{"id":"https://openalex.org/W7204179173","doi":"https://doi.org/10.1186/s40560-026-00932-0","title":"Timing of hemoadsorption in sepsis: redefining early through mediator-guided therapy","display_name":"Timing of hemoadsorption in sepsis: redefining early through mediator-guided therapy","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204179173","doi":"https://doi.org/10.1186/s40560-026-00932-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/42642780"},"language":"en","primary_location":{"id":"doi:10.1186/s40560-026-00932-0","doi":"https://doi.org/10.1186/s40560-026-00932-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40560-026-00932-0","pdf_url":"https://link.springer.com/content/pdf/10.1186/s40560-026-00932-0.pdf","source":{"id":"https://openalex.org/S2764383928","display_name":"Journal of Intensive Care","issn_l":"2052-0492","issn":["2052-0492"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Intensive Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s40560-026-00932-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009601957","display_name":"Prit Kusirisin","orcid":"https://orcid.org/0000-0002-3885-9377","observed_orcids":["https://orcid.org/0000-0002-3885-9377"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]},{"id":"https://openalex.org/I2802209374","display_name":"King Chulalongkorn Memorial Hospital","ror":"https://ror.org/05jd2pj53","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I2802209374"]},{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Prit Kusirisin","raw_affiliation_strings":["Center of Excellence in Critical Care Nephrology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand","Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence in Critical Care Nephrology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand","institution_ids":["https://openalex.org/I158708052"]},{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]},{"raw_affiliation_string":"Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand","institution_ids":["https://openalex.org/I2802209374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021022035","display_name":"John A. Kellum","orcid":"https://orcid.org/0000-0003-1995-2653","observed_orcids":["https://orcid.org/0000-0003-1995-2653"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Kellum","raw_affiliation_strings":["Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090193164","display_name":"Nattachai Srisawat","orcid":"https://orcid.org/0000-0002-8544-8132","observed_orcids":["https://orcid.org/0000-0002-8544-8132"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]},{"id":"https://openalex.org/I2802209374","display_name":"King Chulalongkorn Memorial Hospital","ror":"https://ror.org/05jd2pj53","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I2802209374"]},{"id":"https://openalex.org/I4387154341","display_name":"Office of the Royal Society","ror":"https://ror.org/04v9gtz82","country_code":null,"type":"government","lineage":["https://openalex.org/I4387154341"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Nattachai Srisawat","raw_affiliation_strings":["Academy of Science, Royal Society of Thailand, Bangkok, Thailand. drnattachai@yahoo.com","Center of Excellence in Critical Care Nephrology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. drnattachai@yahoo.com","Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. drnattachai@yahoo.com","Division of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, 10330, Thailand. drnattachai@yahoo.com","Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. drnattachai@yahoo.com"],"raw_orcid":"https://orcid.org/0000-0002-8544-8132","affiliations":[{"raw_affiliation_string":"Academy of Science, Royal Society of Thailand, Bangkok, Thailand. drnattachai@yahoo.com","institution_ids":["https://openalex.org/I4387154341"]},{"raw_affiliation_string":"Center of Excellence in Critical Care Nephrology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. drnattachai@yahoo.com","institution_ids":["https://openalex.org/I158708052"]},{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. drnattachai@yahoo.com","institution_ids":["https://openalex.org/I158708052"]},{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, 10330, Thailand. drnattachai@yahoo.com","institution_ids":["https://openalex.org/I2802209374"]},{"raw_affiliation_string":"Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. drnattachai@yahoo.com","institution_ids":["https://openalex.org/I2802209374"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5090193164"],"corresponding_institution_ids":["https://openalex.org/I158708052","https://openalex.org/I2802209374","https://openalex.org/I4387154341"],"apc_list":{"value":2577,"currency":"USD","value_usd":2577},"apc_paid":{"value":2577,"currency":"USD","value_usd":2577},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6910946,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemadsorption","display_name":"hemoadsorption","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.9980000257492065},{"id":"https://openalex.org/keywords/extracorporeal-blood-purification","display_name":"extracorporeal blood purification","score":0.8429999947547913},{"id":"https://openalex.org/keywords/treatment-timing","display_name":"treatment