{"id":"https://openalex.org/W7204180809","doi":"https://doi.org/10.3791/72266","title":"A Mechanical Acupuncture Instrument for Reproducible Vibratory Stimulation of Acupuncture Points in Rats","display_name":"A Mechanical Acupuncture Instrument for Reproducible Vibratory Stimulation of Acupuncture Points in Rats","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204180809","doi":"https://doi.org/10.3791/72266","pmid":"https://pubmed.ncbi.nlm.nih.gov/42644542"},"language":"en","primary_location":{"id":"doi:10.3791/72266","doi":"https://doi.org/10.3791/72266","is_oa":false,"landing_page_url":"https://doi.org/10.3791/72266","pdf_url":null,"source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101654154","display_name":"Kwang\u2010Ho Choi","orcid":"https://orcid.org/0000-0002-8594-1189","observed_orcids":["https://orcid.org/0000-0002-8594-1189"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwang-Ho Choi","raw_affiliation_strings":["KM Science Research Division, Korea Institute of Oriental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KM Science Research Division, Korea Institute of Oriental Medicine","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029495589","display_name":"Suchan Chang","orcid":"https://orcid.org/0000-0002-6890-9769","observed_orcids":["https://orcid.org/0000-0002-6890-9769"]},"institutions":[{"id":"https://openalex.org/I138826464","display_name":"Daegu Haany University","ror":"https://ror.org/045wr3278","country_code":"KR","type":"education","lineage":["https://openalex.org/I138826464"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Suchan Chang","raw_affiliation_strings":["Department of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu","institution_ids":["https://openalex.org/I138826464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148085204","display_name":"Suhyun Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Suhyun Kim","raw_affiliation_strings":["KM Science Research Division, Korea Institute of Oriental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KM Science Research Division, Korea Institute of Oriental Medicine","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101629794","display_name":"Seong Jin Cho","orcid":"https://orcid.org/0000-0003-4640-7407","observed_orcids":["https://orcid.org/0000-0003-4640-7407"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seong Jin Cho","raw_affiliation_strings":["KM Science Research Division, Korea Institute of Oriental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KM Science Research Division, Korea Institute of Oriental Medicine","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043514285","display_name":"Sun Hee Yeon","orcid":"https://orcid.org/0000-0003-3078-4419","observed_orcids":["https://orcid.org/0000-0003-3078-4419"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sun Hee Yeon","raw_affiliation_strings":["KM Science Research Division, Korea Institute of Oriental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KM Science Research Division, Korea Institute of Oriental Medicine","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030244272","display_name":"Guanghai Nan","orcid":"https://orcid.org/0000-0001-8238-6899","observed_orcids":["https://orcid.org/0000-0001-8238-6899"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Guanghai Nan","raw_affiliation_strings":["Department of Physiology, Yonsei University College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Yonsei University College of Medicine","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148111570","display_name":"Hee Young Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee Young Kim","raw_affiliation_strings":["Department of Physiology, Yonsei University College of Medicine; vet202001@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Yonsei University College of Medicine; vet202001@gmail.com","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009886562","display_name":"Yeonhee Ryu","orcid":"https://orcid.org/0000-0001-7953-7094","observed_orcids":["https://orcid.org/0000-0001-7953-7094","https://orcid.org/0000-0002-8055-4956"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeonhee Ryu","raw_affiliation_strings":["KM Science Research Division, Korea Institute of Oriental Medicine; yhryu@kiom.re.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KM Science Research Division, Korea Institute of Oriental Medicine; yhryu@kiom.re.kr","institution_ids":["https://openalex.org/I4210087584"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73032325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"234","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vibratory-stimulation","display_name":"vibratory stimulation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/acupuncture-points","display_name":"acupuncture points","score":0.8360000252723694},{"id":"https://openalex.org/keywords/ht7","display_name":"HT7","score":0.6890000104904175},{"id":"https://openalex.org/keywords/cocaine-induced-locomotor-activity","display_name":"cocaine-induced locomotor