{"id":"https://openalex.org/W7204180601","doi":"https://doi.org/10.1186/isrctn82977551","title":"Levothyroxine and liothyronine combination therapy in patients with hypothyroidism and persistent symptoms","display_name":"Levothyroxine and liothyronine combination therapy in patients with hypothyroidism and persistent symptoms","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204180601","doi":"https://doi.org/10.1186/isrctn82977551"},"language":"en","primary_location":{"id":"doi:10.1186/isrctn82977551","doi":"https://doi.org/10.1186/isrctn82977551","is_oa":false,"landing_page_url":"https://doi.org/10.1186/isrctn82977551","pdf_url":null,"source":{"id":"https://openalex.org/S4363604101","display_name":"http://isrctn.com/","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"http://isrctn.com/","raw_type":"dataset"},"volume":null,"type":"study-registration","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033746080","display_name":"Katy A. Sanchez-Pozos","orcid":"https://orcid.org/0000-0002-8234-8291","observed_orcids":["https://orcid.org/0000-0002-8234-8291"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Katy Sanchez Pozos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033746080"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levothyroxine","display_name":"levothyroxine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/liothyronine","display_name":"liothyronine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/combination-thyroid-hormone-therapy","display_name":"combination thyroid hormone therapy","score":0.8999999761581421},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.9929999709129333},{"id":"https://openalex.org/keywords/thyroid-hormone-replacement-therapy","display_name":"thyroid hormone replacement","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.85589998960495},{"id":"https://openalex.org/C2775883008","wikidata":"https://www.wikidata.org/wiki/Q773449","display_name":"Levothyroxine","level":3,"score":0.7124999761581421},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.5986999869346619},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5649999976158142},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3878999948501587},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2526000142097473},{"id":"https://openalex.org/C2780101021","wikidata":"https://www.wikidata.org/wiki/Q966229","display_name":"Myxedema","level":3,"score":0.2222999930381775},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.22059999406337738},{"id":"https://openalex.org/C2778696486","wikidata":"https://www.wikidata.org/wiki/Q11835644","display_name":"Thyroiditis","level":3,"score":0.21539999544620514}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/isrctn82977551","doi":"https://doi.org/10.1186/isrctn82977551","is_oa":false,"landing_page_url":"https://doi.org/10.1186/isrctn82977551","pdf_url":null,"source":{"id":"https://openalex.org/S4363604101","display_name":"http://isrctn.com/","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"http://isrctn.com/","raw_type":"dataset"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6941037479","https://openalex.org/W2899755505","https://openalex.org/W4247649233","https://openalex.org/W2295311684","https://openalex.org/W1544972923","https://openalex.org/W4401967681","https://openalex.org/W3080335969","https://openalex.org/W4298210725","https://openalex.org/W4406177213","https://openalex.org/W3188452651"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-08-26T00:00:00"}