timing","score":0.6919999718666077},{"id":"https://openalex.org/keywords/endotoxin-activity-assay","display_name":"endotoxin activity assay","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cytokine-adsorption","display_name":"cytokine adsorption","score":0.9950000047683716},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.7570000290870667},{"id":"https://openalex.org/keywords/hyperinflammation","display_name":"hyperinflammation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/organ-damage","display_name":"organ damage","score":0.6980000138282776},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.7990000247955322},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9334999918937683},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.6656000018119812},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6420000195503235},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6080999970436096},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5396999716758728},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5275999903678894},{"id":"https://openalex.org/C2779915274","wikidata":"https://www.wikidata.org/wiki/Q1115882","display_name":"Extracorporeal","level":2,"score":0.46650001406669617},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.4262999892234802},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.42239999771118164},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.41819998621940613},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.382999986410141},{"id":"https://openalex.org/C3018162438","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Adjunctive treatment","level":2,"score":0.33880001306533813},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32989999651908875},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.325300008058548},{"id":"https://openalex.org/C2776485726","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Rescue therapy","level":2,"score":0.3102000057697296},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.29170000553131104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28529998660087585},{"id":"https://openalex.org/C2992886853","wikidata":"https://www.wikidata.org/wiki/Q18381816","display_name":"Post hoc","level":2,"score":0.28360000252723694},{"id":"https://openalex.org/C2779559532","wikidata":"https://www.wikidata.org/wiki/Q1076369","display_name":"Cytokine storm","level":5,"score":0.2831000089645386},{"id":"https://openalex.org/C2993568657","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critical illness","level":3,"score":0.28139999508857727},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.2777000069618225},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2669999897480011},{"id":"https://openalex.org/C2780675486","wikidata":"https://www.wikidata.org/wiki/Q423765","display_name":"Polymyxin","level":3,"score":0.26339998841285706},{"id":"https://openalex.org/C3019752601","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory mediator","level":3,"score":0.26170000433921814},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.25619998574256897},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.25360000133514404},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.25049999356269836}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s40560-026-00932-0","doi":"https://doi.org/10.1186/s40560-026-00932-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40560-026-00932-0","pdf_url":"https://link.springer.com/content/pdf/10.1186/s40560-026-00932-0.pdf","source":{"id":"https://openalex.org/S2764383928","display_name":"Journal of Intensive Care","issn_l":"2052-0492","issn":["2052-0492"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Intensive Care","raw_type":"journal-article"},{"id":"pmid:42642780","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42642780","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of intensive care","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8e88aef1fdd1474b844c6dbf92a450c2","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8e88aef1fdd1474b844c6dbf92a450c2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Intensive Care, Vol 14, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13504785","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13504785/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Intensive Care","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s40560-026-00932-0","doi":"https://doi.org/10.1186/s40560-026-00932-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40560-026-00932-0","pdf_url":"https://link.springer.com/content/pdf/10.1186/s40560-026-00932-0.pdf","source":{"id":"https://openalex.org/S2764383928","display_name":"Journal of Intensive Care","issn_l":"2052-0492","issn":["2052-0492"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Intensive Care","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7193220257759094,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321557","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204179173.pdf","grobid_xml":"https://content.openalex.org/works/W7204179173.