activity","score":0.8999999761581421},{"id":"https://openalex.org/keywords/mechanoreceptors","display_name":"mechanoreceptors","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dorsal-column-pathway","display_name":"dorsal column pathway","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mesolimbic-reward-circuitry","display_name":"mesolimbic reward circuitry","score":0.9409999847412109},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7918000221252441},{"id":"https://openalex.org/C56837625","wikidata":"https://www.wikidata.org/wiki/Q121713","display_name":"Acupuncture","level":3,"score":0.5099999904632568},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4560000002384186},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4481000006198883},{"id":"https://openalex.org/C3018150462","wikidata":"https://www.wikidata.org/wiki/Q121713","display_name":"Acupuncture needle","level":4,"score":0.4408999979496002},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.37310001254081726},{"id":"https://openalex.org/C2779913722","wikidata":"https://www.wikidata.org/wiki/Q121713","display_name":"Acupuncture point","level":4,"score":0.3547999858856201},{"id":"https://openalex.org/C2910319024","wikidata":"https://www.wikidata.org/wiki/Q859031","display_name":"Physical Stimulation","level":3,"score":0.2621000111103058},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2581999897956848},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.23649999499320984}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014732","descriptor_name":"Vibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014732","descriptor_name":"Vibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015669","descriptor_name":"Acupuncture Points","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015669","descriptor_name":"Acupuncture Points","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015670","descriptor_name":"Acupuncture Therapy","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D015670","descriptor_name":"Acupuncture Therapy","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D015670","descriptor_name":"Acupuncture Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015670","descriptor_name":"Acupuncture Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026881","descriptor_name":"Acupuncture","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D026881","descriptor_name":"Acupuncture","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D026881","descriptor_name":"Acupuncture","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D026881","descriptor_name":"Acupuncture","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3791/72266","doi":"https://doi.org/10.3791/72266","is_oa":false,"landing_page_url":"https://doi.org/10.3791/72266","pdf_url":null,"source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},{"id":"pmid:42644542","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42644542","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of visualized experiments : JoVE","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5369191765785217,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Although":[0],"manual":[1],"acupuncture":[2,31,44,65,75,158],"is":[3,13],"widely":[4],"used":[5],"in":[6,22,67,122,130,160],"experimental":[7,161],"and":[8,83,99,118,149],"clinical":[9],"research,":[10],"its":[11],"application":[12],"limited":[14],"by":[15],"poor":[16],"reproducibility":[17],"resulting":[18],"from":[19],"practitioner-dependent":[20],"variability":[21],"needle":[23,45,77],"manipulation.":[24],"To":[25],"overcome":[26],"this":[27,131],"limitation,":[28],"a":[29,55,147],"mechanical":[30],"instrument":[32],"(MAI)":[33],"was":[34],"developed":[35],"to":[36,62],"deliver":[37],"controlled":[38],"vibratory":[39],"stimulation":[40,61,81,92,159],"through":[41],"an":[42],"inserted":[43],"without":[46],"the":[47,63,74,108,114,141,154],"use":[48],"of":[49,73,80,110,157],"electrical":[50],"current.":[51],"This":[52,144],"article":[53,132],"presents":[54],"standardized":[56],"protocol":[57,145],"for":[58,152],"applying":[59],"MAI":[60,91,142],"HT7":[64,94],"point":[66],"rats,":[68],"including":[69],"animal":[70,162],"preparation,":[71],"localization":[72],"point,":[76],"insertion,":[78],"configuration":[79],"parameters,":[82],"behavioral":[84],"assessment.":[85],"Representative":[86],"validation":[87,138],"studies":[88,106,139],"showed":[89],"that":[90],"at":[93],"reduced":[95],"cocaine-induced":[96],"locomotor":[97],"activity":[98],"preferentially":[100],"activated":[101],"mechanoreceptor-associated":[102],"A-fiber":[103],"pathways.":[104],"Further":[105],"confirmed":[107],"involvement":[109],"peripheral":[111],"ulnar":[112],"afferents,":[113],"dorsal":[115],"column":[116],"pathway,":[117],"mesolimbic":[119],"reward":[120],"circuitry":[121],"mediating":[123],"these":[124],"effects.":[125],"The":[126],"representative":[127],"results":[128],"presented":[129],"are":[133],"based":[134],"on":[135],"previously":[136],"published":[137],"using":[140],"platform.":[143],"provides":[146],"reproducible":[148],"quantitative":[150],"method":[151],"investigating":[153],"neurophysiological":[155],"mechanisms":[156],"models.":[163]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2026-08-26T00:00:00"}