center":[61],"contributing":[62],"center.":[63],"H/L":[64,104,182,216,236],"required":[65,72],"explicit":[66,76],"H/L-origin":[67],"annotation;":[68],"non-Hispanic":[69,77],"White":[70,73],"(NH-W)":[71],"race":[74],"with":[75,193],"ethnicity.":[78],"Primary":[79],"analyses":[80],"compared":[81],"mutually":[87],"exclusive":[88],"adenocarcinoma":[90,93,140,195,259],"non-lung":[92,139],"NSCLC.":[94],"In":[95,138,168],"adenocarcinoma,":[97,171],"was":[101,203],"lower":[102,185],"than":[105,190],"NH-W":[106,191,238],"[7.9%":[110],"vs.":[111,128,151,161],"15.4%;":[112],"odds":[113],"ratio":[114],"(OR),":[115],"0.47;":[116],"95%":[117,132],"confidence":[118],"interval":[119],"(CI),":[120],"0.30-0.74;":[121],"P":[122,135,155,165],"<":[123,136],"0.001]":[124],"(7.2%":[127],"15.1%;":[129],"OR,":[130,153,163],"0.44;":[131],"CI,":[133],"0.33-0.58;":[134],"0.0001).":[137],"NSCLC,":[141],"differences":[142],"were":[143],"smaller":[144],"significant":[147],"(4.8%":[150],"5.1%;":[152],"0.94;":[154],"=":[156,166],"1)":[157],"or":[158],"(4.9%":[160],"6.7%;":[162],"0.73;":[164],"0.461).":[167],"adjustment":[172],"smoking":[174,209],"shifted":[175],"OR":[177],"from":[178],"0.50":[179],"to":[180],"0.68.":[181],"had":[184],"across":[196],"two":[197,247],"real-world":[198,221,270],"clinicogenomic":[199,249],"cohorts.":[200,250],"The":[201],"finding":[202],"histology":[204],"specific":[205],"attenuated":[207],"adjustment,":[210],"supporting":[211],"biomarker-yield":[213],"interpretation.":[214],"SIGNIFICANCE:":[215],"datasets.":[224,272],"This":[225],"study":[226],"provides":[227],"patient-level,":[228],"histology-specific":[229],"estimates":[230],"of":[231,266],"among":[235],"race/ethnicity":[242],"definitions,":[243],"coverage-aware":[244],"denominators,":[245],"large":[248],"These":[251],"findings":[252],"inform":[253],"screening":[255],"yield":[256],"support":[261],"more":[262],"rigorous,":[263],"population-aware":[264],"evaluation":[265],"actionable":[267],"alterations":[268]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2026-08-26T00:00:00"}