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W748993927","https://openalex.org/W1543580221","https://openalex.org/W1547961211","https://openalex.org/W1565500246","https://openalex.org/W1985903451","https://openalex.org/W1988733171","https://openalex.org/W1993825480","https://openalex.org/W2013241336","https://openalex.org/W2028636951","https://openalex.org/W2041335582","https://openalex.org/W2049355053","https://openalex.org/W2054107809","https://openalex.org/W2105981152","https://openalex.org/W2118138330","https://openalex.org/W2147608508","https://openalex.org/W2162298091","https://openalex.org/W2164990391","https://openalex.org/W2183935821","https://openalex.org/W2280404143","https://openalex.org/W2575498525","https://openalex.org/W2601331348","https://openalex.org/W2609260071","https://openalex.org/W2766417400","https://openalex.org/W2897735762","https://openalex.org/W2898599075","https://openalex.org/W2899563816","https://openalex.org/W2901255373","https://openalex.org/W2901933092","https://openalex.org/W2944988359","https://openalex.org/W2945686759","https://openalex.org/W2964667254","https://openalex.org/W2993901028","https://openalex.org/W2997859949","https://openalex.org/W2998853022","https://openalex.org/W3000121253","https://openalex.org/W3003247378","https://openalex.org/W3024752652","https://openalex.org/W3163397984","https://openalex.org/W3202024358","https://openalex.org/W3203011048","https://openalex.org/W4229005160","https://openalex.org/W4280555470","https://openalex.org/W4283014319","https://openalex.org/W4293434373","https://openalex.org/W4312600693","https://openalex.org/W4319346644","https://openalex.org/W4321596088","https://openalex.org/W4362638901","https://openalex.org/W4378348364","https://openalex.org/W4381510384","https://openalex.org/W4383817822","https://openalex.org/W4386102775","https://openalex.org/W4387780683","https://openalex.org/W4388210679","https://openalex.org/W4389793638","https://openalex.org/W4390794118","https://openalex.org/W4391608307","https://openalex.org/W4391969808","https://openalex.org/W4394853589","https://openalex.org/W4405014751","https://openalex.org/W4408345274","https://openalex.org/W4414112913","https://openalex.org/W7127053933","https://openalex.org/W7136080593","https://openalex.org/W7140087835","https://openalex.org/W7140108038","https://openalex.org/W7140125516","https://openalex.org/W7162958902","https://openalex.org/W7164298951","https://openalex.org/W7164676084"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Hemoadsorption":[1],"is":[2,30,68,188],"gaining":[3],"acceptance":[4],"as":[5],"an":[6],"adjunctive":[7],"extracorporeal":[8],"blood":[9,98],"purification":[10,99],"strategy":[11],"in":[12,33,57,75,132,163,185,190],"sepsis":[13],"and":[14,32,52,80,93,111,149,159,207],"septic":[15],"shock;":[16],"however,":[17,115],"its":[18],"clinical":[19,53],"value":[20],"remains":[21,116],"contingent":[22],"on":[23],"two":[24],"closely":[25],"linked":[26],"variables:":[27],"when":[28,106],"therapy":[29],"initiated":[31,189],"whom":[34],"it":[35],"should":[36],"be":[37],"used.":[38],"This":[39],"review":[40],"synthesizes":[41],"the":[42,123],"pathophysiological":[43],"rationale,":[44],"conceptual":[45],"models":[46],"of":[47,97,178],"mediator":[48,73,107],"removal,":[49],"available":[50],"devices,":[51],"evidence":[54,170],"for":[55,103,139],"hemoadsorption":[56,120,187],"sepsis,":[58],"with":[59,192],"particular":[60],"attention":[61],"to":[62,91],"patient":[63],"selection.":[64],"MAIN":[65],"BODY:":[66],"Sepsis":[67],"driven":[69],"by":[70,122],"a":[71,101,129,133,174,182,193,204],"self-amplifying":[72],"cascade":[74],"which":[76,186],"exogenous":[77],"pathogenic":[78],"substances":[79],"host":[81,196],"response":[82],"mediators":[83,201],"increase":[84],"rapidly,":[85],"progressively":[86],"committing":[87],"potentially":[88],"salvageable":[89],"organs":[90],"injury":[92,211],"failure.":[94],"Mechanistic":[95],"theories":[96],"provide":[100],"rationale":[102],"early":[104],"hemoadsorption,":[105],"concentrations":[108],"are":[109],"high":[110],"dysregulated.":[112],"Clinical":[113],"evidence,":[114],"limited:":[117],"polymyxin":[118],"B":[119],"guided":[121],"endotoxin":[124],"activity":[125],"assay":[126],"has":[127],"demonstrated":[128],"survival":[130],"benefit":[131],"randomized":[134,166],"trial,":[135],"whereas":[136],"supportive":[137],"findings":[138,156],"cytokine":[140],"adsorption":[141],"derive":[142],"largely":[143],"from":[144],"small":[145],"trials,":[146],"observational":[147],"cohorts,":[148],"subgroup":[150],"or":[151],"post":[152],"hoc":[153],"analyses.":[154],"These":[155],"remain":[157],"hypothesis-generating":[158],"require":[160],"prospective":[161],"validation":[162],"biomarker-enriched,":[164],"phenotype-guided":[165],"trials.":[167],"CONCLUSION:":[168],"Current":[169],"supports":[171],"moving":[172],"beyond":[173],"fixed":[175],"hours-from-onset":[176],"definition":[177],"\"early\"":[179],"treatment":[180],"toward":[181],"biological":[183],"definition,":[184],"patients":[191],"dysregulated":[194],"hyperinflammatory":[195],"response,":[197],"after":[198],"key":[199],"inflammatory":[200],"have":[202],"crossed":[203],"toxic":[205],"threshold":[206],"before":[208],"irreversible":[209],"organ":[210],"becomes":[212],"established.":[213]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2026-08-26T00:00:00"}